Development Level

Tbio 78 | 11,445
Tchem 28 | 1,598
Tdark 12 | 6,588
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

decreased blood urea nitrogen ... 3 | 51
decreased circulating triglyce... 3 | 79
hyperactivity 3 | 148
hypoactivity 3 | 132
increased leukocyte cell numbe... 3 | 47
preweaning lethality, incomple... 3 | 499
cataract 2 | 92
decreased body weight 2 | 161
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
thrombocytopenia 2 | 56
abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal pupil morphology 1 | 2
abnormal retina morphology 1 | 71
abnormal tibia morphology 1 | 14
decreased body length 1 | 101
decreased circulating LDL chol... 1 | 38
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 31
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased IgA level 1 | 1
increased aggression 1 | 4
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating potassiu... 1 | 29
increased circulating unsatura... 1 | 1
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 92 | 11,493
psoriasis 72 | 6,694
ovarian cancer 52 | 8,520
osteosarcoma 44 | 7,950
lung cancer 43 | 4,740
medulloblastoma, large-cell 42 | 6,241
glioblastoma 40 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
Breast cancer 37 | 3,578
atypical teratoid / rhabdoid tumor 37 | 5,112
ependymoma 36 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
invasive ductal carcinoma 33 | 2,951
Cancer 32 | 2,499
group 3 medulloblastoma 32 | 4,104
interstitial cystitis 32 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
lung carcinoma 31 | 2,843
pancreatic cancer 31 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,962
lung adenocarcinoma 30 | 2,716
adult high grade glioma 27 | 3,801
non-small cell lung cancer 26 | 2,890
Astrocytoma, Pilocytic 25 | 3,081
malignant mesothelioma 24 | 3,232
tuberculosis 24 | 2,010
ulcerative colitis 24 | 1,819
cystic fibrosis 23 | 1,696
Prostatic Neoplasms 22 | 495
primitive neuroectodermal tumor 22 | 3,035
ductal carcinoma in situ 21 | 1,745
oligodendroglioma 21 | 2,850
active Crohn's disease 20 | 922
pituitary cancer 19 | 1,972
Pick disease 18 | 1,894
cutaneous lupus erythematosus 18 | 1,057
astrocytic glioma 17 | 2,597
diabetes mellitus 16 | 1,728
subependymal giant cell astrocytoma 16 | 2,287
Chemical and Drug Induced Liver Injury 15 | 195
Schizophrenia 15 | 1,160
colon cancer 15 | 1,478
breast carcinoma 14 | 1,638
Autosomal recessive predisposition 13 | 1,442
Hypertension 13 | 396
adrenocortical carcinoma 13 | 1,428
Kidney cancer 12 | 2,613
Liver disease 12 | 237
acute quadriplegic myopathy 12 | 1,158
astrocytoma 12 | 1,146
chronic rhinosinusitis 12 | 512
esophageal adenocarcinoma 12 | 737
juvenile dermatomyositis 12 | 1,187
Alzheimer's disease 11 | 658
Anemia 11 | 365
Liver Cirrhosis, Experimental 11 | 769
Melanoma 11 | 711
non primary Sjogren syndrome sicca 11 | 891
Atopic dermatitis 10 | 952
Obesity 10 | 678
nasopharyngeal carcinoma 10 | 1,058
pediatric high grade glioma 10 | 1,064
Drug-Related Side Effects and Adverse Reactions 9 | 62
Sickle Cell Anemia 9 | 53
aldosterone-producing adenoma 9 | 665
Adverse reaction to drug 8 | 61
Bilirubin metabolic disorder 8 | 41
Breast Neoplasms 8 | 445
Cholestasis 8 | 155
Diarrhea 8 | 253
Endometriosis 8 | 540
Epilepsy 8 | 792
Mammary Neoplasms 8 | 425
Rheumatoid arthritis 8 | 1,191
active ulcerative colitis 8 | 764
hepatocellular carcinoma 8 | 547
non diabetic and post-ischemic heart failure 8 | 200
pancreatic carcinoma 8 | 562
Acute kidney injury 7 | 70
Adenocarcinoma 7 | 122
Coronary artery disease 7 | 268
Depressive disorder 7 | 409
Hypertensive disease 7 | 292
Lung Neoplasms 7 | 232
Multiple myeloma 7 | 1,332
Pericholangitis 7 | 8
adrenocortical adenoma 7 | 131
dermatomyositis 7 | 966
fibroadenoma 7 | 559
gastric carcinoma 7 | 807
medulloblastoma 7 | 720
mucosa-associated lymphoid tissue lymphoma 7 | 484
primary Sjogren syndrome 7 | 735
Attention deficit hyperactivity disorder 6 | 278
Cerebrovascular disease 6 | 238
Down syndrome 6 | 499
Kidney disease 6 | 430
Unipolar Depression 6 | 250
Waldenstrons macroglobulinemia 6 | 765
primary pancreatic ductal adenocarcinoma 6 | 1,109

Tissue

Liver and Pancreas 125 | 16,750
Digestive Tract 123 | 17,369
Female tissues 119 | 17,400
Skin and soft tissues 119 | 17,230
Endocrine System 118 | 18,159
Male tissues 117 | 17,142
Urinary Tract 117 | 16,678
Blood and immune system 109 | 16,909
Respiratory system 106 | 16,393
Nervous System 102 | 16,725
Cardiovascular System 87 | 15,192

Target Family

Enzyme 81 | 4,145
Non-IDG 42 | 12,091
Kinase 3 | 634
Ion Channel 2 | 344
Transcription Factor 1 | 1,400

UniProt Keyword

Microsome 129 | 129
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal peptidase complex subunit 1 SPCS1 Tdark Enzyme -0.80900 6.46 44
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
UDP-glucuronosyltransferase 2B7 UGT2B7 Tchem Enzyme -2.31570 219.0 131
Leucine-rich repeat transmembrane protein FLRT2 FLRT2 Tbio Non-IDG -1.09240 12.6 50
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
F-box only protein 2 FBXO2 Tbio Non-IDG -1.36281 26.8 157
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.68998 9.87 74
Thioredoxin reductase 3 TXNRD3 Tdark Enzyme -1.72626 60.0 0
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88