Development Level

Tbio 714 | 11,651
Tdark 136 | 6,593
Tchem 89 | 1,388
Tclin 34 | 612

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 10 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 78 | 979
preweaning lethality, incomple... 31 | 499
abnormal behavior 22 | 298
embryonic lethality prior to o... 17 | 239
abnormal embryo size 16 | 220
embryonic lethality prior to t... 16 | 278
hyperactivity 14 | 148
decreased lean body mass 12 | 135
increased startle reflex 12 | 112
abnormal bone structure 11 | 187
decreased bone mineral content 11 | 151
decreased total body fat amoun... 11 | 207
decreased vertical activity 11 | 208
decreased circulating serum al... 10 | 82
decreased neutrophil cell numb... 10 | 42
decreased grip strength 9 | 116
embryonic growth retardation 9 | 106
increased lean body mass 9 | 172
increased mean corpuscular hem... 9 | 96
abnormal behavioral response t... 8 | 66
abnormal heart morphology 8 | 162
decreased circulating HDL chol... 8 | 68
enlarged heart 8 | 210
increased circulating HDL chol... 8 | 80
increased or absent threshold ... 8 | 101
cataract 7 | 92
decreased body length 7 | 101
decreased body weight 7 | 161
decreased mean corpuscular vol... 7 | 79
edema 7 | 59
improved glucose tolerance 7 | 79
increased bone mineral content 7 | 108
abnormal retina morphology 6 | 71
abnormal sleep behavior 6 | 70
decreased bone mineral density 6 | 126
decreased circulating choleste... 6 | 93
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
increased circulating alkaline... 6 | 122
increased circulating choleste... 6 | 66
increased lymphocyte cell numb... 6 | 32
increased mean corpuscular vol... 6 | 92
increased total body fat amoun... 6 | 134
persistence of hyaloid vascula... 6 | 33
short tibia 6 | 97
abnormal gait 5 | 69
abnormal kidney morphology 5 | 65
abnormal seminal vesicle morph... 5 | 114
decreased circulating glucose ... 5 | 126
decreased erythrocyte cell num... 5 | 62
decreased heart left ventricle... 5 | 28
decreased startle reflex 5 | 75
increased heart weight 5 | 62
increased hematocrit 5 | 46
male infertility 5 | 123
prenatal lethality 5 | 28
prenatal lethality prior to he... 5 | 87
small testis 5 | 58
abnormal coat-hair pigmentatio... 4 | 64
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
absent startle reflex 4 | 24
cardiovascular system phenotyp... 4 | 36
decreased circulating alanine ... 4 | 47
decreased circulating calcium ... 4 | 36
decreased circulating free fat... 4 | 31
decreased circulating fructosa... 4 | 30
decreased circulating total pr... 4 | 49
decreased fasted circulating g... 4 | 65
hemorrhage 4 | 23
hypoactivity 4 | 132
increased fasted circulating g... 4 | 76
increased grip strength 4 | 41
increased heart rate 4 | 23
increased mean platelet volume 4 | 45
limb grasping 4 | 41
pallor 4 | 34
thrombocytopenia 4 | 56
thrombocytosis 4 | 27
abnormal retinal vasculature m... 3 | 27
abnormal testis morphology 3 | 43
decreased blood urea nitrogen ... 3 | 51
decreased circulating alkaline... 3 | 46
decreased circulating aspartat... 3 | 34
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 31
increased bone mineral density 3 | 72
increased circulating alanine ... 3 | 13
increased circulating chloride... 3 | 41
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased hemoglobin content 3 | 45
increased prepulse inhibition 3 | 32
increased red blood cell distr... 3 | 34
microphthalmia 3 | 26
syndactyly 3 | 23
tremors 3 | 39

