Development Level

Tbio 781 | 11,651
Tdark 194 | 6,593
Tchem 96 | 1,388
Tclin 76 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 129 | 979
embryonic lethality prior to o... 35 | 239
embryonic lethality prior to t... 31 | 278
abnormal behavior 22 | 298
preweaning lethality, incomple... 19 | 499
abnormal embryo size 16 | 220
decreased body weight 13 | 161
embryonic growth retardation 13 | 106
cataract 12 | 92
decreased bone mineral content 12 | 151
decreased total body fat amoun... 12 | 207
hyperactivity 12 | 148
increased mean corpuscular hem... 12 | 96
increased total body fat amoun... 12 | 134
abnormal bone structure 11 | 187
abnormal lens morphology 11 | 81
decreased vertical activity 11 | 208
hypoactivity 11 | 132
decreased lean body mass 10 | 135
increased lean body mass 10 | 172
decreased circulating glucose ... 9 | 126
enlarged heart 9 | 210
abnormal heart morphology 8 | 162
increased fasted circulating g... 8 | 76
increased startle reflex 8 | 112
prenatal lethality prior to he... 8 | 87
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
increased circulating choleste... 7 | 66
abnormal seminal vesicle morph... 6 | 114
decreased circulating alkaline... 6 | 46
decreased circulating choleste... 6 | 93
decreased fasted circulating g... 6 | 65
decreased mean corpuscular vol... 6 | 79
increased circulating alkaline... 6 | 122
male infertility 6 | 123
pallor 6 | 34
persistence of hyaloid vascula... 6 | 33
small superior vagus ganglion 6 | 74
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
decreased circulating HDL chol... 5 | 68
decreased circulating LDL chol... 5 | 38
decreased circulating total pr... 5 | 49
decreased leukocyte cell numbe... 5 | 73
decreased red blood cell distr... 5 | 41
increased circulating HDL chol... 5 | 80
increased circulating bilirubi... 5 | 16
increased circulating sodium l... 5 | 71
increased heart weight 5 | 62
increased prepulse inhibition 5 | 32
small testis 5 | 58
thrombocytopenia 5 | 56
abnormal coat-hair pigmentatio... 4 | 64
abnormal cranium morphology 4 | 36
abnormal gait 4 | 69
abnormal neural tube closure 4 | 46
abnormal retina morphology 4 | 71
abnormal testis morphology 4 | 43
decreased body length 4 | 101
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased hematocrit 4 | 46
decreased mean platelet volume 4 | 25
decreased prepulse inhibition 4 | 82
decreased startle reflex 4 | 75
hydrometra 4 | 53
improved glucose tolerance 4 | 79
increased circulating glucose ... 4 | 24
increased circulating phosphat... 4 | 26
increased mean corpuscular vol... 4 | 92
increased or absent threshold ... 4 | 101
increased red blood cell distr... 4 | 34
abnormal behavioral response t... 3 | 66
abnormal bone mineralization 3 | 38
abnormal embryo turning 3 | 31
abnormal heart left ventricle ... 3 | 16
abnormal retinal vasculature m... 3 | 27
abnormal tooth morphology 3 | 24
abnormal vertebrae morphology 3 | 18
decreased circulating alanine ... 3 | 47
decreased circulating aspartat... 3 | 34
decreased circulating chloride... 3 | 30
decreased circulating creatini... 3 | 39
decreased circulating iron lev... 3 | 32
decreased hemoglobin content 3 | 68
decreased total retina thickne... 3 | 17
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating calcium ... 3 | 34
increased circulating serum al... 3 | 22
increased hemoglobin content 3 | 45
increased monocyte cell number 3 | 63
long tibia 3 | 25
pale yolk sac 3 | 25
prenatal lethality 3 | 28
short tibia 3 | 97
thrombocytosis 3 | 27

