Development Level

Tbio 474 | 10,625
Tdark 129 | 7,003
Tchem 127 | 1,890
Tclin 83 | 602

Collection

Eligible non-olfactory GPCR Proteins 9 | 143
Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 27 | 633
preweaning lethality, incomple... 19 | 260
decreased body weight 12 | 174
decreased total body fat amoun... 12 | 186
abnormal behavior 11 | 226
decreased lean body mass 9 | 195
enlarged heart 9 | 111
decreased bone mineral content 8 | 157
decreased circulating triglyce... 8 | 83
hyperactivity 8 | 108
increased mean corpuscular hem... 8 | 93
decreased circulating insulin ... 7 | 75
embryonic lethality prior to t... 7 | 187
increased circulating alkaline... 7 | 119
increased circulating sodium l... 7 | 71
increased or absent threshold ... 7 | 128
abnormal retina morphology 6 | 100
decreased bone mineral density 6 | 126
decreased grip strength 6 | 123
increased circulating chloride... 6 | 43
increased fasted circulating g... 6 | 68
increased mean corpuscular vol... 6 | 91
limb grasping 6 | 35
short tibia 6 | 82
abnormal bone structure 5 | 131
abnormal embryo size 5 | 112
abnormal retinal pigmentation 5 | 61
abnormal sleep behavior 5 | 63
decreased body length 5 | 108
decreased circulating HDL chol... 5 | 77
decreased circulating amylase ... 5 | 24
decreased circulating choleste... 5 | 85
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
decreased mean corpuscular vol... 5 | 50
decreased prepulse inhibition 5 | 52
hypoactivity 5 | 89
increased blood urea nitrogen ... 5 | 44
increased bone mineral content 5 | 92
increased exploration in new e... 5 | 56
increased lean body mass 5 | 107
increased total body fat amoun... 5 | 57
male infertility 5 | 62
abnormal heart morphology 4 | 51
decreased circulating phosphat... 4 | 15
decreased lumbar vertebrae num... 4 | 62
decreased startle reflex 4 | 48
improved glucose tolerance 4 | 56
increased leukocyte cell numbe... 4 | 37
abnormal coat appearance 3 | 25
abnormal rib morphology 3 | 28
abnormal spleen morphology 3 | 36
decreased anxiety-related resp... 3 | 12
decreased caudal vertebrae num... 3 | 49
decreased circulating alkaline... 3 | 41
decreased circulating calcium ... 3 | 33
decreased hemoglobin content 3 | 53
decreased mean corpuscular hem... 3 | 34
decreased mean corpuscular hem... 3 | 19
decreased neutrophil cell numb... 3 | 37
decreased threshold for audito... 3 | 32
embryonic lethality prior to o... 3 | 148
enlarged spleen 3 | 26
impaired glucose tolerance 3 | 52
impaired pupillary reflex 3 | 14
increased circulating HDL chol... 3 | 63
increased circulating potassiu... 3 | 31
increased erythrocyte cell num... 3 | 26
increased grip strength 3 | 83
increased heart weight 3 | 37
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased sacral vertebrae num... 3 | 62
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal whole-body plethysmog... 2 | 4
anophthalmia 2 | 20
convulsive seizures 2 | 11
corneal opacity 2 | 25
decreased circulating LDL chol... 2 | 37
decreased circulating free fat... 2 | 39
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased effector memory CD8-... 2 | 24
decreased eosinophil cell numb... 2 | 41
decreased exploration in new e... 2 | 9
decreased heart weight 2 | 44
decreased rib number 2 | 59
female infertility 2 | 34
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating creatini... 2 | 29
prenatal lethality prior to he... 2 | 64

