Development Level

Tbio 206 | 11,651
Tchem 34 | 1,388
Tdark 15 | 6,593
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 9 | 298
abnormal bone structure 7 | 187
decreased total body fat amoun... 6 | 207
decreased circulating glucose ... 5 | 126
hyperactivity 5 | 148
decreased body weight 4 | 161
decreased prepulse inhibition 4 | 82
impaired glucose tolerance 4 | 75
increased circulating alkaline... 4 | 122
increased circulating triglyce... 4 | 42
increased lean body mass 4 | 172
abnormal embryo size 3 | 220
abnormal gait 3 | 69
abnormal sleep behavior 3 | 70
decreased startle reflex 3 | 75
decreased threshold for audito... 3 | 26
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
enlarged kidney 3 | 14
increased bone mineral content 3 | 108
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal coat appearance 2 | 31
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
cataract 2 | 92
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alkaline... 2 | 46
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased circulating chloride... 2 | 41
increased circulating glucose ... 2 | 24
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
increased vertical activity 2 | 24
male infertility 2 | 123
polycystic kidney 2 | 15
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal startle reflex 1 | 15
abnormal vertebrae morphology 1 | 18
decreased T cell number 1 | 15
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
increased body weight 1 | 25
increased cardiac muscle contr... 1 | 8
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased exploration in new e... 1 | 8
increased hematocrit 1 | 46
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
limb grasping 1 | 41
small testis 1 | 58
thin ventricular wall 1 | 24

Disease

Carcinoma 192 | 11,493
glioblastoma 132 | 5,792
ovarian cancer 132 | 8,520
atypical teratoid / rhabdoid tumor 131 | 5,112
medulloblastoma, large-cell 128 | 6,241
ependymoma 127 | 4,679
osteosarcoma 117 | 7,950
psoriasis 110 | 6,694
adult high grade glioma 102 | 3,801
group 3 medulloblastoma 99 | 4,104
oligodendroglioma 99 | 2,850
lung cancer 92 | 4,740
Astrocytoma, Pilocytic 84 | 3,081
astrocytic glioma 80 | 2,597
Breast cancer 77 | 3,578
Kidney cancer 75 | 2,613
primitive neuroectodermal tumor 71 | 3,035
malignant mesothelioma 70 | 3,232
subependymal giant cell astrocytoma 63 | 2,287
Cancer 61 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 60 | 3,291
Schizophrenia 59 | 1,160
lung carcinoma 58 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,955
Intellectual disability 55 | 1,016
lung adenocarcinoma 54 | 2,716
invasive ductal carcinoma 52 | 2,951
pituitary cancer 52 | 1,972
non-small cell lung cancer 51 | 2,890
Pick disease 47 | 1,894
cystic fibrosis 44 | 1,696
pancreatic cancer 42 | 2,398
breast carcinoma 41 | 1,638
colon cancer 41 | 1,478
group 4 medulloblastoma 39 | 1,855
ductal carcinoma in situ 37 | 1,745
interstitial cystitis 34 | 2,312
tuberculosis 33 | 2,010
Epilepsy 30 | 792
Bipolar Disorder 27 | 666
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
adrenocortical carcinoma 26 | 1,428
Cognitive delay 25 | 608
Global developmental delay 25 | 608
Mental and motor retardation 25 | 608
Liver cancer 24 | 604
Muscle hypotonia 24 | 571
Seizures 24 | 596
Alzheimer's disease 23 | 658
spina bifida 23 | 1,074
Parkinson's disease 22 | 392
juvenile dermatomyositis 22 | 1,187
ulcerative colitis 22 | 1,819
Small head 21 | 374
diabetes mellitus 21 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
nasopharyngeal carcinoma 20 | 1,058
Autistic Disorder 19 | 364
medulloblastoma 19 | 720
Strabismus 18 | 270
astrocytoma 18 | 1,146
pediatric high grade glioma 18 | 1,064
Atopic dermatitis 17 | 952
Autosomal recessive predisposition 17 | 1,442
Depressive disorder 17 | 409
cutaneous lupus erythematosus 17 | 1,057
dermatomyositis 17 | 966
primary pancreatic ductal adenocarcinoma 17 | 1,109
Neurodegenerative disease 16 | 414
Rheumatoid arthritis 16 | 1,191
Short stature 16 | 531
Amyotrophic lateral sclerosis 15 | 451
Melanoma 15 | 711
Mental Depression 15 | 333
Multiple myeloma 15 | 1,332
active Crohn's disease 15 | 922
progressive supranuclear palsy 15 | 676
Congenital deafness 14 | 185
Deafness 14 | 198
Hearing Loss, Partial 14 | 185
Nystagmus 14 | 317
Obesity 14 | 678
Skin cancer 14 | 469
acute quadriplegic myopathy 14 | 1,158
aldosterone-producing adenoma 14 | 665
hearing impairment 14 | 199
Cryptorchidism 13 | 296
Down syndrome 13 | 499
Lissencephaly 13 | 69
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
Duchenne muscular dystrophy 12 | 601
Orbital separation excessive 12 | 244
gastric carcinoma 12 | 807
acute myeloid leukemia 11 | 783
primary Sjogren syndrome 11 | 735

Tissue

Endocrine System 248 | 18,159
Nervous System 246 | 16,725
Digestive Tract 241 | 17,369
Skin and soft tissues 241 | 17,230
Female tissues 236 | 17,400
Blood and immune system 232 | 16,909
Male tissues 232 | 17,142
Liver and Pancreas 230 | 16,750
Urinary Tract 226 | 16,678
Respiratory system 223 | 16,393
Cardiovascular System 208 | 15,192

Target Family

Non-IDG 133 | 12,091
Transcription Factor 57 | 1,400
Kinase 28 | 634
Enzyme 23 | 4,145
Epigenetic 11 | 242
GPCR 4 | 408
TF/Epigenetic 3 | 38
Transporter 1 | 473

UniProt Keyword

Neurogenesis 260 | 260
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
RBPJ-interacting and tubulin-associated protein 1 RITA1 Tbio Non-IDG -0.85891 6.79 61
Immunoglobulin superfamily containing leucine-rich repeat protein 2 ISLR2 Tbio Non-IDG -1.71209 49.0 64
Insulinoma-associated protein 1 INSM1 Tbio Transcription Factor -2.56531 362.4 56
Basic leucine zipper and W2 domain-containing protein 2 BZW2 Tbio Non-IDG -0.20261 1.21 83
Kinase D-interacting substrate of 220 kDa KIDINS220 Tbio Enzyme -2.42897 262.3 191
Semaphorin-3C SEMA3C Tbio Non-IDG -1.95299 88.1 184
Chordin-like protein 1 CHRDL1 Tbio Non-IDG -1.99743 97.9 191
Reticulon-4-interacting protein 1, mitochondrial RTN4IP1 Tbio Enzyme -1.69878 47.3 145
Dynein assembly factor 4, axonemal DNAAF4 Tbio Non-IDG -1.67209 48.6 216