Development Level

Tchem 350 | 1,890
Tbio 202 | 10,625
Tclin 49 | 602
Tdark 36 | 7,003

Collection

Eligible Kinase Proteins 121 | 134

IMPC Term

preweaning lethality, complete... 28 | 633
preweaning lethality, incomple... 12 | 260
embryonic lethality prior to t... 10 | 187
abnormal behavior 9 | 226
decreased body weight 9 | 174
embryonic lethality prior to o... 9 | 148
abnormal embryo size 8 | 112
decreased bone mineral content 7 | 157
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
abnormal seminal vesicle morph... 5 | 47
decreased body length 5 | 108
decreased circulating glucose ... 5 | 121
decreased neutrophil cell numb... 5 | 37
increased bone mineral content 5 | 92
increased circulating alkaline... 5 | 119
increased lean body mass 5 | 107
small testis 5 | 37
abnormal bone structure 4 | 131
abnormal kidney morphology 4 | 30
abnormal lens morphology 4 | 73
decreased circulating serum al... 4 | 79
increased circulating choleste... 4 | 53
increased or absent threshold ... 4 | 128
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal forebrain development 3 | 18
abnormal gait 3 | 51
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
abnormal retina morphology 3 | 100
abnormal spleen morphology 3 | 36
abnormal testis morphology 3 | 30
decreased NK T cell number 3 | 28
decreased blood urea nitrogen ... 3 | 31
decreased bone mineral density 3 | 126
decreased circulating creatini... 3 | 31
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
decreased leukocyte cell numbe... 3 | 54
decreased lumbar vertebrae num... 3 | 62
enlarged heart 3 | 111
increased blood urea nitrogen ... 3 | 44
increased bone mineral density 3 | 52
increased circulating LDL chol... 3 | 15
increased circulating iron lev... 3 | 25
increased erythrocyte cell num... 3 | 26
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
microphthalmia 3 | 15
abnormal epididymis morphology 2 | 31
abnormal eye morphology 2 | 38
abnormal femur morphology 2 | 14
abnormal joint morphology 2 | 14
abnormal maxilla morphology 2 | 16
abnormal pelvic girdle bone mo... 2 | 11
abnormal response to tactile s... 2 | 16
abnormal retinal pigmentation 2 | 61
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
abnormal snout morphology 2 | 18
abnormal startle reflex 2 | 14
abnormal tooth morphology 2 | 24
decreased Ly6C high monocyte n... 2 | 18
decreased circulating HDL chol... 2 | 77
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating bilirubi... 2 | 14
decreased circulating choleste... 2 | 85
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased prepulse inhibition 2 | 52
enlarged epididymis 2 | 27
enlarged lymph nodes 2 | 27
female infertility 2 | 34
hydrops fetalis 2 | 22
improved glucose tolerance 2 | 56
increased NK cell number 2 | 19
increased circulating HDL chol... 2 | 63
increased circulating aspartat... 2 | 17
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mature B cell number 2 | 12
increased neutrophil cell numb... 2 | 15
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
short tibia 2 | 82
small superior vagus ganglion 2 | 20
thick ventricular wall 2 | 7
thrombocytopenia 2 | 46
tremors 2 | 34

