Development Level

Tbio 118 | 10,625
Tchem 46 | 1,890
Tdark 26 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
embryonic lethality prior to o... 6 | 148
decreased lean body mass 5 | 195
embryonic lethality prior to t... 5 | 187
preweaning lethality, incomple... 5 | 260
abnormal retina morphology 4 | 100
decreased blood urea nitrogen ... 4 | 31
decreased circulating glucose ... 4 | 121
abnormal behavior 3 | 226
abnormal coat/hair pigmentatio... 3 | 54
decreased circulating triglyce... 3 | 83
decreased grip strength 3 | 123
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal kidney morphology 2 | 30
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
abnormal skin morphology 2 | 23
decreased body weight 2 | 174
decreased circulating chloride... 2 | 32
decreased eosinophil cell numb... 2 | 41
decreased fasted circulating g... 2 | 49
decreased total body fat amoun... 2 | 186
enlarged heart 2 | 111
increased KLRG1-positive NK ce... 2 | 9
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased or absent threshold ... 2 | 128
short tibia 2 | 82
small testis 2 | 37
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal eyelid morphology 1 | 6
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal mandible morphology 1 | 2
abnormal maxilla morphology 1 | 16
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
absent teeth 1 | 4
absent vibrissae 1 | 14
anophthalmia 1 | 20
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased CD5-positive Ly6C-po... 1 | 4
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased circulating serum al... 1 | 79
decreased gamma-delta T cell n... 1 | 18
decreased kidney weight 1 | 7
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating fructosa... 1 | 11
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased lean body mass 1 | 107
increased prepulse inhibition 1 | 21
increased red blood cell distr... 1 | 21
increased total body fat amoun... 1 | 57
lethargy 1 | 5
limb grasping 1 | 35
microphthalmia 1 | 15
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
small thymus 1 | 11
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 118 | 8,484
osteosarcoma 107 | 7,933
medulloblastoma, large-cell 73 | 6,234
glioblastoma 72 | 5,572
psoriasis 68 | 6,685
atypical teratoid / rhabdoid tumor 60 | 4,369
lung cancer 53 | 4,466
Breast cancer 46 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
primitive neuroectodermal tumor 42 | 3,031
malignant mesothelioma 41 | 3,162
pilocytic astrocytoma 39 | 3,086
invasive ductal carcinoma 38 | 2,950
lung adenocarcinoma 37 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 36 | 2,956
astrocytic glioma 35 | 2,241
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
pediatric high grade glioma 34 | 2,712
Cancer 33 | 2,346
oligodendroglioma 32 | 2,849
adult high grade glioma 30 | 2,148
group 3 medulloblastoma 29 | 2,254
group 4 medulloblastoma 29 | 1,875
lung carcinoma 29 | 2,844
Carcinoma 28 | 2,147
non-small cell lung cancer 28 | 2,798
subependymal giant cell astrocytoma 27 | 2,287
Pick disease 26 | 1,893
ependymoma 26 | 2,514
pituitary cancer 26 | 1,972
interstitial cystitis 25 | 2,299
ulcerative colitis 25 | 2,087
Multiple myeloma 24 | 1,327
medulloblastoma 23 | 1,524
juvenile dermatomyositis 22 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
posterior fossa group A ependymoma 22 | 1,511
cystic fibrosis 21 | 1,665
ductal carcinoma in situ 20 | 1,745
pancreatic cancer 20 | 2,300
astrocytoma 19 | 1,493
colon cancer 19 | 1,475
Rheumatoid Arthritis 18 | 1,160
dermatomyositis 18 | 933
Waldenstrons macroglobulinemia 17 | 765
acute quadriplegic myopathy 17 | 1,157
atypical teratoid/rhabdoid tumor 17 | 1,095
breast carcinoma 17 | 1,614
tuberculosis 17 | 1,557
spina bifida 16 | 1,064
active Crohn's disease 13 | 918
diabetes mellitus 13 | 1,663
posterior fossa group B ependymoma 13 | 1,530
gastric carcinoma 12 | 832
nasopharyngeal carcinoma 12 | 1,056
primary Sjogren syndrome 12 | 789
sonic hedgehog group medulloblastoma 12 | 1,482
Alzheimer's disease 10 | 644
Obesity 10 | 616
adrenocortical carcinoma 10 | 1,427
aldosterone-producing adenoma 10 | 664
cutaneous lupus erythematosus 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
progressive supranuclear palsy 10 | 674
Atopic dermatitis 9 | 944
acute myeloid leukemia 9 | 780
esophageal adenocarcinoma 9 | 737
primary pancreatic ductal adenocarcinoma 9 | 1,271
sarcoidosis 9 | 358
tuberculosis and treatment for 6 months 9 | 686
Prostatic Neoplasms 8 | 471
fibroadenoma 8 | 557
Acquired metabolic disease 7 | 267
Down syndrome 7 | 548
Endometriosis 7 | 535
chronic rhinosinusitis 7 | 512
pancreatic carcinoma 7 | 567
Amyotrophic Lateral Sclerosis 6 | 431
Exostosis 6 | 15
Gaucher disease type 1 6 | 171
IGA Glomerulonephritis 6 | 454
Osteoporosis 6 | 257
facioscapulohumeral dystrophy 6 | 286
nephrosclerosis 6 | 329
non-small cell lung carcinoma 6 | 413
Bipolar Disorder 5 | 266
Craniofacial Abnormalities 5 | 147
Crohn's disease 5 | 304
Liver neoplasms 5 | 109
Mammary Neoplasms 5 | 410
Ollier disease 5 | 15
hereditary spastic paraplegia 5 | 313
Liver carcinoma 4 | 217
Male infertility 4 | 170
Myocardial Ischemia 4 | 169
Stomach Neoplasms 4 | 282
Vascular disease 4 | 281
glioblastoma multiforme 4 | 347
head and neck cancer 4 | 270
inflammatory breast cancer 4 | 404

Tissue

Blood and immune system 191 | 17,995
Cardiovascular System 191 | 17,958
Digestive Tract 191 | 18,473
Female tissues 191 | 18,647
Male tissues 191 | 17,969
Nervous System 191 | 18,561
Endocrine System 190 | 18,512
Liver and Pancreas 190 | 18,136
Respiratory system 189 | 17,484
Skin and soft tissues 189 | 18,115
Urinary Tract 189 | 18,444

Target Family

Enzyme 152 | 4,146
Kinase 27 | 634
Non-IDG 12 | 11,971
Transporter 1 | 473

UniProt Keyword

Manganese 192 | 192
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Beta-1,3-galactosyltransferase 2 B3GALT2 Tdark Enzyme 0.13 0.55 88
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.59340 415.3 337
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
Polypeptide N-acetylgalactosaminyltransferase 18 GALNT18 Tdark Enzyme -0.28065 3.03 33
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.95631 90.0 412
Protein phosphatase PTC7 homolog PPTC7 Tdark Enzyme 0.85 0.09 72
Serine/threonine-protein kinase Nek11 NEK11 Tbio Kinase -0.65413 5.37 127