Development Level

Tbio 232 | 11,445
Tchem 62 | 1,598
Tclin 12 | 613
Tdark 12 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

preweaning lethality, complete... 31 | 979
embryonic lethality prior to o... 13 | 239
embryonic lethality prior to t... 13 | 278
abnormal behavior 12 | 298
preweaning lethality, incomple... 10 | 499
abnormal embryo size 9 | 220
decreased circulating glucose ... 8 | 126
decreased total body fat amoun... 8 | 207
abnormal bone structure 7 | 187
abnormal gait 7 | 69
decreased grip strength 7 | 116
enlarged heart 7 | 210
hyperactivity 7 | 148
increased lean body mass 7 | 172
increased total body fat amoun... 7 | 134
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
decreased hemoglobin content 6 | 68
hypoactivity 6 | 132
increased fasted circulating g... 6 | 76
decreased bone mineral density 5 | 126
decreased circulating serum al... 5 | 82
decreased fasted circulating g... 5 | 65
decreased lymphocyte cell numb... 5 | 83
increased or absent threshold ... 5 | 101
limb grasping 5 | 41
male infertility 5 | 123
abnormal retina morphology 4 | 71
abnormal seminal vesicle morph... 4 | 114
decreased bone mineral content 4 | 151
decreased erythrocyte cell num... 4 | 62
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
decreased startle reflex 4 | 75
decreased vertical activity 4 | 208
impaired glucose tolerance 4 | 75
increased blood urea nitrogen ... 4 | 48
increased body length 4 | 32
increased circulating alkaline... 4 | 122
increased circulating choleste... 4 | 66
small testis 4 | 58
tremors 4 | 39
abnormal behavioral response t... 3 | 66
abnormal skin morphology 3 | 50
cyanosis 3 | 7
decreased basophil cell number 3 | 16
decreased body length 3 | 101
decreased circulating insulin ... 3 | 76
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
decreased heart weight 3 | 27
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
increased bone mineral density 3 | 72
increased circulating amylase ... 3 | 25
increased heart weight 3 | 62
increased lymphocyte cell numb... 3 | 32
increased mean platelet volume 3 | 45
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased red blood cell distr... 3 | 34
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
thrombocytosis 3 | 27
abnormal coat-hair pigmentatio... 2 | 64
abnormal epididymis morphology 2 | 42
abnormal hair growth 2 | 10
abnormal kidney morphology 2 | 65
abnormal sleep behavior 2 | 70
cardiovascular system phenotyp... 2 | 36
decreased circulating HDL chol... 2 | 68
decreased circulating amylase ... 2 | 28
decreased circulating iron lev... 2 | 32
decreased circulating potassiu... 2 | 20
decreased leukocyte cell numbe... 2 | 73
decreased mean platelet volume 2 | 25
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
hemorrhage 2 | 23
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased circulating free fat... 2 | 20
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased heart rate 2 | 23
increased prepulse inhibition 2 | 32
increased startle reflex 2 | 112
premature death 2 | 5
prenatal lethality prior to he... 2 | 87
prolonged ST segment 2 | 36
short tibia 2 | 97
small liver 2 | 8
small thymus 2 | 16

