Development Level

Tbio 254 | 10,625
Tchem 119 | 1,890
Tdark 38 | 7,003
Tclin 16 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 14 | 633
decreased circulating glucose ... 9 | 121
preweaning lethality, incomple... 9 | 260
abnormal lens morphology 8 | 73
decreased total body fat amoun... 7 | 186
decreased lean body mass 6 | 195
abnormal behavior 5 | 226
abnormal retina morphology 5 | 100
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating triglyce... 5 | 83
embryonic lethality prior to o... 5 | 148
decreased body weight 4 | 174
hypoactivity 4 | 89
increased circulating alkaline... 4 | 119
increased circulating sodium l... 4 | 71
increased mean corpuscular hem... 4 | 93
abnormal bone structure 3 | 131
abnormal coat appearance 3 | 25
abnormal embryo size 3 | 112
abnormal retinal pigmentation 3 | 61
abnormal spleen morphology 3 | 36
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating alkaline... 3 | 41
decreased mean corpuscular hem... 3 | 34
enlarged spleen 3 | 26
increased circulating bilirubi... 3 | 16
increased circulating phosphat... 3 | 24
increased grip strength 3 | 83
increased mean platelet volume 3 | 19
increased red blood cell distr... 3 | 21
male infertility 3 | 62
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal hair growth 2 | 8
abnormal locomotor activation 2 | 26
abnormal motor coordination/ b... 2 | 4
abnormal sleep behavior 2 | 63
abnormal vocalization 2 | 21
decreased B cell number 2 | 30
decreased CD8-positive, alpha-... 2 | 26
decreased circulating alanine ... 2 | 53
decreased circulating calcium ... 2 | 33
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased fasted circulating g... 2 | 49
decreased mature B cell number 2 | 25
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to t... 2 | 187
enlarged heart 2 | 111
hydrometra 2 | 13
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating iron lev... 2 | 25
increased fasted circulating g... 2 | 68
increased heart rate 2 | 17
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 25
increased total body fat amoun... 2 | 57
limb grasping 2 | 35
shortened RR interval 2 | 19
small seminal vesicle 2 | 6
small testis 2 | 37
abnormal neural tube closure 1 | 37
abnormal rib morphology 1 | 28
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased IgG1 level 1 | 4
decreased NK cell number 1 | 16
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased circulating creatini... 1 | 29
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
small thymus 1 | 11
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 213 | 8,484
psoriasis 185 | 6,685
osteosarcoma 178 | 7,933
medulloblastoma, large-cell 149 | 6,234
lung cancer 122 | 4,466
glioblastoma 120 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 112 | 3,289
atypical teratoid / rhabdoid tumor 95 | 4,369
pancreatic ductal adenocarcinoma liver metastasis 94 | 1,795
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,956
malignant mesothelioma 93 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 91 | 2,988
invasive ductal carcinoma 89 | 2,950
lung carcinoma 85 | 2,844
interstitial cystitis 78 | 2,299
ulcerative colitis 77 | 2,087
Breast cancer 76 | 3,094
pancreatic cancer 76 | 2,300
non-small cell lung cancer 70 | 2,798
pilocytic astrocytoma 70 | 3,086
oligodendroglioma 68 | 2,849
group 4 medulloblastoma 67 | 1,875
ductal carcinoma in situ 64 | 1,745
lung adenocarcinoma 63 | 2,713
diabetes mellitus 61 | 1,663
ependymoma 60 | 2,514
Obesity 58 | 616
subependymal giant cell astrocytoma 58 | 2,287
primitive neuroectodermal tumor 56 | 3,031
tuberculosis 55 | 1,557
pediatric high grade glioma 54 | 2,712
Pick disease 50 | 1,893
adrenocortical carcinoma 49 | 1,427
active Crohn's disease 48 | 918
adult high grade glioma 48 | 2,148
Cancer 47 | 2,346
astrocytic glioma 46 | 2,241
cystic fibrosis 45 | 1,665
pituitary cancer 44 | 1,972
astrocytoma 43 | 1,493
group 3 medulloblastoma 42 | 2,254
Atopic dermatitis 38 | 944
breast carcinoma 38 | 1,614
colon cancer 37 | 1,475
Atherosclerosis 35 | 275
Multiple myeloma 35 | 1,327
posterior fossa group A ependymoma 35 | 1,511
acute quadriplegic myopathy 34 | 1,157
posterior fossa group B ependymoma 33 | 1,530
primary pancreatic ductal adenocarcinoma 33 | 1,271
Rheumatoid Arthritis 32 | 1,160
esophageal adenocarcinoma 32 | 737
spina bifida 29 | 1,064
Lipid metabolism disorder 28 | 102
cutaneous lupus erythematosus 27 | 1,056
nasopharyngeal carcinoma 27 | 1,056
Coronary artery disease 26 | 240
Fatty liver disease 26 | 84
Neurodegenerative disease 26 | 383
juvenile dermatomyositis 26 | 1,189
medulloblastoma 26 | 1,524
non primary Sjogren syndrome sicca 25 | 840
primary Sjogren syndrome 25 | 789
Carcinoma 24 | 2,147
Alzheimer's disease 23 | 644
Metabolic syndrome X 23 | 155
aldosterone-producing adenoma 23 | 664
Down syndrome 22 | 548
dermatomyositis 22 | 933
progressive supranuclear palsy 22 | 674
Intellectual disability 20 | 573
Prostatic Neoplasms 20 | 471
atypical teratoid/rhabdoid tumor 20 | 1,095
gastric carcinoma 20 | 832
Liver carcinoma 19 | 217
Liver disease 19 | 219
Waldenstrons macroglobulinemia 19 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 499
Peripheral Neuropathy 18 | 303
active ulcerative colitis 18 | 477
pancreatic carcinoma 18 | 567
Schizophrenia 17 | 501
fibroadenoma 17 | 557
hereditary spastic paraplegia 16 | 313
Cardiovascular system disease 15 | 194
Cerebrovascular disease 15 | 231
Hypertension 15 | 287
IGA Glomerulonephritis 15 | 454
Kidney disease 15 | 396
Polycystic Ovary Syndrome 14 | 332
gastric cancer 14 | 430
sonic hedgehog group medulloblastoma 14 | 1,482
Congenital ichthyosiform erythroderma 13 | 27
Duchenne muscular dystrophy 13 | 602
acute myeloid leukemia 13 | 780
chronic rhinosinusitis 13 | 512
non diabetic and post-ischemic heart failure 13 | 200
tuberculosis and treatment for 6 months 13 | 686
Vascular disease 12 | 281
nephrosclerosis 12 | 329

