Development Level

Tbio 2,183 | 11,651
Tdark 919 | 6,593
Tchem 411 | 1,388
Tclin 159 | 612

Collection

RFA-RM-18-021 49 | 328
Kinase: IDG Consortium (Target... 38 | 125
Kinase: IDG Consortium (Comple... 15 | 37
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 189 | 979
preweaning lethality, incomple... 119 | 499
abnormal behavior 68 | 298
embryonic lethality prior to t... 55 | 278
decreased total body fat amoun... 53 | 207
abnormal embryo size 48 | 220
abnormal bone structure 46 | 187
enlarged heart 45 | 210
increased lean body mass 45 | 172
embryonic lethality prior to o... 44 | 239
decreased vertical activity 41 | 208
decreased body weight 39 | 161
abnormal heart morphology 38 | 162
hypoactivity 36 | 132
hyperactivity 34 | 148
decreased bone mineral density 33 | 126
abnormal seminal vesicle morph... 28 | 114
increased startle reflex 28 | 112
decreased circulating glucose ... 27 | 126
increased total body fat amoun... 27 | 134
decreased body length 26 | 101
decreased bone mineral content 26 | 151
decreased lean body mass 26 | 135
increased bone mineral content 26 | 108
cataract 23 | 92
male infertility 23 | 123
short tibia 23 | 97
decreased grip strength 22 | 116
embryonic growth retardation 21 | 106
impaired glucose tolerance 21 | 75
increased bone mineral density 21 | 72
abnormal kidney morphology 20 | 65
increased circulating HDL chol... 20 | 80
increased circulating alkaline... 20 | 122
increased fasted circulating g... 19 | 76
decreased circulating choleste... 18 | 93
decreased circulating serum al... 18 | 82
decreased circulating triglyce... 17 | 79
decreased fasted circulating g... 17 | 65
decreased prepulse inhibition 17 | 82
increased circulating choleste... 17 | 66
prenatal lethality prior to he... 17 | 87
abnormal lens morphology 16 | 81
abnormal spleen morphology 16 | 55
decreased blood urea nitrogen ... 16 | 51
decreased circulating insulin ... 16 | 76
increased circulating sodium l... 16 | 71
increased heart weight 16 | 62
increased mean corpuscular vol... 16 | 92
abnormal eye morphology 15 | 68
abnormal retina morphology 15 | 71
decreased lymphocyte cell numb... 15 | 83
increased mean corpuscular hem... 15 | 96
abnormal gait 14 | 69
decreased circulating HDL chol... 14 | 68
decreased mean corpuscular vol... 14 | 79
decreased startle reflex 14 | 75
increased monocyte cell number 14 | 63
small superior vagus ganglion 14 | 74
abnormal coat-hair pigmentatio... 13 | 64
decreased neutrophil cell numb... 13 | 42
edema 13 | 59
improved glucose tolerance 13 | 79
increased or absent threshold ... 13 | 101
abnormal sleep behavior 12 | 70
decreased circulating calcium ... 12 | 36
decreased circulating total pr... 12 | 49
decreased hemoglobin content 12 | 68
decreased mean corpuscular hem... 12 | 50
enlarged spleen 12 | 41
increased circulating triglyce... 12 | 42
increased mean platelet volume 12 | 45
abnormal behavioral response t... 11 | 66
abnormal retinal blood vessel ... 11 | 26
abnormal skin morphology 11 | 50
decreased circulating alanine ... 11 | 47
decreased circulating iron lev... 11 | 32
decreased leukocyte cell numbe... 11 | 73
female infertility 11 | 60
increased hematocrit 11 | 46
small testis 11 | 58
decreased caudal vertebrae num... 10 | 53
decreased circulating LDL chol... 10 | 38
decreased circulating alkaline... 10 | 46
decreased circulating aspartat... 10 | 34
decreased erythrocyte cell num... 10 | 62
decreased mean platelet volume 10 | 25
decreased red blood cell distr... 10 | 41
increased blood urea nitrogen ... 10 | 48
increased body length 10 | 32
increased erythrocyte cell num... 10 | 39
abnormal bone mineralization 9 | 38
abnormal cranium morphology 9 | 36
abnormal locomotor behavior 9 | 24
decreased circulating phosphat... 9 | 27
decreased mean corpuscular hem... 9 | 31
hydrometra 9 | 53
increased circulating chloride... 9 | 41
limb grasping 9 | 41
increased prepulse inhibition 8 | 32

