Development Level

Tbio 163 | 11,651
Tchem 28 | 1,388
Tdark 23 | 6,593
Tclin 10 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 7 | 499
decreased vertical activity 6 | 208
hypoactivity 5 | 132
abnormal bone structure 4 | 187
decreased circulating triglyce... 4 | 79
abnormal behavior 3 | 298
abnormal sleep behavior 3 | 70
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased bone mineral density 3 | 72
increased lean body mass 3 | 172
abnormal craniofacial morpholo... 2 | 33
abnormal epididymis morphology 2 | 42
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
edema 2 | 59
hyperactivity 2 | 148
increased hematocrit 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal eye anterior chamber ... 1 | 9
abnormal facial morphology 1 | 17
abnormal head shape 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal rib morphology 1 | 10
abnormal vertebrae morphology 1 | 18
abnormal vitreous body morphol... 1 | 10
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased urine magnesium leve... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
hydrometra 1 | 53
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
microphthalmia 1 | 26
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
scaly skin 1 | 4
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thick skin 1 | 4
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 152 | 11,493
ovarian cancer 109 | 8,520
osteosarcoma 105 | 7,950
psoriasis 94 | 6,694
glioblastoma 86 | 5,792
medulloblastoma, large-cell 80 | 6,241
atypical teratoid / rhabdoid tumor 76 | 5,112
ependymoma 62 | 4,679
lung cancer 61 | 4,740
adult high grade glioma 54 | 3,801
group 3 medulloblastoma 50 | 4,104
Breast cancer 46 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
Astrocytoma, Pilocytic 45 | 3,081
malignant mesothelioma 45 | 3,232
invasive ductal carcinoma 43 | 2,951
Kidney cancer 42 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
oligodendroglioma 41 | 2,850
subependymal giant cell astrocytoma 41 | 2,287
interstitial cystitis 39 | 2,312
astrocytic glioma 37 | 2,597
lung carcinoma 37 | 2,843
Cancer 36 | 2,499
primitive neuroectodermal tumor 35 | 3,035
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
non-small cell lung cancer 33 | 2,890
diabetes mellitus 30 | 1,728
ductal carcinoma in situ 30 | 1,745
lung adenocarcinoma 29 | 2,716
pancreatic cancer 27 | 2,398
pituitary cancer 27 | 1,972
Pick disease 24 | 1,894
tuberculosis 24 | 2,010
cystic fibrosis 23 | 1,696
Schizophrenia 21 | 1,160
ulcerative colitis 21 | 1,819
astrocytoma 20 | 1,146
breast carcinoma 20 | 1,638
Atopic dermatitis 19 | 952
pediatric high grade glioma 19 | 1,064
Obesity 18 | 678
adrenocortical carcinoma 18 | 1,428
spina bifida 18 | 1,074
Autosomal recessive predisposition 17 | 1,442
group 4 medulloblastoma 17 | 1,855
Multiple myeloma 16 | 1,332
colon cancer 16 | 1,478
cutaneous lupus erythematosus 16 | 1,057
Prostatic Neoplasms 15 | 495
primary Sjogren syndrome 15 | 735
primary pancreatic ductal adenocarcinoma 15 | 1,109
Alzheimer's disease 14 | 658
non primary Sjogren syndrome sicca 14 | 891
Endometriosis 13 | 540
Waldenstrons macroglobulinemia 13 | 765
active ulcerative colitis 13 | 764
acute quadriplegic myopathy 13 | 1,158
juvenile dermatomyositis 12 | 1,187
Down syndrome 11 | 499
Hypertensive disease 11 | 292
Rheumatoid arthritis 11 | 1,191
progressive supranuclear palsy 11 | 676
Atherosclerosis 10 | 291
Liver Cirrhosis, Experimental 10 | 769
active Crohn's disease 10 | 922
acute myeloid leukemia 10 | 783
nasopharyngeal carcinoma 10 | 1,058
Breast Neoplasms 9 | 445
Coronary artery disease 9 | 268
Crohn's disease 9 | 321
Hypertension 9 | 396
Intellectual disability 9 | 1,016
Mammary Neoplasms 9 | 425
Multiple Sclerosis 9 | 540
Polycystic ovary syndrome 9 | 360
dermatomyositis 9 | 966
gastric carcinoma 9 | 807
mucosa-associated lymphoid tissue lymphoma 9 | 484
pancreatic carcinoma 9 | 562
Bipolar Disorder 8 | 666
Duchenne muscular dystrophy 8 | 601
Infertility 8 | 188
Liver cancer 8 | 604
Myopathy 8 | 185
Osteoporosis 8 | 363
Vascular disease 8 | 319
medulloblastoma 8 | 720
sonic hedgehog group medulloblastoma 8 | 467
Animal Mammary Neoplasms 7 | 136
Autistic Disorder 7 | 364
Depressive disorder 7 | 409
Heart disease 7 | 306
Lipid metabolism disorder 7 | 114
Melanoma 7 | 711
Menopausal flushing 7 | 17
Neurodegenerative disease 7 | 414
Neuropathy 7 | 261
Skin cancer 7 | 469

Tissue

Endocrine System 223 | 18,159
Skin and soft tissues 219 | 17,230
Digestive Tract 218 | 17,369
Female tissues 218 | 17,400
Nervous System 216 | 16,725
Male tissues 215 | 17,142
Blood and immune system 213 | 16,909
Liver and Pancreas 213 | 16,750
Respiratory system 213 | 16,393
Urinary Tract 210 | 16,678
Cardiovascular System 197 | 15,192

Target Family

Non-IDG 174 | 12,091
Enzyme 20 | 4,145
Kinase 10 | 634
Nuclear Receptor 9 | 48
GPCR 7 | 408
Ion Channel 3 | 344
Epigenetic 1 | 242

UniProt Keyword

Lipid-binding 224 | 224
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-22 SNX22 Tdark Non-IDG -0.21085 1.62 25
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
Membrane progestin receptor gamma PAQR5 Tbio Non-IDG -0.86721 7.03 64
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
Sorting nexin-8 SNX8 Tbio Non-IDG -1.38931 25.5 152
Protein kinase C and casein kinase substrate in neurons protein 3 PACSIN3 Tbio Enzyme -0.67239 5.43 259
Phosphatidylcholine transfer protein PCTP Tbio Non-IDG -1.72354 56.3 156
Sorting nexin-11 SNX11 Tdark Non-IDG -0.22185 1.79 111
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248