Development Level

Tbio 310 | 11,178
Tchem 163 | 1,885
Tdark 56 | 6,569
Tclin 29 | 612

Collection

Kinase: IDG Consortium (Target... 39 | 125
Kinase: IDG Consortium (Comple... 15 | 37

IMPC Phenotype

preweaning lethality, complete... 40 | 979
preweaning lethality, incomple... 26 | 499
embryonic lethality prior to o... 14 | 239
abnormal behavior 13 | 298
abnormal bone structure 13 | 187
embryonic lethality prior to t... 12 | 278
abnormal embryo size 11 | 220
decreased total body fat amoun... 9 | 207
enlarged heart 9 | 210
decreased body weight 8 | 161
hyperactivity 8 | 148
increased bone mineral content 8 | 108
increased lean body mass 8 | 172
increased startle reflex 8 | 112
abnormal heart morphology 7 | 162
decreased body length 7 | 101
decreased circulating glucose ... 7 | 126
increased bone mineral density 7 | 72
abnormal retina morphology 6 | 71
decreased circulating HDL chol... 6 | 68
decreased lean body mass 6 | 135
decreased vertical activity 6 | 208
increased circulating HDL chol... 6 | 80
increased heart weight 6 | 62
decreased bone mineral content 5 | 151
decreased circulating triglyce... 5 | 79
decreased fasted circulating g... 5 | 65
decreased prepulse inhibition 5 | 82
edema 5 | 59
increased circulating choleste... 5 | 66
increased total body fat amoun... 5 | 134
abnormal seminal vesicle morph... 4 | 114
abnormal skin morphology 4 | 50
abnormal spleen morphology 4 | 55
decreased circulating choleste... 4 | 93
decreased mean corpuscular vol... 4 | 79
decreased startle reflex 4 | 75
impaired glucose tolerance 4 | 75
increased erythrocyte cell num... 4 | 39
increased monocyte cell number 4 | 63
male infertility 4 | 123
tremors 4 | 39
abnormal behavioral response t... 3 | 66
abnormal coat appearance 3 | 31
abnormal craniofacial morpholo... 3 | 33
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal locomotor behavior 3 | 24
abnormal tibia morphology 3 | 14
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 76
decreased circulating sodium l... 3 | 22
decreased erythrocyte cell num... 3 | 62
decreased heart weight 3 | 27
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
decreased mean platelet volume 3 | 25
embryonic growth retardation 3 | 106
hypoactivity 3 | 132
increased blood urea nitrogen ... 3 | 48
increased circulating triglyce... 3 | 42
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
increased prepulse inhibition 3 | 32
short tibia 3 | 97
small adrenal glands 3 | 16
small superior vagus ganglion 3 | 74
small testis 3 | 58
thrombocytopenia 3 | 56
vertebral fusion 3 | 23
abnormal coat-hair pigmentatio... 2 | 64
abnormal ear morphology 2 | 9
abnormal epididymis morphology 2 | 42
abnormal sleep behavior 2 | 70
abnormal vertebrae morphology 2 | 18
abnormal vibrissa morphology 2 | 25
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating amylase ... 2 | 28
decreased circulating free fat... 2 | 31
decreased circulating serum al... 2 | 82
decreased eosinophil cell numb... 2 | 24
decreased hematocrit 2 | 46
decreased neutrophil cell numb... 2 | 42
increased body weight 2 | 25
increased circulating alkaline... 2 | 122
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
microphthalmia 2 | 26
pale yolk sac 2 | 25
pallor 2 | 34
prenatal lethality prior to he... 2 | 87

