Development Level

Tbio 204 | 10,625
Tchem 65 | 1,890
Tdark 12 | 7,003
Tclin 11 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
abnormal behavior 11 | 226
embryonic lethality prior to t... 9 | 187
decreased total body fat amoun... 8 | 186
embryonic lethality prior to o... 8 | 148
decreased bone mineral content 7 | 157
decreased circulating glucose ... 7 | 121
decreased lean body mass 6 | 195
hyperactivity 6 | 108
increased or absent threshold ... 6 | 128
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
decreased body length 5 | 108
decreased circulating insulin ... 5 | 75
decreased heart weight 5 | 44
decreased rib number 5 | 59
increased circulating alkaline... 5 | 119
preweaning lethality, incomple... 5 | 260
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal retina morphology 4 | 100
decreased body weight 4 | 174
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
decreased hemoglobin content 4 | 53
decreased mean corpuscular hem... 4 | 34
increased bone mineral content 4 | 92
increased circulating choleste... 4 | 53
increased mean corpuscular hem... 4 | 93
limb grasping 4 | 35
male infertility 4 | 62
short tibia 4 | 82
tremors 4 | 34
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating iron lev... 3 | 25
decreased mean corpuscular vol... 3 | 50
enlarged heart 3 | 111
impaired glucose tolerance 3 | 52
improved glucose tolerance 3 | 56
increased bone mineral density 3 | 52
increased circulating sodium l... 3 | 71
increased heart weight 3 | 37
increased lean body mass 3 | 107
increased mean corpuscular hem... 3 | 25
persistence of hyaloid vascula... 3 | 22
abnormal behavioral response t... 2 | 52
abnormal coat/hair pigmentatio... 2 | 54
abnormal coping response 2 | 12
abnormal heart left ventricle ... 2 | 20
abnormal kidney morphology 2 | 30
abnormal limb morphology 2 | 7
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal tooth morphology 2 | 24
abnormal vitreous body morphol... 2 | 7
cardiovascular system phenotyp... 2 | 35
cyanosis 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating bilirubi... 2 | 14
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating glycerol... 2 | 19
decreased circulating potassiu... 2 | 17
decreased fasted circulating g... 2 | 49
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased startle reflex 2 | 48
decreased thoracic vertebrae n... 2 | 7
decreased total retina thickne... 2 | 20
hemorrhage 2 | 12
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased circulating aspartat... 2 | 17
increased circulating bilirubi... 2 | 16
increased circulating chloride... 2 | 43
increased circulating creatini... 2 | 29
increased circulating glucose ... 2 | 16
increased effector memory CD4-... 2 | 15
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased prepulse inhibition 2 | 21
increased red blood cell distr... 2 | 21
increased sacral vertebrae num... 2 | 62
premature death 2 | 5
small liver 2 | 8
small testis 2 | 37
straub tail 2 | 26
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
abnormal neural tube closure 1 | 37

