Development Level

Tbio 528 | 11,651
Tdark 115 | 6,593
Tchem 99 | 1,388
Tclin 83 | 612

Collection

RFA-RM-18-021 15 | 328
GPCR: IDG Consortium (Targets) 6 | 126
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 32 | 499
enlarged heart 18 | 210
abnormal behavior 16 | 298
abnormal heart morphology 14 | 162
decreased total body fat amoun... 14 | 207
abnormal embryo size 13 | 220
decreased vertical activity 13 | 208
embryonic lethality prior to t... 12 | 278
hyperactivity 12 | 148
decreased body weight 11 | 161
decreased bone mineral content 9 | 151
abnormal sleep behavior 8 | 70
cataract 8 | 92
abnormal bone structure 7 | 187
decreased circulating serum al... 7 | 82
decreased lean body mass 7 | 135
embryonic lethality prior to o... 7 | 239
hypoactivity 7 | 132
increased circulating alkaline... 7 | 122
increased circulating chloride... 7 | 41
increased circulating sodium l... 7 | 71
increased lean body mass 7 | 172
increased mean corpuscular hem... 7 | 96
abnormal lens morphology 6 | 81
abnormal retina morphology 6 | 71
decreased bone mineral density 6 | 126
decreased circulating insulin ... 6 | 76
decreased fasted circulating g... 6 | 65
decreased hemoglobin content 6 | 68
decreased startle reflex 6 | 75
embryonic growth retardation 6 | 106
improved glucose tolerance 6 | 79
increased blood urea nitrogen ... 6 | 48
increased mean corpuscular vol... 6 | 92
limb grasping 6 | 41
short tibia 6 | 97
abnormal seminal vesicle morph... 5 | 114
decreased body length 5 | 101
decreased circulating amylase ... 5 | 28
decreased circulating glucose ... 5 | 126
decreased circulating triglyce... 5 | 79
decreased leukocyte cell numbe... 5 | 73
decreased lymphocyte cell numb... 5 | 83
decreased mean corpuscular hem... 5 | 31
decreased mean corpuscular vol... 5 | 79
edema 5 | 59
impaired pupillary reflex 5 | 26
increased fasted circulating g... 5 | 76
increased total body fat amoun... 5 | 134
abnormal coat appearance 4 | 31
abnormal cornea morphology 4 | 31
anophthalmia 4 | 33
decreased circulating HDL chol... 4 | 68
decreased circulating aspartat... 4 | 34
decreased circulating choleste... 4 | 93
decreased circulating sodium l... 4 | 22
decreased heart left ventricle... 4 | 28
decreased hematocrit 4 | 46
decreased mean corpuscular hem... 4 | 50
decreased prepulse inhibition 4 | 82
enlarged spleen 4 | 41
increased erythrocyte cell num... 4 | 39
increased leukocyte cell numbe... 4 | 47
increased monocyte cell number 4 | 63
increased startle reflex 4 | 112
prenatal lethality 4 | 28
abnormal behavioral response t... 3 | 66
abnormal brain morphology 3 | 13
abnormal coat-hair pigmentatio... 3 | 64
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal skin morphology 3 | 50
abnormal spleen morphology 3 | 55
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
decreased circulating calcium ... 3 | 36
decreased circulating total pr... 3 | 49
decreased exploration in new e... 3 | 11
decreased neutrophil cell numb... 3 | 42
enlarged kidney 3 | 14
hydroencephaly 3 | 14
hydrometra 3 | 53
impaired glucose tolerance 3 | 75
increased bone mineral content 3 | 108
increased circulating potassiu... 3 | 29
increased circulating triglyce... 3 | 42
increased heart weight 3 | 62
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 36
increased spleen weight 3 | 10
male infertility 3 | 123
pallor 3 | 34
polycystic kidney 3 | 15
small superior vagus ganglion 3 | 74
small testis 3 | 58
abnormal limb bud morphology 2 | 17
cardiovascular system phenotyp... 2 | 36
prenatal lethality prior to he... 2 | 87

