Development Level

Tbio 116 | 11,445
Tchem 41 | 1,598
Tdark 20 | 6,588
Tclin 12 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 6 | 298
preweaning lethality, incomple... 6 | 499
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased total body fat amoun... 4 | 207
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased circulating choleste... 3 | 93
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased circulating alkaline... 3 | 122
persistence of hyaloid vascula... 3 | 33
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal neural tube closure 2 | 46
abnormal sleep behavior 2 | 70
abnormal stomach morphology 2 | 10
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
small kidney 2 | 16
abnormal allantois morphology 1 | 8
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal rib morphology 1 | 10
abnormal tail bud morphology 1 | 8
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased vertical activity 1 | 24
long tibia 1 | 25
short tibia 1 | 97
shortened RR interval 1 | 17
small heart 1 | 10
small spleen 1 | 19
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 111 | 11,493
ovarian cancer 96 | 8,520
osteosarcoma 84 | 7,950
psoriasis 78 | 6,694
lung cancer 66 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,962
medulloblastoma, large-cell 60 | 6,241
glioblastoma 53 | 5,792
non-small cell lung cancer 53 | 2,890
ependymoma 52 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
atypical teratoid / rhabdoid tumor 47 | 5,112
lung carcinoma 45 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 44 | 2,955
tuberculosis 44 | 2,010
Cancer 43 | 2,499
malignant mesothelioma 43 | 3,232
group 3 medulloblastoma 42 | 4,104
interstitial cystitis 42 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
invasive ductal carcinoma 41 | 2,951
adult high grade glioma 40 | 3,801
Breast cancer 37 | 3,578
lung adenocarcinoma 36 | 2,716
Autosomal recessive predisposition 35 | 1,442
oligodendroglioma 34 | 2,850
Astrocytoma, Pilocytic 32 | 3,081
astrocytic glioma 31 | 2,597
ductal carcinoma in situ 31 | 1,745
primitive neuroectodermal tumor 30 | 3,035
pancreatic cancer 29 | 2,398
cystic fibrosis 27 | 1,696
diabetes mellitus 27 | 1,728
Pick disease 26 | 1,894
Liver Cirrhosis, Experimental 23 | 769
active Crohn's disease 23 | 922
adrenocortical carcinoma 23 | 1,428
Epilepsy 22 | 792
Intellectual disability 22 | 1,016
breast carcinoma 22 | 1,638
pituitary cancer 22 | 1,972
subependymal giant cell astrocytoma 22 | 2,287
ulcerative colitis 22 | 1,819
nasopharyngeal carcinoma 21 | 1,058
Hypertension 19 | 396
Multiple myeloma 19 | 1,332
Prostatic Neoplasms 19 | 495
Seizures 18 | 596
group 4 medulloblastoma 18 | 1,855
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Kidney disease 17 | 430
Mental and motor retardation 17 | 608
Obesity 17 | 678
active ulcerative colitis 17 | 764
colon cancer 17 | 1,478
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
acute quadriplegic myopathy 16 | 1,158
esophageal adenocarcinoma 16 | 737
Chemical and Drug Induced Liver Injury 15 | 195
Muscle hypotonia 15 | 571
Atherosclerosis 14 | 291
Failure to gain weight 14 | 365
Kidney cancer 14 | 2,613
Pediatric failure to thrive 14 | 365
astrocytoma 14 | 1,146
Atopic dermatitis 13 | 952
Endometriosis 13 | 540
Schizophrenia 13 | 1,160
Small head 13 | 374
cutaneous lupus erythematosus 13 | 1,057
spina bifida 13 | 1,074
Carcinoma, Hepatocellular 12 | 228
Liver carcinoma 12 | 240
Breast Neoplasms 11 | 445
Mammary Neoplasms 11 | 425
nephrosclerosis 11 | 333
Alcoholic Intoxication, Chronic 10 | 289
Cerebrovascular disease 10 | 238
Cholestasis 10 | 155
Down syndrome 10 | 499
Liver disease 10 | 237
Rheumatoid arthritis 10 | 1,191
aldosterone-producing adenoma 10 | 665
gastric carcinoma 10 | 807
pediatric high grade glioma 10 | 1,064
Bipolar Disorder 9 | 666
Cataract 9 | 297
Depressive disorder 9 | 409
Stomach Neoplasms 9 | 300
chronic rhinosinusitis 9 | 512
fibroadenoma 9 | 559
mucosa-associated lymphoid tissue lymphoma 9 | 484
non primary Sjogren syndrome sicca 9 | 891
pancreatic carcinoma 9 | 562
progressive supranuclear palsy 9 | 676

Tissue

Digestive Tract 183 | 17,369
Endocrine System 183 | 18,159
Male tissues 183 | 17,142
Skin and soft tissues 183 | 17,230
Female tissues 182 | 17,400
Liver and Pancreas 181 | 16,750
Urinary Tract 181 | 16,678
Blood and immune system 175 | 16,909
Respiratory system 173 | 16,393
Nervous System 172 | 16,725
Cardiovascular System 161 | 15,192

Target Family

Enzyme 166 | 4,145
Non-IDG 18 | 12,091
Ion Channel 3 | 344
Kinase 2 | 634

UniProt Keyword

NADP 189 | 189
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
6-phosphogluconate dehydrogenase, decarboxylating PGD Tchem Enzyme -2.56683 355.7 211
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Dehydrogenase/reductase SDR family member 4 DHRS4 Tbio Enzyme -1.65486 46.6 122
Prostaglandin reductase 1 PTGR1 Tbio Enzyme -1.28265 22.7 156
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
NAD(P) transhydrogenase, mitochondrial NNT Tbio Enzyme -2.49624 309.2 112
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 PYROXD1 Tdark Enzyme 0.36 0.20 47
Quinone oxidoreductase-like protein 1 CRYZL1 Tbio Enzyme -1.37951 20.5 157