Development Level

Tbio 195 | 11,651
Tchem 58 | 1,388
Tclin 33 | 612
Tdark 33 | 6,593

IMPC Phenotype

preweaning lethality, complete... 24 | 979
abnormal behavior 13 | 298
preweaning lethality, incomple... 12 | 499
cataract 8 | 92
decreased vertical activity 8 | 208
embryonic lethality prior to t... 8 | 278
enlarged heart 8 | 210
abnormal bone structure 7 | 187
hypoactivity 7 | 132
abnormal seminal vesicle morph... 6 | 114
decreased bone mineral content 6 | 151
decreased total body fat amoun... 6 | 207
embryonic lethality prior to o... 6 | 239
hyperactivity 6 | 148
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
abnormal lens morphology 5 | 81
decreased bone mineral density 5 | 126
abnormal retinal blood vessel ... 4 | 26
decreased blood urea nitrogen ... 4 | 51
decreased circulating iron lev... 4 | 32
decreased circulating phosphat... 4 | 27
decreased circulating serum al... 4 | 82
embryonic growth retardation 4 | 106
increased bone mineral content 4 | 108
increased circulating alkaline... 4 | 122
increased circulating triglyce... 4 | 42
increased lean body mass 4 | 172
decreased circulating insulin ... 3 | 76
decreased circulating triglyce... 3 | 79
decreased fasted circulating g... 3 | 65
decreased grip strength 3 | 116
increased body length 3 | 32
increased circulating HDL chol... 3 | 80
increased circulating amylase ... 3 | 25
increased circulating choleste... 3 | 66
increased mean corpuscular hem... 3 | 96
small superior vagus ganglion 3 | 74
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal glucose homeostasis 2 | 4
abnormal iris morphology 2 | 13
abnormal kidney morphology 2 | 65
abnormal pupil morphology 2 | 2
abnormal retinal vasculature m... 2 | 27
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating total pr... 2 | 49
decreased heart rate 2 | 18
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased red blood cell distr... 2 | 41
hydrometra 2 | 53
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
polydactyly 2 | 7
prolonged RR interval 2 | 8
small kidney 2 | 16
thin skin 2 | 2
trunk curl 2 | 16
vertebral transformation 2 | 12
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal locomotor activation 1 | 16
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal testis morphology 1 | 43
decreased circulating magnesiu... 1 | 13
decreased exploration in new e... 1 | 11
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased circulating magnesiu... 1 | 10
increased exploration in new e... 1 | 8
limb grasping 1 | 41
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
small spleen 1 | 19
small thymus 1 | 16
stereotypic behavior 1 | 3