Disease

Carcinoma 2,580 | 11,493
osteosarcoma 1,768 | 7,950
ovarian cancer 1,754 | 8,520
medulloblastoma, large-cell 1,284 | 6,241
psoriasis 1,260 | 6,694
glioblastoma 1,191 | 5,792
atypical teratoid / rhabdoid tumor 1,061 | 5,112
lung cancer 984 | 4,740
ependymoma 910 | 4,679
group 3 medulloblastoma 899 | 4,104
adult high grade glioma 757 | 3,801
Breast cancer 743 | 3,578
primitive neuroectodermal tumor 699 | 3,035
malignant mesothelioma 688 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 682 | 3,291
Kidney cancer 678 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 619 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 607 | 2,989
oligodendroglioma 605 | 2,850
Astrocytoma, Pilocytic 591 | 3,081
Cancer 562 | 2,499
invasive ductal carcinoma 553 | 2,951
lung carcinoma 547 | 2,843
non-small cell lung cancer 545 | 2,890
astrocytic glioma 538 | 2,597
lung adenocarcinoma 506 | 2,716
pancreatic cancer 505 | 2,398
subependymal giant cell astrocytoma 462 | 2,287
group 4 medulloblastoma 455 | 1,855
interstitial cystitis 414 | 2,312
Pick disease 409 | 1,894
tuberculosis 406 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 401 | 1,962
pituitary cancer 384 | 1,972
ulcerative colitis 367 | 1,819
cystic fibrosis 357 | 1,696
Autosomal recessive predisposition 334 | 1,442
ductal carcinoma in situ 331 | 1,745
breast carcinoma 313 | 1,638
adrenocortical carcinoma 307 | 1,428
colon cancer 293 | 1,478
diabetes mellitus 280 | 1,728
juvenile dermatomyositis 262 | 1,187
astrocytoma 257 | 1,146
Rheumatoid arthritis 251 | 1,191
Schizophrenia 243 | 1,160
acute quadriplegic myopathy 243 | 1,158
Intellectual disability 237 | 1,016
spina bifida 235 | 1,074
Multiple myeloma 234 | 1,332
primary pancreatic ductal adenocarcinoma 233 | 1,109
pediatric high grade glioma 217 | 1,064
active Crohn's disease 202 | 922
dermatomyositis 195 | 966
Atopic dermatitis 190 | 952
cutaneous lupus erythematosus 188 | 1,057
nasopharyngeal carcinoma 187 | 1,058
non primary Sjogren syndrome sicca 187 | 891
Epilepsy 179 | 792
Melanoma 170 | 711
gastric carcinoma 169 | 807
acute myeloid leukemia 167 | 783
Bipolar Disorder 162 | 666
Liver Cirrhosis, Experimental 159 | 769
Dull intelligence 157 | 645
Low intelligence 157 | 645
Mental Retardation 157 | 645
Mental deficiency 157 | 645
Poor school performance 157 | 645
active ulcerative colitis 156 | 764
esophageal adenocarcinoma 155 | 737
medulloblastoma 153 | 720
Liver cancer 152 | 604
Short stature 148 | 531
progressive supranuclear palsy 145 | 676
Alzheimer's disease 144 | 658
Cognitive delay 144 | 608
Global developmental delay 144 | 608
Mental and motor retardation 144 | 608
Seizures 144 | 596
Muscle hypotonia 141 | 571
aldosterone-producing adenoma 141 | 665
Waldenstrons macroglobulinemia 139 | 765
Obesity 138 | 678
primary Sjogren syndrome 134 | 735
Endometriosis 123 | 540
Prostatic Neoplasms 120 | 495
Amyotrophic lateral sclerosis 119 | 451
Skin cancer 119 | 469
Breast Neoplasms 116 | 445
hepatocellular carcinoma 116 | 547
pancreatic carcinoma 113 | 562
Duchenne muscular dystrophy 112 | 601
Mammary Neoplasms 111 | 425
Hypertension 107 | 396
chronic rhinosinusitis 106 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 103 | 510
Down syndrome 102 | 499
gastric cancer 102 | 459
Depressive disorder 100 | 409

Tissue

Endocrine System 3,553 | 18,159
Digestive Tract 3,468 | 17,369
Female tissues 3,466 | 17,400
Skin and soft tissues 3,448 | 17,230
Male tissues 3,423 | 17,142
Blood and immune system 3,402 | 16,909
Liver and Pancreas 3,399 | 16,750
Nervous System 3,386 | 16,725
Urinary Tract 3,374 | 16,678
Respiratory system 3,329 | 16,393
Cardiovascular System 3,149 | 15,192

Target Family

Non-IDG 1,220 | 12,091
Enzyme 1,204 | 4,145
Transcription Factor 749 | 1,400
Kinase 191 | 634
Epigenetic 136 | 242
Transporter 54 | 473
Nuclear Receptor 46 | 48
Ion Channel 37 | 344
TF/Epigenetic 30 | 38
GPCR 5 | 408

UniProt Keyword

Metal-binding 3,672 | 3,672
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136