Development Level

Tbio 298 | 10,625
Tchem 159 | 1,890
Tdark 58 | 7,003
Tclin 28 | 602

Collection

Eligible Kinase Proteins 39 | 134

IMPC Term

preweaning lethality, complete... 27 | 633
preweaning lethality, incomple... 12 | 260
abnormal behavior 10 | 226
decreased lean body mass 10 | 195
decreased total body fat amoun... 10 | 186
increased bone mineral content 9 | 92
abnormal bone structure 8 | 131
abnormal retina morphology 8 | 100
embryonic lethality prior to o... 8 | 148
embryonic lethality prior to t... 8 | 187
decreased body weight 7 | 174
decreased circulating triglyce... 7 | 83
increased lean body mass 7 | 107
abnormal embryo size 6 | 112
abnormal retinal pigmentation 6 | 61
decreased body length 6 | 108
decreased circulating HDL chol... 6 | 77
decreased circulating serum al... 6 | 79
enlarged heart 6 | 111
abnormal bone mineralization 5 | 55
decreased bone mineral content 5 | 157
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
decreased prepulse inhibition 5 | 52
increased heart weight 5 | 37
increased or absent threshold ... 5 | 128
thrombocytopenia 5 | 46
abnormal lens morphology 4 | 73
abnormal spleen morphology 4 | 36
decreased grip strength 4 | 123
decreased heart weight 4 | 44
decreased rib number 4 | 59
hyperactivity 4 | 108
impaired glucose tolerance 4 | 52
increased bone mineral density 4 | 52
increased circulating choleste... 4 | 53
short tibia 4 | 82
abnormal behavioral response t... 3 | 52
abnormal eye morphology 3 | 38
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
abnormal skin morphology 3 | 23
abnormal sleep behavior 3 | 63
abnormal tibia morphology 3 | 14
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating chloride... 3 | 32
decreased circulating choleste... 3 | 85
decreased circulating glycerol... 3 | 19
decreased erythrocyte cell num... 3 | 43
decreased startle reflex 3 | 48
hydrops fetalis 3 | 22
increased blood urea nitrogen ... 3 | 44
increased circulating HDL chol... 3 | 63
increased circulating bilirubi... 3 | 16
increased circulating sodium l... 3 | 71
increased mature B cell number 3 | 12
increased mean corpuscular vol... 3 | 91
increased rib number 3 | 41
small adrenal glands 3 | 15
small testis 3 | 37
tremors 3 | 34
vertebral fusion 3 | 23
abnormal QRS complex 2 | 25
abnormal coat appearance 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal heart left ventricle ... 2 | 20
abnormal rib morphology 2 | 28
abnormal tail movements 2 | 12
abnormal testis morphology 2 | 30
absent vibrissae 2 | 14
anophthalmia 2 | 20
craniofacial phenotype 2 | 9
decreased NK T cell number 2 | 28
decreased circulating free fat... 2 | 39
decreased circulating sodium l... 2 | 18
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
enlarged lymph nodes 2 | 27
increased NK T cell number 2 | 11
increased body weight 2 | 42
increased caudal vertebrae num... 2 | 8
increased circulating alkaline... 2 | 119
increased circulating aspartat... 2 | 17
increased circulating chloride... 2 | 43
increased circulating iron lev... 2 | 25
increased circulating serum al... 2 | 25
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased fasted circulating g... 2 | 68
increased gamma-delta T cell n... 2 | 16
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
increased prepulse inhibition 2 | 21
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
microphthalmia 2 | 15
small superior vagus ganglion 2 | 20
straub tail 2 | 26

