Development Level

Tbio 1,971 | 10,625
Tdark 988 | 7,003
Tchem 500 | 1,890
Tclin 155 | 602

Collection

Eligible Kinase Proteins 38 | 134
Eligible Ion Channel Proteins 12 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 119 | 633
preweaning lethality, incomple... 64 | 260
abnormal behavior 48 | 226
decreased total body fat amoun... 46 | 186
decreased body weight 40 | 174
decreased lean body mass 39 | 195
embryonic lethality prior to t... 32 | 187
decreased grip strength 29 | 123
decreased bone mineral density 28 | 126
abnormal bone structure 27 | 131
abnormal retina morphology 27 | 100
hyperactivity 27 | 108
hypoactivity 27 | 89
increased bone mineral content 27 | 92
decreased bone mineral content 26 | 157
decreased body length 25 | 108
embryonic lethality prior to o... 25 | 148
enlarged heart 24 | 111
increased lean body mass 24 | 107
abnormal embryo size 23 | 112
decreased circulating glucose ... 22 | 121
increased circulating alkaline... 22 | 119
decreased circulating serum al... 21 | 79
increased or absent threshold ... 21 | 128
short tibia 21 | 82
abnormal lens morphology 20 | 73
decreased circulating HDL chol... 16 | 77
decreased circulating triglyce... 16 | 83
decreased heart weight 16 | 44
abnormal bone mineralization 15 | 55
abnormal gait 15 | 51
decreased circulating choleste... 15 | 85
increased circulating choleste... 15 | 53
increased mean corpuscular vol... 15 | 91
decreased prepulse inhibition 14 | 52
increased circulating HDL chol... 14 | 63
increased circulating sodium l... 14 | 71
abnormal coat/hair pigmentatio... 13 | 54
abnormal retinal pigmentation 13 | 61
decreased blood urea nitrogen ... 13 | 31
decreased fasted circulating g... 13 | 49
decreased rib number 13 | 59
increased fasted circulating g... 13 | 68
prenatal lethality prior to he... 13 | 64
abnormal heart morphology 12 | 51
abnormal spleen morphology 12 | 36
decreased hemoglobin content 12 | 53
impaired glucose tolerance 12 | 52
increased mean corpuscular hem... 12 | 93
increased sacral vertebrae num... 12 | 62
increased total body fat amoun... 12 | 57
decreased circulating alanine ... 11 | 53
decreased circulating insulin ... 11 | 75
increased bone mineral density 11 | 52
abnormal behavioral response t... 10 | 52
abnormal eye morphology 10 | 38
abnormal seminal vesicle morph... 10 | 47
abnormal sleep behavior 10 | 63
decreased circulating LDL chol... 10 | 37
decreased leukocyte cell numbe... 10 | 54
decreased lumbar vertebrae num... 10 | 62
increased body weight 10 | 42
increased exploration in new e... 10 | 56
male infertility 10 | 62
abnormal cranium morphology 9 | 32
abnormal heart left ventricle ... 9 | 20
abnormal kidney morphology 9 | 30
decreased CD4-positive, CD25-p... 9 | 24
decreased caudal vertebrae num... 9 | 49
decreased circulating amylase ... 9 | 24
decreased circulating total pr... 9 | 41
enlarged spleen 9 | 26
increased circulating creatini... 9 | 29
increased grip strength 9 | 83
increased heart weight 9 | 37
increased startle reflex 9 | 38
limb grasping 9 | 35
abnormal retinal blood vessel ... 8 | 18
cataract 8 | 26
decreased circulating alkaline... 8 | 41
decreased circulating chloride... 8 | 32
decreased circulating free fat... 8 | 39
decreased eosinophil cell numb... 8 | 41
decreased mean corpuscular vol... 8 | 50
hydrops fetalis 8 | 22
improved glucose tolerance 8 | 56
increased blood urea nitrogen ... 8 | 44
increased circulating triglyce... 8 | 24
increased erythrocyte cell num... 8 | 26
increased hemoglobin content 8 | 45
abnormal cornea morphology 7 | 24
decreased circulating aspartat... 7 | 27
decreased circulating calcium ... 7 | 33
decreased circulating iron lev... 7 | 25
decreased startle reflex 7 | 48
decreased vertical activity 7 | 22
increased circulating chloride... 7 | 43
increased hematocrit 7 | 36
straub tail 7 | 26
thrombocytopenia 7 | 46

