Development Level

Tbio 4,208 | 11,651
Tdark 2,078 | 6,593
Tchem 618 | 1,388
Tclin 457 | 612

Collection

RFA-RM-18-021 231 | 328
GPCR: IDG Consortium (Targets) 126 | 126
Ion Channel: IDG Consortium (T... 96 | 99
Kinase: IDG Consortium (Target... 31 | 125
GPCR: IDG Consortium (Complete... 25 | 25
Kinase: IDG Consortium (Comple... 8 | 37

IMPC Phenotype

preweaning lethality, complete... 301 | 979
preweaning lethality, incomple... 185 | 499
abnormal behavior 131 | 298
embryonic lethality prior to t... 100 | 278
decreased vertical activity 94 | 208
decreased total body fat amoun... 87 | 207
enlarged heart 85 | 210
embryonic lethality prior to o... 76 | 239
abnormal bone structure 73 | 187
abnormal embryo size 72 | 220
increased lean body mass 70 | 172
hyperactivity 69 | 148
decreased bone mineral content 65 | 151
decreased body weight 63 | 161
increased total body fat amoun... 62 | 134
abnormal heart morphology 61 | 162
hypoactivity 54 | 132
abnormal seminal vesicle morph... 52 | 114
decreased lean body mass 52 | 135
decreased bone mineral density 50 | 126
increased circulating alkaline... 47 | 122
decreased grip strength 46 | 116
decreased circulating glucose ... 45 | 126
increased startle reflex 43 | 112
increased mean corpuscular hem... 42 | 96
increased bone mineral content 40 | 108
decreased circulating choleste... 39 | 93
decreased lymphocyte cell numb... 39 | 83
increased or absent threshold ... 39 | 101
embryonic growth retardation 38 | 106
increased mean corpuscular vol... 37 | 92
impaired glucose tolerance 36 | 75
decreased body length 35 | 101
decreased startle reflex 35 | 75
abnormal sleep behavior 34 | 70
decreased fasted circulating g... 34 | 65
decreased prepulse inhibition 34 | 82
cataract 33 | 92
improved glucose tolerance 33 | 79
decreased circulating serum al... 32 | 82
decreased circulating triglyce... 32 | 79
increased fasted circulating g... 32 | 76
short tibia 32 | 97
abnormal retina morphology 31 | 71
abnormal eye morphology 30 | 68
abnormal gait 30 | 69
decreased mean corpuscular vol... 30 | 79
increased circulating sodium l... 30 | 71
increased monocyte cell number 30 | 63
increased heart weight 29 | 62
small superior vagus ganglion 29 | 74
abnormal lens morphology 28 | 81
decreased circulating HDL chol... 28 | 68
decreased hemoglobin content 28 | 68
male infertility 28 | 123
abnormal kidney morphology 27 | 65
decreased leukocyte cell numbe... 26 | 73
limb grasping 26 | 41
decreased circulating insulin ... 25 | 76
edema 25 | 59
increased circulating HDL chol... 25 | 80
prenatal lethality prior to he... 25 | 87
increased bone mineral density 24 | 72
abnormal behavioral response t... 23 | 66
abnormal epididymis morphology 23 | 42
increased circulating triglyce... 22 | 42
increased leukocyte cell numbe... 22 | 47
abnormal skin morphology 21 | 50
abnormal spleen morphology 21 | 55
decreased erythrocyte cell num... 21 | 62
decreased mean corpuscular hem... 21 | 50
increased neutrophil cell numb... 21 | 46
thrombocytopenia 21 | 56
enlarged spleen 20 | 41
hydrometra 20 | 53
increased circulating calcium ... 20 | 34
abnormal coat-hair pigmentatio... 19 | 64
cardiovascular system phenotyp... 19 | 36
decreased circulating alkaline... 19 | 46
decreased heart weight 19 | 27
enlarged epididymis 19 | 31
increased blood urea nitrogen ... 19 | 48
increased circulating choleste... 19 | 66
increased hematocrit 19 | 46
small testis 19 | 58
tremors 19 | 39
abnormal neural tube closure 18 | 46
decreased circulating LDL chol... 18 | 38
decreased circulating total pr... 18 | 49
abnormal testis morphology 17 | 43
decreased circulating alanine ... 17 | 47
decreased circulating creatini... 17 | 39
decreased hematocrit 17 | 46
increased circulating chloride... 17 | 41
decreased red blood cell distr... 16 | 41
increased grip strength 16 | 41
increased hemoglobin content 16 | 45
increased mean platelet volume 16 | 45
increased red blood cell distr... 16 | 34
prolonged QT interval 16 | 38

