Development Level

Tbio 45 | 11,445
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 3 | 298
hyperactivity 3 | 148
increased or absent threshold ... 3 | 101
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal placenta size 2 | 20
convulsive seizures 2 | 13
decreased body weight 2 | 161
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
increased circulating sodium l... 2 | 71
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal motor learning 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased urine creatinine lev... 1 | 3
edema 1 | 59
embryonic lethality prior to t... 1 | 278
fused cornea and lens 1 | 5
fused phalanges 1 | 1
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased thermal nociceptive ... 1 | 9
increased urine magnesium leve... 1 | 2
increased vertical activity 1 | 24
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 39 | 11,493
Kidney cancer 28 | 2,613
psoriasis 22 | 6,694
ovarian cancer 21 | 8,520
osteosarcoma 20 | 7,950
malignant mesothelioma 14 | 3,232
Breast cancer 13 | 3,578
glioblastoma 12 | 5,792
Autosomal recessive predisposition 11 | 1,442
Liver cancer 11 | 604
lung cancer 11 | 4,740
medulloblastoma, large-cell 11 | 6,241
non-small cell lung cancer 11 | 2,890
acute quadriplegic myopathy 10 | 1,158
adult high grade glioma 10 | 3,801
atypical teratoid / rhabdoid tumor 10 | 5,112
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung carcinoma 10 | 2,843
Melanoma 9 | 711
primitive neuroectodermal tumor 9 | 3,035
ulcerative colitis 9 | 1,819
Nonsyndromic deafness 8 | 142
Sensorineural hearing loss 8 | 106
ependymoma 8 | 4,679
lung adenocarcinoma 8 | 2,716
Hypertrophic Cardiomyopathy 7 | 117
Skin cancer 7 | 469
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
Astrocytoma, Pilocytic 6 | 3,081
Endometrial cancer 6 | 311
Schizophrenia 6 | 1,160
interstitial cystitis 6 | 2,312
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Cardiomyopathy 5 | 116
Distal arthrogryposis 5 | 42
Duchenne muscular dystrophy 5 | 601
Myopathy 5 | 185
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
Amyotrophic lateral sclerosis 4 | 451
Becker muscular dystrophy 4 | 191
Cardiomyopathy, Hypertrophic 4 | 24
Cardiovascular system disease 4 | 246
Dilated cardiomyopathy 4 | 56
Left ventricular noncompaction 4 | 26
Liver Cirrhosis, Experimental 4 | 769
MYH-9 related disease 4 | 12
Ophthalmoplegia 4 | 106
colon cancer 4 | 1,478
group 3 medulloblastoma 4 | 4,104
limb girdle muscular dystrophy 2A 4 | 213
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Acquired scoliosis 3 | 281
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Cardiomyopathy, Familial Hypertrophic, 1 3 | 6
Cardiomyopathy, Hypertrophic, Familial 3 | 9
Curvature of spine 3 | 282
Focal glomerulosclerosis 3 | 37
Glomerulosclerosis, Focal Segmental 3 | 28
Hearing loss, progressive sensorineural 3 | 23
Hodgkin's lymphoma, nodular sclerosis 3 | 22
Myocardial Infarction 3 | 151
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
medulloblastoma 3 | 720
non diabetic and post-ischemic heart failure 3 | 200
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
Atopic dermatitis 2 | 952
Cardiomyopathy, Dilated 2 | 83
Congenital clubfoot 2 | 109
Down syndrome 2 | 499
Epilepsy 2 | 792
Essential Hypertension 2 | 94
Failure to gain weight 2 | 365
Highly variable severity 2 | 157
Infantile onset 2 | 238
Leukemia 2 | 104
Pediatric failure to thrive 2 | 365
Proteinuria 2 | 144
Seizures 2 | 596
Substance-Related Disorders 2 | 115
Variable expressivity 2 | 157
chronic lymphosyte leukemia 2 | 204
posterior fossa group B ependymoma 2 | 416
progressive supranuclear palsy 2 | 676
tuberculosis 2 | 2,010

Tissue

Endocrine System 50 | 18,159
Skin and soft tissues 50 | 17,230
Digestive Tract 48 | 17,369
Male tissues 47 | 17,142
Blood and immune system 46 | 16,909
Cardiovascular System 44 | 15,192
Female tissues 44 | 17,400
Liver and Pancreas 43 | 16,750
Nervous System 43 | 16,725
Urinary Tract 43 | 16,678
Respiratory system 39 | 16,393

Target Family

Non-IDG 48 | 12,091
Kinase 2 | 634

UniProt Keyword

Myosin 50 | 50
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Myosin-IIIb MYO3B Tbio Kinase -0.73450 5.14 127
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Myosin regulatory light chain 2, atrial isoform MYL7 Tbio Non-IDG -0.85198 5.20 169
Unconventional myosin-IXa MYO9A Tdark Non-IDG -0.82985 8.76 21
Myosin-15 MYH15 Tbio Non-IDG -0.95780 9.01 40