Disease

Carcinoma 431 | 11,493
ovarian cancer 364 | 8,520
osteosarcoma 353 | 7,950
glioblastoma 348 | 5,792
medulloblastoma, large-cell 343 | 6,241
psoriasis 335 | 6,694
atypical teratoid / rhabdoid tumor 294 | 5,112
ependymoma 270 | 4,679
adult high grade glioma 244 | 3,801
Astrocytoma, Pilocytic 221 | 3,081
lung cancer 213 | 4,740
group 3 medulloblastoma 201 | 4,104
lung carcinoma 186 | 2,843
oligodendroglioma 182 | 2,850
primitive neuroectodermal tumor 180 | 3,035
astrocytic glioma 174 | 2,597
invasive ductal carcinoma 174 | 2,951
lung adenocarcinoma 168 | 2,716
Cancer 167 | 2,499
intraductal papillary-mucinous neoplasm (IPMN) 165 | 3,291
Breast cancer 163 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 163 | 2,955
non-small cell lung cancer 161 | 2,890
malignant mesothelioma 156 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 145 | 2,989
interstitial cystitis 144 | 2,312
subependymal giant cell astrocytoma 143 | 2,287
pancreatic cancer 131 | 2,398
tuberculosis 126 | 2,010
ductal carcinoma in situ 125 | 1,745
Pick disease 116 | 1,894
group 4 medulloblastoma 116 | 1,855
pituitary cancer 113 | 1,972
cystic fibrosis 104 | 1,696
Schizophrenia 101 | 1,160
ulcerative colitis 101 | 1,819
breast carcinoma 94 | 1,638
colon cancer 93 | 1,478
cutaneous lupus erythematosus 83 | 1,057
Kidney cancer 82 | 2,613
Autosomal recessive predisposition 79 | 1,442
diabetes mellitus 75 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 70 | 1,962
astrocytoma 66 | 1,146
juvenile dermatomyositis 64 | 1,187
Multiple myeloma 63 | 1,332
adrenocortical carcinoma 63 | 1,428
primary pancreatic ductal adenocarcinoma 61 | 1,109
Obesity 60 | 678
Rheumatoid arthritis 58 | 1,191
active Crohn's disease 57 | 922
spina bifida 57 | 1,074
Epilepsy 54 | 792
Liver Cirrhosis, Experimental 54 | 769
Bipolar Disorder 51 | 666
Alzheimer's disease 49 | 658
dermatomyositis 49 | 966
primary Sjogren syndrome 49 | 735
active ulcerative colitis 47 | 764
acute quadriplegic myopathy 47 | 1,158
esophageal adenocarcinoma 47 | 737
Intellectual disability 46 | 1,016
Depressive disorder 45 | 409
Atopic dermatitis 44 | 952
gastric carcinoma 43 | 807
nasopharyngeal carcinoma 43 | 1,058
pediatric high grade glioma 43 | 1,064
Down syndrome 42 | 499
Parkinson's disease 42 | 392
Duchenne muscular dystrophy 40 | 601
fibroadenoma 39 | 559
Alcoholic Intoxication, Chronic 38 | 289
Multiple Sclerosis 38 | 540
Hypertension 37 | 396
non primary Sjogren syndrome sicca 37 | 891
Endometriosis 35 | 540
Mental Depression 35 | 333
Seizures 34 | 596
Waldenstrons macroglobulinemia 33 | 765
mucosa-associated lymphoid tissue lymphoma 33 | 484
Dull intelligence 32 | 645
Low intelligence 32 | 645
Mental Retardation 32 | 645
Mental deficiency 32 | 645
Poor school performance 32 | 645
Vascular disease 32 | 319
aldosterone-producing adenoma 31 | 665
acute myeloid leukemia 30 | 783
Heart disease 28 | 306
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
medulloblastoma 28 | 720
Atherosclerosis 27 | 291
Melanoma 27 | 711
Prostatic Neoplasms 27 | 495
posterior fossa group A ependymoma 27 | 468
progressive supranuclear palsy 27 | 676
Cerebrovascular disease 26 | 238
Kidney disease 26 | 430
Muscle hypotonia 26 | 571
Short stature 26 | 531

Tissue

Endocrine System 794 | 18,159
Digestive Tract 771 | 17,369
Female tissues 760 | 17,400
Skin and soft tissues 757 | 17,230
Nervous System 750 | 16,725
Blood and immune system 749 | 16,909
Male tissues 748 | 17,142
Liver and Pancreas 735 | 16,750
Urinary Tract 734 | 16,678
Respiratory system 719 | 16,393
Cardiovascular System 658 | 15,192

Target Family

Non-IDG 426 | 12,091
Enzyme 255 | 4,145
GPCR 73 | 408
Kinase 33 | 634
Ion Channel 24 | 344
Transporter 7 | 473
Nuclear Receptor 3 | 48
Epigenetic 2 | 242
Transcription Factor 2 | 1,400

UniProt Keyword

Lipoprotein 825 | 825
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Endoplasmic reticulum junction formation protein lunapark LNPK Tbio Non-IDG -1.07127 11.1 9
Alkaline phosphatase, placental type ALPP Tbio Enzyme -2.71952 511.2 929
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154