Disease

osteosarcoma 1,734 | 7,933
ovarian cancer 1,716 | 8,484
medulloblastoma, large-cell 1,258 | 6,234
psoriasis 1,244 | 6,685
glioblastoma 1,115 | 5,572
atypical teratoid / rhabdoid tumor 909 | 4,369
lung cancer 907 | 4,466
primitive neuroectodermal tumor 685 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 673 | 3,289
malignant mesothelioma 666 | 3,162
Breast cancer 623 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 607 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 599 | 2,988
oligodendroglioma 597 | 2,849
pilocytic astrocytoma 578 | 3,086
Carcinoma 545 | 2,147
invasive ductal carcinoma 542 | 2,950
lung carcinoma 537 | 2,844
pediatric high grade glioma 533 | 2,712
non-small cell lung cancer 521 | 2,798
Cancer 511 | 2,346
ependymoma 511 | 2,514
lung adenocarcinoma 495 | 2,713
group 3 medulloblastoma 493 | 2,254
group 4 medulloblastoma 478 | 1,875
pancreatic cancer 471 | 2,300
astrocytic glioma 454 | 2,241
subependymal giant cell astrocytoma 451 | 2,287
adult high grade glioma 421 | 2,148
ulcerative colitis 412 | 2,087
interstitial cystitis 407 | 2,299
Pick disease 398 | 1,893
pituitary cancer 376 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 352 | 1,795
cystic fibrosis 344 | 1,665
astrocytoma 329 | 1,493
ductal carcinoma in situ 326 | 1,745
tuberculosis 323 | 1,557
medulloblastoma 310 | 1,524
adrenocortical carcinoma 307 | 1,427
breast carcinoma 298 | 1,614
sonic hedgehog group medulloblastoma 296 | 1,482
posterior fossa group A ependymoma 292 | 1,511
colon cancer 288 | 1,475
primary pancreatic ductal adenocarcinoma 268 | 1,271
juvenile dermatomyositis 259 | 1,189
diabetes mellitus 255 | 1,663
posterior fossa group B ependymoma 253 | 1,530
acute quadriplegic myopathy 240 | 1,157
Rheumatoid Arthritis 239 | 1,160
Multiple myeloma 230 | 1,327
atypical teratoid/rhabdoid tumor 229 | 1,095
spina bifida 229 | 1,064
active Crohn's disease 198 | 918
dermatomyositis 189 | 933
Atopic dermatitis 186 | 944
cutaneous lupus erythematosus 186 | 1,056
nasopharyngeal carcinoma 186 | 1,056
non primary Sjogren syndrome sicca 173 | 840
gastric carcinoma 171 | 832
acute myeloid leukemia 165 | 780
esophageal adenocarcinoma 153 | 737
tuberculosis and treatment for 6 months 151 | 686
primary Sjogren syndrome 144 | 789
aldosterone-producing adenoma 141 | 664
progressive supranuclear palsy 141 | 674
Waldenstrons macroglobulinemia 140 | 765
Alzheimer's disease 135 | 644
Endometriosis 117 | 535
Intellectual disability 117 | 573
Schizophrenia 115 | 501
pancreatic carcinoma 115 | 567
hepatocellular carcinoma 114 | 532
Amyotrophic Lateral Sclerosis 113 | 431
Duchenne muscular dystrophy 111 | 602
Prostatic Neoplasms 111 | 471
Obesity 110 | 616
Mammary Neoplasms 107 | 410
Down syndrome 105 | 548
chronic rhinosinusitis 105 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 100 | 499
active ulcerative colitis 97 | 477
fibroadenoma 97 | 557
gastric cancer 96 | 430
mucosa-associated lymphoid tissue lymphoma 90 | 480
glioblastoma multiforme 80 | 347
Autistic Disorder 77 | 320
Neurodegenerative disease 77 | 383
inflammatory breast cancer 77 | 404
Multiple Sclerosis 75 | 498
Acquired metabolic disease 74 | 267
non-small cell lung carcinoma 74 | 413
Asthma 72 | 349
Hypertension 72 | 287
Kidney disease 72 | 396
IGA Glomerulonephritis 71 | 454
Vascular disease 71 | 281
Bipolar Disorder 70 | 266
Heart disease 70 | 279
sarcoidosis 70 | 358

Tissue

Nervous System 3,525 | 18,561
Female tissues 3,520 | 18,647
Digestive Tract 3,513 | 18,473
Endocrine System 3,513 | 18,512
Urinary Tract 3,506 | 18,444
Liver and Pancreas 3,496 | 18,136
Blood and immune system 3,489 | 17,995
Cardiovascular System 3,484 | 17,958
Male tissues 3,480 | 17,969
Skin and soft tissues 3,468 | 18,115
Respiratory system 3,425 | 17,484

Target Family

Enzyme 1,193 | 4,146
Non-IDG 1,189 | 11,971
Transcription Factor 747 | 1,400
Kinase 187 | 634
Epigenetic 134 | 242
Transporter 48 | 473
Nuclear Receptor 46 | 48
Ion Channel 36 | 341
TF/Epigenetic 30 | 38
GPCR 4 | 406

UniProt Keyword

Metal-binding 3,614 | 3,614
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121