Disease

ovarian cancer 636 | 8,520
Carcinoma 535 | 11,493
osteosarcoma 507 | 7,950
medulloblastoma, large-cell 365 | 6,241
psoriasis 353 | 6,694
lung cancer 342 | 4,740
glioblastoma 295 | 5,792
atypical teratoid / rhabdoid tumor 279 | 5,112
pancreatic ductal adenocarcinoma liver metastasis 272 | 1,962
ependymoma 226 | 4,679
group 3 medulloblastoma 214 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 208 | 3,291
Breast cancer 198 | 3,578
Autosomal recessive predisposition 195 | 1,442
adult high grade glioma 189 | 3,801
malignant mesothelioma 187 | 3,232
Multiple myeloma 186 | 1,332
astrocytic glioma 168 | 2,597
invasive ductal carcinoma 160 | 2,951
non-small cell lung cancer 158 | 2,890
primitive neuroectodermal tumor 150 | 3,035
lung adenocarcinoma 144 | 2,716
oligodendroglioma 143 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 142 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 142 | 2,989
Cancer 127 | 2,499
Pick disease 125 | 1,894
Astrocytoma, Pilocytic 123 | 3,081
tuberculosis 117 | 2,010
Muscle hypotonia 116 | 571
Epilepsy 111 | 792
lung carcinoma 109 | 2,843
subependymal giant cell astrocytoma 109 | 2,287
Cognitive delay 108 | 608
Global developmental delay 108 | 608
Mental and motor retardation 108 | 608
pancreatic cancer 107 | 2,398
ulcerative colitis 104 | 1,819
group 4 medulloblastoma 103 | 1,855
breast carcinoma 102 | 1,638
diabetes mellitus 101 | 1,728
Seizures 96 | 596
Leigh disease 93 | 100
ductal carcinoma in situ 92 | 1,745
Cerebellar Ataxia 86 | 304
Intellectual disability 86 | 1,016
interstitial cystitis 86 | 2,312
non primary Sjogren syndrome sicca 85 | 891
Acidosis, Lactic 84 | 97
Lactic acidemia 83 | 95
colon cancer 82 | 1,478
Waldenstrons macroglobulinemia 79 | 765
adrenocortical carcinoma 77 | 1,428
pituitary cancer 76 | 1,972
Schizophrenia 75 | 1,160
cystic fibrosis 74 | 1,696
Dull intelligence 73 | 645
Failure to gain weight 73 | 365
Low intelligence 73 | 645
Mental Retardation 73 | 645
Mental deficiency 73 | 645
Pediatric failure to thrive 73 | 365
Poor school performance 73 | 645
acute myeloid leukemia 69 | 783
Neurodegenerative disease 66 | 414
Optic Atrophy 64 | 242
Obesity 61 | 678
Rheumatoid arthritis 61 | 1,191
Dystonia 59 | 164
Hypoglycemia 59 | 152
dermatomyositis 59 | 966
astrocytoma 58 | 1,146
Kidney cancer 57 | 2,613
acute quadriplegic myopathy 56 | 1,158
Increased serum lactate 54 | 60
Nystagmus 54 | 317
juvenile dermatomyositis 53 | 1,187
active ulcerative colitis 52 | 764
Hyperreflexia 51 | 209
nasopharyngeal carcinoma 51 | 1,058
Blepharoptosis 50 | 231
Liver Cirrhosis, Experimental 50 | 769
Alzheimer's disease 49 | 658
Diabetes mellitus type 2 49 | 69
Sensorineural Hearing Loss (disorder) 49 | 284
Treatment Refractory Type 2 Diabetes Mellitus 49 | 53
aldosterone-producing adenoma 49 | 665
medulloblastoma 49 | 720
Vomiting 47 | 116
gastric carcinoma 47 | 807
pediatric high grade glioma 47 | 1,064
Dystonic disease 46 | 106
Highly variable clinical phenotype 46 | 150
Highly variable phenotype and severity 46 | 150
Highly variable phenotype, even within families 46 | 150
Infantile onset 46 | 238
Lethargy 46 | 77
Phenotypic variability 46 | 150
active Crohn's disease 46 | 922
hereditary spastic paraplegia 46 | 318

Tissue

Endocrine System 1,128 | 18,159
Digestive Tract 1,121 | 17,369
Skin and soft tissues 1,117 | 17,230
Female tissues 1,116 | 17,400
Liver and Pancreas 1,112 | 16,750
Male tissues 1,112 | 17,142
Urinary Tract 1,111 | 16,678
Blood and immune system 1,108 | 16,909
Nervous System 1,106 | 16,725
Respiratory system 1,097 | 16,393
Cardiovascular System 1,083 | 15,192

Target Family

Enzyme 569 | 4,145
Non-IDG 451 | 12,091
Transporter 60 | 473
Kinase 49 | 634
Epigenetic 7 | 242
Transcription Factor 5 | 1,400
GPCR 2 | 408
Ion Channel 2 | 344
Nuclear Receptor 2 | 48

UniProt Keyword

Mitochondrion 1,147 | 1,147
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Carbonyl reductase family member 4 CBR4 Tbio Enzyme -1.69083 48.5 128
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Oxidation resistance protein 1 OXR1 Tbio Non-IDG -1.67505 49.4 144
39S ribosomal protein L40, mitochondrial MRPL40 Tbio Non-IDG -0.92179 8.33 105
Protein arginine methyltransferase NDUFAF7, mitochondrial NDUFAF7 Tbio Enzyme -0.45102 2.70 64
Transmembrane protein 11, mitochondrial TMEM11 Tdark Non-IDG -2.44072 252.5 35
DNL-type zinc finger protein DNLZ Tdark Non-IDG -0.90037 8.91 3