Development Level

Tbio 768 | 10,625
Tdark 170 | 7,003
Tchem 127 | 1,890
Tclin 47 | 602

Collection

Eligible Ion Channel Proteins 3 | 117
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 62 | 633
preweaning lethality, incomple... 24 | 260
decreased body weight 22 | 174
embryonic lethality prior to o... 19 | 148
embryonic lethality prior to t... 19 | 187
abnormal behavior 16 | 226
decreased lean body mass 16 | 195
decreased total body fat amoun... 16 | 186
decreased bone mineral content 15 | 157
decreased body length 13 | 108
abnormal bone structure 11 | 131
abnormal embryo size 10 | 112
abnormal retina morphology 10 | 100
decreased bone mineral density 10 | 126
decreased grip strength 9 | 123
increased lean body mass 9 | 107
hyperactivity 8 | 108
increased grip strength 8 | 83
decreased mean corpuscular vol... 7 | 50
increased bone mineral content 7 | 92
increased circulating HDL chol... 7 | 63
increased circulating alkaline... 7 | 119
increased circulating choleste... 7 | 53
increased or absent threshold ... 7 | 128
abnormal bone mineralization 6 | 55
abnormal sleep behavior 6 | 63
decreased circulating choleste... 6 | 85
decreased circulating glucose ... 6 | 121
decreased leukocyte cell numbe... 6 | 54
increased mean corpuscular vol... 6 | 91
prenatal lethality prior to he... 6 | 64
abnormal retinal pigmentation 5 | 61
decreased circulating LDL chol... 5 | 37
decreased circulating serum al... 5 | 79
decreased fasted circulating g... 5 | 49
improved glucose tolerance 5 | 56
increased blood urea nitrogen ... 5 | 44
increased bone mineral density 5 | 52
increased circulating triglyce... 5 | 24
increased fasted circulating g... 5 | 68
thrombocytopenia 5 | 46
abnormal behavioral response t... 4 | 52
abnormal lens morphology 4 | 73
decreased caudal vertebrae num... 4 | 49
decreased circulating HDL chol... 4 | 77
decreased circulating free fat... 4 | 39
decreased circulating insulin ... 4 | 75
decreased circulating iron lev... 4 | 25
decreased circulating triglyce... 4 | 83
decreased hemoglobin content 4 | 53
decreased lymphocyte cell numb... 4 | 9
decreased prepulse inhibition 4 | 52
decreased startle reflex 4 | 48
hypoactivity 4 | 89
increased heart weight 4 | 37
increased hematocrit 4 | 36
increased mean corpuscular hem... 4 | 93
persistence of hyaloid vascula... 4 | 22
polydactyly 4 | 22
short tibia 4 | 82
abnormal coat appearance 3 | 25
abnormal coat/ hair morphology 3 | 18
abnormal coping response 3 | 12
abnormal cornea morphology 3 | 24
abnormal digit morphology 3 | 13
abnormal gait 3 | 51
abnormal neural tube closure 3 | 37
abnormal tooth morphology 3 | 24
corneal opacity 3 | 25
decreased B cell number 3 | 30
decreased KLRG1+ CD8 alpha bet... 3 | 8
decreased Ly6C low monocyte nu... 3 | 23
decreased anxiety-related resp... 3 | 12
decreased circulating alkaline... 3 | 41
decreased circulating bilirubi... 3 | 14
decreased circulating total pr... 3 | 41
decreased lumbar vertebrae num... 3 | 62
decreased monocyte cell number 3 | 28
decreased neutrophil cell numb... 3 | 37
decreased rib number 3 | 59
decreased total retina thickne... 3 | 20
increased body weight 3 | 42
increased circulating amylase ... 3 | 13
increased circulating aspartat... 3 | 17
increased circulating phosphat... 3 | 24
increased circulating sodium l... 3 | 71
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased sacral vertebrae num... 3 | 62
limb grasping 3 | 35
male infertility 3 | 62
thrombocytosis 3 | 23
tremors 3 | 34
abnormal vocalization 2 | 21
decreased T cell number 2 | 31
decreased circulating calcium ... 2 | 33
decreased heart weight 2 | 44
increased blood uric acid leve... 2 | 5
increased circulating iron lev... 2 | 25
straub tail 2 | 26

