Development Level

Tbio 342 | 11,651
Tclin 144 | 612
Tdark 75 | 6,593
Tchem 70 | 1,388

Collection

Ion Channel: IDG Consortium (T... 98 | 99

IMPC Phenotype

preweaning lethality, complete... 39 | 979
preweaning lethality, incomple... 17 | 499
abnormal behavior 16 | 298
embryonic lethality prior to t... 16 | 278
hyperactivity 12 | 148
abnormal embryo size 9 | 220
decreased vertical activity 9 | 208
embryonic lethality prior to o... 9 | 239
increased startle reflex 9 | 112
abnormal bone structure 8 | 187
enlarged heart 8 | 210
impaired glucose tolerance 8 | 75
abnormal seminal vesicle morph... 7 | 114
decreased hemoglobin content 7 | 68
decreased prepulse inhibition 7 | 82
abnormal heart morphology 6 | 162
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
decreased fasted circulating g... 6 | 65
decreased total body fat amoun... 6 | 207
abnormal epididymis morphology 5 | 42
abnormal gait 5 | 69
decreased bone mineral density 5 | 126
decreased grip strength 5 | 116
embryonic growth retardation 5 | 106
increased bone mineral content 5 | 108
increased circulating triglyce... 5 | 42
increased monocyte cell number 5 | 63
increased total body fat amoun... 5 | 134
abnormal sleep behavior 4 | 70
cataract 4 | 92
decreased circulating alkaline... 4 | 46
decreased circulating serum al... 4 | 82
decreased hematocrit 4 | 46
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 50
decreased mean platelet volume 4 | 25
increased circulating alkaline... 4 | 122
increased mean corpuscular vol... 4 | 92
increased mean platelet volume 4 | 45
increased or absent threshold ... 4 | 101
limb grasping 4 | 41
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
abnormal bone mineralization 3 | 38
abnormal eye morphology 3 | 68
abnormal lens morphology 3 | 81
decreased body length 3 | 101
decreased caudal vertebrae num... 3 | 53
decreased circulating amylase ... 3 | 28
decreased circulating calcium ... 3 | 36
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased lean body mass 3 | 135
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
edema 3 | 59
enlarged epididymis 3 | 31
hydrometra 3 | 53
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased circulating HDL chol... 3 | 80
increased circulating creatini... 3 | 38
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
small superior vagus ganglion 3 | 74
abnormal behavioral response t... 2 | 66
abnormal pancreas morphology 2 | 13
abnormal response to tactile s... 2 | 17
abnormal spine curvature 2 | 9
abnormal startle reflex 2 | 15
abnormal vocalization 2 | 21
absent vibrissae 2 | 12
brachydactyly 2 | 19
cardiovascular system phenotyp... 2 | 36
decreased cardiac stroke volum... 2 | 6
decreased circulating HDL chol... 2 | 68
decreased circulating free fat... 2 | 31
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased heart weight 2 | 27
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
enlarged spleen 2 | 41
enlarged uterus 2 | 11
hypoactivity 2 | 132
impaired righting response 2 | 26
increased circulating choleste... 2 | 66
increased heart weight 2 | 62
increased spleen weight 2 | 10
long tibia 2 | 25
prenatal lethality 2 | 28
syndactyly 2 | 23
thrombocytosis 2 | 27

