Development Level

Tbio 50 | 11,651
Tchem 20 | 1,388
Tdark 11 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
cataract 2 | 92
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
embryonic lethality prior to t... 2 | 278
increased startle reflex 2 | 112
abnormal allantois morphology 1 | 8
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating glycerol... 1 | 16
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased anxiety-related resp... 1 | 2
increased bone mineral content 1 | 108
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
long tibia 1 | 25
short tibia 1 | 97
thick ventricular wall 1 | 7
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 61 | 11,493
osteosarcoma 41 | 7,950
ovarian cancer 40 | 8,520
psoriasis 38 | 6,694
medulloblastoma, large-cell 34 | 6,241
lung cancer 31 | 4,740
Kidney cancer 24 | 2,613
atypical teratoid / rhabdoid tumor 24 | 5,112
Autosomal recessive predisposition 23 | 1,442
malignant mesothelioma 22 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
Breast cancer 20 | 3,578
ependymoma 19 | 4,679
glioblastoma 19 | 5,792
invasive ductal carcinoma 19 | 2,951
non-small cell lung cancer 18 | 2,890
Cancer 16 | 2,499
group 3 medulloblastoma 16 | 4,104
lung adenocarcinoma 16 | 2,716
Astrocytoma, Pilocytic 13 | 3,081
Epilepsy 13 | 792
colon cancer 13 | 1,478
lung carcinoma 13 | 2,843
primitive neuroectodermal tumor 13 | 3,035
adult high grade glioma 12 | 3,801
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
Muscle hypotonia 11 | 571
Seizures 11 | 596
group 4 medulloblastoma 11 | 1,855
oligodendroglioma 11 | 2,850
pituitary cancer 11 | 1,972
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Intellectual disability 10 | 1,016
Mental and motor retardation 10 | 608
adrenocortical carcinoma 10 | 1,428
diabetes mellitus 10 | 1,728
pancreatic cancer 10 | 2,398
tuberculosis 10 | 2,010
ulcerative colitis 10 | 1,819
astrocytoma 9 | 1,146
interstitial cystitis 9 | 2,312
subependymal giant cell astrocytoma 9 | 2,287
Obesity 8 | 678
Short stature 8 | 531
active ulcerative colitis 8 | 764
astrocytic glioma 8 | 2,597
breast carcinoma 8 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
spina bifida 8 | 1,074
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Multiple myeloma 7 | 1,332
Poor school performance 7 | 645
acute quadriplegic myopathy 7 | 1,158
Bipolar Disorder 6 | 666
Carcinoma, Hepatocellular 6 | 228
Liver carcinoma 6 | 240
Rheumatoid arthritis 6 | 1,191
Waldenstrons macroglobulinemia 6 | 765
nasopharyngeal carcinoma 6 | 1,058
pediatric high grade glioma 6 | 1,064
Adenocarcinoma of lung 5 | 142
Heart failure 5 | 162
Hepatomegaly 5 | 285
Infantile onset 5 | 238
Liver cancer 5 | 604
Pick disease 5 | 1,894
Prostatic Neoplasms 5 | 495
active Crohn's disease 5 | 922
cystic fibrosis 5 | 1,696
progressive supranuclear palsy 5 | 676
Anemia 4 | 365
Creatine phosphokinase serum increased 4 | 110
Diarrhea 4 | 253
Disease Models, Animal 4 | 155
Elevated creatine kinase 4 | 110
Endometrial cancer 4 | 311
Gait abnormality 4 | 135
Growth delay 4 | 114
Growth failure 4 | 114
Growth retardation 4 | 115
Liver Cirrhosis, Experimental 4 | 769
Melanoma 4 | 711
Myopathy 4 | 185
Neurodegenerative disease 4 | 414
Polycystic ovary syndrome 4 | 360
Poor growth 4 | 114
Prostate cancer 4 | 175
Schizophrenia 4 | 1,160
acute myeloid leukemia 4 | 783
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
dermatomyositis 4 | 966
gastric carcinoma 4 | 807
medulloblastoma 4 | 720

Tissue

Digestive Tract 72 | 17,369
Endocrine System 72 | 18,159
Female tissues 72 | 17,400
Blood and immune system 71 | 16,909
Male tissues 71 | 17,142
Liver and Pancreas 70 | 16,750
Skin and soft tissues 70 | 17,230
Nervous System 69 | 16,725
Urinary Tract 69 | 16,678
Respiratory system 66 | 16,393
Cardiovascular System 63 | 15,192

Target Family

Enzyme 61 | 4,145
Non-IDG 17 | 12,091
Kinase 5 | 634
Epigenetic 1 | 242

UniProt Keyword

Multifunctional enzyme 84 | 84
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
GDP-L-fucose synthase TSTA3 Tbio Enzyme -1.16563 14.3 231
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 HSD3B2 Tclin Enzyme -2.06512 109.2 126
Bifunctional polynucleotide phosphatase/kinase PNKP Tbio Enzyme -1.79273 59.8 231
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 PAPSS1 Tbio Enzyme -2.41857 281.0 125
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Squalene synthase FDFT1 Tchem Enzyme -2.57966 374.3 291
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.99704 989.4 151
Fatty acid synthase FASN Tchem Enzyme -2.61118 400.6 468
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101