Development Level

Tbio 193 | 11,178
Tdark 46 | 6,569
Tchem 33 | 1,885
Tclin 9 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 9 | 499
abnormal embryo size 7 | 220
abnormal behavior 6 | 298
decreased body length 5 | 101
decreased total body fat amoun... 5 | 207
embryonic lethality prior to t... 5 | 278
abnormal bone structure 4 | 187
decreased body weight 4 | 161
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating glucose ... 4 | 126
hyperactivity 4 | 148
increased mean corpuscular vol... 4 | 92
prenatal lethality prior to he... 4 | 87
abnormal lung morphology 3 | 26
abnormal seminal vesicle morph... 3 | 114
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
decreased lean body mass 3 | 135
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
male infertility 3 | 123
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal cranium morphology 2 | 36
abnormal head morphology 2 | 10
abnormal sleep behavior 2 | 70
abnormal tail morphology 2 | 25
abnormal tail movements 2 | 12
absent pinna reflex 2 | 23
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
cyanosis 2 | 7
decreased circulating choleste... 2 | 93
decreased circulating free fat... 2 | 31
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
long tibia 2 | 25
polycystic kidney 2 | 15
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal retinal inner nuclear... 1 | 8
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fluid intake 1 | 3
decreased hemoglobin content 1 | 68
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
microphthalmia 1 | 26
prenatal lethality 1 | 28
scaly skin 1 | 4
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 205 | 11,192
ovarian cancer 140 | 8,297
medulloblastoma, large-cell 126 | 6,086
osteosarcoma 124 | 7,766
glioblastoma 115 | 5,635
ependymoma 114 | 4,559
psoriasis 110 | 6,514
atypical teratoid / rhabdoid tumor 108 | 4,971
group 3 medulloblastoma 98 | 4,002
lung cancer 97 | 4,607
Breast cancer 84 | 3,469
adult high grade glioma 80 | 3,701
primitive neuroectodermal tumor 70 | 2,957
Kidney cancer 67 | 2,548
oligodendroglioma 67 | 2,768
malignant mesothelioma 66 | 3,135
Astrocytoma, Pilocytic 60 | 3,006
non-small cell lung cancer 59 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 57 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,204
invasive ductal carcinoma 53 | 2,867
astrocytic glioma 49 | 2,530
lung adenocarcinoma 47 | 2,627
lung carcinoma 47 | 2,755
Pick disease 46 | 1,856
pancreatic cancer 46 | 2,322
adrenocortical carcinoma 41 | 1,385
colon cancer 41 | 1,428
nasopharyngeal carcinoma 40 | 1,024
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,872
subependymal giant cell astrocytoma 39 | 2,230
ductal carcinoma in situ 38 | 1,686
breast carcinoma 35 | 1,589
group 4 medulloblastoma 34 | 1,806
pituitary cancer 32 | 1,915
Intellectual disability 27 | 998
Atopic dermatitis 26 | 915
Cancer 26 | 2,388
Liver cancer 26 | 589
chronic rhinosinusitis 26 | 505
interstitial cystitis 26 | 2,237
Endometriosis 24 | 521
Autosomal recessive predisposition 23 | 1,407
progressive supranuclear palsy 23 | 656
juvenile dermatomyositis 22 | 1,147
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,911
tuberculosis 21 | 1,963
ulcerative colitis 21 | 1,765
Epilepsy 19 | 775
Microcephaly 19 | 166
astrocytoma 19 | 1,113
pediatric high grade glioma 19 | 1,035
Cognitive delay 18 | 596
Endometrial cancer 18 | 301
Global developmental delay 18 | 596
Mental and motor retardation 18 | 596
Small head 18 | 366
Lissencephaly 17 | 69
Primary ciliary dyskinesia 17 | 75
Seizures 17 | 584
spina bifida 17 | 1,053
Multiple myeloma 16 | 1,296
Schizophrenia 16 | 1,136
acute quadriplegic myopathy 16 | 1,133
primary pancreatic ductal adenocarcinoma 16 | 1,071
Dull intelligence 15 | 634
Low intelligence 15 | 634
Melanoma 15 | 689
Mental Retardation 15 | 634
Mental deficiency 15 | 634
Poor school performance 15 | 634
dermatomyositis 15 | 941
diabetes mellitus 15 | 1,683
Alzheimer's disease 14 | 640
Amyotrophic lateral sclerosis 14 | 437
Neurodegenerative disease 14 | 402
Muscle hypotonia 13 | 562
Skin cancer 13 | 451
acute myeloid leukemia 13 | 760
posterior fossa group B ependymoma 13 | 406
primary Sjogren syndrome 13 | 710
Neuroblastoma 12 | 79
cystic fibrosis 12 | 1,629
hepatocellular carcinoma 12 | 536
medulloblastoma 12 | 702
tuberculosis and treatment for 6 months 12 | 399
cutaneous lupus erythematosus 11 | 1,016
hereditary spastic paraplegia 11 | 313
non-small cell lung carcinoma 11 | 302
Bipolar Disorder 10 | 646
Down syndrome 10 | 480
Kaposi's sarcoma 10 | 22
Neuropathy 10 | 254
Situs Inversus 10 | 61
cystic fibrosis and chronic rhinosinusitis 10 | 211
fibroadenoma 10 | 538
gastric cancer 10 | 445
non primary Sjogren syndrome sicca 10 | 861
Duchenne muscular dystrophy 9 | 587
gastric carcinoma 9 | 781

Tissue

Endocrine System 278 | 18,159
Female tissues 272 | 17,400
Skin and soft tissues 271 | 17,230
Digestive Tract 269 | 17,369
Male tissues 268 | 17,142
Respiratory system 267 | 16,393
Nervous System 266 | 16,725
Urinary Tract 266 | 16,678
Blood and immune system 264 | 16,909
Liver and Pancreas 262 | 16,750
Cardiovascular System 244 | 15,192

Target Family

Non-IDG 250 | 12,091
Enzyme 26 | 4,145
Kinase 4 | 634
Epigenetic 1 | 242

UniProt Keyword

Microtubule 281 | 281
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Protein monoglycylase TTLL8 TTLL8 Tdark Enzyme -0.12494 0.88 19
Dynein heavy chain 5, axonemal DNAH5 Tbio Non-IDG -1.46000 27.2 32
Tubulin polyglutamylase TTLL13P TTLL13P Tdark Enzyme 0.78 0.17 0
Kinesin-like protein KIF17 KIF17 Tbio Non-IDG -2.01401 107.8 73
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
Centriole, cilia and spindle-associated protein CCSAP Tbio Non-IDG -1.93256 89.5 55
Calmodulin-regulated spectrin-associated protein 3 CAMSAP3 Tbio Non-IDG -1.12695 12.1 67
Kinesin heavy chain isoform 5C KIF5C Tbio Non-IDG -1.43450 25.5 119
Serine/threonine-protein kinase Nek7 NEK7 Tchem Kinase -1.31475 20.8 261