Disease

ovarian cancer 662 | 8,484
osteosarcoma 549 | 7,933
psoriasis 447 | 6,685
medulloblastoma, large-cell 432 | 6,234
glioblastoma 376 | 5,572
lung cancer 376 | 4,466
atypical teratoid / rhabdoid tumor 318 | 4,369
Cancer 301 | 2,346
Breast cancer 282 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 244 | 3,289
primitive neuroectodermal tumor 241 | 3,031
malignant mesothelioma 236 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 215 | 2,988
Carcinoma 214 | 2,147
oligodendroglioma 205 | 2,849
invasive ductal carcinoma 201 | 2,950
lung adenocarcinoma 193 | 2,713
pediatric high grade glioma 192 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 190 | 2,956
ependymoma 189 | 2,514
group 3 medulloblastoma 186 | 2,254
non-small cell lung cancer 184 | 2,798
Pick disease 172 | 1,893
Multiple myeloma 165 | 1,327
pancreatic cancer 165 | 2,300
astrocytic glioma 160 | 2,241
acute quadriplegic myopathy 159 | 1,157
subependymal giant cell astrocytoma 158 | 2,287
pilocytic astrocytoma 152 | 3,086
astrocytoma 146 | 1,493
group 4 medulloblastoma 143 | 1,875
dermatomyositis 133 | 933
lung carcinoma 133 | 2,844
juvenile dermatomyositis 132 | 1,189
breast carcinoma 131 | 1,614
ulcerative colitis 128 | 2,087
adult high grade glioma 126 | 2,148
colon cancer 124 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 124 | 1,795
Rheumatoid Arthritis 121 | 1,160
diabetes mellitus 120 | 1,663
ductal carcinoma in situ 117 | 1,745
pituitary cancer 117 | 1,972
Waldenstrons macroglobulinemia 111 | 765
sonic hedgehog group medulloblastoma 110 | 1,482
medulloblastoma 105 | 1,524
primary pancreatic ductal adenocarcinoma 104 | 1,271
posterior fossa group A ependymoma 101 | 1,511
adrenocortical carcinoma 98 | 1,427
tuberculosis 97 | 1,557
acute myeloid leukemia 93 | 780
interstitial cystitis 90 | 2,299
cystic fibrosis 89 | 1,665
progressive supranuclear palsy 81 | 674
spina bifida 72 | 1,064
atypical teratoid/rhabdoid tumor 69 | 1,095
nasopharyngeal carcinoma 69 | 1,056
Mammary Neoplasms 68 | 410
Intellectual disability 67 | 573
tuberculosis and treatment for 6 months 66 | 686
Amyotrophic Lateral Sclerosis 65 | 431
posterior fossa group B ependymoma 65 | 1,530
cutaneous lupus erythematosus 59 | 1,056
Atopic dermatitis 56 | 944
Alzheimer's disease 55 | 644
non primary Sjogren syndrome sicca 54 | 840
gastric cancer 52 | 430
gastric carcinoma 52 | 832
Endometriosis 50 | 535
hepatocellular carcinoma 49 | 532
Down syndrome 48 | 548
primary Sjogren syndrome 48 | 789
autosomal dominant Emery-Dreifuss muscular dystrophy 47 | 499
esophageal adenocarcinoma 47 | 737
Schizophrenia 45 | 501
Prostatic Neoplasms 44 | 471
aldosterone-producing adenoma 44 | 664
pancreatic carcinoma 41 | 567
active Crohn's disease 40 | 918
Obesity 39 | 616
Duchenne muscular dystrophy 38 | 602
Neurodegenerative disease 36 | 383
Liver carcinoma 34 | 217
Kidney disease 33 | 396
Multiple Sclerosis 33 | 498
Stomach Neoplasms 32 | 282
fibroadenoma 32 | 557
non-small cell lung carcinoma 32 | 413
IGA Glomerulonephritis 31 | 454
sarcoidosis 31 | 358
Parkinson's disease 30 | 364
hereditary spastic paraplegia 30 | 313
glioblastoma multiforme 28 | 347
Autistic Disorder 27 | 320
Crohn's disease 27 | 304
Epilepsy 27 | 346
chronic rhinosinusitis 27 | 512
Vascular disease 26 | 281
chronic lymphosyte leukemia 26 | 232
Becker muscular dystrophy 25 | 187

Tissue

Blood and immune system 1,091 | 17,995
Female tissues 1,091 | 18,647
Nervous System 1,091 | 18,561
Cardiovascular System 1,089 | 17,958
Digestive Tract 1,088 | 18,473
Endocrine System 1,088 | 18,512
Liver and Pancreas 1,088 | 18,136
Male tissues 1,088 | 17,969
Urinary Tract 1,087 | 18,444
Respiratory system 1,080 | 17,484
Skin and soft tissues 1,068 | 18,115

Target Family

Non-IDG 611 | 11,971
Transcription Factor 220 | 1,400
Enzyme 135 | 4,146
Epigenetic 60 | 242
Kinase 34 | 634
TF/Epigenetic 15 | 38
Nuclear Receptor 14 | 48
Ion Channel 13 | 341
Transporter 7 | 473
GPCR 3 | 406

UniProt Keyword

Isopeptide bond 1,112 | 1,112
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277