Development Level

Tchem 334 | 1,388
Tbio 215 | 11,651
Tclin 51 | 612
Tdark 37 | 6,593

Collection

Kinase: IDG Consortium (Target... 115 | 125
Kinase: IDG Consortium (Comple... 36 | 37

IMPC Phenotype

preweaning lethality, complete... 42 | 979
preweaning lethality, incomple... 28 | 499
abnormal embryo size 18 | 220
embryonic lethality prior to t... 18 | 278
embryonic lethality prior to o... 17 | 239
abnormal behavior 12 | 298
abnormal bone structure 12 | 187
increased bone mineral content 9 | 108
decreased vertical activity 8 | 208
embryonic growth retardation 8 | 106
enlarged heart 8 | 210
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
increased bone mineral density 7 | 72
abnormal seminal vesicle morph... 6 | 114
decreased bone mineral content 6 | 151
increased circulating alkaline... 6 | 122
increased lean body mass 6 | 172
abnormal spleen morphology 5 | 55
decreased circulating glucose ... 5 | 126
decreased leukocyte cell numbe... 5 | 73
decreased lymphocyte cell numb... 5 | 83
decreased prepulse inhibition 5 | 82
increased circulating choleste... 5 | 66
increased heart weight 5 | 62
increased or absent threshold ... 5 | 101
increased total body fat amoun... 5 | 134
small testis 5 | 58
abnormal behavioral response t... 4 | 66
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
abnormal kidney morphology 4 | 65
abnormal lens morphology 4 | 81
abnormal neural tube closure 4 | 46
decreased blood urea nitrogen ... 4 | 51
decreased body length 4 | 101
decreased fasted circulating g... 4 | 65
decreased lean body mass 4 | 135
decreased neutrophil cell numb... 4 | 42
decreased startle reflex 4 | 75
enlarged lymph nodes 4 | 37
hyperactivity 4 | 148
increased circulating HDL chol... 4 | 80
increased mean corpuscular vol... 4 | 92
increased monocyte cell number 4 | 63
male infertility 4 | 123
abnormal epididymis morphology 3 | 42
abnormal midbrain development 3 | 20
abnormal skin morphology 3 | 50
abnormal testis morphology 3 | 43
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating serum al... 3 | 82
decreased hematocrit 3 | 46
decreased hemoglobin content 3 | 68
decreased large unstained cell... 3 | 11
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
enlarged epididymis 3 | 31
enlarged spleen 3 | 41
improved glucose tolerance 3 | 79
increased blood urea nitrogen ... 3 | 48
increased body length 3 | 32
increased circulating LDL chol... 3 | 13
increased circulating iron lev... 3 | 30
increased circulating sodium l... 3 | 71
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased mean platelet volume 3 | 45
increased startle reflex 3 | 112
microphthalmia 3 | 26
small superior vagus ganglion 3 | 74
thrombocytopenia 3 | 56
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal eye morphology 2 | 68
abnormal retina morphology 2 | 71
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating fructosa... 2 | 30
decreased circulating magnesiu... 2 | 13
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased grip strength 2 | 116
impaired glucose tolerance 2 | 75
increased circulating aspartat... 2 | 15
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
short tibia 2 | 97
thin ventricular wall 2 | 24
thrombocytosis 2 | 27
tremors 2 | 39

