Development Level

Tbio 660 | 10,625
Tdark 156 | 7,003
Tchem 113 | 1,890
Tclin 33 | 602

Collection

Eligible Kinase Proteins 10 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 50 | 633
preweaning lethality, incomple... 21 | 260
abnormal behavior 15 | 226
decreased lean body mass 15 | 195
increased or absent threshold ... 12 | 128
decreased total body fat amoun... 11 | 186
embryonic lethality prior to o... 11 | 148
decreased body weight 10 | 174
decreased grip strength 9 | 123
embryonic lethality prior to t... 9 | 187
increased circulating alkaline... 9 | 119
increased mean corpuscular hem... 9 | 93
abnormal retina morphology 7 | 100
decreased body length 7 | 108
decreased bone mineral density 7 | 126
hyperactivity 7 | 108
abnormal bone structure 6 | 131
abnormal embryo size 6 | 112
decreased circulating calcium ... 6 | 33
decreased circulating serum al... 6 | 79
decreased circulating triglyce... 6 | 83
decreased leukocyte cell numbe... 6 | 54
enlarged heart 6 | 111
improved glucose tolerance 6 | 56
increased bone mineral content 6 | 92
increased circulating HDL chol... 6 | 63
increased grip strength 6 | 83
increased mean corpuscular vol... 6 | 91
short tibia 6 | 82
abnormal retinal pigmentation 5 | 61
decreased bone mineral content 5 | 157
decreased circulating glucose ... 5 | 121
decreased lumbar vertebrae num... 5 | 62
increased hematocrit 5 | 36
increased lean body mass 5 | 107
increased sacral vertebrae num... 5 | 62
abnormal behavioral response t... 4 | 52
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating aspartat... 4 | 27
decreased circulating choleste... 4 | 85
decreased circulating total pr... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased fasted circulating g... 4 | 49
decreased heart weight 4 | 44
increased body weight 4 | 42
increased circulating choleste... 4 | 53
increased heart weight 4 | 37
increased startle reflex 4 | 38
increased total body fat amoun... 4 | 57
limb grasping 4 | 35
male infertility 4 | 62
persistence of hyaloid vascula... 4 | 22
abnormal QRS complex 3 | 25
abnormal gait 3 | 51
abnormal neural tube closure 3 | 37
abnormal sleep behavior 3 | 63
decreased circulating alkaline... 3 | 41
decreased circulating free fat... 3 | 39
decreased circulating fructosa... 3 | 31
decreased circulating insulin ... 3 | 75
decreased neutrophil cell numb... 3 | 37
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
decreased startle reflex 3 | 48
decreased vertical activity 3 | 22
increased circulating aspartat... 3 | 17
increased circulating bilirubi... 3 | 16
increased heart rate 3 | 17
prenatal lethality 3 | 16
prenatal lethality prior to he... 3 | 64
thrombocytopenia 3 | 46
thrombocytosis 3 | 23
tremors 3 | 34
abnormal coat/hair pigmentatio... 2 | 54
abnormal epididymis morphology 2 | 31
abnormal tooth morphology 2 | 24
abnormal vocalization 2 | 21
absent startle reflex 2 | 15
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased NK cell number 2 | 16
decreased T cell number 2 | 31
decreased cervical vertebrae n... 2 | 12
decreased circulating chloride... 2 | 32
decreased eosinophil cell numb... 2 | 41
decreased hemoglobin content 2 | 53
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating chloride... 2 | 43
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
increased respiratory quotient 2 | 12
small testis 2 | 37

