Development Level

Tbio 180 | 10,625
Tchem 49 | 1,890
Tdark 35 | 7,003
Tclin 11 | 602

Collection

GPCR: IDG Consortium (Targets) 1 | 127
Ion Channel: IDG Consortium (Targets) 1 | 102

IMPC Phenotype

decreased total body fat amoun... 8 | 186
preweaning lethality, complete... 7 | 633
abnormal behavior 6 | 226
increased bone mineral content 6 | 92
preweaning lethality, incomple... 6 | 260
short tibia 6 | 82
abnormal bone structure 4 | 131
decreased body length 4 | 108
decreased bone mineral density 4 | 126
increased bone mineral density 4 | 52
increased lean body mass 4 | 107
increased mean corpuscular hem... 4 | 93
thrombocytosis 4 | 23
decreased body weight 3 | 174
decreased rib number 3 | 59
embryonic lethality prior to t... 3 | 187
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
increased circulating alkaline... 3 | 119
increased circulating potassiu... 3 | 31
abnormal bone mineralization 2 | 55
abnormal coat appearance 2 | 25
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
decreased B cell number 2 | 30
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased lean body mass 2 | 195
decreased mean corpuscular hem... 2 | 34
decreased prepulse inhibition 2 | 52
embryonic lethality prior to o... 2 | 148
enlarged lymph nodes 2 | 27
hemorrhage 2 | 12
increased B cell number 2 | 23
small adrenal glands 2 | 15
abnormal behavioral response t... 1 | 52
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal epididymis morphology 1 | 31
abnormal iris morphology 1 | 12
abnormal limb bud morphology 1 | 15
abnormal limb position 1 | 3
abnormal lung morphology 1 | 15
abnormal motor capabilities-co... 1 | 4
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal skin coloration 1 | 18
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 14
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 19
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating bilirubi... 1 | 14
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased red blood cell distr... 1 | 11
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
edema 1 | 11
enlarged urinary bladder 1 | 4
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
improved glucose tolerance 1 | 56
increased NK cell number 1 | 19
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased leukocyte cell numbe... 1 | 37
increased mature B cell number 1 | 12
increased mean corpuscular vol... 1 | 91
pale liver 1 | 5
polycystic kidney 1 | 9
premature death 1 | 5
prenatal lethality prior to he... 1 | 64
straub tail 1 | 26
vertebral transformation 1 | 12