Disease

Carcinoma 517 | 11,493
osteosarcoma 351 | 7,950
ovarian cancer 351 | 8,520
medulloblastoma, large-cell 283 | 6,241
psoriasis 265 | 6,694
glioblastoma 249 | 5,792
atypical teratoid / rhabdoid tumor 231 | 5,112
lung cancer 215 | 4,740
ependymoma 211 | 4,679
Cancer 193 | 2,499
group 3 medulloblastoma 171 | 4,104
Kidney cancer 167 | 2,613
adult high grade glioma 162 | 3,801
Breast cancer 158 | 3,578
malignant mesothelioma 158 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 154 | 3,291
non-small cell lung cancer 138 | 2,890
primitive neuroectodermal tumor 134 | 3,035
Astrocytoma, Pilocytic 133 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 130 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 126 | 2,955
invasive ductal carcinoma 122 | 2,951
oligodendroglioma 122 | 2,850
astrocytic glioma 119 | 2,597
lung carcinoma 116 | 2,843
lung adenocarcinoma 107 | 2,716
pancreatic cancer 105 | 2,398
Pick disease 92 | 1,894
subependymal giant cell astrocytoma 90 | 2,287
ulcerative colitis 89 | 1,819
interstitial cystitis 87 | 2,312
group 4 medulloblastoma 85 | 1,855
tuberculosis 84 | 2,010
pituitary cancer 76 | 1,972
cystic fibrosis 75 | 1,696
Autosomal recessive predisposition 73 | 1,442
adrenocortical carcinoma 71 | 1,428
Renal Cell Carcinoma 70 | 214
breast carcinoma 69 | 1,638
ductal carcinoma in situ 69 | 1,745
Schizophrenia 68 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 68 | 1,962
diabetes mellitus 64 | 1,728
colon cancer 63 | 1,478
astrocytoma 61 | 1,146
Rheumatoid arthritis 59 | 1,191
Chronic Myelocytic Leukemia Accelerated Phase 54 | 59
Blastic phase chronic myeloid leukemia 53 | 58
Intellectual disability 52 | 1,016
spina bifida 51 | 1,074
primary pancreatic ductal adenocarcinoma 50 | 1,109
Gastrointestinal stromal tumor 47 | 62
juvenile dermatomyositis 47 | 1,187
acute quadriplegic myopathy 45 | 1,158
pediatric high grade glioma 45 | 1,064
Multiple myeloma 44 | 1,332
Dull intelligence 42 | 645
Epilepsy 42 | 792
Low intelligence 42 | 645
Mental Retardation 42 | 645
Mental deficiency 42 | 645
Pancreatic Neuroendocrine Tumor 42 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 42 | 47
Poor school performance 42 | 645
Liver cancer 41 | 604
nasopharyngeal carcinoma 41 | 1,058
Chronic phase chronic myeloid leukemia 40 | 45
Melanoma 40 | 711
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 40 | 45
dermatomyositis 39 | 966
Bipolar Disorder 36 | 666
cutaneous lupus erythematosus 35 | 1,057
esophageal adenocarcinoma 35 | 737
primary Sjogren syndrome 35 | 735
Cognitive delay 34 | 608
Global developmental delay 34 | 608
Hamman-Rich syndrome 34 | 34
Mental and motor retardation 34 | 608
Seizures 34 | 596
progressive supranuclear palsy 34 | 676
medulloblastoma 33 | 720
Alzheimer's disease 32 | 658
Short stature 32 | 531
Waldenstrons macroglobulinemia 32 | 765
aldosterone-producing adenoma 32 | 665
Breast Neoplasms 31 | 445
Obesity 31 | 678
Atopic dermatitis 30 | 952
Mammary Neoplasms 30 | 425
Prostatic Neoplasms 30 | 495
Skin cancer 30 | 469
Small head 30 | 374
gastric carcinoma 30 | 807
Down syndrome 29 | 499
Liver Cirrhosis, Experimental 29 | 769
Hypoplastic mandible condyle 28 | 275
Mandibular hypoplasia 28 | 275
Micrognathism 28 | 275
acute myeloid leukemia 28 | 783
Endometriosis 27 | 540

Tissue

Endocrine System 627 | 18,159
Digestive Tract 615 | 17,369
Male tissues 615 | 17,142
Skin and soft tissues 614 | 17,230
Female tissues 613 | 17,400
Liver and Pancreas 608 | 16,750
Blood and immune system 606 | 16,909
Urinary Tract 606 | 16,678
Nervous System 605 | 16,725
Respiratory system 601 | 16,393
Cardiovascular System 583 | 15,192

Target Family

Kinase 592 | 634
Enzyme 40 | 4,145
Non-IDG 3 | 12,091
Epigenetic 1 | 242
Ion Channel 1 | 344

UniProt Keyword

Kinase 637 | 637
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Serine/threonine-protein kinase DCLK2 DCLK2 Tchem Kinase -0.89222 8.01 148
Serine/threonine-protein kinase 3 STK3 Tchem Kinase -1.13339 11.3 303
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Alpha-protein kinase 3 ALPK3 Tdark Kinase -0.76736 5.46 37
Ephrin type-A receptor 6 EPHA6 Tchem Kinase -1.34848 21.8 266
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Serine/threonine-protein kinase DCLK3 DCLK3 Tchem Kinase -2.33084 205.9 71