Development Level

Tbio 7 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal skin morphology 1 | 50
decreased circulating serum al... 1 | 82
decreased food intake 1 | 13
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
preweaning lethality, complete... 1 | 979

Disease

osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
Carcinoma 4 | 11,493
Cleft Lip 3 | 141
Homocystinuria 3 | 21
Hyperhomocysteinemia 3 | 37
Methylmalonic acidemia 3 | 37
Neural tube defect, folate-sensitive 3 | 4
lung cancer 3 | 4,740
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
spina bifida 3 | 1,074
Adverse reaction to drug 2 | 61
Anemia 2 | 365
Anemia, Megaloblastic 2 | 16
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Cancer 2 | 2,499
Cerebral atrophy 2 | 178
Cleft Palate 2 | 271
Cognitive delay 2 | 608
Congenital heart disease 2 | 93
Decreased methionine synthase activity 2 | 4
Decreased methylcobalamin 2 | 4
Degenerative brain disorder 2 | 100
Down syndrome 2 | 499
Drug-Related Side Effects and Adverse Reactions 2 | 62
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Gait abnormality 2 | 135
Global developmental delay 2 | 608
Hyperhomocystinemia 2 | 6
Hypomethioninemia 2 | 4
Infantile onset 2 | 238
Infertility, Male 2 | 46
Male infertility 2 | 206
Mental and motor retardation 2 | 608
Multiple myeloma 2 | 1,332
Muscle hypotonia 2 | 571
Neural tube defects, folate-sensitive 2 | 2
Pediatric failure to thrive 2 | 365
Schizophrenia 2 | 1,160
Seizures 2 | 596
Supratentorial atrophy 2 | 94
group 4 medulloblastoma 2 | 1,855
invasive ductal carcinoma 2 | 2,951
medulloblastoma, large-cell 2 | 6,241
pancreatic cancer 2 | 2,398
psoriasis 2 | 6,694
Adenoma 1 | 167
Adult respiratory distress syndrome 1 | 3
Alcoholic Intoxication 1 | 34
Azoospermia 1 | 110
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Charcot-Marie-Tooth disease type 1D 1 | 3
Charcot-Marie-Tooth disease type 2E 1 | 2
Chromosome 17q11.2 deletion syndrome, 1.4Mb 1 | 15
Colorectal Neoplasms 1 | 243
Decreased nerve conduction velocity 1 | 35
Depressive disorder 1 | 409
Dyskeratosis congenita 1 | 24
Gastrointestinal Diseases 1 | 12
Hematologic Diseases 1 | 8
Hematological Disease 1 | 18
Hemoglobin low 1 | 124
Lethargy 1 | 77
Leukoencephalopathies 1 | 29
Lymphoma 1 | 81
Lymphoma, Follicular 1 | 18
Malnutrition 1 | 11
Mammary Neoplasms 1 | 425
Megaloblastic anemia 1 | 18
Mental Depression 1 | 333
Nervous System Diseases 1 | 53
Neural Tube Defects 1 | 31
OROFACIAL CLEFT 1 1 | 2
Poor coordination 1 | 11
Precursor Cell Lymphoblastic Leukemia-Lymphoma 1 | 49
Prostatic Neoplasms 1 | 495
Refsum disease 1 | 20
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Vitamin B12 deficiency 1 | 20
Waldenstrons macroglobulinemia 1 | 765
acute quadriplegic myopathy 1 | 1,158
adult high grade glioma 1 | 3,801
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
colon cancer 1 | 1,478
cystic fibrosis 1 | 1,696
gastric carcinoma 1 | 807
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
medulloblastoma 1 | 720
nervous system disorder 1 | 53
neural tube defect 1 | 9
pancreatic carcinoma 1 | 562
progressive supranuclear palsy 1 | 676
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 8 | 16,909
Cardiovascular System 8 | 15,192
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Nervous System 8 | 16,725
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678

Target Family

Enzyme 8 | 4,145

UniProt Keyword

Methionine biosynthesis 8 | 8
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.37285 221.6 146
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase ADI1 Tbio Enzyme -2.05198 103.3 194
Methionine synthase MTR Tbio Enzyme -2.56900 300.2 87
Methionine synthase reductase MTRR Tbio Enzyme -2.46986 307.5 53
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Enolase-phosphatase E1 ENOPH1 Tbio Enzyme -0.98363 9.96 124
Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 MTHFD2L Tdark Enzyme -0.45230 2.70 114
Methylthioribulose-1-phosphate dehydratase APIP Tbio Enzyme -0.87551 9.29 210