Development Level

Tbio 170 | 10,625
Tdark 45 | 7,003
Tclin 40 | 602
Tchem 13 | 1,890

IMPC Term

preweaning lethality, complete... 29 | 633
embryonic lethality prior to o... 13 | 148
embryonic lethality prior to t... 10 | 187
abnormal behavior 6 | 226
decreased body weight 6 | 174
prenatal lethality prior to he... 5 | 64
abnormal embryo size 4 | 112
decreased bone mineral content 4 | 157
abnormal neural tube closure 3 | 37
decreased leukocyte cell numbe... 3 | 54
decreased total body fat amoun... 3 | 186
hypoactivity 3 | 89
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased lean body mass 3 | 107
pallor 3 | 13
abnormal lens morphology 2 | 73
abnormal limb bud morphology 2 | 15
abnormal retina morphology 2 | 100
abnormal skin coloration 2 | 18
abnormal tail bud morphology 2 | 6
decreased caudal vertebrae num... 2 | 49
decreased circulating chloride... 2 | 32
decreased circulating triglyce... 2 | 83
decreased lean body mass 2 | 195
decreased red blood cell distr... 2 | 11
decreased startle reflex 2 | 48
embryonic growth retardation 2 | 28
enlarged heart 2 | 111
hyperactivity 2 | 108
increased circulating phosphat... 2 | 24
increased startle reflex 2 | 38
persistence of hyaloid vascula... 2 | 22
prenatal lethality 2 | 16
abnormal QRS complex 1 | 25
abnormal allantois morphology 1 | 3
abnormal coat appearance 1 | 25
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal midbrain development 1 | 22
abnormal neural tube morpholog... 1 | 8
abnormal placenta morphology 1 | 4
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal skin appearance 1 | 8
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
absent pinna reflex 1 | 21
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased follicular B cell nu... 1 | 4
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased monocyte cell number 1 | 28
decreased total retina thickne... 1 | 20
female infertility 1 | 34
impaired righting response 1 | 19
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating calcium ... 1 | 32
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased grip strength 1 | 83
increased marginal zone B cell... 1 | 3
increased mature B cell number 1 | 12
increased mean corpuscular vol... 1 | 91
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
narrow eye opening 1 | 15
thrombocytopenia 1 | 46

