Development Level

Tbio 3,778 | 10,625
Tdark 2,116 | 7,003
Tchem 835 | 1,890
Tclin 450 | 602

Collection

Eligible non-olfactory GPCR Proteins 143 | 143
Eligible Ion Channel Proteins 113 | 117
Eligible Kinase Proteins 32 | 134

IMPC Term

preweaning lethality, complete... 202 | 633
abnormal behavior 99 | 226
preweaning lethality, incomple... 94 | 260
decreased lean body mass 80 | 195
decreased total body fat amoun... 80 | 186
decreased bone mineral content 68 | 157
embryonic lethality prior to t... 67 | 187
decreased body weight 66 | 174
decreased bone mineral density 56 | 126
abnormal bone structure 52 | 131
hyperactivity 52 | 108
decreased grip strength 51 | 123
increased circulating alkaline... 48 | 119
increased or absent threshold ... 47 | 128
increased mean corpuscular hem... 46 | 93
embryonic lethality prior to o... 45 | 148
enlarged heart 45 | 111
decreased circulating glucose ... 43 | 121
hypoactivity 40 | 89
abnormal retina morphology 39 | 100
decreased circulating triglyce... 39 | 83
increased lean body mass 39 | 107
decreased circulating choleste... 37 | 85
increased mean corpuscular vol... 36 | 91
increased bone mineral content 35 | 92
abnormal embryo size 32 | 112
decreased body length 32 | 108
increased circulating sodium l... 32 | 71
increased grip strength 30 | 83
decreased rib number 29 | 59
decreased circulating HDL chol... 28 | 77
short tibia 28 | 82
decreased circulating insulin ... 27 | 75
increased fasted circulating g... 27 | 68
abnormal sleep behavior 26 | 63
decreased fasted circulating g... 26 | 49
decreased prepulse inhibition 26 | 52
increased total body fat amoun... 26 | 57
decreased circulating serum al... 25 | 79
abnormal lens morphology 24 | 73
abnormal retinal pigmentation 24 | 61
impaired glucose tolerance 24 | 52
abnormal gait 23 | 51
decreased circulating alanine ... 23 | 53
improved glucose tolerance 23 | 56
increased bone mineral density 23 | 52
decreased heart weight 21 | 44
decreased lumbar vertebrae num... 21 | 62
decreased startle reflex 21 | 48
increased exploration in new e... 21 | 56
increased sacral vertebrae num... 21 | 62
abnormal bone mineralization 20 | 55
abnormal seminal vesicle morph... 20 | 47
cardiovascular system phenotyp... 20 | 35
decreased hemoglobin content 20 | 53
decreased leukocyte cell numbe... 20 | 54
decreased mean corpuscular vol... 20 | 50
increased blood urea nitrogen ... 20 | 44
increased heart weight 20 | 37
limb grasping 20 | 35
prenatal lethality prior to he... 20 | 64
decreased caudal vertebrae num... 19 | 49
increased circulating HDL chol... 19 | 63
increased circulating calcium ... 19 | 32
increased circulating choleste... 19 | 53
increased circulating potassiu... 19 | 31
male infertility 19 | 62
abnormal heart morphology 18 | 51
increased hemoglobin content 18 | 45
thrombocytopenia 18 | 46
abnormal eye morphology 17 | 38
decreased eosinophil cell numb... 17 | 41
decreased mean corpuscular hem... 17 | 34
enlarged epididymis 17 | 27
increased body weight 17 | 42
increased hematocrit 17 | 36
abnormal epididymis morphology 16 | 31
abnormal neural tube closure 16 | 37
decreased NK T cell number 16 | 28
decreased circulating LDL chol... 16 | 37
increased leukocyte cell numbe... 16 | 37
tremors 16 | 34
increased circulating chloride... 15 | 43
increased rib number 15 | 41
abnormal behavioral response t... 14 | 52
abnormal coat appearance 14 | 25
decreased T cell number 14 | 31
decreased circulating alkaline... 14 | 41
decreased circulating total pr... 14 | 41
abnormal QRS complex 13 | 25
abnormal coat/hair pigmentatio... 13 | 54
decreased blood urea nitrogen ... 13 | 31
decreased circulating calcium ... 13 | 33
decreased circulating free fat... 13 | 39
decreased erythrocyte cell num... 13 | 43
decreased vertical activity 13 | 22
enlarged spleen 13 | 26
female infertility 13 | 34
increased circulating phosphat... 13 | 24
straub tail 13 | 26