Disease

Neurodegenerative disease 315 | 414
Carcinoma 226 | 11,493
ovarian cancer 199 | 8,520
osteosarcoma 161 | 7,950
medulloblastoma, large-cell 143 | 6,241
glioblastoma 137 | 5,792
Autosomal recessive predisposition 129 | 1,442
atypical teratoid / rhabdoid tumor 117 | 5,112
psoriasis 117 | 6,694
ependymoma 105 | 4,679
lung cancer 102 | 4,740
Neuropathy 95 | 261
group 3 medulloblastoma 92 | 4,104
adult high grade glioma 81 | 3,801
Intellectual disability 80 | 1,016
Dysarthria 79 | 192
malignant mesothelioma 79 | 3,232
oligodendroglioma 74 | 2,850
Hyperreflexia 71 | 209
Astrocytoma, Pilocytic 67 | 3,081
Epilepsy 67 | 792
astrocytic glioma 67 | 2,597
Cerebellar Ataxia 66 | 304
Kidney cancer 65 | 2,613
primitive neuroectodermal tumor 62 | 3,035
Breast cancer 60 | 3,578
hereditary spastic paraplegia 60 | 318
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
lung carcinoma 58 | 2,843
Progressive disorder 57 | 142
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,989
Congenital pes cavus 55 | 88
Pick disease 54 | 1,894
Seizures 54 | 596
Muscle Spasticity 53 | 195
Charcot-Marie-Tooth disease 52 | 62
Decreased tendon reflex 52 | 122
subependymal giant cell astrocytoma 52 | 2,287
Babinski Reflex 51 | 100
Cognitive delay 51 | 608
Global developmental delay 51 | 608
Mental and motor retardation 51 | 608
Atrophy of cerebellum 50 | 103
Cancer 50 | 2,499
Cerebellar degeneration 50 | 103
Infratentorial atrophy 50 | 103
Amyotrophic lateral sclerosis 49 | 451
Dementia 49 | 175
Dull intelligence 48 | 645
Low intelligence 48 | 645
Mental Retardation 48 | 645
Mental deficiency 48 | 645
Poor school performance 48 | 645
Slow progression 48 | 89
Absent reflex 47 | 92
Absent tendon reflex 47 | 92
Depressive disorder 47 | 409
Muscle hypotonia 47 | 571
Reflex, Deep Tendon, Absent 47 | 92
Alzheimer's disease 46 | 658
diabetes mellitus 46 | 1,728
invasive ductal carcinoma 46 | 2,951
Paraplegia 44 | 74
Parkinson's disease 44 | 392
Deglutition Disorders 41 | 132
Distal sensory impairment 41 | 52
Neurogenic Muscular Atrophy 41 | 139
Neurogenic muscle atrophy, especially in the lower limbs 41 | 139
Nystagmus 41 | 317
Skeletal muscle atrophy 41 | 139
muscle degeneration 41 | 139
non-small cell lung cancer 41 | 2,890
Cerebral atrophy 40 | 178
Distal limb muscle weakness due to peripheral neuropathy 40 | 62
Distal muscle weakness 40 | 62
Schizophrenia 40 | 1,160
tuberculosis 40 | 2,010
Distal amyotrophy 39 | 51
Multiple myeloma 39 | 1,332
Nerve Degeneration 39 | 121
astrocytoma 39 | 1,146
colon cancer 38 | 1,478
lung adenocarcinoma 38 | 2,716
Dystonia 37 | 164
Gait abnormality 37 | 135
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,962
pancreatic cancer 36 | 2,398
Spastic Paraplegia 35 | 42
dermatomyositis 34 | 966
ulcerative colitis 33 | 1,819
Optic Atrophy 32 | 242
group 4 medulloblastoma 32 | 1,855
interstitial cystitis 32 | 2,312
Neurodegenerative Disorders 31 | 79
Parkinsonian Disorders 31 | 56
Autosomal dominant cerebellar ataxia 30 | 33
Dystonic disease 30 | 106
juvenile dermatomyositis 29 | 1,187
pituitary cancer 29 | 1,972

Tissue

Endocrine System 316 | 18,159
Nervous System 314 | 16,725
Digestive Tract 313 | 17,369
Female tissues 313 | 17,400
Male tissues 313 | 17,142
Skin and soft tissues 309 | 17,230
Urinary Tract 309 | 16,678
Liver and Pancreas 308 | 16,750
Respiratory system 307 | 16,393
Blood and immune system 306 | 16,909
Cardiovascular System 299 | 15,192

Target Family

Non-IDG 178 | 12,091
Enzyme 90 | 4,145
Kinase 18 | 634
Ion Channel 11 | 344
Transporter 11 | 473
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Neurodegeneration 318 | 318
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Tubulin-specific chaperone D TBCD Tbio Non-IDG -1.71996 50.5 50
Ceroid-lipofuscinosis neuronal protein 6 CLN6 Tbio Non-IDG -1.87357 0.00000 103
Sorting nexin-14 SNX14 Tbio Non-IDG -0.86091 6.82 56
Huntingtin HTT Tchem Non-IDG -3.36282 2294.8 599
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Protein-glutamine gamma-glutamyltransferase 6 TGM6 Tchem Enzyme -2.07471 113.3 54
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Feline leukemia virus subgroup C receptor-related protein 1 FLVCR1 Tbio Non-IDG -1.54460 33.8 139
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.37125 226.3 178