Development Level

Tbio 39 | 11,445
Tchem 24 | 1,598
Tclin 13 | 613
Tdark 5 | 6,588

IMPC Phenotype

decreased total body fat amoun... 3 | 207
increased circulating alkaline... 3 | 122
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating phosphat... 2 | 27
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
small kidney 2 | 16
abnormal clavicle morphology 1 | 6
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal male genitalia morpho... 1 | 3
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal scapula morphology 1 | 3
abnormal tail bud morphology 1 | 8
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
absent external male genitalia 1 | 1
absent mammary gland 1 | 1
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating unsatura... 1 | 1
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
oligodactyly 1 | 1
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small heart 1 | 10
small ovary 1 | 1
small spleen 1 | 19
small uterus 1 | 3
thin skin 1 | 2

Disease

Carcinoma 67 | 11,493
psoriasis 39 | 6,694
osteosarcoma 26 | 7,950
lung cancer 25 | 4,740
medulloblastoma, large-cell 24 | 6,241
lung carcinoma 22 | 2,843
ovarian cancer 21 | 8,520
ependymoma 20 | 4,679
glioblastoma 20 | 5,792
interstitial cystitis 20 | 2,312
non-small cell lung cancer 20 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Autosomal recessive predisposition 19 | 1,442
Cancer 19 | 2,499
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
adult high grade glioma 18 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
Astrocytoma, Pilocytic 17 | 3,081
atypical teratoid / rhabdoid tumor 17 | 5,112
group 3 medulloblastoma 17 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
Breast cancer 15 | 3,578
adrenocortical carcinoma 15 | 1,428
Prostatic Neoplasms 14 | 495
oligodendroglioma 14 | 2,850
Schizophrenia 13 | 1,160
lung adenocarcinoma 13 | 2,716
malignant mesothelioma 13 | 3,232
Hypertension 12 | 396
cutaneous lupus erythematosus 12 | 1,057
tuberculosis 12 | 2,010
ductal carcinoma in situ 11 | 1,745
primitive neuroectodermal tumor 11 | 3,035
cystic fibrosis 10 | 1,696
ulcerative colitis 10 | 1,819
Chemical and Drug Induced Liver Injury 9 | 195
Depressive disorder 9 | 409
Liver disease 9 | 237
Pick disease 9 | 1,894
invasive ductal carcinoma 9 | 2,951
pancreatic cancer 9 | 2,398
pituitary cancer 9 | 1,972
Major Depressive Disorder 8 | 301
Unipolar Depression 8 | 250
active Crohn's disease 8 | 922
astrocytic glioma 8 | 2,597
chronic rhinosinusitis 8 | 512
Attention deficit hyperactivity disorder 7 | 278
Breast Neoplasms 7 | 445
Congenital adrenal hyperplasia 7 | 73
Mammary Neoplasms 7 | 425
Melanoma 7 | 711
adrenocortical adenoma 7 | 131
aldosterone-producing adenoma 7 | 665
breast carcinoma 7 | 1,638
diabetes mellitus 7 | 1,728
nephrosclerosis 7 | 333
Adenocarcinoma 6 | 122
Alcoholic Intoxication, Chronic 6 | 289
Cholestasis 6 | 155
Epilepsy 6 | 792
Hypertensive disease 6 | 292
Kidney cancer 6 | 2,613
Lung Neoplasms 6 | 232
Mental Depression 6 | 333
Osteoporosis 6 | 363
Adenoma 5 | 167
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Cushing's syndrome 5 | 48
Drug-Related Side Effects and Adverse Reactions 5 | 62
Endometriosis 5 | 540
Failure to gain weight 5 | 365
Increase in blood pressure 5 | 119
Liver Cirrhosis, Experimental 5 | 769
Malaria 5 | 160
Mood Disorders 5 | 184
Obesity 5 | 678
Pediatric failure to thrive 5 | 365
Psychotic Disorders 5 | 151
Seizures 5 | 596
Skin cancer 5 | 469
astrocytoma 5 | 1,146
gastric carcinoma 5 | 807
group 4 medulloblastoma 5 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 5 | 239
nasopharyngeal carcinoma 5 | 1,058
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Alzheimer's disease 4 | 658
Atrial Fibrillation 4 | 124
Delayed bone age 4 | 136
Hepatomegaly 4 | 285
Hyperandrogenism 4 | 34
Male infertility 4 | 206
Polycystic ovary syndrome 4 | 360
esophageal adenocarcinoma 4 | 737
mucosa-associated lymphoid tissue lymphoma 4 | 484
non diabetic and post-ischemic heart failure 4 | 200
substance-related disorder 4 | 162

Tissue

Endocrine System 75 | 18,159
Digestive Tract 72 | 17,369
Female tissues 72 | 17,400
Liver and Pancreas 70 | 16,750
Skin and soft tissues 70 | 17,230
Male tissues 69 | 17,142
Urinary Tract 66 | 16,678
Blood and immune system 65 | 16,909
Respiratory system 63 | 16,393
Nervous System 62 | 16,725
Cardiovascular System 45 | 15,192

Target Family

Enzyme 49 | 4,145
Non-IDG 32 | 12,091

UniProt Keyword

Monooxygenase 81 | 81
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tbio Enzyme -2.95336 876.7 309
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.68998 9.87 74
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial COQ6 Tbio Enzyme -1.26796 18.5 102
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
Cytochrome P450 11B1, mitochondrial CYP11B1 Tclin Enzyme -2.66308 432.9 136
[F-actin]-monooxygenase MICAL2 MICAL2 Tbio Enzyme -0.47649 3.62 57
Cytochrome P450 4A11 CYP4A11 Tbio Non-IDG -1.97180 93.7 142