Development Level

Tbio 712 | 10,625
Tdark 208 | 7,003
Tchem 122 | 1,890
Tclin 73 | 602

Collection

Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 71 | 633
embryonic lethality prior to o... 26 | 148
embryonic lethality prior to t... 21 | 187
decreased body weight 16 | 174
abnormal behavior 14 | 226
abnormal embryo size 10 | 112
abnormal lens morphology 10 | 73
decreased lean body mass 10 | 195
decreased total body fat amoun... 10 | 186
hypoactivity 10 | 89
preweaning lethality, incomple... 10 | 260
abnormal bone structure 9 | 131
decreased bone mineral content 9 | 157
decreased circulating glucose ... 9 | 121
increased mean corpuscular hem... 9 | 93
abnormal retina morphology 8 | 100
increased mean corpuscular vol... 8 | 91
prenatal lethality prior to he... 8 | 64
decreased circulating triglyce... 7 | 83
decreased grip strength 7 | 123
decreased leukocyte cell numbe... 7 | 54
embryonic growth retardation 7 | 28
increased grip strength 7 | 83
increased startle reflex 7 | 38
hyperactivity 6 | 108
increased circulating alkaline... 6 | 119
increased circulating choleste... 6 | 53
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
increased heart weight 6 | 37
increased lean body mass 6 | 107
decreased body length 5 | 108
decreased circulating alkaline... 5 | 41
decreased circulating choleste... 5 | 85
decreased circulating serum al... 5 | 79
decreased rib number 5 | 59
increased circulating HDL chol... 5 | 63
increased circulating phosphat... 5 | 24
abnormal bone mineralization 4 | 55
abnormal retinal pigmentation 4 | 61
abnormal testis morphology 4 | 30
decreased T cell number 4 | 31
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating total pr... 4 | 41
decreased heart weight 4 | 44
decreased total retina thickne... 4 | 20
increased NK cell number 4 | 19
increased circulating bilirubi... 4 | 16
increased exploration in new e... 4 | 56
increased red blood cell distr... 4 | 21
male infertility 4 | 62
short tibia 4 | 82
small testis 4 | 37
thrombocytopenia 4 | 46
abnormal behavioral response t... 3 | 52
abnormal cranium morphology 3 | 32
abnormal gait 3 | 51
abnormal heart left ventricle ... 3 | 20
abnormal neural tube closure 3 | 37
abnormal tooth morphology 3 | 24
abnormal vertebrae morphology 3 | 14
decreased CD4-positive, alpha ... 3 | 19
decreased CD8-positive, alpha-... 3 | 26
decreased Ly6C low monocyte nu... 3 | 23
decreased blood urea nitrogen ... 3 | 31
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating creatini... 3 | 31
decreased circulating fructosa... 3 | 31
decreased circulating iron lev... 3 | 25
decreased fasted circulating g... 3 | 49
decreased follicular B cell nu... 3 | 4
decreased lumbar vertebrae num... 3 | 62
decreased mean platelet volume 3 | 12
decreased red blood cell distr... 3 | 11
decreased startle reflex 3 | 48
enlarged heart 3 | 111
female infertility 3 | 34
improved glucose tolerance 3 | 56
increased bone mineral content 3 | 92
increased circulating glucose ... 3 | 16
increased erythrocyte cell num... 3 | 26
increased or absent threshold ... 3 | 128
pallor 3 | 13
persistence of hyaloid vascula... 3 | 22
abnormal coat appearance 2 | 25
abnormal locomotor activation 2 | 26
abnormal vocalization 2 | 21
decreased circulating potassiu... 2 | 17
decreased effector memory CD8-... 2 | 24
decreased mean corpuscular vol... 2 | 50
decreased vertical activity 2 | 22
increased circulating aspartat... 2 | 17
increased circulating calcium ... 2 | 32
increased circulating iron lev... 2 | 25
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
thrombocytosis 2 | 23