Disease

Neurodegenerative disease 290 | 383
ovarian cancer 183 | 8,484
osteosarcoma 144 | 7,933
medulloblastoma, large-cell 132 | 6,234
glioblastoma 121 | 5,572
psoriasis 108 | 6,685
atypical teratoid / rhabdoid tumor 86 | 4,369
lung cancer 84 | 4,466
Neuropathy 83 | 210
malignant mesothelioma 70 | 3,162
oligodendroglioma 69 | 2,849
pilocytic astrocytoma 65 | 3,086
pediatric high grade glioma 64 | 2,712
primitive neuroectodermal tumor 59 | 3,031
Charcot-Marie-Tooth disease 58 | 74
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,956
ependymoma 55 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,988
lung carcinoma 54 | 2,844
Pick disease 52 | 1,893
hereditary spastic paraplegia 52 | 313
astrocytoma 51 | 1,493
Carcinoma 50 | 2,147
astrocytic glioma 50 | 2,241
subependymal giant cell astrocytoma 49 | 2,287
Amyotrophic Lateral Sclerosis 48 | 431
Breast cancer 48 | 3,094
Alzheimer's disease 47 | 644
Intellectual disability 46 | 573
Cancer 45 | 2,346
Paraplegia 44 | 71
group 3 medulloblastoma 42 | 2,254
invasive ductal carcinoma 42 | 2,950
Parkinson's disease 40 | 364
diabetes mellitus 40 | 1,663
Cerebellar Ataxia 38 | 72
adult high grade glioma 37 | 2,148
Multiple myeloma 36 | 1,327
non-small cell lung cancer 36 | 2,798
colon cancer 35 | 1,475
lung adenocarcinoma 35 | 2,713
Dementia 33 | 129
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
dermatomyositis 32 | 933
sonic hedgehog group medulloblastoma 32 | 1,482
tuberculosis 32 | 1,557
ulcerative colitis 31 | 2,087
Autosomal dominant cerebellar ataxia 29 | 34
group 4 medulloblastoma 29 | 1,875
medulloblastoma 29 | 1,524
juvenile dermatomyositis 28 | 1,189
pancreatic cancer 28 | 2,300
posterior fossa group B ependymoma 28 | 1,530
Epilepsy 27 | 346
interstitial cystitis 27 | 2,299
pituitary cancer 27 | 1,972
atypical teratoid/rhabdoid tumor 26 | 1,095
Peripheral Neuropathy 24 | 303
breast carcinoma 24 | 1,614
progressive supranuclear palsy 24 | 674
acute quadriplegic myopathy 23 | 1,157
Waldenstrons macroglobulinemia 22 | 765
posterior fossa group A ependymoma 22 | 1,511
primary pancreatic ductal adenocarcinoma 20 | 1,271
Rheumatoid Arthritis 19 | 1,160
cystic fibrosis 19 | 1,665
non primary Sjogren syndrome sicca 19 | 840
Frontotemporal dementia 18 | 41
gastric carcinoma 18 | 832
adrenocortical carcinoma 17 | 1,427
spina bifida 17 | 1,064
Toxic encephalopathy 16 | 131
Down syndrome 15 | 548
ductal carcinoma in situ 15 | 1,745
Atopic dermatitis 14 | 944
Brain disease 14 | 83
Nerve Degeneration 14 | 73
Neuronal ceroid lipofuscinosis 14 | 28
aldosterone-producing adenoma 14 | 664
Axonal neuropathy 13 | 17
Dystonia 13 | 77
Multiple Sclerosis 13 | 498
Obesity 13 | 616
Parkinson Disease 13 | 102
Pontocerebellar hypoplasia 13 | 29
Schizophrenia 13 | 501
esophageal adenocarcinoma 13 | 737
tuberculosis and treatment for 6 months 13 | 686
Microcephaly 12 | 149
Muscular atrophy 12 | 67
active Crohn's disease 12 | 918
cutaneous lupus erythematosus 12 | 1,056
Amyloidosis 11 | 68
Motor neuron disease 11 | 39
Multiple system atrophy 11 | 27
Polyneuropathy 11 | 30
Prostatic Neoplasms 11 | 471
acute myeloid leukemia 11 | 780
primary Sjogren syndrome 10 | 789

Tissue

Cardiovascular System 291 | 17,958
Digestive Tract 291 | 18,473
Endocrine System 291 | 18,512
Female tissues 291 | 18,647
Liver and Pancreas 291 | 18,136
Nervous System 291 | 18,561
Respiratory system 291 | 17,484
Urinary Tract 291 | 18,444
Blood and immune system 290 | 17,995
Male tissues 290 | 17,969
Skin and soft tissues 290 | 18,115

Target Family

Non-IDG 161 | 11,971
Enzyme 85 | 4,146
Kinase 17 | 634
Ion Channel 11 | 341
Transporter 9 | 473
Epigenetic 3 | 242
Transcription Factor 3 | 1,400
GPCR 1 | 406
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

UniProt Keyword

Neurodegeneration 292 | 292
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.85387 67.6 146
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Protein BEAN1 BEAN1 Tbio Non-IDG -1.84308 76.0 68
Elongation of very long chain fatty acids protein 5 ELOVL5 Tchem Non-IDG -1.81279 72.3 189