Development Level

Tbio 144 | 10,625
Tchem 33 | 1,890
Tdark 21 | 7,003
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 6 | 633
increased or absent threshold ... 5 | 128
preweaning lethality, incomple... 5 | 260
decreased lean body mass 4 | 195
decreased rib number 4 | 59
hypoactivity 4 | 89
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased body length 3 | 108
decreased body weight 3 | 174
decreased circulating glucose ... 3 | 121
decreased grip strength 3 | 123
decreased lumbar vertebrae num... 3 | 62
decreased threshold for audito... 3 | 32
enlarged heart 3 | 111
increased body weight 3 | 42
abnormal lens morphology 2 | 73
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating triglyce... 2 | 83
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased total body fat amoun... 2 | 186
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
increased hematocrit 2 | 36
increased sacral vertebrae num... 2 | 62
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal eye anterior chamber ... 1 | 3
abnormal hair growth 1 | 8
abnormal iris morphology 1 | 12
abnormal liver morphology 1 | 5
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal sleep behavior 1 | 63
abnormal tibia morphology 1 | 14
abnormal vertebrae morphology 1 | 14
absent pinna reflex 1 | 21
absent startle reflex 1 | 15
cataract 1 | 26
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating aspartat... 1 | 27
decreased circulating bilirubi... 1 | 14
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lactate dehydrogenas... 1 | 14
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged spleen 1 | 26
hyperactivity 1 | 108
improved glucose tolerance 1 | 56
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased fasted circulating g... 1 | 68
increased mean corpuscular vol... 1 | 91
increased memory CD4-positive,... 1 | 3
irregularly shaped pupil 1 | 7
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened ST segment 1 | 9
vertebral fusion 1 | 23

Disease

ovarian cancer 103 | 8,492
osteosarcoma 94 | 7,933
psoriasis 87 | 6,685
glioblastoma 73 | 5,572
medulloblastoma, large-cell 69 | 6,234
atypical teratoid / rhabdoid tumor 57 | 4,369
lung cancer 54 | 4,473
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
Breast cancer 42 | 3,099
malignant mesothelioma 42 | 3,163
invasive ductal carcinoma 40 | 2,950
pediatric high grade glioma 40 | 2,712
pilocytic astrocytoma 38 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
interstitial cystitis 36 | 2,299
lung carcinoma 35 | 2,844
oligodendroglioma 35 | 2,849
subependymal giant cell astrocytoma 35 | 2,287
primitive neuroectodermal tumor 34 | 3,031
Cancer 31 | 2,346
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,795
astrocytic glioma 30 | 2,241
non-small cell lung cancer 30 | 2,798
diabetes mellitus 29 | 1,663
ependymoma 29 | 2,514
ductal carcinoma in situ 27 | 1,745
lung adenocarcinoma 27 | 2,714
ulcerative colitis 27 | 2,087
adult high grade glioma 25 | 2,148
group 3 medulloblastoma 25 | 2,254
pancreatic cancer 24 | 2,300
pituitary cancer 24 | 1,972
Carcinoma 23 | 2,147
Pick disease 22 | 1,893
astrocytoma 21 | 1,493
cystic fibrosis 21 | 1,670
group 4 medulloblastoma 21 | 1,875
posterior fossa group A ependymoma 20 | 1,511
breast carcinoma 19 | 1,614
adrenocortical carcinoma 18 | 1,427
tuberculosis 18 | 1,563
Atopic dermatitis 17 | 944
Multiple myeloma 16 | 1,328
Obesity 16 | 616
primary pancreatic ductal adenocarcinoma 16 | 1,271
spina bifida 16 | 1,064
atypical teratoid/rhabdoid tumor 15 | 1,095
colon cancer 15 | 1,475
cutaneous lupus erythematosus 15 | 1,056
Alzheimer's disease 14 | 644
Prostatic Neoplasms 14 | 471
medulloblastoma 14 | 1,524
primary Sjogren syndrome 14 | 789
Endometriosis 13 | 535
non primary Sjogren syndrome sicca 13 | 840
posterior fossa group B ependymoma 13 | 1,530
sonic hedgehog group medulloblastoma 13 | 1,482
Waldenstrons macroglobulinemia 12 | 765
Down syndrome 11 | 548
IGA Glomerulonephritis 11 | 454
Rheumatoid Arthritis 11 | 1,171
acute quadriplegic myopathy 11 | 1,157
juvenile dermatomyositis 11 | 1,189
active Crohn's disease 10 | 918
acute myeloid leukemia 10 | 785
progressive supranuclear palsy 10 | 674
Atherosclerosis 9 | 275
Coronary artery disease 9 | 240
Crohn's disease 9 | 304
gastric carcinoma 9 | 832
Hypertensive disease 8 | 193
Mammary Neoplasms 8 | 410
Metabolic syndrome X 8 | 155
dermatomyositis 8 | 967
mucosa-associated lymphoid tissue lymphoma 8 | 480
nasopharyngeal carcinoma 8 | 1,056
pancreatic carcinoma 8 | 567
Animal Mammary Neoplasms 7 | 136
Duchenne muscular dystrophy 7 | 602
Infertility 7 | 163
Mammary Neoplasms, Experimental 7 | 150
Menopausal flushing 7 | 17
Polycystic Ovary Syndrome 7 | 335
Adenoma 6 | 165
Amyotrophic Lateral Sclerosis 6 | 432
Asthma 6 | 349
Atrophic vaginitis 6 | 14
Autistic Disorder 6 | 320
Heart disease 6 | 279
Hypertension 6 | 293
Intellectual disability 6 | 573
Multiple Sclerosis 6 | 498
Parkinson's disease 6 | 364
Prostate cancer 6 | 172
Vascular disease 6 | 281
aldosterone-producing adenoma 6 | 664
chronic rhinosinusitis 6 | 512
nephrosclerosis 6 | 329
tuberculosis and treatment for 6 months 6 | 686

Tissue

Digestive Tract 205 | 18,473
Endocrine System 205 | 18,512
Liver and Pancreas 205 | 18,136
Nervous System 205 | 18,561
Female tissues 204 | 18,647
Skin and soft tissues 204 | 18,115
Blood and immune system 203 | 17,995
Cardiovascular System 203 | 17,958
Urinary Tract 203 | 18,444
Respiratory system 202 | 17,484
Male tissues 201 | 17,969

Target Family

Non-IDG 161 | 11,969
Enzyme 19 | 4,146
Kinase 10 | 634
Nuclear Receptor 9 | 48
GPCR 7 | 408
Epigenetic 1 | 242

UniProt Keyword

Lipid-binding 207 | 207
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.72520 53.3 32
Calcium-dependent secretion activator 2 CADPS2 Tbio Non-IDG -1.08328 13.0 28
Vacuolar protein-sorting-associated protein 36 VPS36 Tbio Non-IDG -1.27330 17.9 26
Extended synaptotagmin-1 ESYT1 Tbio Non-IDG -1.25329 16.9 149
Cytohesin-4 CYTH4 Tbio Non-IDG -0.94527 9.29 127
Acyl-CoA-binding domain-containing protein 6 ACBD6 Tbio Non-IDG -0.24304 2.77 143
Sorting nexin-24 SNX24 Tdark Non-IDG 0.40 0.57 106
PCTP-like protein STARD10 Tbio Non-IDG -0.72839 6.77 62
Fatty acid-binding protein, epidermal FABP5 Tchem Non-IDG -1.89658 125.5 197
Endophilin-B1 SH3GLB1 Tbio Non-IDG -1.09363 4.54 332