Development Level

Tbio 101 | 11,445
Tchem 28 | 1,598
Tdark 20 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 27 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 6 | 278
decreased body weight 5 | 161
decreased lean body mass 5 | 135
abnormal bone structure 4 | 187
decreased bone mineral content 4 | 151
decreased total body fat amoun... 4 | 207
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
decreased bone mineral density 3 | 126
decreased grip strength 3 | 116
increased heart weight 3 | 62
abnormal behavioral response t... 2 | 66
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
decreased body length 2 | 101
decreased circulating glucose ... 2 | 126
decreased fasted circulating g... 2 | 65
decreased hemoglobin content 2 | 68
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal QT variability 1 | 10
abnormal allantois morphology 1 | 8
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal sleep behavior 1 | 70
abnormal social-conspecific in... 1 | 3
abnormal spinal cord morpholog... 1 | 9
abnormal spine curvature 1 | 9
abnormal tail movements 1 | 12
abnormal tibia morphology 1 | 14
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased urine magnesium leve... 1 | 3
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
vertebral transformation 1 | 12

Disease

Carcinoma 131 | 11,493
ovarian cancer 83 | 8,520
osteosarcoma 64 | 7,950
lung cancer 61 | 4,740
medulloblastoma, large-cell 55 | 6,241
psoriasis 53 | 6,694
glioblastoma 47 | 5,792
atypical teratoid / rhabdoid tumor 46 | 5,112
Autosomal recessive predisposition 33 | 1,442
group 3 medulloblastoma 33 | 4,104
ependymoma 31 | 4,679
malignant mesothelioma 28 | 3,232
Breast cancer 26 | 3,578
primitive neuroectodermal tumor 26 | 3,035
Kidney cancer 25 | 2,613
non-small cell lung cancer 25 | 2,890
Multiple myeloma 24 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 24 | 1,962
Cancer 22 | 2,499
adult high grade glioma 22 | 3,801
astrocytic glioma 22 | 2,597
Astrocytoma, Pilocytic 21 | 3,081
Pick disease 21 | 1,894
lung adenocarcinoma 20 | 2,716
oligodendroglioma 20 | 2,850
tuberculosis 20 | 2,010
Epilepsy 19 | 792
invasive ductal carcinoma 19 | 2,951
interstitial cystitis 18 | 2,312
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
Muscle hypotonia 17 | 571
astrocytoma 17 | 1,146
diabetes mellitus 16 | 1,728
lung carcinoma 16 | 2,843
Rheumatoid arthritis 15 | 1,191
adrenocortical carcinoma 15 | 1,428
Seizures 14 | 596
colon cancer 14 | 1,478
dermatomyositis 14 | 966
juvenile dermatomyositis 14 | 1,187
pituitary cancer 14 | 1,972
Failure to gain weight 13 | 365
Pediatric failure to thrive 13 | 365
pancreatic cancer 13 | 2,398
subependymal giant cell astrocytoma 13 | 2,287
Intellectual disability 12 | 1,016
Neurodegenerative disease 12 | 414
acute myeloid leukemia 12 | 783
acute quadriplegic myopathy 12 | 1,158
ductal carcinoma in situ 12 | 1,745
Schizophrenia 11 | 1,160
active Crohn's disease 11 | 922
ulcerative colitis 11 | 1,819
Neuropathy 10 | 261
Obesity 10 | 678
Waldenstrons macroglobulinemia 10 | 765
breast carcinoma 10 | 1,638
nasopharyngeal carcinoma 10 | 1,058
Anemia 9 | 365
Cerebral atrophy 9 | 178
Degenerative brain disorder 9 | 100
Dull intelligence 9 | 645
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Myositis 9 | 30
Poor school performance 9 | 645
medulloblastoma 9 | 720
progressive supranuclear palsy 9 | 676
Acidosis, Lactic 8 | 97
Atopic dermatitis 8 | 952
Distal sensory impairment 8 | 52
Lactic acidemia 8 | 95
Leigh disease 8 | 100
Small head 8 | 374
Supratentorial atrophy 8 | 94
active ulcerative colitis 8 | 764
chronic rhinosinusitis 8 | 512
cystic fibrosis 8 | 1,696
pediatric high grade glioma 8 | 1,064
Cerebellar Ataxia 7 | 304
Charcot-Marie-Tooth disease 7 | 62
Down syndrome 7 | 499
Hemoglobin low 7 | 124
Hepatomegaly 7 | 285
Hyperammonemia 7 | 30
Nystagmus 7 | 317
Alzheimer's disease 6 | 658
Decreased tendon reflex 6 | 122
Hyperreflexia 6 | 209
Infantile onset 6 | 238
Methylmalonic acidemia 6 | 37
Short stature 6 | 531
cutaneous lupus erythematosus 6 | 1,057
esophageal adenocarcinoma 6 | 737

Tissue

Endocrine System 151 | 18,159
Liver and Pancreas 148 | 16,750
Skin and soft tissues 148 | 17,230
Urinary Tract 148 | 16,678
Digestive Tract 147 | 17,369
Female tissues 147 | 17,400
Nervous System 147 | 16,725
Blood and immune system 145 | 16,909
Male tissues 145 | 17,142
Respiratory system 144 | 16,393
Cardiovascular System 141 | 15,192

Target Family

Enzyme 122 | 4,145
Non-IDG 16 | 12,091
Transcription Factor 6 | 1,400
Transporter 6 | 473
Epigenetic 1 | 242

UniProt Keyword

Ligase 151 | 151
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 Tbio Enzyme -1.91194 82.4 102
Beta-citrylglutamate synthase B RIMKLB Tdark Enzyme -0.33579 2.63 48
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
CTP synthase 1 CTPS1 Tbio Enzyme -2.29349 196.5 107
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.64427 4.21 70
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Tyrosine--tRNA ligase, cytoplasmic YARS Tchem Enzyme -2.45633 272.6 180
Tubulin polyglutamylase TTLL5 TTLL5 Tbio Enzyme -0.67048 4.78 28
Glycine--tRNA ligase GARS Tbio Enzyme -2.62899 412.8 178
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189