Disease

ovarian cancer 158 | 8,491
osteosarcoma 122 | 7,933
glioblastoma 106 | 5,572
medulloblastoma, large-cell 97 | 6,234
lung cancer 77 | 4,473
psoriasis 76 | 6,685
malignant mesothelioma 66 | 3,163
atypical teratoid / rhabdoid tumor 62 | 4,369
lung carcinoma 61 | 2,844
pilocytic astrocytoma 60 | 3,086
diabetes mellitus 55 | 1,663
invasive ductal carcinoma 55 | 2,950
subependymal giant cell astrocytoma 55 | 2,287
tuberculosis 55 | 1,563
pediatric high grade glioma 52 | 2,712
astrocytoma 45 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 45 | 3,289
ulcerative colitis 45 | 2,087
Rheumatoid Arthritis 43 | 1,170
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,956
Cancer 41 | 2,346
group 4 medulloblastoma 41 | 1,875
non-small cell lung cancer 41 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 41 | 1,795
Multiple myeloma 40 | 1,327
interstitial cystitis 40 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
pancreatic cancer 37 | 2,300
Breast cancer 36 | 3,098
lung adenocarcinoma 35 | 2,714
oligodendroglioma 35 | 2,849
dermatomyositis 33 | 966
ependymoma 33 | 2,514
juvenile dermatomyositis 32 | 1,189
posterior fossa group A ependymoma 32 | 1,511
primitive neuroectodermal tumor 31 | 3,031
breast carcinoma 30 | 1,614
Pick disease 27 | 1,893
primary Sjogren syndrome 27 | 788
primary pancreatic ductal adenocarcinoma 27 | 1,271
cutaneous lupus erythematosus 26 | 1,056
cystic fibrosis 26 | 1,670
Neurodegenerative disease 25 | 383
Waldenstrons macroglobulinemia 25 | 764
acute quadriplegic myopathy 25 | 1,157
ductal carcinoma in situ 25 | 1,745
Multiple Sclerosis 24 | 498
adult high grade glioma 24 | 2,148
esophageal adenocarcinoma 24 | 737
sarcoidosis 24 | 368
active Crohn's disease 23 | 918
Alzheimer's disease 22 | 644
Duchenne muscular dystrophy 22 | 602
adrenocortical carcinoma 22 | 1,427
group 3 medulloblastoma 22 | 2,254
medulloblastoma 22 | 1,524
posterior fossa group B ependymoma 22 | 1,530
systemic lupus erythematosus 22 | 172
Down syndrome 21 | 548
astrocytic glioma 21 | 2,241
pituitary cancer 21 | 1,972
Carcinoma 20 | 2,147
colon cancer 20 | 1,475
atypical teratoid/rhabdoid tumor 19 | 1,095
gastric carcinoma 19 | 832
Narcolepsy 18 | 69
mucosa-associated lymphoid tissue lymphoma 17 | 480
Mucopolysaccharidosis 16 | 24
Berylliosis 15 | 28
IGA Glomerulonephritis 15 | 454
Narcolepsy-cataplexy 15 | 21
non primary Sjogren syndrome sicca 15 | 840
pancreatic carcinoma 15 | 567
Asthma 14 | 349
Atopic dermatitis 14 | 944
Multiple Sclerosis, Susceptibility to 14 | 15
follicular lymphoma 14 | 17
Diffuse cutaneous systemic sclerosis 13 | 17
Obesity 13 | 616
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
active ulcerative colitis 13 | 477
aldosterone-producing adenoma 13 | 664
limited scleroderma 13 | 19
spina bifida 13 | 1,064
Hypersensitivity reaction type II disease 12 | 235
Neuronal ceroid lipofuscinosis 12 | 28
sonic hedgehog group medulloblastoma 12 | 1,482
tuberculosis and treatment for 6 months 12 | 686
Coronary artery disease 11 | 240
Hermansky-Pudlak syndrome 11 | 43
acute myeloid leukemia 11 | 785
hepatocellular carcinoma 11 | 550
nephrosclerosis 11 | 329
progressive supranuclear palsy 11 | 674
tuberculosis and treatment for 3 months 11 | 327
Gangliosidosis 10 | 17
Type 1 diabetes mellitus 10 | 104
Cerebrovascular disease 9 | 231
gastric cancer 9 | 436

Tissue

Digestive Tract 265 | 18,472
Nervous System 265 | 18,560
Urinary Tract 265 | 18,443
Blood and immune system 264 | 17,994
Female tissues 264 | 18,646
Liver and Pancreas 264 | 18,135
Endocrine System 263 | 18,511
Male tissues 263 | 17,968
Cardiovascular System 262 | 17,957
Respiratory system 262 | 17,483
Skin and soft tissues 258 | 18,114

Target Family

Non-IDG 149 | 11,969
Enzyme 97 | 4,146
Transporter 16 | 473
Ion Channel 5 | 341
Kinase 5 | 634
GPCR 2 | 408
Transcription Factor 1 | 1,400

UniProt Keyword

Lysosome 275 | 275
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine-threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.24582 1740.5 143
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Two pore calcium channel protein 1 TPCN1 Tbio Ion Channel -1.84159 59.3 38
Pleckstrin homology domain-containing family F member 1 PLEKHF1 Tbio Non-IDG -1.78639 62.5 99
Synaptotagmin-7 SYT7 Tbio Non-IDG -1.72363 48.4 144
Hyaluronidase-1 HYAL1 Tbio Enzyme -1.85417 78.6 191
Transmembrane protein 59 TMEM59 Tbio Non-IDG -1.33352 18.7 53
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.26523 184.9 247
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.63101 403.7 216