Development Level

Tbio 83 | 11,445
Tchem 52 | 1,598
Tdark 15 | 6,588
Tclin 3 | 613

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 5 | 979
hypoactivity 4 | 132
abnormal behavior 3 | 298
abnormal cranium morphology 3 | 36
abnormal tail morphology 3 | 25
decreased body length 3 | 101
decreased body weight 3 | 161
decreased circulating triglyce... 3 | 79
increased mean corpuscular vol... 3 | 92
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal skin coloration 2 | 25
abnormal vertebrae morphology 2 | 18
abnormal vertebral arch morpho... 2 | 9
cataract 2 | 92
decreased circulating aspartat... 2 | 34
decreased circulating chloride... 2 | 30
decreased circulating phosphat... 2 | 27
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
thrombocytosis 2 | 27
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal esophagus morphology 1 | 5
abnormal hair texture 1 | 4
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 17
abnormal pancreas morphology 1 | 13
abnormal pelvic girdle bone mo... 1 | 12
abnormal radius morphology 1 | 8
abnormal rib morphology 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vibrissa morphology 1 | 25
absent lymph nodes 1 | 3
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased food intake 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
long tail 1 | 1
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
short tibia 1 | 97
small superior vagus ganglion 1 | 74
thick tail 1 | 1
vertebral fusion 1 | 23

Disease

Carcinoma 131 | 11,493
osteosarcoma 77 | 7,950
ovarian cancer 73 | 8,520
glioblastoma 48 | 5,792
psoriasis 47 | 6,694
atypical teratoid / rhabdoid tumor 45 | 5,112
lung cancer 41 | 4,740
medulloblastoma, large-cell 41 | 6,241
non-small cell lung cancer 41 | 2,890
Breast cancer 38 | 3,578
ependymoma 37 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 37 | 3,291
invasive ductal carcinoma 37 | 2,951
Kidney cancer 36 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
adult high grade glioma 33 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
malignant mesothelioma 32 | 3,232
lung adenocarcinoma 31 | 2,716
ulcerative colitis 31 | 1,819
lung carcinoma 30 | 2,843
Cancer 29 | 2,499
cystic fibrosis 29 | 1,696
ductal carcinoma in situ 27 | 1,745
Astrocytoma, Pilocytic 26 | 3,081
interstitial cystitis 26 | 2,312
oligodendroglioma 25 | 2,850
group 3 medulloblastoma 24 | 4,104
pancreatic cancer 24 | 2,398
astrocytic glioma 22 | 2,597
primitive neuroectodermal tumor 22 | 3,035
group 4 medulloblastoma 20 | 1,855
Autosomal recessive predisposition 18 | 1,442
breast carcinoma 18 | 1,638
colon cancer 18 | 1,478
active Crohn's disease 17 | 922
diabetes mellitus 17 | 1,728
cutaneous lupus erythematosus 16 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
primary pancreatic ductal adenocarcinoma 15 | 1,109
tuberculosis 15 | 2,010
Atopic dermatitis 14 | 952
Liver Cirrhosis, Experimental 14 | 769
Rheumatoid arthritis 14 | 1,191
adrenocortical carcinoma 14 | 1,428
Alzheimer's disease 13 | 658
Asthma 13 | 385
Melanoma 13 | 711
Schizophrenia 13 | 1,160
Skin cancer 12 | 469
pituitary cancer 12 | 1,972
Hypertension 11 | 396
Pick disease 11 | 1,894
nasopharyngeal carcinoma 11 | 1,058
pediatric high grade glioma 11 | 1,064
subependymal giant cell astrocytoma 11 | 2,287
Acquired metabolic disease 10 | 336
Arthritis 10 | 290
Atherosclerosis 10 | 291
Endometriosis 10 | 540
esophageal adenocarcinoma 10 | 737
head and neck cancer and chronic obstructive pulmonary disease 10 | 239
active ulcerative colitis 9 | 764
periodontitis 9 | 293
Bipolar Disorder 8 | 666
Breast Neoplasms 8 | 445
Coronary artery disease 8 | 268
Mammary Neoplasms 8 | 425
Multiple myeloma 8 | 1,332
Osteoporosis 8 | 363
Short stature 8 | 531
Waldenstrons macroglobulinemia 8 | 765
astrocytoma 8 | 1,146
gastric carcinoma 8 | 807
juvenile dermatomyositis 8 | 1,187
medulloblastoma 8 | 720
non primary Sjogren syndrome sicca 8 | 891
progressive supranuclear palsy 8 | 676
Abortion, Spontaneous 7 | 109
Cerebrovascular disease 7 | 238
Degenerative disc disease 7 | 35
Dental caries 7 | 164
Down syndrome 7 | 499
Hypertensive disease 7 | 292
Kidney disease 7 | 430
Liver cancer 7 | 604
Spontaneous abortion 7 | 113
Vascular disease 7 | 319
Anemia 6 | 365
Carcinoma, Hepatocellular 6 | 228
Liver carcinoma 6 | 240
Lung Neoplasms 6 | 232
Neoplasm Invasiveness 6 | 161
Neoplasm Metastasis 6 | 168
Neurodegenerative disease 6 | 414
Prostatic Neoplasms 6 | 495
acute myeloid leukemia 6 | 783
acute quadriplegic myopathy 6 | 1,158
atypical teratoid/rhabdoid tumor 6 | 357
primary Sjogren syndrome 6 | 735

Tissue

Female tissues 149 | 17,400
Endocrine System 148 | 18,159
Digestive Tract 146 | 17,369
Male tissues 146 | 17,142
Urinary Tract 146 | 16,678
Skin and soft tissues 144 | 17,230
Blood and immune system 143 | 16,909
Liver and Pancreas 141 | 16,750
Nervous System 138 | 16,725
Respiratory system 136 | 16,393
Cardiovascular System 123 | 15,192

Target Family

Enzyme 136 | 4,145
Non-IDG 13 | 12,091
Ion Channel 3 | 344
Transcription Factor 1 | 1,400

UniProt Keyword

Metalloprotease 153 | 153
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 Tbio Enzyme -1.87527 79.6 110
Carboxypeptidase Q CPQ Tbio Enzyme -2.51783 330.9 81
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
A disintegrin and metalloproteinase with thrombospondin motifs 7 ADAMTS7 Tbio Enzyme -1.43732 33.7 98
Dipeptidyl peptidase 3 DPP3 Tbio Enzyme -1.99939 105.7 213
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
A disintegrin and metalloproteinase with thrombospondin motifs 14 ADAMTS14 Tbio Enzyme -0.89572 7.58 29
Archaemetzincin-2 AMZ2 Tdark Enzyme 0.26 0.50 46