Development Level

Tbio 123 | 11,445
Tdark 37 | 6,588
Tchem 21 | 1,598
Tclin 12 | 613

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 9 | 499
decreased total body fat amoun... 6 | 207
abnormal behavior 4 | 298
decreased bone mineral content 4 | 151
decreased fasted circulating g... 4 | 65
hyperactivity 4 | 148
abnormal bone structure 3 | 187
abnormal coat appearance 3 | 31
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
cataract 3 | 92
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased startle reflex 3 | 75
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
increased mean corpuscular hem... 3 | 96
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal retinal blood vessel ... 2 | 26
abnormal spleen morphology 2 | 55
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
male infertility 2 | 123
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating free fat... 1 | 31
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
enlarged thymus 1 | 5
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
syndactyly 1 | 23

Disease

ovarian cancer 95 | 8,520
osteosarcoma 93 | 7,950
Carcinoma 92 | 11,493
medulloblastoma, large-cell 87 | 6,241
glioblastoma 85 | 5,792
atypical teratoid / rhabdoid tumor 76 | 5,112
psoriasis 60 | 6,694
ependymoma 59 | 4,679
adult high grade glioma 54 | 3,801
Astrocytoma, Pilocytic 50 | 3,081
group 3 medulloblastoma 49 | 4,104
primitive neuroectodermal tumor 47 | 3,035
lung cancer 46 | 4,740
oligodendroglioma 46 | 2,850
astrocytic glioma 45 | 2,597
invasive ductal carcinoma 41 | 2,951
Breast cancer 35 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
lung adenocarcinoma 35 | 2,716
lung carcinoma 35 | 2,843
subependymal giant cell astrocytoma 35 | 2,287
tuberculosis 35 | 2,010
interstitial cystitis 34 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
malignant mesothelioma 31 | 3,232
ductal carcinoma in situ 30 | 1,745
non-small cell lung cancer 29 | 2,890
Pick disease 28 | 1,894
group 4 medulloblastoma 28 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
ulcerative colitis 28 | 1,819
Cancer 26 | 2,499
breast carcinoma 25 | 1,638
cystic fibrosis 25 | 1,696
pancreatic cancer 25 | 2,398
pituitary cancer 22 | 1,972
colon cancer 21 | 1,478
cutaneous lupus erythematosus 21 | 1,057
Multiple myeloma 20 | 1,332
astrocytoma 19 | 1,146
Rheumatoid arthritis 18 | 1,191
Kidney cancer 17 | 2,613
juvenile dermatomyositis 16 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary pancreatic ductal adenocarcinoma 15 | 1,109
Waldenstrons macroglobulinemia 14 | 765
medulloblastoma 14 | 720
spina bifida 14 | 1,074
Autosomal recessive predisposition 13 | 1,442
Liver Cirrhosis, Experimental 13 | 769
dermatomyositis 13 | 966
diabetes mellitus 13 | 1,728
esophageal adenocarcinoma 13 | 737
Schizophrenia 12 | 1,160
active ulcerative colitis 12 | 764
primary Sjogren syndrome 12 | 735
active Crohn's disease 11 | 922
acute myeloid leukemia 11 | 783
adrenocortical carcinoma 11 | 1,428
fibroadenoma 11 | 559
non primary Sjogren syndrome sicca 11 | 891
pediatric high grade glioma 11 | 1,064
Alzheimer's disease 10 | 658
Blastic phase chronic myeloid leukemia 10 | 58
Breast Neoplasms 10 | 445
Chronic Lymphocytic Leukemia 10 | 262
Chronic Myelocytic Leukemia Accelerated Phase 10 | 59
Duchenne muscular dystrophy 10 | 601
Obesity 10 | 678
acute quadriplegic myopathy 10 | 1,158
gastric carcinoma 10 | 807
Mammary Neoplasms 9 | 425
Retinitis Pigmentosa 9 | 226
posterior fossa group A ependymoma 9 | 468
progressive supranuclear palsy 9 | 676
Atopic dermatitis 8 | 952
Bipolar Disorder 8 | 666
Chronic phase chronic myeloid leukemia 8 | 45
Crohn's disease 8 | 321
Depressive disorder 8 | 409
Down syndrome 8 | 499
Heart disease 8 | 306
Kidney disease 8 | 430
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 8 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 8 | 47
sarcoidosis 8 | 370
Retinal Degeneration 7 | 106
aldosterone-producing adenoma 7 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
mucosa-associated lymphoid tissue lymphoma 7 | 484
Acquired metabolic disease 6 | 336
Cognitive delay 6 | 608
Diarrhea 6 | 253
Endometriosis 6 | 540
Global developmental delay 6 | 608
Intellectual disability 6 | 1,016
Mental and motor retardation 6 | 608
Stomach Neoplasms 6 | 300
chronic lymphosyte leukemia 6 | 204
facioscapulohumeral dystrophy 6 | 288

Tissue

Endocrine System 180 | 18,159
Digestive Tract 175 | 17,369
Skin and soft tissues 174 | 17,230
Liver and Pancreas 173 | 16,750
Female tissues 172 | 17,400
Nervous System 172 | 16,725
Blood and immune system 171 | 16,909
Male tissues 171 | 17,142
Urinary Tract 170 | 16,678
Respiratory system 168 | 16,393
Cardiovascular System 161 | 15,192

Target Family

Non-IDG 111 | 12,091
Enzyme 58 | 4,145
Kinase 21 | 634
Epigenetic 1 | 242
Ion Channel 1 | 344
Transporter 1 | 473

UniProt Keyword

Myristate 193 | 193
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Niban-like protein 1 FAM129B Tdark Non-IDG -0.43933 4.02 100
ADP-ribosylation factor-like protein 4A ARL4A Tbio Enzyme -0.78144 7.85 138
ADP-ribosylation factor-like protein 1 ARL1 Tbio Enzyme -0.41493 3.54 208
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Enteropeptidase TMPRSS15 Tchem Enzyme -2.78466 584.5 140
Inward rectifier potassium channel 2 KCNJ2 Tchem Ion Channel -2.36978 224.8 221
A-kinase anchor protein 12 AKAP12 Tbio Enzyme -2.00948 126.8 160
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67762 525.7 663
Mitochondrial peptide methionine sulfoxide reductase MSRA Tbio Enzyme -1.92325 88.1 167