Development Level

Tbio 26 | 11,445
Tdark 3 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal pericardium morpholog... 1 | 26
abnormal vitreous body morphol... 1 | 10
decreased body length 1 | 101
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
exencephaly 1 | 2
impaired pupillary reflex 1 | 26
increased heart weight 1 | 62
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 19 | 8,520
Carcinoma 18 | 11,493
osteosarcoma 11 | 7,950
psoriasis 11 | 6,694
acute quadriplegic myopathy 9 | 1,158
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
medulloblastoma, large-cell 8 | 6,241
Kidney cancer 7 | 2,613
Breast cancer 6 | 3,578
breast carcinoma 6 | 1,638
Multiple myeloma 5 | 1,332
astrocytoma 5 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
Intellectual disability 4 | 1,016
diabetes mellitus 4 | 1,728
glioblastoma 4 | 5,792
non-small cell lung cancer 4 | 2,890
spina bifida 4 | 1,074
Autosomal recessive predisposition 3 | 1,442
Pick disease 3 | 1,894
Waldenstrons macroglobulinemia 3 | 765
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
oligodendroglioma 3 | 2,850
progressive supranuclear palsy 3 | 676
Acquired immunodeficiency syndrome 2 | 197
Acrofacial dysostosis 2 | 8
Amyotrophic lateral sclerosis 2 | 451
Anemia 2 | 365
Bilateral fifth finger clinodactyly 2 | 110
Blood Coagulation Disorders 2 | 42
Cleft Palate 2 | 271
Coagulation abnormalities 2 | 27
Cognitive delay 2 | 608
Curvature of little finger 2 | 110
Decreased platelet count 2 | 111
Dull intelligence 2 | 645
Dyskeratosis congenita 2 | 24
Global developmental delay 2 | 608
Hemoglobin low 2 | 124
Hemorrhagic Disorders 2 | 30
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
Short stature 2 | 531
Thrombocytopenia 2 | 197
Ullrich congenital muscular dystrophy 2 | 5
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
juvenile dermatomyositis 2 | 1,187
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
primitive neuroectodermal tumor 2 | 3,035
tuberculosis and treatment for 6 months 2 | 409
Abnormal pigmentation 1 | 25
Abnormality of female internal genitalia 1 | 13
Abnormality of the fingernails 1 | 51
Abnormality of the pharynx 1 | 19
Absent radii and thrombocytopenia 1 | 1
Anorectal Malformations 1 | 8
Aplasia/Hypoplasia of the skin 1 | 16
Aplasia/hypoplasia of the humerus 1 | 1
Bipolar I disorder 1 | 23
Bone marrow hypocellularity 1 | 20
Coxa valga deformity 1 | 22
Dysseborrheic dermatitis 1 | 13
Esophageal Stenosis 1 | 15
Gingival Diseases 1 | 19
Hyperpigmented macules 1 | 42
Hypodontia 1 | 81
Hypoplasia or unilateral/bilateral absence of ulna 1 | 3
Hypoplastic-absent toenails 1 | 11
Leukokeratosis 1 | 19
Leukoplakia, Oral 1 | 20
Patella aplasia-hypoplasia 1 | 12
Patellar aplasia 1 | 8
Periodontal Diseases 1 | 21
Radial aplasia-thrombocytopenia syndrome 1 | 1
Rough bone trabeculation 1 | 11
Shoulder muscle hypoplasia 1 | 1
Skin Ulcer 1 | 48
Systemic scleroderma 1 | 60
Taurodontism 1 | 14
Tracheoesophageal Fistula 1 | 36
Urethral Stricture 1 | 18
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Nervous System 30 | 16,725
Respiratory system 30 | 16,393
Skin and soft tissues 30 | 17,230
Cardiovascular System 29 | 15,192
Urinary Tract 29 | 16,678

Target Family

Non-IDG 22 | 12,091
Enzyme 7 | 4,145
Kinase 1 | 634

UniProt Keyword

Nonsense-mediated mRNA decay 30 | 30
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37
CBP80/20-dependent translation initiation factor CTIF Tbio Non-IDG -0.75021 5.74 44
Eukaryotic peptide chain release factor subunit 1 ETF1 Tbio Enzyme -1.75590 53.5 113
Protein SMG5 SMG5 Tbio Non-IDG -1.02024 9.67 88
mRNA-decapping enzyme 1B DCP1B Tdark Non-IDG -0.31352 1.45 115
Protein SMG7 SMG7 Tbio Non-IDG -1.17329 16.2 66