Development Level

Tbio 15 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal sleep behavior 1 | 70
decreased circulating glucose ... 1 | 126
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
impaired righting response 1 | 26
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased total body fat amoun... 1 | 134

Disease

osteosarcoma 13 | 7,950
ovarian cancer 13 | 8,520
Carcinoma 12 | 11,493
lung cancer 8 | 4,740
glioblastoma 7 | 5,792
group 3 medulloblastoma 7 | 4,104
Breast cancer 6 | 3,578
medulloblastoma, large-cell 6 | 6,241
Multiple myeloma 5 | 1,332
adult high grade glioma 4 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
psoriasis 4 | 6,694
Cerebellar Ataxia 3 | 304
diabetes mellitus 3 | 1,728
ependymoma 3 | 4,679
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
malignant mesothelioma 3 | 3,232
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung cancer 3 | 2,890
Acidosis, Lactic 2 | 97
Alpers syndrome 2 | 9
Autosomal recessive predisposition 2 | 1,442
Blepharoptosis 2 | 231
Cancer 2 | 2,499
Chronic progressive external ophthalmoplegia 2 | 26
Cognitive delay 2 | 608
Decreased activity of cytochrome C oxidase in muscle tissue 2 | 10
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Hepatomegaly 2 | 285
Impaired exercise tolerance 2 | 42
Increased serum lactate 2 | 60
Lactic acidemia 2 | 95
Liver Dysfunction 2 | 99
Malaria 2 | 160
Mental and motor retardation 2 | 608
Mitochondrial encephalomyopathy 2 | 15
Muscle hypotonia 2 | 571
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Optic Atrophy 2 | 242
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1 2 | 5
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 2 | 5
Ptosis 2 | 48
Respiratory insufficiency due to muscle weakness 2 | 37
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 2 | 2
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
tuberculosis 2 | 2,010
Ataxia, Appendicular 1 | 25
Atrophy of testis 1 | 14
Baller-Gerold syndrome 1 | 12
Blindness, Cortical 1 | 24
Branchiootic syndrome 1 | 12
Cortical blindness 1 | 16
Cortical visual impairment 1 | 24
Cytochrome-c Oxidase Deficiency 1 | 17
Dysphonia 1 | 7
Dyspnea on exertion 1 | 24
EMG: myopathic abnormalities 1 | 22
Gait, Drop Foot 1 | 24
Gastroparesis 1 | 22
Glycosuria 1 | 29
Infantile onset spinocerebellar ataxia 1 | 7
Juvenile xanthogranuloma 1 | 7
Lyme disease 1 | 26
MERRF syndrome 1 | 6
Measles 1 | 22
Micronodular cirrhosis 1 | 12
Mitochondrial Complex 3 Deficiency, Nuclear Type 7 1 | 1
Mitochondrial Complex III Deficiency 1 | 9
Mitral Valve Prolapse Syndrome 1 | 39
Mitral regurgitation, mild 1 | 32
Neurofibroma 1 | 8
Paraparesis, Spastic 1 | 16
Peliosis Hepatis 1 | 4
Polyneuropathy 1 | 64
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Renal tubular disorder 1 | 12
Seizures, Focal 1 | 14
Skin Abnormalities 1 | 37
Tonic - clonic seizures 1 | 44
Variation in muscle fiber size 1 | 16
cytochrome-c oxidase deficiency disease 1 | 19

Tissue

Blood and immune system 18 | 16,909
Cardiovascular System 18 | 15,192
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678

Target Family

Enzyme 12 | 4,145
Non-IDG 5 | 12,091
Transcription Factor 1 | 1,400

UniProt Keyword

Mitochondrion nucleoid 18 | 18
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATPase family AAA domain-containing protein 3A ATAD3A Tbio Enzyme -1.10725 16.5 114
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.53008 34.4 21
G-rich sequence factor 1 GRSF1 Tbio Non-IDG -1.05585 12.0 138
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial CLPX Tbio Enzyme -2.32024 211.2 76
Transcription factor A, mitochondrial TFAM Tbio Transcription Factor -2.72618 499.4 378
FAST kinase domain-containing protein 5, mitochondrial FASTKD5 Tdark Enzyme 0.49 0.33 40
FAST kinase domain-containing protein 2, mitochondrial FASTKD2 Tbio Enzyme -0.76901 6.84 141
Twinkle protein, mitochondrial TWNK Tbio Non-IDG -2.18726 156.1 146
Transcription elongation factor, mitochondrial TEFM Tbio Non-IDG -0.67099 4.91 61