Disease

ovarian cancer 3,021 | 8,484
osteosarcoma 2,913 | 7,933
psoriasis 2,529 | 6,685
medulloblastoma, large-cell 2,463 | 6,234
glioblastoma 2,245 | 5,572
atypical teratoid / rhabdoid tumor 1,763 | 4,369
lung cancer 1,582 | 4,466
pilocytic astrocytoma 1,447 | 3,086
lung carcinoma 1,372 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 1,279 | 3,289
invasive ductal carcinoma 1,217 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,204 | 2,956
oligodendroglioma 1,174 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 1,162 | 2,988
primitive neuroectodermal tumor 1,149 | 3,031
Breast cancer 1,143 | 3,094
non-small cell lung cancer 1,136 | 2,798
pediatric high grade glioma 1,135 | 2,712
lung adenocarcinoma 1,132 | 2,713
malignant mesothelioma 1,109 | 3,162
interstitial cystitis 1,100 | 2,299
ependymoma 1,034 | 2,514
subependymal giant cell astrocytoma 980 | 2,287
pancreatic cancer 962 | 2,300
ulcerative colitis 929 | 2,087
Carcinoma 913 | 2,147
astrocytic glioma 896 | 2,241
adult high grade glioma 886 | 2,148
Cancer 863 | 2,346
pituitary cancer 835 | 1,972
Pick disease 770 | 1,893
ductal carcinoma in situ 730 | 1,745
group 4 medulloblastoma 720 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 700 | 1,795
diabetes mellitus 680 | 1,663
cystic fibrosis 676 | 1,665
group 3 medulloblastoma 676 | 2,254
tuberculosis 670 | 1,557
posterior fossa group A ependymoma 657 | 1,511
medulloblastoma 624 | 1,524
breast carcinoma 619 | 1,614
astrocytoma 609 | 1,493
primary pancreatic ductal adenocarcinoma 537 | 1,271
colon cancer 535 | 1,475
sonic hedgehog group medulloblastoma 528 | 1,482
posterior fossa group B ependymoma 517 | 1,530
adrenocortical carcinoma 513 | 1,427
cutaneous lupus erythematosus 489 | 1,056
Rheumatoid Arthritis 482 | 1,160
atypical teratoid/rhabdoid tumor 453 | 1,095
Multiple myeloma 450 | 1,327
active Crohn's disease 422 | 918
juvenile dermatomyositis 399 | 1,189
spina bifida 391 | 1,064
acute quadriplegic myopathy 382 | 1,157
primary Sjogren syndrome 351 | 789
gastric carcinoma 342 | 832
nasopharyngeal carcinoma 334 | 1,056
dermatomyositis 331 | 933
Atopic dermatitis 323 | 944
non primary Sjogren syndrome sicca 315 | 840
esophageal adenocarcinoma 312 | 737
Alzheimer's disease 298 | 644
aldosterone-producing adenoma 283 | 664
Obesity 269 | 616
Down syndrome 262 | 548
Multiple Sclerosis 261 | 498
Duchenne muscular dystrophy 258 | 602
Schizophrenia 258 | 501
mucosa-associated lymphoid tissue lymphoma 256 | 480
progressive supranuclear palsy 244 | 674
acute myeloid leukemia 243 | 780
pancreatic carcinoma 238 | 567
fibroadenoma 236 | 557
Waldenstrons macroglobulinemia 234 | 765
active ulcerative colitis 231 | 477
tuberculosis and treatment for 6 months 224 | 686
Epilepsy 215 | 346
Intellectual disability 204 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 198 | 499
IGA Glomerulonephritis 196 | 454
non-small cell lung carcinoma 187 | 413
Neurodegenerative disease 184 | 383
Prostatic Neoplasms 184 | 471
Endometriosis 175 | 535
Kidney disease 174 | 396
Parkinson's disease 172 | 364
hepatocellular carcinoma 166 | 532
Autistic Disorder 164 | 320
Asthma 155 | 349
Hypersensitivity reaction type II disease 150 | 235
sarcoidosis 150 | 358
Amyotrophic Lateral Sclerosis 149 | 431
chronic rhinosinusitis 148 | 512
nephrosclerosis 146 | 329
glioblastoma multiforme 145 | 347
hereditary spastic paraplegia 142 | 313
Hypertension 141 | 287
gastric cancer 141 | 430
urothelial carcinoma 140 | 318

Tissue

Female tissues 6,745 | 18,647
Urinary Tract 6,701 | 18,444
Nervous System 6,677 | 18,561
Endocrine System 6,660 | 18,512
Digestive Tract 6,642 | 18,473
Skin and soft tissues 6,517 | 18,115
Liver and Pancreas 6,490 | 18,136
Blood and immune system 6,430 | 17,995
Cardiovascular System 6,418 | 17,958
Male tissues 6,381 | 17,969
Respiratory system 6,278 | 17,484

Target Family

Non-IDG 3,834 | 11,971
Enzyme 1,437 | 4,146
Transporter 464 | 473
oGPCR 421 | 421
GPCR 406 | 406
Ion Channel 337 | 341
Kinase 236 | 634
Transcription Factor 32 | 1,400
Epigenetic 9 | 242
Nuclear Receptor 3 | 48

UniProt Keyword

Membrane 7,179 | 7,179
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193