Development Level

Tbio 75 | 11,445
Tchem 23 | 1,598
Tdark 17 | 6,588
Tclin 6 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 4 | 499
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
embryonic growth retardation 2 | 106
increased leukocyte cell numbe... 2 | 47
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal pupil morphology 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
absent pinna reflex 1 | 23
corneal opacity 1 | 32
decreased B cell number 1 | 5
decreased basophil cell number 1 | 16
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87

Disease

ovarian cancer 64 | 8,520
Carcinoma 58 | 11,493
osteosarcoma 43 | 7,950
lung cancer 39 | 4,740
psoriasis 38 | 6,694
glioblastoma 36 | 5,792
medulloblastoma, large-cell 34 | 6,241
ependymoma 32 | 4,679
group 3 medulloblastoma 31 | 4,104
atypical teratoid / rhabdoid tumor 29 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
Breast cancer 25 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
malignant mesothelioma 25 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,962
Astrocytoma, Pilocytic 24 | 3,081
non-small cell lung cancer 24 | 2,890
adult high grade glioma 23 | 3,801
pancreatic cancer 23 | 2,398
Cancer 22 | 2,499
lung adenocarcinoma 22 | 2,716
Autosomal recessive predisposition 18 | 1,442
invasive ductal carcinoma 18 | 2,951
Pick disease 16 | 1,894
Rheumatoid arthritis 15 | 1,191
group 4 medulloblastoma 15 | 1,855
pituitary cancer 15 | 1,972
astrocytic glioma 14 | 2,597
ductal carcinoma in situ 14 | 1,745
subependymal giant cell astrocytoma 14 | 2,287
tuberculosis 14 | 2,010
Multiple myeloma 12 | 1,332
diabetes mellitus 12 | 1,728
lung carcinoma 12 | 2,843
oligodendroglioma 12 | 2,850
primitive neuroectodermal tumor 12 | 3,035
ulcerative colitis 12 | 1,819
colon cancer 11 | 1,478
Atopic dermatitis 10 | 952
Bipolar Disorder 10 | 666
Intellectual disability 10 | 1,016
Muscle hypotonia 10 | 571
Prostatic Neoplasms 10 | 495
Schizophrenia 10 | 1,160
active Crohn's disease 10 | 922
acute quadriplegic myopathy 10 | 1,158
adrenocortical carcinoma 10 | 1,428
astrocytoma 10 | 1,146
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Waldenstrons macroglobulinemia 9 | 765
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
interstitial cystitis 9 | 2,312
pancreatic carcinoma 9 | 562
pediatric high grade glioma 9 | 1,064
Failure to gain weight 8 | 365
Pediatric failure to thrive 8 | 365
juvenile dermatomyositis 8 | 1,187
Dull intelligence 7 | 645
Kidney cancer 7 | 2,613
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Osteoporosis 7 | 363
Poor school performance 7 | 645
Prevention of Cardiac Transplant Rejection 7 | 15
Prevention of Kidney Transplant Rejection 7 | 17
Prevention of Liver Transplant Rejection 7 | 15
acute myeloid leukemia 7 | 783
dermatomyositis 7 | 966
gastric carcinoma 7 | 807
non primary Sjogren syndrome sicca 7 | 891
primary pancreatic ductal adenocarcinoma 7 | 1,109
progressive supranuclear palsy 7 | 676
Hepatomegaly 6 | 285
Polycystic ovary syndrome 6 | 360
Stomach Neoplasms 6 | 300
esophageal adenocarcinoma 6 | 737
spina bifida 6 | 1,074
Acquired scoliosis 5 | 281
Cerebellar Ataxia 5 | 304
Congenital disorder of glycosylation 5 | 54
Curvature of spine 5 | 282
Diarrhea 5 | 253
Duchenne muscular dystrophy 5 | 601
Epilepsy 5 | 792
Highly variable clinical phenotype 5 | 150
Highly variable phenotype and severity 5 | 150
Highly variable phenotype, even within families 5 | 150
Liver Cirrhosis, Experimental 5 | 769
Phenotypic variability 5 | 150
Short stature 5 | 531
Splenomegaly 5 | 190
Vomiting 5 | 116
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
gastric cancer 5 | 459

Tissue

Endocrine System 119 | 18,159
Skin and soft tissues 118 | 17,230
Digestive Tract 117 | 17,369
Nervous System 117 | 16,725
Blood and immune system 116 | 16,909
Female tissues 116 | 17,400
Male tissues 116 | 17,142
Liver and Pancreas 114 | 16,750
Urinary Tract 112 | 16,678
Respiratory system 111 | 16,393
Cardiovascular System 108 | 15,192

Target Family

Enzyme 113 | 4,145
Non-IDG 7 | 12,091
Kinase 1 | 634

UniProt Keyword

Isomerase 121 | 121
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Peptidyl-prolyl cis-trans isomerase FKBP7 FKBP7 Tbio Enzyme -1.41965 24.7 112
Dermatan-sulfate epimerase DSE Tbio Enzyme -2.57112 360.0 44
DNA topoisomerase 3-beta-1 TOP3B Tbio Enzyme -1.06981 9.54 153
Methylthioribose-1-phosphate isomerase MRI1 Tbio Enzyme -2.37285 221.6 146
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.62147 370.7 267
tRNA pseudouridine synthase A PUS1 Tbio Enzyme -1.66676 46.4 119
Pseudouridylate synthase 7 homolog PUS7 Tbio Enzyme -1.01773 8.78 58
Peptidyl-prolyl cis-trans isomerase FKBP14 FKBP14 Tbio Enzyme -1.72246 54.5 157
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Peptidyl-prolyl cis-trans isomerase A-like 4C PPIAL4C Tdark Enzyme 0.15 0.70 5