Development Level

Tbio 1,241 | 11,651
Tdark 311 | 6,593
Tchem 135 | 1,388
Tclin 52 | 612

Collection

Kinase: IDG Consortium (Comple... 4 | 37
Kinase: IDG Consortium (Target... 4 | 125
Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

preweaning lethality, complete... 174 | 979
preweaning lethality, incomple... 53 | 499
embryonic lethality prior to o... 37 | 239
embryonic lethality prior to t... 37 | 278
abnormal embryo size 36 | 220
abnormal behavior 32 | 298
decreased body weight 24 | 161
decreased total body fat amoun... 22 | 207
increased lean body mass 20 | 172
abnormal bone structure 19 | 187
increased startle reflex 18 | 112
hypoactivity 15 | 132
abnormal heart morphology 14 | 162
decreased lean body mass 14 | 135
enlarged heart 14 | 210
increased bone mineral density 14 | 72
decreased vertical activity 13 | 208
hyperactivity 13 | 148
increased circulating alkaline... 13 | 122
increased total body fat amoun... 13 | 134
decreased circulating glucose ... 12 | 126
decreased prepulse inhibition 12 | 82
embryonic growth retardation 12 | 106
increased circulating HDL chol... 12 | 80
increased mean corpuscular vol... 12 | 92
male infertility 12 | 123
increased mean corpuscular hem... 11 | 96
prenatal lethality prior to he... 11 | 87
decreased bone mineral content 10 | 151
decreased bone mineral density 10 | 126
decreased circulating HDL chol... 10 | 68
decreased circulating serum al... 10 | 82
decreased circulating triglyce... 10 | 79
decreased grip strength 10 | 116
decreased lymphocyte cell numb... 10 | 83
decreased body length 9 | 101
decreased circulating alanine ... 9 | 47
decreased circulating choleste... 9 | 93
decreased leukocyte cell numbe... 9 | 73
decreased mean corpuscular vol... 9 | 79
increased fasted circulating g... 9 | 76
increased or absent threshold ... 9 | 101
small superior vagus ganglion 9 | 74
abnormal cornea morphology 8 | 31
abnormal neural tube closure 8 | 46
increased bone mineral content 8 | 108
increased circulating choleste... 8 | 66
increased grip strength 8 | 41
increased monocyte cell number 8 | 63
increased neutrophil cell numb... 8 | 46
abnormal coat-hair pigmentatio... 7 | 64
abnormal gait 7 | 69
abnormal seminal vesicle morph... 7 | 114
cataract 7 | 92
decreased blood urea nitrogen ... 7 | 51
edema 7 | 59
female infertility 7 | 60
increased mean platelet volume 7 | 45
small testis 7 | 58
abnormal bone mineralization 6 | 38
abnormal retina morphology 6 | 71
abnormal spleen morphology 6 | 55
corneal opacity 6 | 32
decreased caudal vertebrae num... 6 | 53
decreased circulating insulin ... 6 | 76
decreased erythrocyte cell num... 6 | 62
decreased hemoglobin content 6 | 68
decreased red blood cell distr... 6 | 41
improved glucose tolerance 6 | 79
increased body weight 6 | 25
increased circulating triglyce... 6 | 42
increased mean corpuscular hem... 6 | 36
pallor 6 | 34
thrombocytopenia 6 | 56
abnormal lens morphology 5 | 81
decreased circulating LDL chol... 5 | 38
decreased fasted circulating g... 5 | 65
decreased hematocrit 5 | 46
decreased mean corpuscular hem... 5 | 31
decreased neutrophil cell numb... 5 | 42
hemorrhage 5 | 23
increased blood urea nitrogen ... 5 | 48
increased circulating iron lev... 5 | 30
increased heart weight 5 | 62
increased hematocrit 5 | 46
increased hemoglobin content 5 | 45
increased lymphocyte cell numb... 5 | 32
increased vertical activity 5 | 24
persistence of hyaloid vascula... 5 | 33
short tibia 5 | 97
thrombocytosis 5 | 27
tremors 5 | 39
abnormal locomotor behavior 4 | 24
abnormal retinal vasculature m... 4 | 27
anophthalmia 4 | 33
decreased circulating iron lev... 4 | 32
decreased startle reflex 4 | 75
impaired glucose tolerance 4 | 75
increased circulating chloride... 4 | 41
increased circulating phosphat... 4 | 26

