Development Level

Tbio 98 | 11,445
Tchem 41 | 1,598
Tdark 11 | 6,588
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
decreased bone mineral content 3 | 151
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased mean platelet volume 2 | 25
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged spleen 2 | 41
improved glucose tolerance 2 | 79
increased anti-nuclear antigen... 2 | 19
increased body length 2 | 32
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased heart rate 2 | 23
increased lean body mass 2 | 172
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
small seminal vesicle 2 | 10
small testis 2 | 58
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged thymus 1 | 5
enlarged urinary bladder 1 | 8
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
microphthalmia 1 | 26
shortened RR interval 1 | 17
syndactyly 1 | 23
vertebral fusion 1 | 23

Disease

Carcinoma 81 | 11,493
ovarian cancer 81 | 8,520
psoriasis 72 | 6,694
osteosarcoma 71 | 7,950
medulloblastoma, large-cell 61 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 54 | 3,291
glioblastoma 48 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
atypical teratoid / rhabdoid tumor 43 | 5,112
invasive ductal carcinoma 41 | 2,951
lung cancer 41 | 4,740
malignant mesothelioma 41 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,989
Breast cancer 38 | 3,578
ependymoma 38 | 4,679
group 3 medulloblastoma 38 | 4,104
ductal carcinoma in situ 35 | 1,745
oligodendroglioma 34 | 2,850
non-small cell lung cancer 33 | 2,890
lung carcinoma 32 | 2,843
pancreatic cancer 32 | 2,398
Pick disease 30 | 1,894
Astrocytoma, Pilocytic 28 | 3,081
adult high grade glioma 28 | 3,801
interstitial cystitis 28 | 2,312
tuberculosis 27 | 2,010
astrocytic glioma 25 | 2,597
lung adenocarcinoma 25 | 2,716
group 4 medulloblastoma 24 | 1,855
subependymal giant cell astrocytoma 24 | 2,287
primitive neuroectodermal tumor 23 | 3,035
active Crohn's disease 22 | 922
breast carcinoma 22 | 1,638
cystic fibrosis 21 | 1,696
pituitary cancer 20 | 1,972
Autosomal recessive predisposition 19 | 1,442
ulcerative colitis 19 | 1,819
Cancer 18 | 2,499
Intellectual disability 18 | 1,016
Multiple myeloma 18 | 1,332
Atopic dermatitis 17 | 952
Obesity 17 | 678
adrenocortical carcinoma 16 | 1,428
spina bifida 15 | 1,074
diabetes mellitus 14 | 1,728
esophageal adenocarcinoma 14 | 737
non primary Sjogren syndrome sicca 13 | 891
primary pancreatic ductal adenocarcinoma 13 | 1,109
progressive supranuclear palsy 13 | 676
Dull intelligence 12 | 645
Epilepsy 12 | 792
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Rheumatoid arthritis 12 | 1,191
Schizophrenia 12 | 1,160
pediatric high grade glioma 12 | 1,064
Liver Cirrhosis, Experimental 11 | 769
active ulcerative colitis 11 | 764
acute quadriplegic myopathy 11 | 1,158
juvenile dermatomyositis 11 | 1,187
nasopharyngeal carcinoma 11 | 1,058
Seizures 10 | 596
Waldenstrons macroglobulinemia 10 | 765
aldosterone-producing adenoma 10 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
colon cancer 10 | 1,478
dermatomyositis 10 | 966
primary Sjogren syndrome 10 | 735
Cataract 9 | 297
Fatty liver disease 9 | 103
Kidney cancer 9 | 2,613
Muscle hypotonia 9 | 571
astrocytoma 9 | 1,146
Alzheimer's disease 8 | 658
Carcinoma, Hepatocellular 8 | 228
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Liver carcinoma 8 | 240
Mental and motor retardation 8 | 608
gastric carcinoma 8 | 807
Bipolar Disorder 7 | 666
Chemical and Drug Induced Liver Injury 7 | 195
Failure to gain weight 7 | 365
Heart failure 7 | 162
Hydrolethalus syndrome 7 | 128
Nystagmus 7 | 317
Pediatric failure to thrive 7 | 365
acute myeloid leukemia 7 | 783
pancreatic carcinoma 7 | 562
Duchenne muscular dystrophy 6 | 601
Hepatomegaly 6 | 285
Prostatic Neoplasms 6 | 495
Small head 6 | 374
chronic rhinosinusitis 6 | 512
cutaneous lupus erythematosus 6 | 1,057
fibroadenoma 6 | 559
non diabetic and post-ischemic heart failure 6 | 200

Tissue

Female tissues 153 | 17,400
Skin and soft tissues 153 | 17,230
Digestive Tract 152 | 17,369
Endocrine System 151 | 18,159
Male tissues 151 | 17,142
Nervous System 149 | 16,725
Urinary Tract 148 | 16,678
Blood and immune system 147 | 16,909
Liver and Pancreas 147 | 16,750
Respiratory system 147 | 16,393
Cardiovascular System 146 | 15,192

Target Family

Enzyme 121 | 4,145
Non-IDG 20 | 12,091
Kinase 9 | 634
Transcription Factor 6 | 1,400

UniProt Keyword

Lipid biosynthesis 156 | 156
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OXSM Tbio Enzyme -1.82909 65.1 127
Choline-phosphate cytidylyltransferase B PCYT1B Tbio Enzyme -1.46937 28.8 40
Putative fatty acid desaturase 2-like protein FADS2P1 FADS2P1 Tdark Enzyme 0.00000 0
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.87118 6.24 100
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177