Disease

Carcinoma 400 | 11,192
ovarian cancer 314 | 8,297
osteosarcoma 297 | 7,766
medulloblastoma, large-cell 241 | 6,086
glioblastoma 210 | 5,635
psoriasis 203 | 6,514
atypical teratoid / rhabdoid tumor 192 | 4,971
lung cancer 171 | 4,607
ependymoma 165 | 4,559
adult high grade glioma 143 | 3,701
group 3 medulloblastoma 142 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 135 | 3,204
Breast cancer 132 | 3,469
malignant mesothelioma 121 | 3,135
primitive neuroectodermal tumor 121 | 2,957
Kidney cancer 109 | 2,548
Astrocytoma, Pilocytic 107 | 3,006
astrocytic glioma 104 | 2,530
intraductal papillary-mucinous carcinoma (IPMC) 103 | 2,902
Cancer 101 | 2,388
intraductal papillary-mucinous adenoma (IPMA) 101 | 2,872
invasive ductal carcinoma 98 | 2,867
non-small cell lung cancer 97 | 2,799
pancreatic cancer 95 | 2,322
oligodendroglioma 94 | 2,768
lung carcinoma 93 | 2,755
lung adenocarcinoma 82 | 2,627
Pick disease 79 | 1,856
subependymal giant cell astrocytoma 78 | 2,230
group 4 medulloblastoma 77 | 1,806
pancreatic ductal adenocarcinoma liver metastasis 70 | 1,911
ulcerative colitis 69 | 1,765
tuberculosis 68 | 1,963
interstitial cystitis 67 | 2,237
pituitary cancer 64 | 1,915
Autosomal recessive predisposition 59 | 1,407
cystic fibrosis 59 | 1,629
ductal carcinoma in situ 59 | 1,686
colon cancer 54 | 1,428
Multiple myeloma 53 | 1,296
adrenocortical carcinoma 53 | 1,385
breast carcinoma 48 | 1,589
juvenile dermatomyositis 48 | 1,147
Rheumatoid arthritis 47 | 1,156
astrocytoma 46 | 1,113
Schizophrenia 42 | 1,136
Epilepsy 41 | 775
Intellectual disability 40 | 998
dermatomyositis 40 | 941
primary pancreatic ductal adenocarcinoma 40 | 1,071
acute quadriplegic myopathy 39 | 1,133
Waldenstrons macroglobulinemia 38 | 742
diabetes mellitus 38 | 1,683
active Crohn's disease 36 | 882
Bipolar Disorder 34 | 646
nasopharyngeal carcinoma 34 | 1,024
pediatric high grade glioma 34 | 1,035
spina bifida 34 | 1,053
Dull intelligence 33 | 634
Low intelligence 33 | 634
Melanoma 33 | 689
Mental Retardation 33 | 634
Mental deficiency 33 | 634
Poor school performance 33 | 634
medulloblastoma 33 | 702
Seizures 32 | 584
Cognitive delay 29 | 596
Global developmental delay 29 | 596
Mental and motor retardation 29 | 596
Muscle hypotonia 28 | 562
active ulcerative colitis 28 | 736
non primary Sjogren syndrome sicca 28 | 861
cutaneous lupus erythematosus 27 | 1,016
pancreatic carcinoma 26 | 555
Liver Cirrhosis, Experimental 25 | 733
Atopic dermatitis 24 | 915
Liver cancer 24 | 589
acute myeloid leukemia 24 | 760
posterior fossa group B ependymoma 24 | 406
Alzheimer's disease 23 | 640
Parkinson's disease 23 | 378
Short stature 22 | 514
chronic rhinosinusitis 22 | 505
gastric carcinoma 22 | 781
hepatocellular carcinoma 22 | 536
aldosterone-producing adenoma 21 | 646
primary Sjogren syndrome 21 | 710
Anemia 20 | 353
progressive supranuclear palsy 20 | 656
Acquired metabolic disease 19 | 329
Asthma 19 | 370
Attention deficit hyperactivity disorder 19 | 272
Depressive disorder 19 | 401
Failure to gain weight 19 | 359
Neurodegenerative disease 19 | 402
Obesity 19 | 655
Pediatric failure to thrive 19 | 359
Prostatic Neoplasms 19 | 472
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 492
esophageal adenocarcinoma 19 | 696

Tissue

Endocrine System 552 | 18,159
Digestive Tract 543 | 17,369
Female tissues 538 | 17,400
Skin and soft tissues 538 | 17,230
Blood and immune system 534 | 16,909
Urinary Tract 533 | 16,678
Liver and Pancreas 532 | 16,750
Male tissues 531 | 17,142
Nervous System 528 | 16,725
Respiratory system 523 | 16,393
Cardiovascular System 506 | 15,192

Target Family

Enzyme 278 | 4,145
Kinase 164 | 634
Non-IDG 68 | 12,091
Transporter 38 | 473
Ion Channel 8 | 344
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

UniProt Keyword

Magnesium 558 | 558
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242
Diphosphoinositol polyphosphate phosphohydrolase 3-beta NUDT11 Tdark Enzyme -0.57393 3.94 17
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A STT3A Tbio Enzyme -1.76110 54.3 68
Probable phospholipid-transporting ATPase VA ATP10A Tbio Transporter -1.17971 17.2 12
Acyl-coenzyme A synthetase ACSM4, mitochondrial ACSM4 Tdark Enzyme 0.00000 1.21 51
Inorganic pyrophosphatase PPA1 Tbio Enzyme -2.82678 691.2 169
Adenylate cyclase type 3 ADCY3 Tbio Enzyme -2.31593 204.4 82
Serine/threonine-protein kinase MARK1 MARK1 Tchem Kinase -1.77236 56.1 318