Development Level

Tbio 133 | 11,651
Tchem 39 | 1,388
Tdark 20 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 18 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 9 | 278
preweaning lethality, incomple... 9 | 499
abnormal embryo size 6 | 220
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
increased lean body mass 5 | 172
abnormal kidney morphology 4 | 65
decreased circulating glucose ... 4 | 126
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased bone mineral content 4 | 108
abnormal coat-hair pigmentatio... 3 | 64
abnormal heart morphology 3 | 162
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased vertical activity 3 | 208
increased circulating choleste... 3 | 66
male infertility 3 | 123
abnormal eye morphology 2 | 68
abnormal locomotor behavior 2 | 24
abnormal rib morphology 2 | 10
abnormal skin morphology 2 | 50
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased heart weight 2 | 62
increased monocyte cell number 2 | 63
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eyelid morphology 1 | 7
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pancreas morphology 1 | 13
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent spleen 1 | 3
absent teeth 1 | 3
anophthalmia 1 | 33
brachydactyly 1 | 19
decreased body length 1 | 101
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hydrometra 1 | 53
increased anti-nuclear antigen... 1 | 19
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
limb grasping 1 | 41
long tibia 1 | 25
microphthalmia 1 | 26
small adrenal glands 1 | 16
small kidney 1 | 16
small thymus 1 | 16
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 139 | 11,493
ovarian cancer 120 | 8,520
osteosarcoma 108 | 7,950
glioblastoma 77 | 5,792
medulloblastoma, large-cell 76 | 6,241
atypical teratoid / rhabdoid tumor 72 | 5,112
psoriasis 71 | 6,694
ependymoma 57 | 4,679
lung cancer 55 | 4,740
adult high grade glioma 52 | 3,801
Breast cancer 51 | 3,578
group 3 medulloblastoma 48 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
primitive neuroectodermal tumor 44 | 3,035
Astrocytoma, Pilocytic 41 | 3,081
malignant mesothelioma 41 | 3,232
Cancer 40 | 2,499
Kidney cancer 40 | 2,613
astrocytic glioma 39 | 2,597
invasive ductal carcinoma 38 | 2,951
lung adenocarcinoma 37 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,989
oligodendroglioma 34 | 2,850
non-small cell lung cancer 31 | 2,890
lung carcinoma 29 | 2,843
group 4 medulloblastoma 28 | 1,855
subependymal giant cell astrocytoma 28 | 2,287
Autosomal recessive predisposition 27 | 1,442
Pick disease 26 | 1,894
pituitary cancer 26 | 1,972
interstitial cystitis 25 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Multiple myeloma 24 | 1,332
juvenile dermatomyositis 22 | 1,187
pancreatic cancer 22 | 2,398
tuberculosis 22 | 2,010
ulcerative colitis 22 | 1,819
cystic fibrosis 21 | 1,696
Rheumatoid arthritis 20 | 1,191
colon cancer 20 | 1,478
ductal carcinoma in situ 20 | 1,745
breast carcinoma 19 | 1,638
dermatomyositis 18 | 966
acute quadriplegic myopathy 17 | 1,158
astrocytoma 17 | 1,146
medulloblastoma 17 | 720
Epilepsy 16 | 792
Seizures 16 | 596
Waldenstrons macroglobulinemia 16 | 765
spina bifida 16 | 1,074
diabetes mellitus 15 | 1,728
pediatric high grade glioma 15 | 1,064
active Crohn's disease 14 | 922
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Muscle hypotonia 13 | 571
nasopharyngeal carcinoma 13 | 1,058
Alzheimer's disease 12 | 658
Obesity 12 | 678
Schizophrenia 12 | 1,160
gastric carcinoma 12 | 807
non primary Sjogren syndrome sicca 12 | 891
Bipolar Disorder 11 | 666
Intellectual disability 11 | 1,016
Liver Cirrhosis, Experimental 11 | 769
adrenocortical carcinoma 11 | 1,428
primary Sjogren syndrome 11 | 735
Short stature 10 | 531
aldosterone-producing adenoma 10 | 665
cutaneous lupus erythematosus 10 | 1,057
progressive supranuclear palsy 10 | 676
sarcoidosis 10 | 370
Acquired metabolic disease 9 | 336
Acquired scoliosis 9 | 281
Atopic dermatitis 9 | 952
Curvature of spine 9 | 282
Prostatic Neoplasms 9 | 495
acute myeloid leukemia 9 | 783
esophageal adenocarcinoma 9 | 737
atypical teratoid/rhabdoid tumor 8 | 357
fibroadenoma 8 | 559
primary pancreatic ductal adenocarcinoma 8 | 1,109
Down syndrome 7 | 499
Endometriosis 7 | 540
Gaucher disease type 1 7 | 180
Liver cancer 7 | 604
Melanoma 7 | 711
Myopathy 7 | 185
active ulcerative colitis 7 | 764
chronic rhinosinusitis 7 | 512
tuberculosis and treatment for 6 months 7 | 409
Attention deficit hyperactivity disorder 6 | 278
Crohn's disease 6 | 321
Dull intelligence 6 | 645
Hypoplastic mandible condyle 6 | 275
Low intelligence 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645

Tissue

Endocrine System 194 | 18,159
Liver and Pancreas 191 | 16,750
Blood and immune system 190 | 16,909
Digestive Tract 190 | 17,369
Female tissues 190 | 17,400
Nervous System 190 | 16,725
Skin and soft tissues 190 | 17,230
Male tissues 189 | 17,142
Urinary Tract 189 | 16,678
Respiratory system 187 | 16,393
Cardiovascular System 182 | 15,192

Target Family

Enzyme 152 | 4,145
Kinase 28 | 634
Non-IDG 13 | 12,091
Transporter 2 | 473

UniProt Keyword

Manganese 195 | 195
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Ethanolaminephosphotransferase 1 SELENOI Tbio Enzyme -2.01142 98.3 12
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
Poly(A) polymerase beta PAPOLB Tbio Enzyme -1.66566 44.9 59
Beta-1,3-galactosyltransferase 6 B3GALT6 Tbio Enzyme -1.00350 10.1 132
Choline/ethanolaminephosphotransferase 1 CEPT1 Tbio Enzyme -1.65915 46.8 82
Protein phosphatase 1E PPM1E Tbio Enzyme -0.97004 9.49 44
Probable polypeptide N-acetylgalactosaminyltransferase 8 GALNT8 Tbio Enzyme -0.64755 3.62 54
Protein argonaute-2 AGO2 Tbio Non-IDG -2.97243 867.1 202
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303