Development Level

Tbio 248 | 10,625
Tdark 46 | 7,003
Tchem 37 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 20 | 633
decreased body weight 9 | 174
decreased lean body mass 9 | 195
abnormal behavior 6 | 226
embryonic lethality prior to o... 6 | 148
preweaning lethality, incomple... 6 | 260
abnormal bone structure 5 | 131
decreased total body fat amoun... 5 | 186
embryonic lethality prior to t... 5 | 187
abnormal retina morphology 4 | 100
decreased body length 4 | 108
decreased bone mineral content 4 | 157
decreased bone mineral density 4 | 126
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal sleep behavior 3 | 63
decreased circulating triglyce... 3 | 83
decreased heart weight 3 | 44
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
increased monocyte cell number 3 | 27
increased or absent threshold ... 3 | 128
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal spleen morphology 2 | 36
abnormal tail movements 2 | 12
decreased CD4-positive, CD25-p... 2 | 24
decreased CD8-positive, alpha-... 2 | 26
decreased circulating HDL chol... 2 | 77
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased eosinophil cell numb... 2 | 41
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
female infertility 2 | 34
hypoactivity 2 | 89
increased bone mineral content 2 | 92
increased effector memory CD4-... 2 | 15
increased exploration in new e... 2 | 56
increased gamma-delta T cell n... 2 | 16
increased mean corpuscular vol... 2 | 91
abnormal QRS complex 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal heart left ventricle ... 1 | 20
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal neural tube closure 1 | 37
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
cataract 1 | 26
corneal opacity 1 | 25
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased T-helper cell number 1 | 4
decreased alpha-beta T cell nu... 1 | 12
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased vertical activity 1 | 22
dilated heart left ventricle 1 | 10
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased KLRG1+ CD4 alpha bet... 1 | 5
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased red blood cell distr... 1 | 21
narrow eye opening 1 | 15
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
prolonged RR interval 1 | 2
shortened ST segment 1 | 9
thrombocytopenia 1 | 46
vertebral transformation 1 | 12

Disease

ovarian cancer 195 | 8,484
osteosarcoma 157 | 7,933
medulloblastoma, large-cell 119 | 6,234
psoriasis 104 | 6,685
glioblastoma 98 | 5,572
lung cancer 98 | 4,466
atypical teratoid / rhabdoid tumor 76 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
malignant mesothelioma 56 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,988
Breast cancer 54 | 3,094
primitive neuroectodermal tumor 53 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,956
pilocytic astrocytoma 48 | 3,086
subependymal giant cell astrocytoma 46 | 2,287
oligodendroglioma 45 | 2,849
Multiple myeloma 44 | 1,327
Cancer 42 | 2,346
astrocytic glioma 42 | 2,241
lung adenocarcinoma 42 | 2,713
Carcinoma 41 | 2,147
Pick disease 41 | 1,893
adult high grade glioma 41 | 2,148
juvenile dermatomyositis 40 | 1,189
ependymoma 39 | 2,514
non-small cell lung cancer 39 | 2,798
group 3 medulloblastoma 38 | 2,254
invasive ductal carcinoma 37 | 2,950
ulcerative colitis 37 | 2,087
pancreatic cancer 36 | 2,300
Rheumatoid Arthritis 34 | 1,160
interstitial cystitis 34 | 2,299
lung carcinoma 34 | 2,844
pediatric high grade glioma 34 | 2,712
group 4 medulloblastoma 33 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 33 | 1,795
astrocytoma 31 | 1,493
sonic hedgehog group medulloblastoma 31 | 1,482
dermatomyositis 28 | 933
medulloblastoma 27 | 1,524
tuberculosis 27 | 1,557
acute quadriplegic myopathy 26 | 1,157
breast carcinoma 26 | 1,614
atypical teratoid/rhabdoid tumor 25 | 1,095
adrenocortical carcinoma 24 | 1,427
pituitary cancer 24 | 1,972
tuberculosis and treatment for 6 months 24 | 686
active Crohn's disease 22 | 918
ductal carcinoma in situ 22 | 1,745
posterior fossa group B ependymoma 22 | 1,530
Waldenstrons macroglobulinemia 21 | 765
diabetes mellitus 21 | 1,663
acute myeloid leukemia 20 | 780
colon cancer 20 | 1,475
primary pancreatic ductal adenocarcinoma 20 | 1,271
cystic fibrosis 19 | 1,665
posterior fossa group A ependymoma 19 | 1,511
spina bifida 19 | 1,064
progressive supranuclear palsy 18 | 674
primary Sjogren syndrome 17 | 789
Neurodegenerative disease 16 | 383
Atopic dermatitis 15 | 944
gastric carcinoma 14 | 832
Obesity 13 | 616
cutaneous lupus erythematosus 13 | 1,056
esophageal adenocarcinoma 13 | 737
glioblastoma multiforme 13 | 347
hepatocellular carcinoma 13 | 532
nasopharyngeal carcinoma 13 | 1,056
Down syndrome 11 | 548
Intellectual disability 11 | 573
Neuropathy 11 | 210
chronic rhinosinusitis 11 | 512
non primary Sjogren syndrome sicca 11 | 840
Multiple Sclerosis 10 | 498
aldosterone-producing adenoma 10 | 664
Alzheimer's disease 9 | 644
Charcot-Marie-Tooth disease 9 | 74
Epilepsy 9 | 346
IGA Glomerulonephritis 9 | 454
Myositis 9 | 24
hereditary spastic paraplegia 9 | 313
inflammatory breast cancer 9 | 404
Gaucher disease type 1 8 | 171
pancreatic carcinoma 8 | 567
sarcoidosis 8 | 358
Chronic Lymphocytic Leukemia 7 | 242
Methylmalonic acidemia 7 | 39
gastric cancer 7 | 430
mucosa-associated lymphoid tissue lymphoma 7 | 480
Autistic Disorder 6 | 320
Cardiovascular system disease 6 | 194
Duchenne muscular dystrophy 6 | 602
Leigh disease 6 | 81
Prostatic Neoplasms 6 | 471
facioscapulohumeral dystrophy 6 | 286
non-small cell lung carcinoma 6 | 413
Endometriosis 5 | 535
nephrosclerosis 5 | 329
urothelial carcinoma 5 | 318

Tissue

Digestive Tract 329 | 18,473
Female tissues 329 | 18,647
Nervous System 329 | 18,561
Cardiovascular System 328 | 17,958
Endocrine System 328 | 18,512
Liver and Pancreas 328 | 18,136
Urinary Tract 328 | 18,444
Blood and immune system 327 | 17,995
Skin and soft tissues 327 | 18,115
Male tissues 325 | 17,969
Respiratory system 324 | 17,484

Target Family

Enzyme 271 | 4,146
Non-IDG 36 | 11,971
Transcription Factor 10 | 1,400
Epigenetic 9 | 242
Transporter 6 | 473

UniProt Keyword

Ligase 332 | 332
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon regulatory factor 2-binding protein 1 IRF2BP1 Tdark Non-IDG -0.29200 1.63 121
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
E3 ubiquitin-protein ligase ZSWIM2 ZSWIM2 Tbio Enzyme -2.21919 171.7 87
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
Phosphoribosylformylglycinamidine synthase PFAS Tbio Enzyme -2.68616 520.0 75
E3 ubiquitin-protein ligase TRIM62 TRIM62 Tbio Enzyme -0.57145 6.96 129
Glutathione synthetase GSS Tbio Enzyme -2.75264 568.9 200