Tissue

Digestive Tract 424 | 18,473
Nervous System 424 | 18,561
Female tissues 423 | 18,647
Liver and Pancreas 422 | 18,136
Urinary Tract 422 | 18,444
Endocrine System 421 | 18,512
Skin and soft tissues 421 | 18,115
Cardiovascular System 420 | 17,958
Male tissues 418 | 17,969
Blood and immune system 417 | 17,995
Respiratory system 414 | 17,484

Target Family

Enzyme 329 | 4,146
Non-IDG 73 | 11,971
Kinase 9 | 634
Transcription Factor 8 | 1,400
Transporter 8 | 473

UniProt Keyword

Lipid metabolism 427 | 427
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Sialidase-3 NEU3 Tbio Enzyme -1.97558 109.4 23
Transmembrane 6 superfamily member 2 TM6SF2 Tbio Non-IDG -1.59935 44.0 21
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Peroxisomal multifunctional enzyme type 2 HSD17B4 Tbio Non-IDG -2.15826 152.2 203
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Ceramide synthase 3 CERS3 Tbio Transcription Factor -0.90774 9.32 99
Apolipoprotein A-I APOA1 Tchem Non-IDG -3.60439 3516.7 901
Apolipoprotein C-II APOC2 Tbio Non-IDG -2.49982 337.4 18