Disease

ovarian cancer 613 | 8,484
osteosarcoma 489 | 7,933
medulloblastoma, large-cell 351 | 6,234
psoriasis 344 | 6,685
lung cancer 329 | 4,466
glioblastoma 275 | 5,572
pancreatic ductal adenocarcinoma liver metastasis 253 | 1,795
atypical teratoid / rhabdoid tumor 221 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 201 | 3,289
Multiple myeloma 182 | 1,327
Breast cancer 177 | 3,094
malignant mesothelioma 174 | 3,162
invasive ductal carcinoma 151 | 2,950
non-small cell lung cancer 150 | 2,798
astrocytic glioma 148 | 2,241
ependymoma 148 | 2,514
primitive neuroectodermal tumor 145 | 3,031
lung adenocarcinoma 141 | 2,713
oligodendroglioma 139 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 134 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 134 | 2,988
ulcerative colitis 127 | 2,087
group 3 medulloblastoma 123 | 2,254
Pick disease 120 | 1,893
pediatric high grade glioma 119 | 2,712
pilocytic astrocytoma 119 | 3,086
Cancer 117 | 2,346
adult high grade glioma 108 | 2,148
lung carcinoma 107 | 2,844
subependymal giant cell astrocytoma 106 | 2,287
pancreatic cancer 103 | 2,300
group 4 medulloblastoma 94 | 1,875
medulloblastoma 92 | 1,524
breast carcinoma 91 | 1,614
tuberculosis 88 | 1,557
diabetes mellitus 87 | 1,663
ductal carcinoma in situ 87 | 1,745
interstitial cystitis 85 | 2,299
non primary Sjogren syndrome sicca 83 | 840
Waldenstrons macroglobulinemia 77 | 765
colon cancer 77 | 1,475
Leigh disease 75 | 81
adrenocortical carcinoma 73 | 1,427
astrocytoma 73 | 1,493
pituitary cancer 72 | 1,972
cystic fibrosis 70 | 1,665
sonic hedgehog group medulloblastoma 67 | 1,482
Neurodegenerative disease 65 | 383
acute myeloid leukemia 65 | 780
Rheumatoid Arthritis 61 | 1,160
posterior fossa group B ependymoma 61 | 1,530
atypical teratoid/rhabdoid tumor 56 | 1,095
dermatomyositis 56 | 933
Obesity 55 | 616
primary pancreatic ductal adenocarcinoma 54 | 1,271
acute quadriplegic myopathy 53 | 1,157
juvenile dermatomyositis 52 | 1,189
nasopharyngeal carcinoma 52 | 1,056
Diabetes mellitus type 2 49 | 69
Treatment Refractory Type 2 Diabetes Mellitus 49 | 53
posterior fossa group A ependymoma 49 | 1,511
gastric carcinoma 48 | 832
aldosterone-producing adenoma 47 | 664
Alzheimer's disease 46 | 644
tuberculosis and treatment for 6 months 46 | 686
hereditary spastic paraplegia 44 | 313
active Crohn's disease 43 | 918
cutaneous lupus erythematosus 40 | 1,056
primary Sjogren syndrome 39 | 789
Mammary Neoplasms 38 | 410
Atopic dermatitis 36 | 944
Parkinson's disease 36 | 364
MITOCHONDRIAL COMPLEX I DEFICIENCY 35 | 37
Stomach Neoplasms 35 | 282
Prostatic Neoplasms 34 | 471
progressive supranuclear palsy 34 | 674
spina bifida 34 | 1,064
Carcinoma 33 | 2,147
hepatocellular carcinoma 33 | 532
Lactic acidosis 32 | 42
pancreatic carcinoma 32 | 567
esophageal adenocarcinoma 31 | 737
Down syndrome 30 | 548
Neuropathy 29 | 210
nephrosclerosis 29 | 329
Schizophrenia 27 | 501
Liver carcinoma 26 | 217
IGA Glomerulonephritis 25 | 454
Multiple Sclerosis 25 | 498
Polycystic Ovary Syndrome 25 | 332
active ulcerative colitis 25 | 477
fibroadenoma 25 | 557
inflammatory breast cancer 25 | 404
Amyotrophic Lateral Sclerosis 24 | 431
Disease Progression 24 | 125
Duchenne muscular dystrophy 24 | 602
Epilepsy 24 | 346
Intellectual disability 24 | 573
Vascular disease 24 | 281
gastric cancer 24 | 430

Tissue

Female tissues 1,103 | 18,647
Nervous System 1,103 | 18,561
Blood and immune system 1,102 | 17,995
Digestive Tract 1,101 | 18,473
Liver and Pancreas 1,101 | 18,136
Urinary Tract 1,101 | 18,444
Endocrine System 1,100 | 18,512
Cardiovascular System 1,099 | 17,958
Male tissues 1,099 | 17,969
Skin and soft tissues 1,092 | 18,115
Respiratory system 1,090 | 17,484

Target Family

Enzyme 559 | 4,146
Non-IDG 431 | 11,971
Transporter 60 | 473
Kinase 49 | 634
Epigenetic 7 | 242
Transcription Factor 4 | 1,400
Ion Channel 2 | 341
Nuclear Receptor 2 | 48
GPCR 1 | 406

UniProt Keyword

Mitochondrion 1,115 | 1,115
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
NADH-ubiquinone oxidoreductase chain 6 MT-ND6 Tclin Enzyme -2.74395 585.6 62
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.21960 180.2 229
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
39S ribosomal protein L37, mitochondrial MRPL37 Tdark Non-IDG -0.30103 2.00 47