Disease

ovarian cancer 536 | 8,484
osteosarcoma 477 | 7,933
medulloblastoma, large-cell 401 | 6,234
psoriasis 399 | 6,685
glioblastoma 367 | 5,572
atypical teratoid / rhabdoid tumor 303 | 4,369
lung cancer 287 | 4,466
oligodendroglioma 218 | 2,849
Breast cancer 209 | 3,094
primitive neuroectodermal tumor 207 | 3,031
ependymoma 198 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 193 | 3,289
pediatric high grade glioma 193 | 2,712
Cancer 192 | 2,346
malignant mesothelioma 192 | 3,162
pilocytic astrocytoma 188 | 3,086
invasive ductal carcinoma 181 | 2,950
lung adenocarcinoma 174 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 173 | 2,988
Carcinoma 172 | 2,147
astrocytoma 168 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 167 | 2,956
subependymal giant cell astrocytoma 153 | 2,287
Pick disease 151 | 1,893
astrocytic glioma 146 | 2,241
non-small cell lung cancer 144 | 2,798
Multiple myeloma 137 | 1,327
group 3 medulloblastoma 134 | 2,254
lung carcinoma 128 | 2,844
pancreatic cancer 126 | 2,300
adult high grade glioma 124 | 2,148
group 4 medulloblastoma 121 | 1,875
medulloblastoma 117 | 1,524
acute quadriplegic myopathy 107 | 1,157
breast carcinoma 107 | 1,614
ductal carcinoma in situ 107 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 107 | 1,795
dermatomyositis 105 | 933
pituitary cancer 104 | 1,972
sonic hedgehog group medulloblastoma 96 | 1,482
Waldenstrons macroglobulinemia 94 | 765
colon cancer 92 | 1,475
diabetes mellitus 87 | 1,663
atypical teratoid/rhabdoid tumor 86 | 1,095
cystic fibrosis 81 | 1,665
interstitial cystitis 81 | 2,299
Rheumatoid Arthritis 80 | 1,160
posterior fossa group A ependymoma 80 | 1,511
primary pancreatic ductal adenocarcinoma 75 | 1,271
ulcerative colitis 75 | 2,087
tuberculosis 74 | 1,557
spina bifida 72 | 1,064
juvenile dermatomyositis 68 | 1,189
posterior fossa group B ependymoma 67 | 1,530
adrenocortical carcinoma 63 | 1,427
acute myeloid leukemia 58 | 780
Intellectual disability 56 | 573
cutaneous lupus erythematosus 54 | 1,056
nasopharyngeal carcinoma 50 | 1,056
progressive supranuclear palsy 50 | 674
Amyotrophic Lateral Sclerosis 49 | 431
non primary Sjogren syndrome sicca 43 | 840
Alzheimer's disease 42 | 644
Neurodegenerative disease 42 | 383
esophageal adenocarcinoma 41 | 737
Mammary Neoplasms 39 | 410
gastric carcinoma 39 | 832
tuberculosis and treatment for 6 months 39 | 686
Schizophrenia 38 | 501
aldosterone-producing adenoma 37 | 664
non-small cell lung carcinoma 37 | 413
hepatocellular carcinoma 36 | 532
pancreatic carcinoma 35 | 567
Prostatic Neoplasms 34 | 471
Stomach Neoplasms 34 | 282
gastric cancer 34 | 430
Atopic dermatitis 33 | 944
Endometriosis 33 | 535
Down syndrome 31 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 31 | 499
Duchenne muscular dystrophy 30 | 602
IGA Glomerulonephritis 30 | 454
active Crohn's disease 30 | 918
primary Sjogren syndrome 30 | 789
Obesity 28 | 616
Parkinson's disease 28 | 364
Epilepsy 27 | 346
Liver carcinoma 26 | 217
hereditary spastic paraplegia 26 | 313
fibroadenoma 25 | 557
Cardiomyopathy 24 | 110
Mammary Neoplasms, Experimental 24 | 150
interstitial lung disease 24 | 291
Animal Mammary Neoplasms 23 | 136
Gaucher disease type 1 23 | 171
chronic rhinosinusitis 22 | 512
glioblastoma multiforme 22 | 347
inflammatory breast cancer 22 | 404
active ulcerative colitis 21 | 477
Polycystic Ovary Syndrome 20 | 332

Tissue

Blood and immune system 953 | 17,995
Digestive Tract 953 | 18,473
Endocrine System 953 | 18,512
Male tissues 953 | 17,969
Nervous System 953 | 18,561
Female tissues 952 | 18,647
Cardiovascular System 951 | 17,958
Urinary Tract 951 | 18,444
Liver and Pancreas 950 | 18,136
Respiratory system 942 | 17,484
Skin and soft tissues 931 | 18,115

Target Family

Non-IDG 606 | 11,971
Enzyme 200 | 4,146
Transcription Factor 60 | 1,400
Epigenetic 36 | 242
Kinase 31 | 634
Ion Channel 10 | 341
Nuclear Receptor 7 | 48
Transporter 6 | 473
GPCR 4 | 406
TF/Epigenetic 2 | 38

UniProt Keyword

Methylation 962 | 962
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244