Development Level

Tbio 225 | 10,625
Tchem 34 | 1,890
Tclin 21 | 602
Tdark 19 | 7,003

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 19 | 633
abnormal behavior 12 | 226
decreased body weight 11 | 174
decreased lean body mass 9 | 195
preweaning lethality, incomple... 8 | 260
decreased body length 7 | 108
decreased bone mineral content 7 | 157
decreased total body fat amoun... 6 | 186
embryonic lethality prior to t... 6 | 187
increased or absent threshold ... 6 | 128
decreased bone mineral density 5 | 126
decreased grip strength 5 | 123
increased circulating HDL chol... 5 | 63
abnormal cranium morphology 4 | 32
abnormal embryo size 4 | 112
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to o... 4 | 148
short tibia 4 | 82
thrombocytopenia 4 | 46
abnormal gait 3 | 51
abnormal head morphology 3 | 10
abnormal retina morphology 3 | 100
corneal opacity 3 | 25
decreased circulating LDL chol... 3 | 37
decreased leukocyte cell numbe... 3 | 54
decreased startle reflex 3 | 48
increased circulating calcium ... 3 | 32
increased circulating choleste... 3 | 53
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
increased total body fat amoun... 3 | 57
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo turning 2 | 15
abnormal heart morphology 2 | 51
abnormal humerus morphology 2 | 11
abnormal joint morphology 2 | 14
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal snout morphology 2 | 18
abnormal tail movements 2 | 12
abnormal tibia morphology 2 | 14
abnormal tooth morphology 2 | 24
abnormal vitreous body morphol... 2 | 7
absent pinna reflex 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased CD8-positive, alpha-... 2 | 26
decreased KLRG1-positive NK ce... 2 | 9
decreased Ly6C high monocyte n... 2 | 18
decreased NK T cell number 2 | 28
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased effector memory CD8-... 2 | 24
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
embryonic growth retardation 2 | 28
enlarged heart 2 | 111
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased Ly6C high monocyte n... 2 | 12
increased blood urea nitrogen ... 2 | 44
increased circulating alanine ... 2 | 11
increased circulating alkaline... 2 | 119
increased circulating serum al... 2 | 25
increased circulating total pr... 2 | 20
increased hematocrit 2 | 36
increased lean body mass 2 | 107
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
prenatal lethality prior to he... 2 | 64
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 52
abnormal motor capabilities/co... 1 | 4
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased cervical vertebrae n... 1 | 12
decreased circulating chloride... 1 | 32
decreased eosinophil cell numb... 1 | 41
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased bone mineral density 1 | 52
increased eosinophil cell numb... 1 | 9
increased mean platelet volume 1 | 19
straub tail 1 | 26

