Development Level

Tclin 44 | 612
Tchem 18 | 1,388
Tbio 16 | 11,651
Tdark 1 | 6,593

Collection

Ion Channel: IDG Consortium (T... 14 | 99
RFA-RM-18-021 13 | 328

IMPC Phenotype

preweaning lethality, complete... 4 | 979
increased startle reflex 3 | 112
abnormal epididymis morphology 2 | 42
decreased body weight 2 | 161
decreased heart weight 2 | 27
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal skin morphology 1 | 50
brachydactyly 1 | 19
cataract 1 | 92
decreased circulating glycerol... 1 | 16
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
small epididymis 1 | 3
syndactyly 1 | 23

Disease

Carcinoma 70 | 11,493
psoriasis 37 | 6,694
Schizophrenia 35 | 1,160
medulloblastoma, large-cell 35 | 6,241
atypical teratoid / rhabdoid tumor 33 | 5,112
glioblastoma 33 | 5,792
Kidney cancer 31 | 2,613
Epilepsy 30 | 792
ependymoma 30 | 4,679
Bipolar Disorder 28 | 666
adult high grade glioma 28 | 3,801
General anesthesia 27 | 53
group 3 medulloblastoma 25 | 4,104
Astrocytoma, Pilocytic 24 | 3,081
oligodendroglioma 23 | 2,850
primitive neuroectodermal tumor 23 | 3,035
astrocytic glioma 22 | 2,597
lung carcinoma 20 | 2,843
osteosarcoma 20 | 7,950
Alcoholic Intoxication, Chronic 19 | 289
Autistic Disorder 18 | 364
Depressive disorder 18 | 409
Tonic-clonic epilepsy 18 | 47
Autosomal recessive predisposition 17 | 1,442
Local anesthesia 17 | 40
Mental Depression 17 | 333
Nicotine dependence 17 | 54
lung cancer 16 | 4,740
Alcohol dependence 15 | 107
ovarian cancer 15 | 8,520
subependymal giant cell astrocytoma 15 | 2,287
Lennox-Gastaut syndrome 14 | 34
pituitary cancer 14 | 1,972
Breast cancer 13 | 3,578
Pick disease 13 | 1,894
Seizures 13 | 596
Simple partial seizure 13 | 26
Alcoholism 12 | 45
Intellectual disability 12 | 1,016
Liver cancer 12 | 604
Epilepsy characterized by intractable complex partial seizures 11 | 28
Irritable bowel syndrome 11 | 60
Migraine Prevention 11 | 23
Parkinson's disease 11 | 392
Major Depressive Disorder 10 | 301
Melanoma 10 | 711
Anxiety 9 | 136
Dull intelligence 9 | 645
Insomnia 9 | 20
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Mood Disorders 9 | 184
Panic disorder 9 | 61
Poor school performance 9 | 645
Sedation as Adjunct to Anesthesia 9 | 15
Chemotherapy-induced nausea and vomiting 8 | 18
Muscle hypotonia 8 | 571
Skin cancer 8 | 469
Spasticity 8 | 26
Toxic encephalopathy 8 | 141
Arteriosclerotic Parkinsonism 7 | 8
Benzodiazepine Induced Sedation 7 | 8
Benzodiazepine Maintained Anesthesia 7 | 8
Benzodiazepine Toxicity 7 | 8
Extrapyramidal disease 7 | 8
Frontal lobe epilepsy 7 | 10
Generalized anxiety disorder 7 | 29
Infantile onset 7 | 238
Influenza A Prevention 7 | 7
Influenza due to Influenza A virus 7 | 7
Muscle relaxation, function 7 | 8
Parkinsonism 7 | 18
Postencephalitic parkinsonism 7 | 12
Schizoaffective Disorder 7 | 55
Status Epilepticus 7 | 98
Substance Withdrawal Syndrome 7 | 55
Tetanus 7 | 68
interstitial cystitis 7 | 2,312
lung adenocarcinoma 7 | 2,716
ulcerative colitis 7 | 1,819
Alcohol withdrawal delirium 6 | 11
Alcohol withdrawal syndrome 6 | 20
Alzheimer's disease 6 | 658
Attention deficit hyperactivity disorder 6 | 278
Blepharoptosis 6 | 231
Byzanthine arch palate 6 | 194
Cocaine Dependence 6 | 51
Endometrial cancer 6 | 311
Induce Anterograde Amnesia 6 | 9
Multiple pterygium syndrome 6 | 18
Ophthalmoplegia 6 | 106
Partial Epilepsy Treatment Adjunct 6 | 16
Preoperative Anxiety 6 | 9
Sedation 6 | 11
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic cancer 6 | 2,398

Tissue

Endocrine System 75 | 18,159
Nervous System 70 | 16,725
Digestive Tract 68 | 17,369
Skin and soft tissues 64 | 17,230
Female tissues 63 | 17,400
Male tissues 62 | 17,142
Blood and immune system 59 | 16,909
Urinary Tract 57 | 16,678
Liver and Pancreas 56 | 16,750
Respiratory system 53 | 16,393
Cardiovascular System 43 | 15,192

Target Family

Ion Channel 79 | 344

UniProt Keyword

Ligand-gated ion channel 79 | 79
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-gated cation channel alpha-1 CNGA1 Tchem Ion Channel -1.86143 69.8 62
Glutamate receptor ionotropic, NMDA 2C GRIN2C Tclin Ion Channel -2.21470 153.6 208
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.57182 33.7 130
Glutamate receptor ionotropic, kainate 1 GRIK1 Tclin Ion Channel -2.44487 279.7 219
Glutamate receptor ionotropic, NMDA 2A GRIN2A Tclin Ion Channel -3.09828 1158.1 555
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
5-hydroxytryptamine receptor 3A HTR3A Tclin Ion Channel -3.38661 2426.7 262
P2X purinoceptor 6 P2RX6 Tbio Ion Channel -1.46307 26.2 147
Glutamate receptor 4 GRIA4 Tclin Ion Channel -2.43418 256.1 326
P2X purinoceptor 1 P2RX1 Tchem Ion Channel -2.41145 259.4 137