Development Level

Tbio 49 | 10,625
Tchem 21 | 1,890
Tdark 11 | 7,003
Tclin 3 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal retinal pigmentation 2 | 61
decreased body weight 2 | 174
decreased lean body mass 2 | 195
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal spinal cord morpholog... 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
cataract 1 | 26
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased granulocyte number 1 | 8
decreased neutrophil cell numb... 1 | 37
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
female infertility 1 | 34
hyperactivity 1 | 108
increased B cell number 1 | 23
increased anxiety-related resp... 1 | 1
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased prepulse inhibition 1 | 21
increased rib number 1 | 41
increased total body fat amoun... 1 | 57
long tibia 1 | 13
preweaning lethality, incomple... 1 | 260
thick ventricular wall 1 | 7
thin ventricular wall 1 | 5
tremors 1 | 34

Disease

osteosarcoma 41 | 7,933
ovarian cancer 40 | 8,484
psoriasis 38 | 6,685
medulloblastoma, large-cell 34 | 6,234
lung cancer 28 | 4,466
malignant mesothelioma 22 | 3,162
Carcinoma 21 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,795
Breast cancer 19 | 3,094
invasive ductal carcinoma 19 | 2,950
glioblastoma 18 | 5,572
non-small cell lung cancer 17 | 2,798
lung adenocarcinoma 16 | 2,713
atypical teratoid / rhabdoid tumor 15 | 4,369
Cancer 14 | 2,346
pilocytic astrocytoma 14 | 3,086
colon cancer 13 | 1,475
lung carcinoma 13 | 2,844
primitive neuroectodermal tumor 13 | 3,031
ulcerative colitis 13 | 2,087
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
astrocytoma 11 | 1,493
group 4 medulloblastoma 11 | 1,875
oligodendroglioma 11 | 2,849
pituitary cancer 11 | 1,972
adrenocortical carcinoma 10 | 1,427
atypical teratoid/rhabdoid tumor 10 | 1,095
diabetes mellitus 10 | 1,663
pancreatic cancer 10 | 2,300
pediatric high grade glioma 10 | 2,712
group 3 medulloblastoma 9 | 2,254
interstitial cystitis 9 | 2,299
medulloblastoma 9 | 1,524
subependymal giant cell astrocytoma 9 | 2,287
Obesity 8 | 616
adult high grade glioma 8 | 2,148
breast carcinoma 8 | 1,614
ependymoma 8 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
posterior fossa group A ependymoma 8 | 1,511
spina bifida 8 | 1,064
Multiple myeloma 7 | 1,327
acute quadriplegic myopathy 7 | 1,157
tuberculosis 7 | 1,557
Epilepsy 6 | 346
Intellectual disability 6 | 573
Liver carcinoma 6 | 217
Rheumatoid Arthritis 6 | 1,160
Waldenstrons macroglobulinemia 6 | 765
astrocytic glioma 6 | 2,241
nasopharyngeal carcinoma 6 | 1,056
posterior fossa group B ependymoma 6 | 1,530
Pick disease 5 | 1,893
Prostatic Neoplasms 5 | 471
active Crohn's disease 5 | 918
cystic fibrosis 5 | 1,665
progressive supranuclear palsy 5 | 674
Biotin deficiency 4 | 9
Down syndrome 4 | 548
Neurodegenerative disease 4 | 383
Orotic aciduria 4 | 16
Polycystic Ovary Syndrome 4 | 332
active ulcerative colitis 4 | 477
acute myeloid leukemia 4 | 780
aldosterone-producing adenoma 4 | 664
cutaneous lupus erythematosus 4 | 1,056
dermatomyositis 4 | 933
gastric carcinoma 4 | 832
sonic hedgehog group medulloblastoma 4 | 1,482
tuberculosis and treatment for 6 months 4 | 686
Celiac disease 3 | 112
Cerebrovascular disease 3 | 231
Diarrhea 3 | 155
Hyperandrogenism 3 | 32
Hypoglycemia 3 | 81
IGA Glomerulonephritis 3 | 454
Metabolic syndrome X 3 | 155
Myocardial Ischemia 3 | 169
Osteoporosis 3 | 257
Peripheral Neuropathy 3 | 303
Prostate cancer 3 | 172
Werner syndrome 3 | 29
nephrosclerosis 3 | 329
non-small cell lung carcinoma 3 | 413
primary Sjogren syndrome 3 | 789
primary pancreatic ductal adenocarcinoma 3 | 1,271
Alzheimer's disease 2 | 644
Atopic dermatitis 2 | 944
Cockayne syndrome 2 | 54
Diabetes Mellitus, Non-Insulin-Dependent 2 | 157
Kidney disease 2 | 396
Seizures 2 | 95
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 557
hepatocellular carcinoma 2 | 532
inflammatory breast cancer 2 | 404
mucosa-associated lymphoid tissue lymphoma 2 | 480

Tissue

Blood and immune system 73 | 17,995
Cardiovascular System 73 | 17,958
Digestive Tract 73 | 18,473
Female tissues 73 | 18,647
Liver and Pancreas 73 | 18,136
Male tissues 73 | 17,969
Nervous System 73 | 18,561
Endocrine System 72 | 18,512
Urinary Tract 72 | 18,444
Respiratory system 71 | 17,484
Skin and soft tissues 71 | 18,115

Target Family

Enzyme 61 | 4,146
Non-IDG 17 | 11,971
Kinase 5 | 634
Epigenetic 1 | 242

UniProt Keyword

Multifunctional enzyme 84 | 84
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

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