Development Level

Tbio 93 | 11,445
Tchem 34 | 1,598
Tclin 27 | 613
Tdark 19 | 6,588

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 4 | 298
decreased total body fat amoun... 4 | 207
embryonic lethality prior to t... 4 | 278
increased lean body mass 4 | 172
increased startle reflex 4 | 112
abnormal skin morphology 3 | 50
decreased circulating alkaline... 3 | 46
decreased erythrocyte cell num... 3 | 62
decreased lean body mass 3 | 135
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased hematocrit 2 | 46
decreased lactate dehydrogenas... 2 | 16
enlarged heart 2 | 210
hyperactivity 2 | 148
increased body length 2 | 32
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal eyelid morphology 1 | 7
abnormal facial morphology 1 | 17
abnormal head size 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cleft palate 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PQ interval 1 | 5
scaly skin 1 | 4
short tibia 1 | 97
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 100 | 11,493
ovarian cancer 89 | 8,520
osteosarcoma 78 | 7,950
psoriasis 70 | 6,694
medulloblastoma, large-cell 51 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 50 | 1,962
glioblastoma 45 | 5,792
atypical teratoid / rhabdoid tumor 43 | 5,112
ependymoma 43 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,291
lung cancer 40 | 4,740
group 3 medulloblastoma 35 | 4,104
Cancer 33 | 2,499
invasive ductal carcinoma 33 | 2,951
interstitial cystitis 32 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Autosomal recessive predisposition 31 | 1,442
lung adenocarcinoma 31 | 2,716
malignant mesothelioma 31 | 3,232
non-small cell lung cancer 31 | 2,890
astrocytic glioma 30 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
lung carcinoma 30 | 2,843
Breast cancer 28 | 3,578
adult high grade glioma 28 | 3,801
cystic fibrosis 27 | 1,696
diabetes mellitus 27 | 1,728
oligodendroglioma 27 | 2,850
pancreatic cancer 27 | 2,398
primitive neuroectodermal tumor 26 | 3,035
Multiple myeloma 24 | 1,332
Astrocytoma, Pilocytic 23 | 3,081
Epilepsy 23 | 792
colon cancer 23 | 1,478
ductal carcinoma in situ 23 | 1,745
subependymal giant cell astrocytoma 23 | 2,287
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Intellectual disability 20 | 1,016
Mental and motor retardation 20 | 608
ulcerative colitis 20 | 1,819
Seizures 18 | 596
active ulcerative colitis 18 | 764
Liver Cirrhosis, Experimental 17 | 769
Muscle hypotonia 17 | 571
Obesity 17 | 678
Pick disease 17 | 1,894
adrenocortical carcinoma 17 | 1,428
nasopharyngeal carcinoma 17 | 1,058
tuberculosis 17 | 2,010
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
esophageal adenocarcinoma 16 | 737
Atopic dermatitis 15 | 952
Cerebellar Ataxia 15 | 304
Failure to gain weight 15 | 365
Leigh disease 15 | 100
Pediatric failure to thrive 15 | 365
Sensorineural Hearing Loss (disorder) 15 | 284
active Crohn's disease 15 | 922
acute myeloid leukemia 15 | 783
breast carcinoma 15 | 1,638
Alcoholic Intoxication, Chronic 14 | 289
Diabetes mellitus type 2 14 | 69
Mitochondrial complex I deficiency 14 | 46
Prostatic Neoplasms 14 | 495
Schizophrenia 14 | 1,160
Treatment Refractory Type 2 Diabetes Mellitus 14 | 53
group 4 medulloblastoma 14 | 1,855
pituitary cancer 14 | 1,972
Acidosis, Lactic 13 | 97
Blepharoptosis 13 | 231
Lactic acidemia 13 | 95
Waldenstrons macroglobulinemia 13 | 765
cutaneous lupus erythematosus 13 | 1,057
primary pancreatic ductal adenocarcinoma 13 | 1,109
Short stature 12 | 531
acute quadriplegic myopathy 12 | 1,158
Developmental regression 11 | 95
Dystonia 11 | 164
Highly variable clinical phenotype 11 | 150
Highly variable phenotype and severity 11 | 150
Highly variable phenotype, even within families 11 | 150
Kidney cancer 11 | 2,613
Loss of developmental milestones 11 | 95
Mental deterioration in childhood 11 | 95
Neurodevelopmental regression 11 | 95
Nystagmus 11 | 317
Phenotypic variability 11 | 150
Polycystic ovary syndrome 11 | 360
Psychomotor regression 11 | 95
Psychomotor regression beginning in infancy 11 | 95
Psychomotor regression in infants 11 | 95
Psychomotor regression, progressive 11 | 95
nephrosclerosis 11 | 333
Optic Atrophy 10 | 242
gastric carcinoma 10 | 807

Tissue

Endocrine System 172 | 18,159
Female tissues 172 | 17,400
Digestive Tract 171 | 17,369
Skin and soft tissues 171 | 17,230
Liver and Pancreas 170 | 16,750
Blood and immune system 169 | 16,909
Male tissues 169 | 17,142
Urinary Tract 169 | 16,678
Respiratory system 168 | 16,393
Nervous System 165 | 16,725
Cardiovascular System 161 | 15,192

Target Family

Enzyme 149 | 4,145
Non-IDG 14 | 12,091
Epigenetic 8 | 242
Kinase 2 | 634

UniProt Keyword

NAD 173 | 173
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tchem Epigenetic -2.36015 219.3 427
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
3-hydroxybutyrate dehydrogenase type 2 BDH2 Tbio Enzyme -1.15003 15.8 112
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
NADH-cytochrome b5 reductase 2 CYB5R2 Tbio Enzyme -0.96076 7.49 58