Development Level

Tbio 156 | 11,178
Tchem 35 | 1,885
Tdark 23 | 6,569
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 7 | 499
decreased vertical activity 6 | 208
hypoactivity 5 | 132
abnormal bone structure 4 | 187
decreased circulating triglyce... 4 | 79
abnormal behavior 3 | 298
abnormal sleep behavior 3 | 70
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
abnormal craniofacial morpholo... 2 | 33
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
hyperactivity 2 | 148
increased hematocrit 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal eye anterior chamber ... 1 | 9
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased urine magnesium leve... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
microphthalmia 1 | 26
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
scaly skin 1 | 4
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thick skin 1 | 4
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 150 | 11,192
ovarian cancer 107 | 8,297
osteosarcoma 104 | 7,766
psoriasis 91 | 6,514
glioblastoma 85 | 5,635
medulloblastoma, large-cell 80 | 6,086
atypical teratoid / rhabdoid tumor 74 | 4,971
ependymoma 62 | 4,559
lung cancer 59 | 4,607
adult high grade glioma 53 | 3,701
group 3 medulloblastoma 50 | 4,002
Breast cancer 46 | 3,469
Astrocytoma, Pilocytic 44 | 3,006
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,204
malignant mesothelioma 44 | 3,135
Kidney cancer 42 | 2,548
invasive ductal carcinoma 42 | 2,867
oligodendroglioma 41 | 2,768
subependymal giant cell astrocytoma 41 | 2,230
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,902
interstitial cystitis 37 | 2,237
lung carcinoma 37 | 2,755
astrocytic glioma 36 | 2,530
primitive neuroectodermal tumor 34 | 2,957
Cancer 33 | 2,388
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,911
non-small cell lung cancer 32 | 2,799
diabetes mellitus 30 | 1,683
ductal carcinoma in situ 30 | 1,686
lung adenocarcinoma 29 | 2,627
pituitary cancer 27 | 1,915
pancreatic cancer 26 | 2,322
Pick disease 24 | 1,856
tuberculosis 24 | 1,963
cystic fibrosis 23 | 1,629
Schizophrenia 21 | 1,136
astrocytoma 20 | 1,113
breast carcinoma 20 | 1,589
ulcerative colitis 20 | 1,765
Atopic dermatitis 19 | 915
pediatric high grade glioma 19 | 1,035
Obesity 18 | 655
adrenocortical carcinoma 18 | 1,385
spina bifida 18 | 1,053
group 4 medulloblastoma 17 | 1,806
Autosomal recessive predisposition 16 | 1,407
cutaneous lupus erythematosus 16 | 1,016
Multiple myeloma 15 | 1,296
Prostatic Neoplasms 15 | 472
colon cancer 15 | 1,428
primary Sjogren syndrome 15 | 710
Alzheimer's disease 14 | 640
primary pancreatic ductal adenocarcinoma 14 | 1,071
Waldenstrons macroglobulinemia 13 | 742
active ulcerative colitis 13 | 736
acute quadriplegic myopathy 13 | 1,133
non primary Sjogren syndrome sicca 13 | 861
Endometriosis 12 | 521
juvenile dermatomyositis 12 | 1,147
Down syndrome 11 | 480
Hypertensive disease 11 | 278
Rheumatoid arthritis 11 | 1,156
progressive supranuclear palsy 11 | 656
Atherosclerosis 10 | 276
Liver Cirrhosis, Experimental 10 | 733
active Crohn's disease 10 | 882
acute myeloid leukemia 10 | 760
nasopharyngeal carcinoma 10 | 1,024
Breast Neoplasms 9 | 423
Coronary artery disease 9 | 253
Hypertension 9 | 372
Intellectual disability 9 | 998
Mammary Neoplasms 9 | 403
Multiple Sclerosis 9 | 527
dermatomyositis 9 | 941
gastric carcinoma 9 | 781
mucosa-associated lymphoid tissue lymphoma 9 | 473
pancreatic carcinoma 9 | 555
Bipolar Disorder 8 | 646
Crohn's disease 8 | 311
Duchenne muscular dystrophy 8 | 587
Liver cancer 8 | 589
Myopathy 8 | 185
Polycystic ovary syndrome 8 | 348
Vascular disease 8 | 294
medulloblastoma 8 | 702
Autistic Disorder 7 | 358
Depressive disorder 7 | 401
Heart disease 7 | 288
Infertility 7 | 176
Lipid metabolism disorder 7 | 111
Melanoma 7 | 689
Menopausal flushing 7 | 17
Neurodegenerative disease 7 | 402
Neuropathy 7 | 254
Skin cancer 7 | 451
sonic hedgehog group medulloblastoma 7 | 459
aldosterone-producing adenoma 6 | 646
nephrosclerosis 6 | 314

Tissue

Endocrine System 223 | 18,159
Skin and soft tissues 219 | 17,230
Digestive Tract 218 | 17,369
Female tissues 218 | 17,400
Nervous System 216 | 16,725
Male tissues 215 | 17,142
Blood and immune system 213 | 16,909
Liver and Pancreas 213 | 16,750
Respiratory system 213 | 16,393
Urinary Tract 210 | 16,678
Cardiovascular System 197 | 15,192

Target Family

Non-IDG 174 | 12,091
Enzyme 20 | 4,145
Kinase 10 | 634
Nuclear Receptor 9 | 48
GPCR 7 | 408
Ion Channel 3 | 344
Epigenetic 1 | 242

UniProt Keyword

Lipid-binding 224 | 224
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
Tyrosine-protein kinase Fes/Fps FES Tchem Kinase -3.05038 1109.2 314
CMRF35-like molecule 1 CD300LF Tbio Non-IDG -1.58161 43.4 183
Serine/threonine-protein kinase MARK1 MARK1 Tchem Kinase -1.77236 56.1 318
Glucose-dependent insulinotropic receptor GPR119 Tchem GPCR -2.06190 120.0 180
WASH complex subunit 2A WASHC2A Tdark Non-IDG 0.00000 8
Steroid 21-hydroxylase CYP21A2 Tbio Enzyme 0.00000 214
Phosphatidylethanolamine-binding protein 1 PEBP1 Tbio Non-IDG -2.62467 484.3 511