Disease

Carcinoma 659 | 11,493
ovarian cancer 546 | 8,520
osteosarcoma 485 | 7,950
medulloblastoma, large-cell 408 | 6,241
psoriasis 403 | 6,694
glioblastoma 387 | 5,792
atypical teratoid / rhabdoid tumor 368 | 5,112
ependymoma 320 | 4,679
lung cancer 304 | 4,740
group 3 medulloblastoma 284 | 4,104
Breast cancer 247 | 3,578
adult high grade glioma 239 | 3,801
oligodendroglioma 220 | 2,850
primitive neuroectodermal tumor 211 | 3,035
Cancer 209 | 2,499
Kidney cancer 207 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 200 | 3,291
malignant mesothelioma 200 | 3,232
astrocytic glioma 193 | 2,597
Astrocytoma, Pilocytic 187 | 3,081
invasive ductal carcinoma 183 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 180 | 2,989
lung adenocarcinoma 179 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 173 | 2,955
subependymal giant cell astrocytoma 156 | 2,287
Pick disease 153 | 1,894
non-small cell lung cancer 150 | 2,890
pancreatic cancer 145 | 2,398
Multiple myeloma 141 | 1,332
lung carcinoma 131 | 2,843
astrocytoma 126 | 1,146
group 4 medulloblastoma 121 | 1,855
breast carcinoma 115 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 114 | 1,962
acute quadriplegic myopathy 111 | 1,158
ductal carcinoma in situ 108 | 1,745
dermatomyositis 107 | 966
pituitary cancer 106 | 1,972
diabetes mellitus 98 | 1,728
Waldenstrons macroglobulinemia 95 | 765
colon cancer 95 | 1,478
tuberculosis 93 | 2,010
Schizophrenia 86 | 1,160
cystic fibrosis 84 | 1,696
pediatric high grade glioma 84 | 1,064
Rheumatoid arthritis 83 | 1,191
interstitial cystitis 83 | 2,312
Intellectual disability 81 | 1,016
Autosomal recessive predisposition 75 | 1,442
Epilepsy 74 | 792
spina bifida 73 | 1,074
juvenile dermatomyositis 72 | 1,187
primary pancreatic ductal adenocarcinoma 71 | 1,109
ulcerative colitis 65 | 1,819
adrenocortical carcinoma 64 | 1,428
Muscle hypotonia 58 | 571
acute myeloid leukemia 58 | 783
cutaneous lupus erythematosus 56 | 1,057
Seizures 53 | 596
nasopharyngeal carcinoma 52 | 1,058
progressive supranuclear palsy 52 | 676
Amyotrophic lateral sclerosis 51 | 451
Alzheimer's disease 49 | 658
Short stature 49 | 531
Liver cancer 48 | 604
non primary Sjogren syndrome sicca 48 | 891
Melanoma 47 | 711
Breast Neoplasms 45 | 445
Bipolar Disorder 44 | 666
Cognitive delay 44 | 608
Dull intelligence 44 | 645
Global developmental delay 44 | 608
Low intelligence 44 | 645
Mental Retardation 44 | 645
Mental and motor retardation 44 | 608
Mental deficiency 44 | 645
Neurodegenerative disease 44 | 414
Poor school performance 44 | 645
Mammary Neoplasms 43 | 425
esophageal adenocarcinoma 41 | 737
gastric carcinoma 41 | 807
Failure to gain weight 40 | 365
Obesity 40 | 678
Pediatric failure to thrive 40 | 365
hepatocellular carcinoma 39 | 547
medulloblastoma 39 | 720
Liver Cirrhosis, Experimental 38 | 769
Prostatic Neoplasms 38 | 495
Stomach Neoplasms 37 | 300
aldosterone-producing adenoma 37 | 665
gastric cancer 37 | 459
Acquired scoliosis 36 | 281
Curvature of spine 36 | 282
pancreatic carcinoma 36 | 562
Cryptorchidism 35 | 296
autosomal dominant Emery-Dreifuss muscular dystrophy 35 | 510
Hypoplastic mandible condyle 34 | 275
Mandibular hypoplasia 34 | 275
Micrognathism 34 | 275
Small head 34 | 374

Tissue

Endocrine System 960 | 18,159
Digestive Tract 953 | 17,369
Skin and soft tissues 953 | 17,230
Female tissues 949 | 17,400
Male tissues 945 | 17,142
Blood and immune system 941 | 16,909
Nervous System 940 | 16,725
Urinary Tract 935 | 16,678
Liver and Pancreas 934 | 16,750
Respiratory system 927 | 16,393
Cardiovascular System 909 | 15,192

Target Family

Non-IDG 616 | 12,091
Enzyme 198 | 4,145
Transcription Factor 62 | 1,400
Epigenetic 36 | 242
Kinase 32 | 634
Ion Channel 10 | 344
Nuclear Receptor 7 | 48
Transporter 6 | 473
GPCR 4 | 408
TF/Epigenetic 2 | 38

UniProt Keyword

Methylation 973 | 973
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Kelch domain-containing protein 10 KLHDC10 Tbio Non-IDG -0.13806 1.70 17
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44