Development Level

Tbio 84 | 10,625
Tdark 25 | 7,003
Tchem 16 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
abnormal retina morphology 3 | 100
decreased bone mineral density 3 | 126
embryonic lethality prior to o... 3 | 148
increased circulating HDL chol... 3 | 63
abnormal bone structure 2 | 131
abnormal lens morphology 2 | 73
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
decreased rib number 2 | 59
increased circulating choleste... 2 | 53
increased exploration in new e... 2 | 56
preweaning lethality, incomple... 2 | 260
abnormal autopod morphology 1 | 1
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal clavicle morphology 1 | 5
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal digit morphology 1 | 13
abnormal eye morphology 1 | 38
abnormal heart left ventricle ... 1 | 20
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal motor capabilities/co... 1 | 4
abnormal nail morphology 1 | 7
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin coloration 1 | 18
abnormal spine curvature 1 | 7
abnormal stomach morphology 1 | 4
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thoracic vertebrae mo... 1 | 16
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
aorta stenosis 1 | 1
brachydactyly 1 | 2
cataract 1 | 26
decreased CD4-positive, CD25-p... 1 | 24
decreased CD5-positive gamma-d... 1 | 3
decreased Ly6C high monocyte n... 1 | 18
decreased NK T cell number 1 | 28
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased cardiac stroke volum... 1 | 3
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased heart left ventricle... 1 | 2
decreased heart weight 1 | 44
decreased kidney weight 1 | 7
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
embryonic lethality prior to t... 1 | 187
fusion of vertebral arches 1 | 7
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased circulating chloride... 1 | 43
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
kinked tail 1 | 3
prenatal lethality prior to he... 1 | 64
short tail 1 | 4
short tibia 1 | 82
small testis 1 | 37
straub tail 1 | 26
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 73 | 7,933
ovarian cancer 53 | 8,492
psoriasis 43 | 6,685
medulloblastoma, large-cell 37 | 6,234
lung cancer 29 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
glioblastoma 25 | 5,572
group 3 medulloblastoma 24 | 2,254
Breast cancer 22 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
Cancer 19 | 2,346
atypical teratoid / rhabdoid tumor 19 | 4,369
malignant mesothelioma 19 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
primitive neuroectodermal tumor 18 | 3,031
invasive ductal carcinoma 16 | 2,950
pancreatic cancer 14 | 2,300
group 4 medulloblastoma 13 | 1,875
non-small cell lung cancer 13 | 2,798
astrocytic glioma 12 | 2,241
lung adenocarcinoma 12 | 2,714
Multiple myeloma 11 | 1,328
colon cancer 11 | 1,475
pancreatic carcinoma 11 | 567
pediatric high grade glioma 11 | 2,712
pilocytic astrocytoma 11 | 3,086
ulcerative colitis 11 | 2,087
Carcinoma 10 | 2,147
Pick disease 10 | 1,893
Waldenstrons macroglobulinemia 10 | 765
oligodendroglioma 10 | 2,849
sonic hedgehog group medulloblastoma 10 | 1,482
subependymal giant cell astrocytoma 10 | 2,287
astrocytoma 9 | 1,493
non primary Sjogren syndrome sicca 9 | 840
pituitary cancer 9 | 1,972
Fanconi's anemia 8 | 50
adrenocortical carcinoma 8 | 1,427
diabetes mellitus 8 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Atopic dermatitis 7 | 944
Rheumatoid Arthritis 7 | 1,171
ductal carcinoma in situ 7 | 1,745
ependymoma 7 | 2,514
hepatocellular carcinoma 7 | 550
interstitial cystitis 7 | 2,299
juvenile dermatomyositis 7 | 1,189
nasopharyngeal carcinoma 7 | 1,056
posterior fossa group B ependymoma 7 | 1,530
tuberculosis 7 | 1,563
tuberculosis and treatment for 6 months 7 | 686
Cockayne syndrome 6 | 54
Xeroderma pigmentosum 6 | 41
acute quadriplegic myopathy 6 | 1,157
adult high grade glioma 6 | 2,148
atypical teratoid/rhabdoid tumor 6 | 1,095
cutaneous lupus erythematosus 6 | 1,056
dermatomyositis 6 | 967
primary Sjogren syndrome 6 | 789
progressive supranuclear palsy 6 | 674
Aicardi-Goutieres syndrome 5 | 18
Bloom syndrome 5 | 30
Neurodegenerative disease 5 | 383
Peripheral Neuropathy 5 | 303
Prostatic Neoplasms 5 | 471
breast carcinoma 5 | 1,614
gastric cancer 5 | 436
lung carcinoma 5 | 2,844
posterior fossa group A ependymoma 5 | 1,511
spina bifida 5 | 1,064
Connective tissue disease 4 | 59
Endometriosis 4 | 535
IGA Glomerulonephritis 4 | 454
Lynch syndrome 4 | 35
Photosensitive trichothiodystrophy 4 | 24
Seckel syndrome 4 | 35
Werner syndrome 4 | 29
acute myeloid leukemia 4 | 785
aldosterone-producing adenoma 4 | 664
cystic fibrosis 4 | 1,670
systemic lupus erythematosus 4 | 172
Chronic progressive external ophthalmoplegia 3 | 18
Colorectal Neoplasms 3 | 217
Crohn's disease 3 | 304
Dyskeratosis congenita 3 | 24
Intellectual disability 3 | 573
Liver carcinoma 3 | 217
Lupus Erythematosus, Systemic 3 | 73
Neoplasm Metastasis 3 | 138
Perlman syndrome 3 | 9
Prostate cancer 3 | 172
active Crohn's disease 3 | 918
inflammatory breast cancer 3 | 404
medulloblastoma 3 | 1,524
Allergic hypersensitivity disease 2 | 123
Alzheimer's disease 2 | 644
Male infertility 2 | 170
fibroadenoma 2 | 557
mucosa-associated lymphoid tissue lymphoma 2 | 480
nephrosclerosis 2 | 329

Tissue

Nervous System 115 | 18,561
Cardiovascular System 114 | 17,958
Endocrine System 114 | 18,512
Male tissues 114 | 17,969
Blood and immune system 113 | 17,995
Digestive Tract 113 | 18,473
Female tissues 113 | 18,647
Liver and Pancreas 113 | 18,136
Respiratory system 113 | 17,484
Skin and soft tissues 113 | 18,115
Urinary Tract 113 | 18,444

Target Family

Enzyme 101 | 4,146
Non-IDG 23 | 11,969
Epigenetic 1 | 242
Kinase 1 | 634

UniProt Keyword

Nuclease 126 | 126
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
PAB-dependent poly(A)-specific ribonuclease subunit PAN2 PAN2 Tbio Enzyme -0.60206 3.89 74
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.03905 126.5 179
Crossover junction endonuclease MUS81 MUS81 Tbio Enzyme -2.03597 106.6 73
Mitochondrial genome maintenance exonuclease 1 MGME1 Tbio Enzyme -0.86557 7.27 37
Apoptosis-enhancing nuclease AEN Tbio Enzyme -1.57962 38.5 48
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.47978 31.8 25
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.13819 136.3 864
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.13927 142.2 263
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.44060 2815.1 550