Disease

osteosarcoma 350 | 7,933
ovarian cancer 341 | 8,484
medulloblastoma, large-cell 281 | 6,234
psoriasis 265 | 6,685
glioblastoma 236 | 5,572
lung cancer 195 | 4,466
atypical teratoid / rhabdoid tumor 193 | 4,369
Cancer 184 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 153 | 3,289
malignant mesothelioma 152 | 3,162
Carcinoma 151 | 2,147
Breast cancer 137 | 3,094
non-small cell lung cancer 137 | 2,798
primitive neuroectodermal tumor 132 | 3,031
pilocytic astrocytoma 131 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 126 | 2,956
ependymoma 123 | 2,514
invasive ductal carcinoma 121 | 2,950
oligodendroglioma 121 | 2,849
pediatric high grade glioma 121 | 2,712
lung carcinoma 115 | 2,844
lung adenocarcinoma 106 | 2,713
astrocytic glioma 100 | 2,241
pancreatic cancer 98 | 2,300
ulcerative colitis 97 | 2,087
group 3 medulloblastoma 92 | 2,254
Pick disease 91 | 1,893
subependymal giant cell astrocytoma 88 | 2,287
interstitial cystitis 86 | 2,299
adult high grade glioma 83 | 2,148
medulloblastoma 81 | 1,524
astrocytoma 77 | 1,493
group 4 medulloblastoma 75 | 1,875
pituitary cancer 75 | 1,972
posterior fossa group B ependymoma 72 | 1,530
cystic fibrosis 71 | 1,665
adrenocortical carcinoma 70 | 1,427
ductal carcinoma in situ 68 | 1,745
Renal Cell Carcinoma 66 | 199
breast carcinoma 64 | 1,614
colon cancer 62 | 1,475
tuberculosis 61 | 1,557
diabetes mellitus 60 | 1,663
primary pancreatic ductal adenocarcinoma 60 | 1,271
Rheumatoid Arthritis 58 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,795
sonic hedgehog group medulloblastoma 55 | 1,482
Chronic Myelocytic Leukemia Accelerated Phase 54 | 59
posterior fossa group A ependymoma 54 | 1,511
Blastic phase chronic myeloid leukemia 53 | 58
spina bifida 51 | 1,064
atypical teratoid/rhabdoid tumor 49 | 1,095
Gastrointestinal stromal tumor 47 | 61
juvenile dermatomyositis 47 | 1,189
acute quadriplegic myopathy 45 | 1,157
Multiple myeloma 42 | 1,327
Pancreatic Neuroendocrine Tumor 42 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 42 | 47
Chronic phase chronic myeloid leukemia 40 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 40 | 45
dermatomyositis 39 | 933
nasopharyngeal carcinoma 39 | 1,056
Hamman-Rich syndrome 35 | 35
cutaneous lupus erythematosus 35 | 1,056
esophageal adenocarcinoma 35 | 737
primary Sjogren syndrome 35 | 789
progressive supranuclear palsy 34 | 674
Waldenstrons macroglobulinemia 32 | 765
aldosterone-producing adenoma 32 | 664
Down syndrome 31 | 548
tuberculosis and treatment for 6 months 31 | 686
Atopic dermatitis 30 | 944
Schizophrenia 30 | 501
Alzheimer's disease 29 | 644
Mammary Neoplasms 29 | 410
Obesity 29 | 616
IGA Glomerulonephritis 28 | 454
gastric carcinoma 28 | 832
Intellectual disability 27 | 573
Prostatic Neoplasms 27 | 471
acute myeloid leukemia 27 | 780
Amyotrophic Lateral Sclerosis 26 | 431
Endometriosis 25 | 535
Parkinson's disease 25 | 364
Peripheral Neuropathy 25 | 303
non-small cell lung carcinoma 24 | 413
Neurodegenerative disease 23 | 383
Vascular disease 23 | 281
active Crohn's disease 23 | 918
pancreatic carcinoma 22 | 567
fibroadenoma 21 | 557
Lung Neoplasms 20 | 171
Melanoma 20 | 261
non primary Sjogren syndrome sicca 20 | 840
Chronic Lymphocytic Leukemia 19 | 242
Colorectal Neoplasms 19 | 217
Hypertension 18 | 287
Kidney disease 17 | 396
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499

Tissue

Blood and immune system 626 | 17,995
Endocrine System 626 | 18,512
Liver and Pancreas 626 | 18,136
Nervous System 626 | 18,561
Cardiovascular System 625 | 17,958
Digestive Tract 625 | 18,473
Female tissues 625 | 18,647
Urinary Tract 625 | 18,444
Male tissues 624 | 17,969
Respiratory system 618 | 17,484
Skin and soft tissues 616 | 18,115

Target Family

Kinase 592 | 634
Enzyme 40 | 4,146
Non-IDG 3 | 11,971
Epigenetic 1 | 242
Ion Channel 1 | 341

UniProt Keyword

Kinase 637 | 637
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Inositol-trisphosphate 3-kinase B ITPKB Tbio Kinase -1.40405 29.1 141
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Calcium/calmodulin-dependent protein kinase type 1D CAMK1D Tchem Kinase -1.06137 12.5 282
Calcium/calmodulin-dependent protein kinase type 1B PNCK Tbio Kinase -1.08940 47.1 143
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104