Development Level

Tbio 277 | 11,445
Tchem 107 | 1,598
Tdark 32 | 6,588
Tclin 16 | 613

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 19 | 499
decreased circulating glucose ... 10 | 126
abnormal lens morphology 7 | 81
decreased bone mineral content 7 | 151
decreased circulating choleste... 7 | 93
increased lean body mass 7 | 172
abnormal bone structure 6 | 187
decreased total body fat amoun... 6 | 207
embryonic lethality prior to o... 6 | 239
increased circulating alkaline... 6 | 122
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
cataract 5 | 92
decreased circulating HDL chol... 5 | 68
decreased circulating triglyce... 5 | 79
enlarged heart 5 | 210
hydrometra 5 | 53
hypoactivity 5 | 132
increased mean platelet volume 5 | 45
increased total body fat amoun... 5 | 134
male infertility 5 | 123
decreased circulating iron lev... 4 | 32
decreased lymphocyte cell numb... 4 | 83
increased circulating choleste... 4 | 66
increased circulating phosphat... 4 | 26
increased circulating sodium l... 4 | 71
increased grip strength 4 | 41
increased red blood cell distr... 4 | 34
small superior vagus ganglion 4 | 74
abnormal gait 3 | 69
abnormal retina morphology 3 | 71
abnormal retinal blood vessel ... 3 | 26
abnormal retinal vasculature m... 3 | 27
abnormal seminal vesicle morph... 3 | 114
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral density 3 | 126
decreased circulating alanine ... 3 | 47
decreased erythrocyte cell num... 3 | 62
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular hem... 3 | 50
decreased mean platelet volume 3 | 25
decreased vertical activity 3 | 208
embryonic lethality prior to t... 3 | 278
improved glucose tolerance 3 | 79
increased anti-nuclear antigen... 3 | 19
increased circulating HDL chol... 3 | 80
increased circulating bilirubi... 3 | 16
increased circulating iron lev... 3 | 30
increased circulating triglyce... 3 | 42
increased monocyte cell number 3 | 63
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
limb grasping 3 | 41
small testis 3 | 58
thrombocytopenia 3 | 56
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal hair growth 2 | 10
abnormal neural tube closure 2 | 46
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
anophthalmia 2 | 33
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating serum al... 2 | 82
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating amylase ... 2 | 25
increased circulating creatini... 2 | 38
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased heart rate 2 | 23
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
persistence of hyaloid vascula... 2 | 33
small seminal vesicle 2 | 10
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
increased bone mineral density 1 | 72
vertebral fusion 1 | 23

Disease

Carcinoma 262 | 11,493
ovarian cancer 216 | 8,520
psoriasis 188 | 6,694
osteosarcoma 180 | 7,950
medulloblastoma, large-cell 150 | 6,241
lung cancer 127 | 4,740
glioblastoma 124 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 113 | 3,291
atypical teratoid / rhabdoid tumor 110 | 5,112
ependymoma 102 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 101 | 1,962
malignant mesothelioma 96 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 93 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,989
invasive ductal carcinoma 89 | 2,951
group 3 medulloblastoma 87 | 4,104
lung carcinoma 85 | 2,843
Breast cancer 82 | 3,578
interstitial cystitis 79 | 2,312
pancreatic cancer 77 | 2,398
adult high grade glioma 75 | 3,801
Autosomal recessive predisposition 74 | 1,442
non-small cell lung cancer 73 | 2,890
Astrocytoma, Pilocytic 70 | 3,081
oligodendroglioma 69 | 2,850
Obesity 67 | 678
tuberculosis 65 | 2,010
ductal carcinoma in situ 64 | 1,745
lung adenocarcinoma 64 | 2,716
diabetes mellitus 62 | 1,728
ulcerative colitis 61 | 1,819
subependymal giant cell astrocytoma 58 | 2,287
primitive neuroectodermal tumor 57 | 3,035
astrocytic glioma 54 | 2,597
group 4 medulloblastoma 52 | 1,855
Cancer 51 | 2,499
Pick disease 50 | 1,894
active Crohn's disease 49 | 922
adrenocortical carcinoma 49 | 1,428
Kidney cancer 48 | 2,613
cystic fibrosis 46 | 1,696
pituitary cancer 46 | 1,972
breast carcinoma 40 | 1,638
Atopic dermatitis 39 | 952
Epilepsy 39 | 792
Schizophrenia 38 | 1,160
colon cancer 38 | 1,478
astrocytoma 37 | 1,146
Intellectual disability 36 | 1,016
Multiple myeloma 36 | 1,332
Muscle hypotonia 36 | 571
active ulcerative colitis 36 | 764
acute quadriplegic myopathy 34 | 1,158
Seizures 33 | 596
esophageal adenocarcinoma 33 | 737
Atherosclerosis 32 | 291
Lipid metabolism disorder 32 | 114
Rheumatoid arthritis 31 | 1,191
spina bifida 30 | 1,074
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Hepatomegaly 29 | 285
Mental and motor retardation 29 | 608
Neurodegenerative disease 28 | 414
nasopharyngeal carcinoma 28 | 1,058
pediatric high grade glioma 28 | 1,064
Dull intelligence 27 | 645
Fatty liver disease 27 | 103
Liver Cirrhosis, Experimental 27 | 769
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
cutaneous lupus erythematosus 27 | 1,057
non primary Sjogren syndrome sicca 27 | 891
primary pancreatic ductal adenocarcinoma 27 | 1,109
Coronary artery disease 26 | 268
juvenile dermatomyositis 26 | 1,187
Alzheimer's disease 23 | 658
aldosterone-producing adenoma 23 | 665
primary Sjogren syndrome 23 | 735
Down syndrome 22 | 499
Failure to gain weight 22 | 365
Pediatric failure to thrive 22 | 365
dermatomyositis 22 | 966
progressive supranuclear palsy 22 | 676
Liver disease 21 | 237
Melanoma 21 | 711
Polycystic ovary syndrome 21 | 360
Prostatic Neoplasms 21 | 495
Bipolar Disorder 20 | 666
Carcinoma, Hepatocellular 20 | 228
Liver carcinoma 20 | 240
gastric carcinoma 20 | 807
Hypertension 19 | 396
Waldenstrons macroglobulinemia 19 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 19 | 510
Splenomegaly 18 | 190
pancreatic carcinoma 18 | 562
fibroadenoma 17 | 559

Tissue

Digestive Tract 424 | 17,369
Female tissues 421 | 17,400
Skin and soft tissues 420 | 17,230
Endocrine System 419 | 18,159
Blood and immune system 411 | 16,909
Male tissues 410 | 17,142
Urinary Tract 409 | 16,678
Liver and Pancreas 408 | 16,750
Nervous System 399 | 16,725
Respiratory system 393 | 16,393
Cardiovascular System 377 | 15,192

Target Family

Enzyme 334 | 4,145
Non-IDG 73 | 12,091
Kinase 9 | 634
Transcription Factor 8 | 1,400
Transporter 8 | 473

UniProt Keyword

Lipid metabolism 432 | 432
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Retinoic acid receptor responder protein 3 RARRES3 Tbio Non-IDG -1.84020 71.0 164
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
HRAS-like suppressor 2 HRASLS2 Tbio Non-IDG -0.19299 1.65 72
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Galactocerebrosidase GALC Tbio Enzyme -2.56924 363.2 143