Disease

ovarian cancer 303 | 8,484
osteosarcoma 291 | 7,933
medulloblastoma, large-cell 234 | 6,234
psoriasis 198 | 6,685
glioblastoma 193 | 5,572
atypical teratoid / rhabdoid tumor 160 | 4,369
lung cancer 156 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 134 | 3,289
Breast cancer 121 | 3,094
primitive neuroectodermal tumor 118 | 3,031
malignant mesothelioma 116 | 3,162
pilocytic astrocytoma 102 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 101 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 99 | 2,956
ependymoma 97 | 2,514
invasive ductal carcinoma 96 | 2,950
Cancer 95 | 2,346
oligodendroglioma 94 | 2,849
pediatric high grade glioma 94 | 2,712
Carcinoma 92 | 2,147
lung carcinoma 92 | 2,844
non-small cell lung cancer 91 | 2,798
astrocytic glioma 90 | 2,241
pancreatic cancer 88 | 2,300
lung adenocarcinoma 79 | 2,713
adult high grade glioma 78 | 2,148
ulcerative colitis 78 | 2,087
Pick disease 75 | 1,893
subependymal giant cell astrocytoma 75 | 2,287
group 3 medulloblastoma 74 | 2,254
group 4 medulloblastoma 72 | 1,875
interstitial cystitis 68 | 2,299
pituitary cancer 63 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 62 | 1,795
posterior fossa group B ependymoma 59 | 1,530
ductal carcinoma in situ 58 | 1,745
cystic fibrosis 57 | 1,665
medulloblastoma 57 | 1,524
sonic hedgehog group medulloblastoma 57 | 1,482
astrocytoma 56 | 1,493
tuberculosis 55 | 1,557
Multiple myeloma 53 | 1,327
adrenocortical carcinoma 53 | 1,427
colon cancer 51 | 1,475
juvenile dermatomyositis 49 | 1,189
Rheumatoid Arthritis 44 | 1,160
breast carcinoma 44 | 1,614
primary pancreatic ductal adenocarcinoma 44 | 1,271
dermatomyositis 41 | 933
acute quadriplegic myopathy 39 | 1,157
posterior fossa group A ependymoma 39 | 1,511
Waldenstrons macroglobulinemia 38 | 765
atypical teratoid/rhabdoid tumor 38 | 1,095
diabetes mellitus 36 | 1,663
active Crohn's disease 35 | 918
spina bifida 34 | 1,064
nasopharyngeal carcinoma 32 | 1,056
cutaneous lupus erythematosus 28 | 1,056
non primary Sjogren syndrome sicca 27 | 840
pancreatic carcinoma 27 | 567
Atopic dermatitis 23 | 944
Parkinson's disease 23 | 364
acute myeloid leukemia 23 | 780
gastric carcinoma 22 | 832
hepatocellular carcinoma 22 | 532
primary Sjogren syndrome 22 | 789
tuberculosis and treatment for 6 months 22 | 686
Alzheimer's disease 21 | 644
IGA Glomerulonephritis 21 | 454
aldosterone-producing adenoma 21 | 664
chronic rhinosinusitis 21 | 512
progressive supranuclear palsy 21 | 674
Schizophrenia 20 | 501
Bipolar Disorder 19 | 266
esophageal adenocarcinoma 19 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
Endometriosis 17 | 535
Epilepsy 17 | 346
Mammary Neoplasms 17 | 410
Neurodegenerative disease 17 | 383
Obesity 17 | 616
Prostatic Neoplasms 17 | 471
Crohn's disease 16 | 304
Intellectual disability 16 | 573
Asthma 15 | 349
Down syndrome 15 | 548
Duchenne muscular dystrophy 15 | 602
active ulcerative colitis 15 | 477
non-small cell lung carcinoma 15 | 413
Acquired metabolic disease 14 | 267
Melanoma 14 | 261
Renal Cell Carcinoma 14 | 199
Hypertension 13 | 287
Liver carcinoma 13 | 217
Osteoporosis 13 | 257
Vascular disease 13 | 281
gastric cancer 13 | 430
glioblastoma multiforme 13 | 347
hereditary spastic paraplegia 13 | 313
urothelial carcinoma 13 | 318

Tissue

Endocrine System 539 | 18,512
Digestive Tract 537 | 18,473
Nervous System 537 | 18,561
Blood and immune system 536 | 17,995
Female tissues 536 | 18,647
Male tissues 536 | 17,969
Urinary Tract 536 | 18,444
Liver and Pancreas 535 | 18,136
Skin and soft tissues 532 | 18,115
Respiratory system 531 | 17,484
Cardiovascular System 530 | 17,958

Target Family

Enzyme 271 | 4,146
Kinase 161 | 634
Non-IDG 65 | 11,971
Transporter 36 | 473
Ion Channel 8 | 341
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Magnesium 543 | 543
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 NMNAT2 Tbio Enzyme -1.43192 31.0 94
Putative GTP-binding protein 6 GTPBP6 Tdark Non-IDG -1.08636 13.1 0
Inositol polyphosphate 1-phosphatase INPP1 Tbio Enzyme -1.22269 17.2 73
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225
Phosphoribosylformylglycinamidine synthase PFAS Tbio Enzyme -2.68616 520.0 75