Development Level

Tbio 96 | 11,445
Tdark 52 | 6,588
Tchem 32 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 12 | 499
abnormal behavior 8 | 298
decreased total body fat amoun... 8 | 207
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
embryonic lethality prior to t... 6 | 278
abnormal embryo size 4 | 220
decreased mean corpuscular vol... 4 | 79
increased circulating HDL chol... 4 | 80
increased startle reflex 4 | 112
male infertility 4 | 123
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating alanine ... 3 | 47
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
decreased prepulse inhibition 3 | 82
embryonic growth retardation 3 | 106
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased circulating triglyce... 3 | 42
increased mean corpuscular vol... 3 | 92
increased mean platelet volume 3 | 45
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal coat appearance 2 | 31
abnormal coat-hair pigmentatio... 2 | 64
abnormal retinal vasculature m... 2 | 27
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
female infertility 2 | 60
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased blood urea nitrogen ... 2 | 48
increased bone mineral density 2 | 72
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal vertebrae morphology 1 | 18
absent spleen 1 | 3
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hydrometra 1 | 53
increased cardiac muscle contr... 1 | 8
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
small spleen 1 | 19
small testis 1 | 58
trunk curl 1 | 16

Disease

Carcinoma 106 | 11,493
osteosarcoma 92 | 7,950
ovarian cancer 87 | 8,520
medulloblastoma, large-cell 53 | 6,241
psoriasis 49 | 6,694
group 3 medulloblastoma 48 | 4,104
atypical teratoid / rhabdoid tumor 47 | 5,112
glioblastoma 45 | 5,792
malignant mesothelioma 40 | 3,232
ependymoma 38 | 4,679
lung cancer 38 | 4,740
primitive neuroectodermal tumor 33 | 3,035
Cancer 32 | 2,499
Breast cancer 31 | 3,578
adult high grade glioma 31 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
Astrocytoma, Pilocytic 21 | 3,081
Kidney cancer 21 | 2,613
non-small cell lung cancer 21 | 2,890
Pick disease 20 | 1,894
Intellectual disability 19 | 1,016
astrocytic glioma 18 | 2,597
oligodendroglioma 18 | 2,850
pancreatic cancer 18 | 2,398
lung adenocarcinoma 16 | 2,716
subependymal giant cell astrocytoma 16 | 2,287
spina bifida 15 | 1,074
Breast Neoplasms 14 | 445
Schizophrenia 14 | 1,160
group 4 medulloblastoma 14 | 1,855
pituitary cancer 13 | 1,972
Mammary Neoplasms 12 | 425
Multiple myeloma 12 | 1,332
ductal carcinoma in situ 11 | 1,745
juvenile dermatomyositis 11 | 1,187
tuberculosis 11 | 2,010
tuberculosis and treatment for 6 months 11 | 409
Rheumatoid arthritis 10 | 1,191
acute myeloid leukemia 10 | 783
acute quadriplegic myopathy 10 | 1,158
adrenocortical carcinoma 10 | 1,428
dermatomyositis 10 | 966
hepatocellular carcinoma 10 | 547
interstitial cystitis 10 | 2,312
lung carcinoma 10 | 2,843
progressive supranuclear palsy 10 | 676
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Poor school performance 9 | 645
Waldenstrons macroglobulinemia 9 | 765
diabetes mellitus 8 | 1,728
gastric cancer 8 | 459
pediatric high grade glioma 8 | 1,064
Autosomal recessive predisposition 7 | 1,442
Cleft Palate 7 | 271
Liver cancer 7 | 604
Muscle hypotonia 7 | 571
Short stature 7 | 531
breast carcinoma 7 | 1,638
cystic fibrosis 7 | 1,696
non primary Sjogren syndrome sicca 7 | 891
Carcinoma, Hepatocellular 6 | 228
Congenital Epicanthus 6 | 177
Epilepsy 6 | 792
Leukemia, Myelocytic, Acute 6 | 120
Liver carcinoma 6 | 240
Lymphoid leukemia 6 | 160
Neurodevelopmental Disorders 6 | 70
Orbital separation excessive 6 | 244
Prostatic Neoplasms 6 | 495
colon cancer 6 | 1,478
medulloblastoma 6 | 720
Alzheimer's disease 5 | 658
Attention deficit hyperactivity disorder 5 | 278
Bipolar Disorder 5 | 666
Failure to gain weight 5 | 365
Feeding difficulties in infancy 5 | 175
Hypoplastic mandible condyle 5 | 275
Immune system cancer 5 | 140
Language Delay 5 | 112
Leukemia 5 | 104
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Pediatric failure to thrive 5 | 365
Seizures 5 | 596
Strabismus 5 | 270
astrocytoma 5 | 1,146
gastric carcinoma 5 | 807
nasopharyngeal carcinoma 5 | 1,058
primary Sjogren syndrome 5 | 735
ulcerative colitis 5 | 1,819

Tissue

Endocrine System 178 | 18,159
Liver and Pancreas 176 | 16,750
Nervous System 176 | 16,725
Female tissues 175 | 17,400
Male tissues 175 | 17,142
Skin and soft tissues 175 | 17,230
Cardiovascular System 172 | 15,192
Digestive Tract 172 | 17,369
Respiratory system 172 | 16,393
Urinary Tract 172 | 16,678
Blood and immune system 170 | 16,909

Target Family

Enzyme 116 | 4,145
Epigenetic 43 | 242
TF/Epigenetic 15 | 38
Non-IDG 10 | 12,091

UniProt Keyword

Methyltransferase 184 | 184
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Putative methyltransferase NSUN5C NSUN5P2 Tdark Enzyme 0.00000 0
Nicotinamide N-methyltransferase NNMT Tchem Enzyme -2.09313 121.9 268
Putative methyltransferase-like protein 21E pseudogene METTL21EP Tdark Enzyme 0.00000 0
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
Methyltransferase-like protein 23 METTL23 Tdark Enzyme -0.17609 1.92 6
HemK methyltransferase family member 1 HEMK1 Tbio Enzyme -1.21836 16.3 126
Histone-lysine N-methyltransferase KMT5C KMT5C Tchem Epigenetic 1.18 0.06 46
Putative protein FAM86C2P FAM86C2P Tdark Enzyme 0.00000 0
Methylated-DNA--protein-cysteine methyltransferase MGMT Tchem Enzyme -3.13356 1426.9 560