Development Level

Tbio 68 | 10,625
Tchem 10 | 1,890
Tdark 7 | 7,003
Tclin 2 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

increased or absent threshold ... 8 | 128
decreased prepulse inhibition 5 | 52
absent pinna reflex 4 | 21
decreased startle reflex 4 | 48
preweaning lethality, complete... 4 | 633
absent startle reflex 3 | 15
decreased circulating free fat... 3 | 39
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
increased circulating sodium l... 3 | 71
abnormal craniofacial morpholo... 2 | 12
abnormal ear morphology 2 | 5
abnormal embryo size 2 | 112
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
enlarged heart 2 | 111
impaired righting response 2 | 19
increased circulating chloride... 2 | 43
increased mean corpuscular hem... 2 | 93
limb grasping 2 | 35
stereotypic behavior 2 | 3
trunk curl 2 | 15
abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal clavicle morphology 1 | 5
abnormal cranium morphology 1 | 32
abnormal digestive system phys... 1 | 1
abnormal embryo turning 1 | 15
abnormal glucose homeostasis 1 | 5
abnormal heart left ventricle ... 1 | 20
abnormal locomotor activation 1 | 26
abnormal motor coordination/ b... 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal posture 1 | 5
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal sleep behavior 1 | 63
abnormal vitreous body morphol... 1 | 7
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased lean body mass 1 | 195
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
hydrops fetalis 1 | 22
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260
sclerocornea 1 | 2
small adrenal glands 1 | 15

Disease

Nonsyndromic deafness 87 | 121
Sensorineural hearing loss 38 | 107
psoriasis 38 | 6,685
ovarian cancer 35 | 8,484
osteosarcoma 32 | 7,933
medulloblastoma, large-cell 30 | 6,234
glioblastoma 23 | 5,572
pilocytic astrocytoma 23 | 3,086
Carcinoma 22 | 2,147
Hodgkin's lymphoma, nodular sclerosis 21 | 24
lung cancer 21 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,289
non-small cell lung cancer 19 | 2,798
atypical teratoid / rhabdoid tumor 18 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
lung carcinoma 18 | 2,844
Breast cancer 17 | 3,094
invasive ductal carcinoma 17 | 2,950
malignant mesothelioma 17 | 3,162
pituitary cancer 17 | 1,972
ependymoma 16 | 2,514
interstitial cystitis 16 | 2,299
primitive neuroectodermal tumor 16 | 3,031
oligodendroglioma 14 | 2,849
pediatric high grade glioma 14 | 2,712
cystic fibrosis 13 | 1,665
lung adenocarcinoma 13 | 2,713
subependymal giant cell astrocytoma 13 | 2,287
adult high grade glioma 12 | 2,148
Cancer 11 | 2,346
astrocytoma 11 | 1,493
ductal carcinoma in situ 11 | 1,745
pancreatic cancer 11 | 2,300
ulcerative colitis 11 | 2,087
breast carcinoma 10 | 1,614
group 3 medulloblastoma 10 | 2,254
nasopharyngeal carcinoma 10 | 1,056
posterior fossa group B ependymoma 10 | 1,530
spina bifida 10 | 1,064
astrocytic glioma 9 | 2,241
colon cancer 9 | 1,475
Deafness 8 | 18
Usher syndrome 8 | 34
group 4 medulloblastoma 8 | 1,875
medulloblastoma 8 | 1,524
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,557
Neuropathy 7 | 210
Retinitis pigmentosa 7 | 153
Rheumatoid Arthritis 7 | 1,160
atypical teratoid/rhabdoid tumor 7 | 1,095
primary pancreatic ductal adenocarcinoma 7 | 1,271
adrenocortical carcinoma 6 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Atopic dermatitis 5 | 944
Blindness 5 | 84
Down syndrome 5 | 548
Epilepsy 5 | 346
Pick disease 5 | 1,893
acute quadriplegic myopathy 5 | 1,157
esophageal adenocarcinoma 5 | 737
fibroadenoma 5 | 557
posterior fossa group A ependymoma 5 | 1,511
Endometriosis 4 | 535
Enlarged vestibular aqueduct 4 | 10
Multiple Sclerosis 4 | 498
Sensorineural Hearing Loss (disorder) 4 | 11
acute myeloid leukemia 4 | 780
dermatomyositis 4 | 933
juvenile dermatomyositis 4 | 1,189
non primary Sjogren syndrome sicca 4 | 840
Animal Mammary Neoplasms 3 | 136
Asthma 3 | 349
Clouston syndrome 3 | 9
Craniofacial Abnormalities 3 | 147
DEAFNESS, AUTOSOMAL RECESSIVE 1A (disorder) 3 | 3
Duchenne muscular dystrophy 3 | 602
Erythrokeratodermia variabilis 3 | 10
Intellectual disability 3 | 573
Kidney disease 3 | 396
Liver carcinoma 3 | 217
Mammary Neoplasms, Experimental 3 | 150
Multiple myeloma 3 | 1,327
Neoplasm Invasiveness 3 | 127
Neurodegenerative disease 3 | 383
Palmoplantar keratosis 3 | 36
Prostatic Neoplasms 3 | 471
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 664
cutaneous lupus erythematosus 3 | 1,056
diabetes mellitus 3 | 1,663
facioscapulohumeral dystrophy 3 | 286
gastric carcinoma 3 | 832
hearing impairment 3 | 40
mucosa-associated lymphoid tissue lymphoma 3 | 480
non diabetic and post-ischemic heart failure 3 | 200
non-small cell lung carcinoma 3 | 413
progressive supranuclear palsy 3 | 674
Myocardial Ischemia 2 | 169

Tissue

Digestive Tract 87 | 18,473
Endocrine System 87 | 18,512
Female tissues 87 | 18,647
Urinary Tract 87 | 18,444
Nervous System 86 | 18,561
Liver and Pancreas 85 | 18,136
Cardiovascular System 84 | 17,958
Skin and soft tissues 84 | 18,115
Blood and immune system 82 | 17,995
Male tissues 82 | 17,969
Respiratory system 82 | 17,484

Target Family

Non-IDG 58 | 11,971
Enzyme 13 | 4,146
Ion Channel 4 | 341
Transcription Factor 4 | 1,400
Kinase 3 | 634
Transporter 3 | 473
GPCR 1 | 406
Nuclear Receptor 1 | 48

UniProt Keyword

Non-syndromic deafness 87 | 87
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Stereocilin STRC Tbio Non-IDG 35.9 7
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Otoancorin OTOA Tdark Non-IDG -1.29628 19.3 48
Vesicular glutamate transporter 3 SLC17A8 Tbio Transporter -1.97274 103.1 38
Transmembrane O-methyltransferase LRTOMT Tbio Enzyme 13.4 29
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
Radixin RDX Tbio Non-IDG -2.45592 216.9 310
Collagen alpha-2(XI) chain COL11A2 Tchem Non-IDG -1.86796 68.8 95
Carcinoembryonic antigen-related cell adhesion molecule 16 CEACAM16 Tbio Non-IDG -0.73655 11.1 64