Disease

Carcinoma 4,505 | 11,493
ovarian cancer 3,068 | 8,520
osteosarcoma 2,959 | 7,950
psoriasis 2,564 | 6,694
medulloblastoma, large-cell 2,480 | 6,241
glioblastoma 2,348 | 5,792
atypical teratoid / rhabdoid tumor 2,086 | 5,112
ependymoma 1,904 | 4,679
lung cancer 1,728 | 4,740
adult high grade glioma 1,621 | 3,801
Astrocytoma, Pilocytic 1,454 | 3,081
group 3 medulloblastoma 1,386 | 4,104
lung carcinoma 1,378 | 2,843
Breast cancer 1,350 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 1,289 | 3,291
invasive ductal carcinoma 1,227 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,221 | 2,955
non-small cell lung cancer 1,196 | 2,890
oligodendroglioma 1,188 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 1,175 | 2,989
primitive neuroectodermal tumor 1,151 | 3,035
lung adenocarcinoma 1,143 | 2,716
malignant mesothelioma 1,138 | 3,232
interstitial cystitis 1,122 | 2,312
Kidney cancer 1,066 | 2,613
astrocytic glioma 1,057 | 2,597
pancreatic cancer 1,019 | 2,398
subependymal giant cell astrocytoma 986 | 2,287
Cancer 926 | 2,499
tuberculosis 890 | 2,010
pituitary cancer 842 | 1,972
ulcerative colitis 820 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 780 | 1,962
Pick disease 775 | 1,894
group 4 medulloblastoma 744 | 1,855
ductal carcinoma in situ 732 | 1,745
diabetes mellitus 712 | 1,728
cystic fibrosis 695 | 1,696
breast carcinoma 636 | 1,638
Autosomal recessive predisposition 617 | 1,442
Schizophrenia 563 | 1,160
colon cancer 541 | 1,478
adrenocortical carcinoma 515 | 1,428
Rheumatoid arthritis 510 | 1,191
cutaneous lupus erythematosus 493 | 1,057
primary pancreatic ductal adenocarcinoma 470 | 1,109
astrocytoma 465 | 1,146
Multiple myeloma 456 | 1,332
active Crohn's disease 427 | 922
pediatric high grade glioma 412 | 1,064
juvenile dermatomyositis 404 | 1,187
spina bifida 399 | 1,074
acute quadriplegic myopathy 391 | 1,158
Epilepsy 388 | 792
active ulcerative colitis 365 | 764
dermatomyositis 365 | 966
Intellectual disability 363 | 1,016
non primary Sjogren syndrome sicca 341 | 891
nasopharyngeal carcinoma 340 | 1,058
gastric carcinoma 335 | 807
Atopic dermatitis 332 | 952
primary Sjogren syndrome 332 | 735
Liver Cirrhosis, Experimental 328 | 769
Melanoma 328 | 711
Bipolar Disorder 318 | 666
esophageal adenocarcinoma 317 | 737
Alzheimer's disease 308 | 658
Obesity 287 | 678
aldosterone-producing adenoma 287 | 665
Liver cancer 280 | 604
Multiple Sclerosis 277 | 540
medulloblastoma 267 | 720
Duchenne muscular dystrophy 259 | 601
Seizures 258 | 596
mucosa-associated lymphoid tissue lymphoma 257 | 484
Skin cancer 248 | 469
progressive supranuclear palsy 245 | 676
acute myeloid leukemia 244 | 783
Down syndrome 240 | 499
Muscle hypotonia 239 | 571
fibroadenoma 239 | 559
Waldenstrons macroglobulinemia 238 | 765
pancreatic carcinoma 238 | 562
Dull intelligence 237 | 645
Low intelligence 237 | 645
Mental Retardation 237 | 645
Mental deficiency 237 | 645
Poor school performance 237 | 645
Cognitive delay 232 | 608
Global developmental delay 232 | 608
Mental and motor retardation 232 | 608
autosomal dominant Emery-Dreifuss muscular dystrophy 202 | 510
Depressive disorder 199 | 409
Neurodegenerative disease 199 | 414
Prostatic Neoplasms 197 | 495
Hypertension 196 | 396
Kidney disease 189 | 430
Short stature 187 | 531
Parkinson's disease 184 | 392
posterior fossa group A ependymoma 184 | 468

Tissue

Endocrine System 6,494 | 18,159
Digestive Tract 6,223 | 17,369
Female tissues 6,216 | 17,400
Skin and soft tissues 6,130 | 17,230
Male tissues 6,122 | 17,142
Blood and immune system 6,028 | 16,909
Nervous System 6,026 | 16,725
Liver and Pancreas 6,004 | 16,750
Urinary Tract 6,002 | 16,678
Respiratory system 5,835 | 16,393
Cardiovascular System 5,363 | 15,192

Target Family

Non-IDG 3,995 | 12,091
Enzyme 1,448 | 4,145
Transporter 464 | 473
oGPCR 421 | 421
GPCR 408 | 408
Ion Channel 340 | 344
Kinase 238 | 634
Transcription Factor 35 | 1,400
Epigenetic 9 | 242
Nuclear Receptor 3 | 48

UniProt Keyword

Membrane 7,361 | 7,361
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418