Development Level

Tbio 191 | 10,625
Tchem 39 | 1,890
Tdark 17 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, incomple... 9 | 260
preweaning lethality, complete... 8 | 633
decreased total body fat amoun... 7 | 186
abnormal behavior 6 | 226
abnormal bone structure 5 | 131
decreased circulating glucose ... 5 | 121
decreased lean body mass 5 | 195
hyperactivity 5 | 108
abnormal sleep behavior 4 | 63
decreased body weight 4 | 174
increased circulating alkaline... 4 | 119
increased lean body mass 4 | 107
abnormal gait 3 | 51
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating free fat... 3 | 39
decreased lumbar vertebrae num... 3 | 62
increased bone mineral density 3 | 52
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal lumbar vertebrae morp... 2 | 6
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased grip strength 2 | 123
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased startle reflex 2 | 48
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
enlarged kidney 2 | 7
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating glucose ... 2 | 16
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased hemoglobin content 2 | 45
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
male infertility 2 | 62
polycystic kidney 2 | 9
prenatal lethality prior to he... 2 | 64
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal ear morphology 1 | 5
abnormal embryo size 1 | 112
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
abnormal vertebrae morphology 1 | 14
corneal opacity 1 | 25
decreased NK T cell number 1 | 28
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating phosphat... 1 | 15
decreased mean corpuscular vol... 1 | 50
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
female infertility 1 | 34
hydrometra 1 | 13
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased coping response 1 | 3
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hematocrit 1 | 36
limb grasping 1 | 35
prenatal lethality 1 | 16
small testis 1 | 37

Disease

ovarian cancer 128 | 8,484
glioblastoma 127 | 5,572
medulloblastoma, large-cell 126 | 6,234
atypical teratoid / rhabdoid tumor 114 | 4,369
osteosarcoma 114 | 7,933
psoriasis 105 | 6,685
oligodendroglioma 97 | 2,849
lung cancer 85 | 4,466
pilocytic astrocytoma 84 | 3,086
ependymoma 72 | 2,514
pediatric high grade glioma 71 | 2,712
primitive neuroectodermal tumor 68 | 3,031
malignant mesothelioma 64 | 3,162
astrocytic glioma 63 | 2,241
subependymal giant cell astrocytoma 61 | 2,287
Carcinoma 60 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,289
Breast cancer 59 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
Cancer 58 | 2,346
lung carcinoma 56 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 55 | 2,956
invasive ductal carcinoma 52 | 2,950
lung adenocarcinoma 52 | 2,713
pituitary cancer 52 | 1,972
Pick disease 46 | 1,893
adult high grade glioma 46 | 2,148
non-small cell lung cancer 46 | 2,798
group 3 medulloblastoma 45 | 2,254
cystic fibrosis 43 | 1,665
group 4 medulloblastoma 42 | 1,875
Intellectual disability 40 | 573
colon cancer 40 | 1,475
sonic hedgehog group medulloblastoma 39 | 1,482
breast carcinoma 37 | 1,614
ductal carcinoma in situ 37 | 1,745
medulloblastoma 37 | 1,524
pancreatic cancer 37 | 2,300
astrocytoma 34 | 1,493
interstitial cystitis 34 | 2,299
posterior fossa group A ependymoma 34 | 1,511
Schizophrenia 28 | 501
posterior fossa group B ependymoma 28 | 1,530
tuberculosis 28 | 1,557
adrenocortical carcinoma 26 | 1,427
ulcerative colitis 25 | 2,087
spina bifida 24 | 1,064
atypical teratoid/rhabdoid tumor 23 | 1,095
Alzheimer's disease 21 | 644
juvenile dermatomyositis 21 | 1,189
diabetes mellitus 20 | 1,663
nasopharyngeal carcinoma 20 | 1,056
primary pancreatic ductal adenocarcinoma 20 | 1,271
Parkinson's disease 19 | 364
Autistic Disorder 17 | 320
dermatomyositis 17 | 933
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
Atopic dermatitis 16 | 944
cutaneous lupus erythematosus 16 | 1,056
Epilepsy 15 | 346
Rheumatoid Arthritis 15 | 1,160
active Crohn's disease 15 | 918
Multiple myeloma 14 | 1,327
Obesity 14 | 616
acute quadriplegic myopathy 14 | 1,157
aldosterone-producing adenoma 14 | 664
progressive supranuclear palsy 14 | 674
Down syndrome 13 | 548
Neurodegenerative disease 13 | 383
Duchenne muscular dystrophy 12 | 602
Lissencephaly 12 | 61
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
gastric carcinoma 12 | 832
Amyotrophic Lateral Sclerosis 11 | 431
Bipolar Disorder 11 | 266
acute myeloid leukemia 11 | 780
primary Sjogren syndrome 11 | 789
inflammatory breast cancer 10 | 404
non-small cell lung carcinoma 10 | 413
Endometriosis 9 | 535
Mammary Neoplasms 9 | 410
Neuroblastoma 9 | 78
Neuropathy 9 | 210
Vascular disease 9 | 281
Waldenstrons macroglobulinemia 9 | 765
esophageal adenocarcinoma 9 | 737
fibroadenoma 9 | 557
hereditary spastic paraplegia 9 | 313
Blastic phase chronic myeloid leukemia 8 | 58
Chronic Myelocytic Leukemia Accelerated Phase 8 | 59
Coffin-Siris syndrome 8 | 17
Craniofacial Abnormalities 8 | 147
Hirschsprung's disease 8 | 42
Prostatic Neoplasms 8 | 471
Attention deficit hyperactivity disorder 7 | 156
IGA Glomerulonephritis 7 | 454
Microcephaly 7 | 149
Toxic encephalopathy 7 | 131
active ulcerative colitis 7 | 477
tuberculosis and treatment for 6 months 7 | 686

Tissue

Endocrine System 248 | 18,512
Nervous System 248 | 18,561
Digestive Tract 247 | 18,473
Female tissues 247 | 18,647
Urinary Tract 247 | 18,444
Skin and soft tissues 244 | 18,115
Cardiovascular System 243 | 17,958
Liver and Pancreas 243 | 18,136
Blood and immune system 242 | 17,995
Male tissues 241 | 17,969
Respiratory system 232 | 17,484

Target Family

Non-IDG 126 | 11,971
Transcription Factor 55 | 1,400
Kinase 28 | 634
Enzyme 22 | 4,146
Epigenetic 11 | 242
GPCR 3 | 406
TF/Epigenetic 3 | 38
Transporter 1 | 473

UniProt Keyword

Neurogenesis 249 | 249
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Pancreas transcription factor 1 subunit alpha PTF1A Tbio Transcription Factor -2.56282 377.5 283
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282
Dynein light chain Tctex-type 1 DYNLT1 Tbio Non-IDG -2.32941 210.3 40
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
Transcription factor HES-5 HES5 Tbio Transcription Factor -2.02060 88.8 104
G-protein-signaling modulator 1 GPSM1 Tbio Non-IDG -1.32467 28.6 99
Semaphorin-3E SEMA3E Tbio Non-IDG -1.51645 40.3 201