Disease

Carcinoma 1,265 | 11,493
ovarian cancer 1,035 | 8,520
osteosarcoma 891 | 7,950
medulloblastoma, large-cell 665 | 6,241
psoriasis 642 | 6,694
lung cancer 611 | 4,740
glioblastoma 587 | 5,792
group 3 medulloblastoma 551 | 4,104
atypical teratoid / rhabdoid tumor 531 | 5,112
Breast cancer 450 | 3,578
ependymoma 448 | 4,679
Cancer 427 | 2,499
malignant mesothelioma 370 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 362 | 3,291
primitive neuroectodermal tumor 359 | 3,035
Kidney cancer 344 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 329 | 2,989
adult high grade glioma 313 | 3,801
oligodendroglioma 302 | 2,850
invasive ductal carcinoma 293 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 283 | 2,955
non-small cell lung cancer 278 | 2,890
lung adenocarcinoma 277 | 2,716
astrocytic glioma 263 | 2,597
Multiple myeloma 258 | 1,332
pancreatic cancer 244 | 2,398
Pick disease 239 | 1,894
acute quadriplegic myopathy 223 | 1,158
subependymal giant cell astrocytoma 214 | 2,287
diabetes mellitus 202 | 1,728
Astrocytoma, Pilocytic 201 | 3,081
group 4 medulloblastoma 196 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 196 | 1,962
breast carcinoma 185 | 1,638
juvenile dermatomyositis 185 | 1,187
dermatomyositis 184 | 966
Waldenstrons macroglobulinemia 183 | 765
tuberculosis 181 | 2,010
Rheumatoid arthritis 179 | 1,191
Intellectual disability 174 | 1,016
lung carcinoma 174 | 2,843
astrocytoma 170 | 1,146
colon cancer 170 | 1,478
pituitary cancer 166 | 1,972
ductal carcinoma in situ 160 | 1,745
ulcerative colitis 152 | 1,819
adrenocortical carcinoma 150 | 1,428
acute myeloid leukemia 136 | 783
pediatric high grade glioma 135 | 1,064
primary pancreatic ductal adenocarcinoma 131 | 1,109
interstitial cystitis 129 | 2,312
cystic fibrosis 119 | 1,696
Schizophrenia 116 | 1,160
nasopharyngeal carcinoma 113 | 1,058
progressive supranuclear palsy 108 | 676
Autosomal recessive predisposition 107 | 1,442
Dull intelligence 107 | 645
Low intelligence 107 | 645
Mental Retardation 107 | 645
Mental deficiency 107 | 645
Poor school performance 107 | 645
spina bifida 104 | 1,074
Breast Neoplasms 94 | 445
Short stature 94 | 531
Mammary Neoplasms 91 | 425
Amyotrophic lateral sclerosis 87 | 451
Epilepsy 87 | 792
Cognitive delay 84 | 608
Global developmental delay 84 | 608
Mental and motor retardation 84 | 608
non primary Sjogren syndrome sicca 81 | 891
cutaneous lupus erythematosus 79 | 1,057
hepatocellular carcinoma 79 | 547
Alzheimer's disease 77 | 658
Atopic dermatitis 77 | 952
Muscle hypotonia 77 | 571
gastric cancer 76 | 459
Small head 75 | 374
aldosterone-producing adenoma 74 | 665
medulloblastoma 72 | 720
Liver cancer 71 | 604
Endometriosis 70 | 540
Prostatic Neoplasms 70 | 495
Obesity 69 | 678
tuberculosis and treatment for 6 months 69 | 409
primary Sjogren syndrome 67 | 735
autosomal dominant Emery-Dreifuss muscular dystrophy 66 | 510
Seizures 65 | 596
gastric carcinoma 65 | 807
active Crohn's disease 62 | 922
Bipolar Disorder 60 | 666
pancreatic carcinoma 59 | 562
esophageal adenocarcinoma 55 | 737
Hypoplastic mandible condyle 54 | 275
Liver Cirrhosis, Experimental 54 | 769
Mandibular hypoplasia 54 | 275
Micrognathism 54 | 275
Stomach Neoplasms 54 | 300
Melanoma 53 | 711
Strabismus 53 | 270

Tissue

Endocrine System 1,707 | 18,159
Female tissues 1,699 | 17,400
Digestive Tract 1,696 | 17,369
Skin and soft tissues 1,696 | 17,230
Nervous System 1,694 | 16,725
Male tissues 1,692 | 17,142
Blood and immune system 1,691 | 16,909
Urinary Tract 1,686 | 16,678
Liver and Pancreas 1,684 | 16,750
Respiratory system 1,683 | 16,393
Cardiovascular System 1,659 | 15,192

Target Family

Non-IDG 940 | 12,091
Transcription Factor 411 | 1,400
Enzyme 199 | 4,145
Epigenetic 96 | 242
Kinase 41 | 634
TF/Epigenetic 20 | 38
Nuclear Receptor 15 | 48
Ion Channel 11 | 344
Transporter 4 | 473
GPCR 2 | 408

UniProt Keyword

Isopeptide bond 1,739 | 1,739
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pre-mRNA-splicing factor CWC25 homolog CWC25 Tdark Non-IDG -0.71222 5.53 18
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
Zinc finger protein 561 ZNF561 Tdark Transcription Factor 0.00000 36
Zinc finger protein 808 ZNF808 Tdark Transcription Factor 0.00000 1.00 0