Disease

ovarian cancer 359 | 8,484
osteosarcoma 348 | 7,933
medulloblastoma, large-cell 338 | 6,234
psoriasis 329 | 6,685
glioblastoma 328 | 5,572
atypical teratoid / rhabdoid tumor 234 | 4,369
pilocytic astrocytoma 219 | 3,086
lung cancer 204 | 4,466
lung carcinoma 183 | 2,844
oligodendroglioma 179 | 2,849
primitive neuroectodermal tumor 179 | 3,031
invasive ductal carcinoma 173 | 2,950
lung adenocarcinoma 166 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 162 | 3,289
Cancer 161 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 160 | 2,956
pediatric high grade glioma 154 | 2,712
malignant mesothelioma 153 | 3,162
non-small cell lung cancer 152 | 2,798
ependymoma 148 | 2,514
Breast cancer 147 | 3,094
interstitial cystitis 144 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 141 | 2,988
subependymal giant cell astrocytoma 141 | 2,287
astrocytic glioma 137 | 2,241
adult high grade glioma 132 | 2,148
pancreatic cancer 125 | 2,300
ductal carcinoma in situ 124 | 1,745
ulcerative colitis 120 | 2,087
Pick disease 114 | 1,893
pituitary cancer 111 | 1,972
group 4 medulloblastoma 103 | 1,875
cystic fibrosis 102 | 1,665
astrocytoma 101 | 1,493
tuberculosis 101 | 1,557
medulloblastoma 97 | 1,524
group 3 medulloblastoma 96 | 2,254
breast carcinoma 91 | 1,614
colon cancer 90 | 1,475
posterior fossa group A ependymoma 87 | 1,511
cutaneous lupus erythematosus 82 | 1,056
atypical teratoid/rhabdoid tumor 79 | 1,095
posterior fossa group B ependymoma 77 | 1,530
Carcinoma 75 | 2,147
diabetes mellitus 71 | 1,663
primary pancreatic ductal adenocarcinoma 69 | 1,271
sonic hedgehog group medulloblastoma 65 | 1,482
Multiple myeloma 63 | 1,327
juvenile dermatomyositis 63 | 1,189
adrenocortical carcinoma 62 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 60 | 1,795
Rheumatoid Arthritis 56 | 1,160
active Crohn's disease 56 | 918
spina bifida 53 | 1,064
Schizophrenia 51 | 501
primary Sjogren syndrome 51 | 789
Obesity 49 | 616
esophageal adenocarcinoma 49 | 737
dermatomyositis 48 | 933
acute quadriplegic myopathy 45 | 1,157
gastric carcinoma 45 | 832
Alzheimer's disease 44 | 644
Atopic dermatitis 43 | 944
Down syndrome 43 | 548
nasopharyngeal carcinoma 43 | 1,056
Parkinson's disease 40 | 364
Duchenne muscular dystrophy 39 | 602
fibroadenoma 37 | 557
Endometriosis 35 | 535
Epilepsy 35 | 346
Multiple Sclerosis 35 | 498
non primary Sjogren syndrome sicca 34 | 840
Waldenstrons macroglobulinemia 33 | 765
mucosa-associated lymphoid tissue lymphoma 33 | 480
acute myeloid leukemia 31 | 780
aldosterone-producing adenoma 31 | 664
Cerebrovascular disease 28 | 231
IGA Glomerulonephritis 28 | 454
Hypertension 27 | 287
autosomal dominant Emery-Dreifuss muscular dystrophy 27 | 499
Autistic Disorder 26 | 320
active ulcerative colitis 26 | 477
progressive supranuclear palsy 26 | 674
tuberculosis and treatment for 6 months 26 | 686
Chronic Lymphocytic Leukemia 25 | 242
Heart disease 25 | 279
Mammary Neoplasms 25 | 410
non-small cell lung carcinoma 25 | 413
pancreatic carcinoma 25 | 567
sarcoidosis 25 | 358
Intellectual disability 24 | 573
Prostatic Neoplasms 24 | 471
Vascular disease 24 | 281
hepatocellular carcinoma 24 | 532
Atherosclerosis 23 | 275
Crohn's disease 23 | 304
Kidney disease 22 | 396
Neurodegenerative disease 22 | 383
Stomach Neoplasms 22 | 282
Asthma 21 | 349

Tissue

Digestive Tract 780 | 18,473
Nervous System 779 | 18,561
Endocrine System 777 | 18,512
Female tissues 776 | 18,647
Urinary Tract 776 | 18,444
Male tissues 770 | 17,969
Liver and Pancreas 768 | 18,136
Skin and soft tissues 765 | 18,115
Cardiovascular System 760 | 17,958
Blood and immune system 759 | 17,995
Respiratory system 750 | 17,484

Target Family

Non-IDG 417 | 11,971
Enzyme 254 | 4,146
GPCR 73 | 406
Kinase 33 | 634
Ion Channel 22 | 341
Transporter 7 | 473
Nuclear Receptor 3 | 48
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

UniProt Keyword

Lipoprotein 813 | 813
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.55651 32.2 97
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Dymeclin DYM Tbio Non-IDG -1.45800 31.6 59
Contactin-6 CNTN6 Tbio Non-IDG -2.02527 101.3 65
Serine protease 41 PRSS41 Tdark Enzyme 0.00000 0
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901