Disease

Intellectual disability 299 | 573
ovarian cancer 195 | 8,492
osteosarcoma 158 | 7,933
medulloblastoma, large-cell 151 | 6,234
glioblastoma 128 | 5,572
psoriasis 116 | 6,685
atypical teratoid / rhabdoid tumor 109 | 4,369
lung cancer 98 | 4,473
Carcinoma 85 | 2,147
primitive neuroectodermal tumor 79 | 3,031
oligodendroglioma 74 | 2,849
malignant mesothelioma 73 | 3,163
pediatric high grade glioma 72 | 2,712
pilocytic astrocytoma 70 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
Breast cancer 66 | 3,099
ependymoma 64 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,956
astrocytic glioma 59 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,988
invasive ductal carcinoma 57 | 2,950
lung adenocarcinoma 57 | 2,714
subependymal giant cell astrocytoma 57 | 2,287
Pick disease 56 | 1,893
group 3 medulloblastoma 51 | 2,254
lung carcinoma 51 | 2,844
Epilepsy 50 | 346
Cancer 48 | 2,346
adult high grade glioma 48 | 2,148
medulloblastoma 48 | 1,524
non-small cell lung cancer 46 | 2,798
Microcephaly 43 | 149
group 4 medulloblastoma 41 | 1,875
posterior fossa group A ependymoma 39 | 1,511
astrocytoma 38 | 1,493
colon cancer 36 | 1,475
ductal carcinoma in situ 36 | 1,745
sonic hedgehog group medulloblastoma 36 | 1,482
ulcerative colitis 36 | 2,087
posterior fossa group B ependymoma 35 | 1,530
adrenocortical carcinoma 33 | 1,427
pancreatic cancer 32 | 2,300
pituitary cancer 32 | 1,972
acute quadriplegic myopathy 31 | 1,157
Multiple myeloma 30 | 1,328
atypical teratoid/rhabdoid tumor 30 | 1,095
Obesity 28 | 616
juvenile dermatomyositis 27 | 1,189
Autistic Disorder 26 | 320
tuberculosis 26 | 1,563
Neurodegenerative disease 25 | 383
breast carcinoma 25 | 1,614
diabetes mellitus 25 | 1,663
interstitial cystitis 25 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
Rheumatoid Arthritis 24 | 1,171
dermatomyositis 24 | 967
spina bifida 24 | 1,064
Craniofacial Abnormalities 22 | 147
Schizophrenia 21 | 503
cystic fibrosis 21 | 1,670
Polydactyly 20 | 93
nasopharyngeal carcinoma 19 | 1,056
primary pancreatic ductal adenocarcinoma 19 | 1,271
Alzheimer's disease 18 | 644
Bardet-Biedl Syndrome 18 | 40
progressive supranuclear palsy 18 | 674
Bardet-Biedl syndrome 1 16 | 22
Mental Retardation, X-Linked 16 | 23
Waldenstrons macroglobulinemia 15 | 765
Mammary Neoplasms 14 | 410
Parkinson's disease 14 | 364
acute myeloid leukemia 14 | 785
primary Sjogren syndrome 14 | 789
Ciliopathy 13 | 57
aldosterone-producing adenoma 13 | 664
non primary Sjogren syndrome sicca 13 | 840
Atopic dermatitis 12 | 944
Fundus dystrophy 12 | 77
Renal Cell Carcinoma 12 | 199
gastric carcinoma 12 | 832
tuberculosis and treatment for 6 months 12 | 686
Adenoid Cystic Carcinoma 11 | 99
Amyotrophic Lateral Sclerosis 11 | 432
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
chronic rhinosinusitis 11 | 512
hepatocellular carcinoma 11 | 550
Coffin-Siris syndrome 10 | 17
Cone dystrophy 10 | 59
Liver carcinoma 10 | 217
Retinitis pigmentosa 10 | 156
active Crohn's disease 10 | 918
active ulcerative colitis 10 | 477
cutaneous lupus erythematosus 10 | 1,056
gastric cancer 10 | 436
non-small cell lung carcinoma 10 | 413
Cleft palate 9 | 125
Lung Neoplasms 9 | 171
Seckel syndrome 9 | 35
inflammatory breast cancer 9 | 404

Tissue

Blood and immune system 297 | 17,995
Nervous System 297 | 18,561
Skin and soft tissues 297 | 18,115
Cardiovascular System 296 | 17,958
Digestive Tract 296 | 18,473
Urinary Tract 296 | 18,444
Endocrine System 295 | 18,512
Female tissues 295 | 18,647
Liver and Pancreas 295 | 18,136
Male tissues 294 | 17,969
Respiratory system 293 | 17,484

Target Family

Non-IDG 145 | 11,969
Enzyme 70 | 4,146
Transcription Factor 30 | 1,400
Epigenetic 17 | 242
Kinase 16 | 634
Ion Channel 12 | 341
Transporter 7 | 473
GPCR 1 | 408
TF/Epigenetic 1 | 38

UniProt Keyword

Mental retardation 299 | 299
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
THO complex subunit 6 homolog THOC6 Tbio Non-IDG -1.72319 50.1 112
Zinc finger protein 711 ZNF711 Tdark Transcription Factor -0.77910 5.17 33
Dipeptidyl aminopeptidase-like protein 6 DPP6 Tbio Enzyme -2.02374 108.0 115
RNA-binding protein 28 RBM28 Tbio Non-IDG -1.85274 73.2 99
Post-GPI attachment to proteins factor 2 PGAP2 Tdark Non-IDG -1.00968 10.0 45
von Willebrand factor A domain-containing protein 3B VWA3B Tdark Non-IDG 0.48 0.75 52
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIGY Tdark Enzyme -0.25795 2.82 51
Protein C10 C12orf57 Tbio Non-IDG -2.16744 143.6 14
Centromere protein J CENPJ Tbio Non-IDG -1.78980 57.1 86
Zinc finger and BTB domain-containing protein 20 ZBTB20 Tbio Transcription Factor -2.09716 123.5 71