Development Level

Tbio 84 | 10,625
Tchem 43 | 1,890
Tclin 27 | 602
Tdark 21 | 7,003

IMPC Term

preweaning lethality, complete... 6 | 633
decreased circulating HDL chol... 4 | 77
decreased lean body mass 4 | 195
decreased erythrocyte cell num... 3 | 43
decreased rib number 3 | 59
increased bone mineral density 3 | 52
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal gait 2 | 51
abnormal retina morphology 2 | 100
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating choleste... 2 | 85
decreased grip strength 2 | 123
decreased lactate dehydrogenas... 2 | 14
decreased lumbar vertebrae num... 2 | 62
decreased neutrophil cell numb... 2 | 37
decreased spleen weight 2 | 13
decreased threshold for audito... 2 | 32
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
increased circulating choleste... 2 | 53
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eyelid morphology 1 | 6
abnormal facial morphology 1 | 9
abnormal head shape 1 | 4
abnormal head size 1 | 1
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
anophthalmia 1 | 20
cleft palate 1 | 6
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
facial cleft 1 | 3
female infertility 1 | 34
hyperactivity 1 | 108
increased NK cell number 1 | 19
increased bone mineral content 1 | 92
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
mydriasis 1 | 9
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small adrenal glands 1 | 15

Disease

ovarian cancer 91 | 8,492
osteosarcoma 78 | 7,933
psoriasis 71 | 6,685
medulloblastoma, large-cell 51 | 6,234
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,795
glioblastoma 44 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 42 | 3,289
lung cancer 40 | 4,473
atypical teratoid / rhabdoid tumor 39 | 4,369
invasive ductal carcinoma 33 | 2,950
interstitial cystitis 32 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,956
ependymoma 31 | 2,514
lung adenocarcinoma 31 | 2,714
malignant mesothelioma 31 | 3,163
Cancer 30 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,988
lung carcinoma 30 | 2,844
non-small cell lung cancer 30 | 2,798
ulcerative colitis 28 | 2,087
oligodendroglioma 27 | 2,849
pancreatic cancer 27 | 2,300
cystic fibrosis 26 | 1,670
primitive neuroectodermal tumor 26 | 3,031
Breast cancer 25 | 3,099
Multiple myeloma 25 | 1,328
astrocytic glioma 25 | 2,241
diabetes mellitus 25 | 1,663
colon cancer 23 | 1,475
ductal carcinoma in situ 23 | 1,745
subependymal giant cell astrocytoma 23 | 2,287
pilocytic astrocytoma 22 | 3,086
adult high grade glioma 18 | 2,148
pediatric high grade glioma 18 | 2,712
Pick disease 17 | 1,893
adrenocortical carcinoma 17 | 1,427
group 4 medulloblastoma 17 | 1,875
nasopharyngeal carcinoma 17 | 1,056
Obesity 16 | 616
esophageal adenocarcinoma 16 | 737
group 3 medulloblastoma 16 | 2,254
tuberculosis 16 | 1,563
Atopic dermatitis 15 | 944
active Crohn's disease 15 | 918
acute myeloid leukemia 15 | 785
breast carcinoma 15 | 1,614
Diabetes mellitus type 2 14 | 69
Leigh disease 14 | 81
Mitochondrial complex I deficiency 14 | 37
Prostatic Neoplasms 14 | 471
Treatment Refractory Type 2 Diabetes Mellitus 14 | 53
Waldenstrons macroglobulinemia 14 | 765
astrocytoma 14 | 1,493
pituitary cancer 14 | 1,972
primary pancreatic ductal adenocarcinoma 14 | 1,271
sonic hedgehog group medulloblastoma 14 | 1,482
cutaneous lupus erythematosus 13 | 1,056
acute quadriplegic myopathy 12 | 1,157
medulloblastoma 12 | 1,524
Polycystic Ovary Syndrome 11 | 335
nephrosclerosis 11 | 329
Alcohol dependence 10 | 107
Leigh syndrome 10 | 34
Mitochondrial Complex 1 Deficiency 10 | 28
active ulcerative colitis 10 | 477
gastric carcinoma 10 | 832
posterior fossa group B ependymoma 10 | 1,530
Intellectual disability 9 | 573
Succinic semialdehyde dehydrogenase deficiency 9 | 16
aldosterone-producing adenoma 9 | 664
chronic rhinosinusitis 9 | 512
dermatomyositis 9 | 967
fibroadenoma 9 | 557
primary Sjogren syndrome 9 | 789
spina bifida 9 | 1,064
Mammary Neoplasms 8 | 410
inflammatory breast cancer 8 | 404
non primary Sjogren syndrome sicca 8 | 840
Alzheimer's disease 7 | 644
Degenerative polyarthritis 7 | 93
Leber hereditary optic neuropathy 7 | 17
Leber's optic atrophy 7 | 10
Liver Cirrhosis, Experimental 7 | 108
Liver disease 7 | 219
Malignant tumor of ovary 7 | 25
Metabolic syndrome X 7 | 155
Mitochondrial myopathy 7 | 24
NADH:Q(1) Oxidoreductase deficiency 7 | 20
Optic Atrophy, Hereditary, Leber 7 | 14
Stomach Neoplasms 7 | 282
juvenile dermatomyositis 7 | 1,189
Carcinoma 6 | 2,147
Duchenne muscular dystrophy 6 | 602
Kidney disease 6 | 397
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 6 | 14
Mouth Neoplasms 6 | 44
Neurodegenerative disease 6 | 383
Rheumatoid Arthritis 6 | 1,171
atypical teratoid/rhabdoid tumor 6 | 1,095
posterior fossa group A ependymoma 6 | 1,511

Tissue

Blood and immune system 175 | 17,995
Cardiovascular System 175 | 17,958
Digestive Tract 175 | 18,473
Endocrine System 175 | 18,512
Female tissues 175 | 18,647
Liver and Pancreas 175 | 18,136
Male tissues 175 | 17,969
Nervous System 175 | 18,561
Skin and soft tissues 175 | 18,115
Urinary Tract 175 | 18,444
Respiratory system 174 | 17,484

Target Family

Enzyme 151 | 4,146
Non-IDG 14 | 11,969
Epigenetic 8 | 242
Kinase 2 | 634

UniProt Keyword

NAD 175 | 175
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH Tbio Enzyme -1.15886 14.3 180
Short-chain dehydrogenase/reductase family 42E member 1 SDR42E1 Tdark Enzyme 0.00000 11
Ecto-ADP-ribosyltransferase 3 ART3 Tbio Enzyme -1.29743 20.5 266
Lambda-crystallin homolog CRYL1 Tbio Enzyme -1.48253 26.6 35
Glyceraldehyde-3-phosphate dehydrogenase GAPDH Tchem Enzyme -3.66772 4499.1 1649
NAD(P) transhydrogenase, mitochondrial NNT Tbio Enzyme -2.48103 302.5 108
Metalloreductase STEAP1 STEAP1 Tbio Enzyme -1.63486 43.9 294
3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Tbio Enzyme -2.11508 131.7 319
Apoptosis-inducing factor 1, mitochondrial AIFM1 Tbio Non-IDG -1.65992 43.9 549
Poly [ADP-ribose] polymerase 14 PARP14 Tbio Enzyme -1.43012 25.9 32