Disease

ovarian cancer 137 | 8,484
osteosarcoma 102 | 7,933
medulloblastoma, large-cell 74 | 6,234
psoriasis 72 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 65 | 1,795
Multiple myeloma 64 | 1,327
lung cancer 63 | 4,466
glioblastoma 61 | 5,572
atypical teratoid / rhabdoid tumor 52 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
ependymoma 44 | 2,514
astrocytic glioma 38 | 2,241
Diabetes mellitus type 2 37 | 69
Treatment Refractory Type 2 Diabetes Mellitus 37 | 53
Breast cancer 36 | 3,094
Pick disease 30 | 1,893
oligodendroglioma 30 | 2,849
Leigh disease 29 | 81
malignant mesothelioma 29 | 3,162
medulloblastoma 29 | 1,524
primitive neuroectodermal tumor 27 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,988
invasive ductal carcinoma 26 | 2,950
non-small cell lung cancer 26 | 2,798
pediatric high grade glioma 26 | 2,712
pilocytic astrocytoma 26 | 3,086
Waldenstrons macroglobulinemia 25 | 765
adult high grade glioma 25 | 2,148
lung adenocarcinoma 24 | 2,713
subependymal giant cell astrocytoma 24 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
non primary Sjogren syndrome sicca 22 | 840
diabetes mellitus 21 | 1,663
lung carcinoma 21 | 2,844
MITOCHONDRIAL COMPLEX I DEFICIENCY 20 | 37
breast carcinoma 19 | 1,614
acute myeloid leukemia 18 | 780
astrocytoma 18 | 1,493
ulcerative colitis 18 | 2,087
Rheumatoid Arthritis 17 | 1,160
group 3 medulloblastoma 17 | 2,254
pancreatic cancer 16 | 2,300
Cancer 14 | 2,346
NADH:Q(1) Oxidoreductase deficiency 14 | 20
pituitary cancer 14 | 1,972
tuberculosis 14 | 1,557
atypical teratoid/rhabdoid tumor 13 | 1,095
group 4 medulloblastoma 13 | 1,875
Alzheimer's disease 12 | 644
adrenocortical carcinoma 12 | 1,427
ductal carcinoma in situ 12 | 1,745
hereditary spastic paraplegia 12 | 313
Neurodegenerative disease 11 | 383
acute quadriplegic myopathy 11 | 1,157
posterior fossa group B ependymoma 11 | 1,530
sonic hedgehog group medulloblastoma 11 | 1,482
Cardiomyopathy 10 | 110
Obesity 10 | 616
aldosterone-producing adenoma 10 | 664
cystic fibrosis 10 | 1,665
Leber hereditary optic neuropathy 9 | 17
Optic atrophy 9 | 43
interstitial cystitis 9 | 2,299
posterior fossa group A ependymoma 9 | 1,511
Anemia 8 | 252
Deafness dystonia syndrome 8 | 20
Down syndrome 8 | 548
IGA Glomerulonephritis 8 | 454
Myopathy 8 | 128
Neuropathy 8 | 210
gastric carcinoma 8 | 832
tuberculosis and treatment for 6 months 8 | 686
3-methylglutaconic aciduria 7 | 29
Intellectual disability 7 | 573
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 7 | 14
Lactic acidosis 7 | 42
Mitochondrial myopathy 7 | 23
Multiple acyl-CoA dehydrogenase deficiency 7 | 26
Parkinson's disease 7 | 364
Stomach Neoplasms 7 | 282
colon cancer 7 | 1,475
dermatomyositis 7 | 933
inflammatory breast cancer 7 | 404
Barth syndrome 6 | 23
Carnitine palmitoyltransferase II deficiency 6 | 16
Duchenne muscular dystrophy 6 | 602
Dystonia 6 | 77
Liver carcinoma 6 | 217
Malaria 6 | 140
Optic Atrophy, Hereditary, Leber 6 | 14
Pneumonia 6 | 133
Schizophrenia 6 | 501
juvenile dermatomyositis 6 | 1,189
nasopharyngeal carcinoma 6 | 1,056
pancreatic carcinoma 6 | 567
primary pancreatic ductal adenocarcinoma 6 | 1,271
cutaneous lupus erythematosus 5 | 1,056
fibroadenoma 5 | 557
primary Sjogren syndrome 5 | 789
progressive supranuclear palsy 5 | 674

Tissue

Blood and immune system 266 | 17,995
Endocrine System 266 | 18,512
Urinary Tract 266 | 18,444
Cardiovascular System 265 | 17,958
Digestive Tract 265 | 18,473
Female tissues 265 | 18,647
Liver and Pancreas 265 | 18,136
Male tissues 265 | 17,969
Nervous System 265 | 18,561
Respiratory system 264 | 17,484
Skin and soft tissues 263 | 18,115

Target Family

Enzyme 147 | 4,146
Non-IDG 65 | 11,971
Transporter 50 | 473
Kinase 5 | 634
Ion Channel 1 | 341

UniProt Keyword

Mitochondrion inner membrane 268 | 268
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Cytochrome c oxidase subunit 6A1, mitochondrial COX6A1 Tbio Enzyme -1.00384 11.8 165
Heat shock protein 75 kDa, mitochondrial TRAP1 Tchem Non-IDG -1.12188 14.9 328
Cytochrome c oxidase subunit 7C, mitochondrial COX7C Tdark Enzyme -0.99133 9.67 34
Cytochrome b MT-CYB Tbio Non-IDG -3.74473 5676.0 122
MICOS complex subunit MIC10 MINOS1 Tdark Non-IDG -0.09691 1.46 40
Glycine amidinotransferase, mitochondrial GATM Tbio Enzyme -2.31313 210.4 193
Dual specificity protein phosphatase 18 DUSP18 Tbio Enzyme -0.67210 5.47 19