Disease

Carcinoma 209 | 11,493
ovarian cancer 150 | 8,520
psoriasis 138 | 6,694
osteosarcoma 135 | 7,950
medulloblastoma, large-cell 107 | 6,241
lung cancer 92 | 4,740
glioblastoma 91 | 5,792
Cancer 79 | 2,499
atypical teratoid / rhabdoid tumor 79 | 5,112
group 3 medulloblastoma 76 | 4,104
ependymoma 73 | 4,679
non-small cell lung cancer 71 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 69 | 3,291
Autosomal recessive predisposition 67 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 67 | 1,962
malignant mesothelioma 66 | 3,232
adult high grade glioma 64 | 3,801
Breast cancer 62 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,955
lung adenocarcinoma 58 | 2,716
lung carcinoma 58 | 2,843
pancreatic cancer 57 | 2,398
invasive ductal carcinoma 56 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,989
tuberculosis 54 | 2,010
primitive neuroectodermal tumor 53 | 3,035
oligodendroglioma 51 | 2,850
interstitial cystitis 48 | 2,312
cystic fibrosis 43 | 1,696
diabetes mellitus 42 | 1,728
Astrocytoma, Pilocytic 41 | 3,081
astrocytic glioma 41 | 2,597
subependymal giant cell astrocytoma 41 | 2,287
ulcerative colitis 40 | 1,819
adrenocortical carcinoma 39 | 1,428
ductal carcinoma in situ 39 | 1,745
breast carcinoma 37 | 1,638
pituitary cancer 35 | 1,972
Pick disease 34 | 1,894
Schizophrenia 34 | 1,160
Kidney cancer 32 | 2,613
Intellectual disability 30 | 1,016
Seizures 30 | 596
Anemia 28 | 365
Epilepsy 28 | 792
Hypertension 28 | 396
group 4 medulloblastoma 28 | 1,855
Prostatic Neoplasms 27 | 495
Muscle hypotonia 25 | 571
aldosterone-producing adenoma 25 | 665
Depressive disorder 24 | 409
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Obesity 24 | 678
Poor school performance 24 | 645
astrocytoma 24 | 1,146
Atopic dermatitis 23 | 952
Cognitive delay 23 | 608
Global developmental delay 23 | 608
Mental and motor retardation 23 | 608
Rheumatoid arthritis 23 | 1,191
active Crohn's disease 22 | 922
colon cancer 22 | 1,478
primary pancreatic ductal adenocarcinoma 22 | 1,109
Failure to gain weight 21 | 365
Kidney disease 21 | 430
Liver Cirrhosis, Experimental 21 | 769
Pediatric failure to thrive 21 | 365
cutaneous lupus erythematosus 21 | 1,057
non primary Sjogren syndrome sicca 21 | 891
Breast Neoplasms 19 | 445
Heart failure 19 | 162
Multiple myeloma 19 | 1,332
Alzheimer's disease 18 | 658
Cerebellar Ataxia 18 | 304
Liver disease 18 | 237
Short stature 18 | 531
active ulcerative colitis 18 | 764
pancreatic carcinoma 18 | 562
Autistic Disorder 17 | 364
Bipolar Disorder 17 | 666
Hepatomegaly 17 | 285
Hypertensive disease 17 | 292
Mammary Neoplasms 17 | 425
acute myeloid leukemia 17 | 783
chronic rhinosinusitis 17 | 512
esophageal adenocarcinoma 17 | 737
pediatric high grade glioma 17 | 1,064
spina bifida 17 | 1,074
Atherosclerosis 16 | 291
Chemical and Drug Induced Liver Injury 16 | 195
Endometriosis 16 | 540
Melanoma 16 | 711
Osteoporosis 16 | 363
Vascular disease 16 | 319
nasopharyngeal carcinoma 16 | 1,058
Malaria 15 | 160
juvenile dermatomyositis 15 | 1,187

Tissue

Endocrine System 308 | 18,159
Female tissues 304 | 17,400
Digestive Tract 302 | 17,369
Skin and soft tissues 301 | 17,230
Liver and Pancreas 300 | 16,750
Male tissues 297 | 17,142
Blood and immune system 296 | 16,909
Urinary Tract 290 | 16,678
Nervous System 289 | 16,725
Respiratory system 287 | 16,393
Cardiovascular System 254 | 15,192

Target Family

Enzyme 167 | 4,145
Non-IDG 117 | 12,091
Epigenetic 20 | 242
Transporter 6 | 473
TF/Epigenetic 4 | 38
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

UniProt Keyword

Iron 319 | 319
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
4-aminobutyrate aminotransferase, mitochondrial ABAT Tclin Enzyme -2.02391 104.3 204
Lysine-specific demethylase 4E KDM4E Tchem Epigenetic -0.86891 5.72 23
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Deoxyhypusine hydroxylase DOHH Tbio Enzyme -1.34014 21.0 26
E3 ubiquitin-protein ligase MYLIP MYLIP Tbio Enzyme -2.05580 115.6 135
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117
Hypoxia-inducible factor 1-alpha inhibitor HIF1AN Tbio Non-IDG -1.91636 75.1 429