Disease

Carcinoma 470 | 11,493
medulloblastoma, large-cell 250 | 6,241
osteosarcoma 241 | 7,950
ovarian cancer 231 | 8,520
glioblastoma 229 | 5,792
psoriasis 228 | 6,694
atypical teratoid / rhabdoid tumor 217 | 5,112
ependymoma 208 | 4,679
adult high grade glioma 175 | 3,801
group 3 medulloblastoma 156 | 4,104
lung cancer 153 | 4,740
Kidney cancer 146 | 2,613
oligodendroglioma 144 | 2,850
Astrocytoma, Pilocytic 140 | 3,081
primitive neuroectodermal tumor 137 | 3,035
lung carcinoma 132 | 2,843
astrocytic glioma 124 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 116 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,955
subependymal giant cell astrocytoma 110 | 2,287
Epilepsy 108 | 792
Breast cancer 104 | 3,578
malignant mesothelioma 103 | 3,232
pituitary cancer 96 | 1,972
lung adenocarcinoma 94 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 93 | 2,989
Pick disease 85 | 1,894
pancreatic cancer 84 | 2,398
Schizophrenia 81 | 1,160
Autosomal recessive predisposition 80 | 1,442
cystic fibrosis 74 | 1,696
invasive ductal carcinoma 74 | 2,951
non-small cell lung cancer 74 | 2,890
interstitial cystitis 73 | 2,312
Bipolar Disorder 66 | 666
pancreatic ductal adenocarcinoma liver metastasis 59 | 1,962
ulcerative colitis 58 | 1,819
Intellectual disability 56 | 1,016
tuberculosis 56 | 2,010
Seizures 53 | 596
colon cancer 53 | 1,478
group 4 medulloblastoma 51 | 1,855
ductal carcinoma in situ 49 | 1,745
Multiple Sclerosis 48 | 540
active Crohn's disease 45 | 922
Melanoma 44 | 711
diabetes mellitus 43 | 1,728
breast carcinoma 42 | 1,638
Autistic Disorder 40 | 364
Eaton-Lambert syndrome 40 | 40
Hypertension 40 | 396
Liver cancer 40 | 604
General anesthesia 39 | 53
Cancer 38 | 2,499
Atrial Fibrillation 37 | 124
Skin cancer 37 | 469
active ulcerative colitis 37 | 764
adrenocortical carcinoma 37 | 1,428
Dull intelligence 36 | 645
Low intelligence 36 | 645
Mental Retardation 36 | 645
Mental deficiency 36 | 645
Muscle hypotonia 36 | 571
Poor school performance 36 | 645
Tonic-clonic epilepsy 35 | 47
Parkinson's disease 34 | 392
Multiple myeloma 32 | 1,332
astrocytoma 32 | 1,146
non primary Sjogren syndrome sicca 32 | 891
pediatric high grade glioma 32 | 1,064
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Local anesthesia 30 | 40
Mental and motor retardation 30 | 608
Alcoholic Intoxication, Chronic 29 | 289
Alzheimer's disease 29 | 658
Cerebellar Ataxia 29 | 304
cutaneous lupus erythematosus 29 | 1,057
primary pancreatic ductal adenocarcinoma 29 | 1,109
Depressive disorder 28 | 409
Failure to gain weight 28 | 365
Kidney disease 28 | 430
Pediatric failure to thrive 28 | 365
nasopharyngeal carcinoma 28 | 1,058
Mental Depression 27 | 333
Neurodegenerative disease 27 | 414
medulloblastoma 27 | 720
Rheumatoid arthritis 26 | 1,191
gastric carcinoma 26 | 807
Diarrhea 25 | 253
Infantile onset 25 | 238
Lennox-Gastaut syndrome 25 | 34
progressive supranuclear palsy 25 | 676
Hypertensive disease 24 | 292
Anemia 23 | 365
Status Epilepticus 23 | 98
nephrosclerosis 23 | 333
Nystagmus 22 | 317
Obesity 22 | 678
primary Sjogren syndrome 22 | 735

Tissue

Endocrine System 610 | 18,159
Digestive Tract 583 | 17,369
Nervous System 576 | 16,725
Female tissues 574 | 17,400
Skin and soft tissues 565 | 17,230
Male tissues 561 | 17,142
Urinary Tract 552 | 16,678
Liver and Pancreas 545 | 16,750
Blood and immune system 542 | 16,909
Respiratory system 517 | 16,393
Cardiovascular System 445 | 15,192

Target Family

Ion Channel 343 | 344
Transporter 167 | 473
Non-IDG 65 | 12,091
Enzyme 55 | 4,145
Kinase 1 | 634

UniProt Keyword

Ion transport 631 | 631
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Calcium homeostasis modulator protein 6 CALHM6 Tdark Ion Channel -0.43644 4.12 26
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Sodium channel protein type 7 subunit alpha SCN7A Tclin Ion Channel -0.99420 8.52 83
Sodium/hydrogen exchanger 5 SLC9A5 Tbio Transporter -1.15040 17.1 43
Gastric intrinsic factor GIF Tbio Non-IDG -3.20615 1559.4 172
Cation channel sperm-associated protein 3 CATSPER3 Tchem Ion Channel -1.09150 13.5 31
Potassium voltage-gated channel subfamily E member 2 KCNE2 Tbio Ion Channel -2.00780 91.4 120