Development Level

Tbio 215 | 11,651
Tchem 41 | 1,388
Tdark 33 | 6,593
Tclin 12 | 612

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
increased circulating alkaline... 7 | 122
short tibia 7 | 97
embryonic lethality prior to t... 6 | 278
decreased total body fat amoun... 5 | 207
embryonic lethality prior to o... 5 | 239
increased bone mineral content 5 | 108
abnormal bone structure 4 | 187
edema 4 | 59
hypoactivity 4 | 132
increased bone mineral density 4 | 72
increased circulating potassiu... 4 | 29
increased mean corpuscular hem... 4 | 96
thrombocytosis 4 | 27
abnormal craniofacial morpholo... 3 | 33
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal pericardium morpholog... 3 | 26
decreased body weight 3 | 161
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
impaired glucose tolerance 3 | 75
increased lean body mass 3 | 172
prenatal lethality 3 | 28
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal sleep behavior 2 | 70
cataract 2 | 92
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating aspartat... 2 | 34
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating triglyce... 2 | 42
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small adrenal glands 2 | 16
abnormal coat appearance 1 | 31
abnormal ear morphology 1 | 9
abnormal epididymis morphology 1 | 42
abnormal head shape 1 | 10
abnormal head size 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal iris morphology 1 | 13
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
anophthalmia 1 | 33
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged urinary bladder 1 | 8
hyperactivity 1 | 148
impaired pupillary reflex 1 | 26
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
polycystic kidney 1 | 15
premature death 1 | 5
small superior vagus ganglion 1 | 74

Disease

Carcinoma 172 | 11,493
ovarian cancer 170 | 8,520
osteosarcoma 131 | 7,950
glioblastoma 115 | 5,792
medulloblastoma, large-cell 105 | 6,241
lung cancer 83 | 4,740
psoriasis 83 | 6,694
atypical teratoid / rhabdoid tumor 79 | 5,112
ependymoma 75 | 4,679
tuberculosis 71 | 2,010
malignant mesothelioma 68 | 3,232
Astrocytoma, Pilocytic 66 | 3,081
lung carcinoma 65 | 2,843
invasive ductal carcinoma 60 | 2,951
Autosomal recessive predisposition 59 | 1,442
diabetes mellitus 59 | 1,728
subependymal giant cell astrocytoma 57 | 2,287
adult high grade glioma 53 | 3,801
Breast cancer 49 | 3,578
Rheumatoid arthritis 49 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,962
Cancer 47 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,291
group 3 medulloblastoma 45 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 45 | 2,955
non-small cell lung cancer 45 | 2,890
interstitial cystitis 43 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,989
Multiple myeloma 41 | 1,332
astrocytoma 41 | 1,146
group 4 medulloblastoma 40 | 1,855
pancreatic cancer 40 | 2,398
ulcerative colitis 39 | 1,819
lung adenocarcinoma 37 | 2,716
oligodendroglioma 37 | 2,850
Epilepsy 36 | 792
dermatomyositis 35 | 966
primitive neuroectodermal tumor 35 | 3,035
juvenile dermatomyositis 33 | 1,187
Hepatomegaly 31 | 285
Intellectual disability 31 | 1,016
Kidney cancer 31 | 2,613
breast carcinoma 31 | 1,638
Pick disease 30 | 1,894
Seizures 30 | 596
astrocytic glioma 30 | 2,597
pediatric high grade glioma 30 | 1,064
Multiple Sclerosis 29 | 540
acute quadriplegic myopathy 29 | 1,158
Splenomegaly 28 | 190
cystic fibrosis 28 | 1,696
Liver Cirrhosis, Experimental 27 | 769
Neurodegenerative disease 27 | 414
Waldenstrons macroglobulinemia 27 | 765
cutaneous lupus erythematosus 27 | 1,057
Dull intelligence 26 | 645
Low intelligence 26 | 645
Mental Retardation 26 | 645
Mental deficiency 26 | 645
Poor school performance 26 | 645
active Crohn's disease 26 | 922
adrenocortical carcinoma 26 | 1,428
ductal carcinoma in situ 26 | 1,745
primary Sjogren syndrome 26 | 735
Muscle hypotonia 25 | 571
primary pancreatic ductal adenocarcinoma 25 | 1,109
esophageal adenocarcinoma 24 | 737
active ulcerative colitis 23 | 764
pituitary cancer 23 | 1,972
sarcoidosis 23 | 370
Alzheimer's disease 22 | 658
Down syndrome 22 | 499
Duchenne muscular dystrophy 22 | 601
Systemic lupus erythematosus 22 | 194
Schizophrenia 21 | 1,160
colon cancer 21 | 1,478
gastric carcinoma 21 | 807
Coarse facial features 20 | 108
Thickened facial skin with coarse facial features 20 | 108
Congenital deafness 18 | 185
Deafness 18 | 198
Hearing Loss, Partial 18 | 185
Narcolepsy 18 | 72
Short stature 18 | 531
hearing impairment 18 | 199
non primary Sjogren syndrome sicca 18 | 891
Atopic dermatitis 17 | 952
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Mucopolysaccharidosis 17 | 26
mucosa-associated lymphoid tissue lymphoma 17 | 484
Dementia 16 | 175
pancreatic carcinoma 16 | 562
Berylliosis 15 | 28
Cerebellar Ataxia 15 | 304
Narcolepsy-cataplexy 15 | 21
Arthritis 14 | 290
Asthma 14 | 385
Muscle Spasticity 14 | 195

Tissue

Blood and immune system 284 | 16,909
Skin and soft tissues 284 | 17,230
Digestive Tract 283 | 17,369
Endocrine System 283 | 18,159
Female tissues 283 | 17,400
Liver and Pancreas 282 | 16,750
Male tissues 282 | 17,142
Respiratory system 282 | 16,393
Urinary Tract 280 | 16,678
Nervous System 278 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Non-IDG 168 | 12,091
Enzyme 100 | 4,145
Transporter 16 | 473
Ion Channel 8 | 344
Kinase 5 | 634
GPCR 2 | 408
Transcription Factor 2 | 1,400

UniProt Keyword

Lysosome 301 | 301
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
Sialin SLC17A5 Tbio Transporter -2.93541 845.6 63
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
KICSTOR complex protein kaptin KPTN Tbio Non-IDG -1.45875 26.8 153
Ganglioside GM2 activator GM2A Tbio Non-IDG -2.03952 111.9 325
Sialidase-4 NEU4 Tchem Enzyme -1.39624 25.1 115
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766