Development Level

Tbio 290 | 11,651
Tchem 35 | 1,388
Tclin 24 | 612
Tdark 13 | 6,593

Collection

RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 43 | 979
preweaning lethality, incomple... 18 | 499
abnormal behavior 13 | 298
decreased body weight 13 | 161
decreased lean body mass 11 | 135
abnormal embryo size 9 | 220
embryonic lethality prior to t... 9 | 278
decreased bone mineral content 8 | 151
decreased bone mineral density 8 | 126
embryonic growth retardation 8 | 106
increased total body fat amoun... 8 | 134
decreased total body fat amoun... 7 | 207
embryonic lethality prior to o... 7 | 239
hypoactivity 6 | 132
increased circulating alkaline... 6 | 122
increased startle reflex 6 | 112
short tibia 6 | 97
decreased body length 5 | 101
decreased grip strength 5 | 116
decreased startle reflex 5 | 75
increased circulating HDL chol... 5 | 80
increased lean body mass 5 | 172
increased or absent threshold ... 5 | 101
male infertility 5 | 123
abnormal bone structure 4 | 187
abnormal cranium morphology 4 | 36
abnormal retina morphology 4 | 71
impaired glucose tolerance 4 | 75
increased mean corpuscular hem... 4 | 96
increased mean corpuscular vol... 4 | 92
prenatal lethality prior to he... 4 | 87
abnormal gait 3 | 69
abnormal head morphology 3 | 10
abnormal heart morphology 3 | 162
corneal opacity 3 | 32
decreased circulating HDL chol... 3 | 68
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased mean corpuscular vol... 3 | 79
hyperactivity 3 | 148
increased bone mineral density 3 | 72
increased circulating calcium ... 3 | 34
increased circulating choleste... 3 | 66
mammalian phenotype 3 | 17
thrombocytopenia 3 | 56
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal joint morphology 2 | 23
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal retinal vasculature m... 2 | 27
abnormal snout morphology 2 | 23
abnormal tail movements 2 | 12
abnormal tibia morphology 2 | 14
absent pinna reflex 2 | 23
cataract 2 | 92
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased heart rate 2 | 18
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased anti-nuclear antigen... 2 | 19
increased bone mineral content 2 | 108
increased circulating alanine ... 2 | 13
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating serum al... 2 | 22
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased prepulse inhibition 2 | 32
prolonged PR interval 2 | 15
vertebral fusion 2 | 23
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
decreased T cell number 1 | 15
enlarged spleen 1 | 41
increased circulating triglyce... 1 | 42

