Development Level

Tbio 57 | 11,445
Tdark 4 | 6,588
Tchem 2 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased leukocyte cell numbe... 2 | 73
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal motor learning 1 | 3
abnormal response to new envir... 1 | 10
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating sodium l... 1 | 22
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased urine creatinine lev... 1 | 3
edema 1 | 59
hyperactivity 1 | 148
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tibia 1 | 25
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

Carcinoma 41 | 11,493
psoriasis 35 | 6,694
acute quadriplegic myopathy 25 | 1,158
Breast cancer 20 | 3,578
glioblastoma 20 | 5,792
Kidney cancer 19 | 2,613
ovarian cancer 19 | 8,520
Hypertrophic Cardiomyopathy 17 | 117
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 16 | 5,112
colon cancer 16 | 1,478
Autosomal recessive predisposition 15 | 1,442
Myopathy 15 | 185
lung cancer 15 | 4,740
osteosarcoma 15 | 7,950
Distal arthrogryposis 14 | 42
Duchenne muscular dystrophy 14 | 601
invasive ductal carcinoma 14 | 2,951
malignant mesothelioma 14 | 3,232
Cardiomyopathy 13 | 116
Dilated cardiomyopathy 13 | 56
lung adenocarcinoma 13 | 2,716
Cardiomyopathy, Dilated 12 | 83
breast carcinoma 12 | 1,638
group 3 medulloblastoma 12 | 4,104
lung carcinoma 12 | 2,843
pancreatic cancer 12 | 2,398
Melanoma 11 | 711
Skin cancer 11 | 469
diabetes mellitus 11 | 1,728
ependymoma 11 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
primitive neuroectodermal tumor 11 | 3,035
Acquired scoliosis 10 | 281
Curvature of spine 10 | 282
adult high grade glioma 10 | 3,801
cystic fibrosis 10 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
Amyotrophic lateral sclerosis 9 | 451
Arthrogryposis 9 | 54
Byzanthine arch palate 9 | 194
Familial isolated dilated cardiomyopathy 9 | 41
LEFT VENTRICULAR NONCOMPACTION 10 9 | 40
LEFT VENTRICULAR NONCOMPACTION 8 9 | 40
non-small cell lung cancer 9 | 2,890
Astrocytoma, Pilocytic 8 | 3,081
Congenital clubfoot 8 | 109
Congestive heart failure 8 | 113
Left ventricular noncompaction 8 | 26
Liver cancer 8 | 604
Proximal muscle weakness 8 | 47
Proximal neurogenic muscle weakness 8 | 47
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
group 4 medulloblastoma 8 | 1,855
juvenile dermatomyositis 8 | 1,187
Becker muscular dystrophy 7 | 191
Bell Palsy 7 | 58
Blepharoptosis 7 | 231
Cardiomyopathy, Hypertrophic, Familial 7 | 9
Deglutition Disorders 7 | 132
Facial Paresis 7 | 59
Facial muscle weakness of muscles innervated by CN VII 7 | 58
Feeding difficulties 7 | 127
Narrow face 7 | 54
Neck muscle weakness 7 | 17
Nemaline myopathy 7 | 17
Neonatal Hypotonia 7 | 64
Pick disease 7 | 1,894
Respiratory Insufficiency 7 | 132
Respiratory function loss 7 | 121
Thin face 7 | 54
astrocytic glioma 7 | 2,597
limb girdle muscular dystrophy 2A 7 | 213
Bulbar palsy 6 | 19
Bulbar weakness 6 | 19
Cardiomyopathy, Hypertrophic 6 | 24
Clubfoot 6 | 39
Congenital fiber-type disproportion 6 | 8
Distal arthrogryposis syndrome 6 | 8
EMG: myopathic abnormalities 6 | 22
Flexion contracture of proximal interphalangeal joint 6 | 75
Generalized muscle weakness 6 | 57
Heart disease 6 | 306
Heart failure 6 | 162
Highly variable severity 6 | 157
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Primary cutaneous amyloidosis 6 | 29
Respiratory insufficiency due to muscle weakness 6 | 37
Variable expressivity 6 | 157
non diabetic and post-ischemic heart failure 6 | 200
oligodendroglioma 6 | 2,850
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Cancer 5 | 2,499
adrenocortical carcinoma 5 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Endocrine System 64 | 18,159
Skin and soft tissues 64 | 17,230
Digestive Tract 63 | 17,369
Male tissues 62 | 17,142
Blood and immune system 61 | 16,909
Cardiovascular System 59 | 15,192
Female tissues 59 | 17,400
Liver and Pancreas 59 | 16,750
Urinary Tract 59 | 16,678
Nervous System 56 | 16,725
Respiratory system 54 | 16,393

Target Family

Non-IDG 59 | 12,091
Kinase 4 | 634
Enzyme 1 | 4,145

UniProt Keyword

Muscle protein 64 | 64
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Myomesin-1 MYOM1 Tbio Non-IDG -1.21420 16.8 127
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myosin light chain 1/3, skeletal muscle isoform MYL1 Tbio Non-IDG -2.11698 129.3 109
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Myosin-15 MYH15 Tbio Non-IDG -0.95780 9.01 40
Myosin regulatory light chain 2, atrial isoform MYL7 Tbio Non-IDG -0.85198 5.20 169
Tripartite motif-containing protein 55 TRIM55 Tdark Non-IDG -0.69631 4.68 132