Disease

Intellectual disability 361 | 1,016
Carcinoma 302 | 11,493
ovarian cancer 229 | 8,520
osteosarcoma 194 | 7,950
medulloblastoma, large-cell 182 | 6,241
Dull intelligence 170 | 645
Low intelligence 170 | 645
Mental Retardation 170 | 645
Mental deficiency 170 | 645
Poor school performance 170 | 645
glioblastoma 166 | 5,792
atypical teratoid / rhabdoid tumor 159 | 5,112
psoriasis 141 | 6,694
ependymoma 140 | 4,679
Kidney cancer 127 | 2,613
group 3 medulloblastoma 124 | 4,104
lung cancer 124 | 4,740
Epilepsy 122 | 792
Cognitive delay 117 | 608
Global developmental delay 117 | 608
Mental and motor retardation 117 | 608
adult high grade glioma 117 | 3,801
Breast cancer 98 | 3,578
Muscle hypotonia 98 | 571
malignant mesothelioma 97 | 3,232
oligodendroglioma 94 | 2,850
primitive neuroectodermal tumor 92 | 3,035
Short stature 91 | 531
Seizures 89 | 596
astrocytic glioma 89 | 2,597
Autosomal recessive predisposition 85 | 1,442
Astrocytoma, Pilocytic 83 | 3,081
Small head 79 | 374
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,291
Pick disease 75 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,955
subependymal giant cell astrocytoma 70 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 67 | 2,989
lung adenocarcinoma 67 | 2,716
invasive ductal carcinoma 64 | 2,951
lung carcinoma 63 | 2,843
non-small cell lung cancer 58 | 2,890
Cancer 56 | 2,499
Cryptorchidism 54 | 296
group 4 medulloblastoma 54 | 1,855
Schizophrenia 52 | 1,160
Strabismus 51 | 270
Acquired scoliosis 49 | 281
Curvature of spine 49 | 282
Microcephaly 47 | 166
pancreatic cancer 44 | 2,398
colon cancer 43 | 1,478
Concave bridge of nose 42 | 195
Depressed nasal bridge 42 | 195
Depressed nasal root/bridge 42 | 195
Hypoplastic mandible condyle 41 | 275
Mandibular hypoplasia 41 | 275
Micrognathism 41 | 275
Orbital separation excessive 41 | 244
Byzanthine arch palate 40 | 194
Delayed speech and language development 40 | 112
Language Delay 40 | 112
Obesity 40 | 678
Speech Delay 40 | 112
Speech impairment 40 | 112
ductal carcinoma in situ 40 | 1,745
Autistic Disorder 39 | 364
Downward slant of palpebral fissure 39 | 158
Multiple myeloma 39 | 1,332
Severe mental retardation (I.Q. 20-34) 39 | 99
acute quadriplegic myopathy 39 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 39 | 1,962
tuberculosis 39 | 2,010
Nystagmus 38 | 317
Anteverted nostril 37 | 191
pituitary cancer 37 | 1,972
ulcerative colitis 36 | 1,819
X- linked recessive 35 | 110
adrenocortical carcinoma 35 | 1,428
diabetes mellitus 35 | 1,728
Congenital hypoplasia of penis 34 | 176
Endometrial cancer 34 | 311
Liver cancer 34 | 604
Low set ears 33 | 181
Neurodegenerative disease 33 | 414
breast carcinoma 33 | 1,638
Cerebral atrophy 32 | 178
juvenile dermatomyositis 32 | 1,187
astrocytoma 31 | 1,146
dermatomyositis 31 | 966
Blepharoptosis 30 | 231
Congenital Epicanthus 30 | 177
Hyperreflexia 30 | 209
Short nose 30 | 132
Small nose 30 | 132
pediatric high grade glioma 30 | 1,064
Broad flat nasal bridge 29 | 236
Feeding difficulties in infancy 29 | 175
Intrauterine retardation 29 | 176
cystic fibrosis 29 | 1,696

Tissue

Digestive Tract 360 | 17,369
Endocrine System 360 | 18,159
Nervous System 359 | 16,725
Female tissues 356 | 17,400
Skin and soft tissues 355 | 17,230
Male tissues 352 | 17,142
Blood and immune system 351 | 16,909
Liver and Pancreas 350 | 16,750
Respiratory system 346 | 16,393
Urinary Tract 345 | 16,678
Cardiovascular System 334 | 15,192

Target Family

Non-IDG 174 | 12,091
Enzyme 85 | 4,145
Transcription Factor 37 | 1,400
Epigenetic 21 | 242
Kinase 20 | 634
Ion Channel 15 | 344
Transporter 8 | 473
GPCR 1 | 408
TF/Epigenetic 1 | 38

UniProt Keyword

Mental retardation 362 | 362
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase FTSJ1 Tbio Enzyme -1.64419 45.9 108
Chromosome alignment-maintaining phosphoprotein 1 CHAMP1 Tbio Non-IDG -0.61730 4.58 106
Protein phosphatase 1 regulatory subunit 15B PPP1R15B Tbio Enzyme -1.42081 25.8 85
Collagen and calcium-binding EGF domain-containing protein 1 CCBE1 Tbio Non-IDG -1.27652 20.3 165
SET domain-containing protein 5 SETD5 Tbio Epigenetic -0.91515 9.39 43
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
AMME syndrome candidate gene 1 protein AMMECR1 Tbio Non-IDG -0.63077 4.76 84
Transcriptional repressor p66-beta GATAD2B Tbio Transcription Factor -1.00210 9.37 215