Development Level

Tbio 285 | 10,625
Tclin 143 | 602
Tchem 122 | 1,890
Tdark 78 | 7,003

Collection

Eligible Ion Channel Proteins 116 | 117

IMPC Term

preweaning lethality, complete... 30 | 633
embryonic lethality prior to t... 13 | 187
embryonic lethality prior to o... 9 | 148
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased bone mineral density 8 | 126
abnormal bone structure 7 | 131
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
hyperactivity 6 | 108
preweaning lethality, incomple... 6 | 260
decreased bone mineral content 5 | 157
decreased fasted circulating g... 5 | 49
impaired glucose tolerance 5 | 52
abnormal epididymis morphology 4 | 31
decreased grip strength 4 | 123
decreased hemoglobin content 4 | 53
decreased rib number 4 | 59
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 68
limb grasping 4 | 35
abnormal bone mineralization 3 | 55
abnormal embryo size 3 | 112
abnormal gait 3 | 51
abnormal lens morphology 3 | 73
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
abnormal seminal vesicle morph... 3 | 47
decreased caudal vertebrae num... 3 | 49
decreased circulating amylase ... 3 | 24
decreased circulating serum al... 3 | 79
decreased circulating sodium l... 3 | 18
decreased circulating triglyce... 3 | 83
decreased erythrocyte cell num... 3 | 43
decreased heart weight 3 | 44
decreased mean corpuscular vol... 3 | 50
decreased prepulse inhibition 3 | 52
enlarged epididymis 3 | 27
enlarged heart 3 | 111
increased circulating alkaline... 3 | 119
increased circulating magnesiu... 3 | 10
increased grip strength 3 | 83
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased startle reflex 3 | 38
prenatal lethality prior to he... 3 | 64
short tibia 3 | 82
abnormal eye morphology 2 | 38
abnormal response to tactile s... 2 | 16
abnormal sleep behavior 2 | 63
abnormal startle reflex 2 | 14
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased body length 2 | 108
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased circulating glycerol... 2 | 19
decreased circulating insulin ... 2 | 75
decreased circulating iron lev... 2 | 25
decreased eosinophil cell numb... 2 | 41
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular hem... 2 | 19
decreased mean platelet volume 2 | 12
hypoactivity 2 | 89
impaired righting response 2 | 19
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased caudal vertebrae num... 2 | 8
increased circulating HDL chol... 2 | 63
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating potassiu... 2 | 31
increased circulating triglyce... 2 | 24
kyphosis 2 | 5
prenatal lethality 2 | 16
thrombocytosis 2 | 23
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
decreased NK cell number 1 | 16
decreased effector memory CD8-... 1 | 24
embryonic growth retardation 1 | 28
female infertility 1 | 34
increased CD4-positive, CD25-p... 1 | 18
increased body length 1 | 20
increased mean platelet volume 1 | 19
long tibia 1 | 13
straub tail 1 | 26
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

medulloblastoma, large-cell 249 | 6,234
osteosarcoma 237 | 7,933
ovarian cancer 228 | 8,484
psoriasis 227 | 6,685
glioblastoma 218 | 5,572
atypical teratoid / rhabdoid tumor 171 | 4,369
oligodendroglioma 144 | 2,849
pilocytic astrocytoma 141 | 3,086
Carcinoma 139 | 2,147
lung cancer 137 | 4,466
primitive neuroectodermal tumor 137 | 3,031
lung carcinoma 132 | 2,844
ependymoma 126 | 2,514
pediatric high grade glioma 119 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 114 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 112 | 2,956
subependymal giant cell astrocytoma 110 | 2,287
astrocytic glioma 107 | 2,241
malignant mesothelioma 99 | 3,162
pituitary cancer 96 | 1,972
lung adenocarcinoma 93 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 92 | 2,988
Epilepsy 89 | 346
adult high grade glioma 88 | 2,148
Pick disease 85 | 1,893
Breast cancer 80 | 3,094
medulloblastoma 78 | 1,524
pancreatic cancer 76 | 2,300
invasive ductal carcinoma 73 | 2,950
interstitial cystitis 71 | 2,299
non-small cell lung cancer 71 | 2,798
ulcerative colitis 70 | 2,087
cystic fibrosis 69 | 1,665
posterior fossa group A ependymoma 63 | 1,511
sonic hedgehog group medulloblastoma 60 | 1,482
group 3 medulloblastoma 58 | 2,254
group 4 medulloblastoma 58 | 1,875
atypical teratoid/rhabdoid tumor 57 | 1,095
colon cancer 53 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
astrocytoma 49 | 1,493
ductal carcinoma in situ 48 | 1,745
Multiple Sclerosis 47 | 498
active Crohn's disease 44 | 918
tuberculosis 44 | 1,557
Schizophrenia 42 | 501
breast carcinoma 41 | 1,614
diabetes mellitus 41 | 1,663
Eaton-Lambert syndrome 40 | 40
General anesthesia 39 | 53
posterior fossa group B ependymoma 39 | 1,530
adrenocortical carcinoma 37 | 1,427
Autistic Disorder 36 | 320
Cancer 36 | 2,346
primary pancreatic ductal adenocarcinoma 36 | 1,271
Atrial Fibrillation 35 | 110
Tonic-clonic epilepsy 35 | 47
Intellectual disability 34 | 573
Parkinson's disease 33 | 364
Multiple myeloma 32 | 1,327
non primary Sjogren syndrome sicca 32 | 840
Alzheimer's disease 30 | 644
Local anesthesia 30 | 40
cutaneous lupus erythematosus 29 | 1,056
Bipolar Disorder 27 | 266
Long QT syndrome 27 | 52
nasopharyngeal carcinoma 27 | 1,056
active ulcerative colitis 26 | 477
Hypertension 25 | 287
Hypertensive disease 25 | 193
Lennox-Gastaut syndrome 25 | 34
Neurodegenerative disease 25 | 383
gastric carcinoma 25 | 832
progressive supranuclear palsy 25 | 674
Kidney disease 24 | 396
Rheumatoid Arthritis 24 | 1,160
nephrosclerosis 23 | 329
Epilepsy characterized by intractable complex partial seizures 22 | 28
Simple partial seizure 22 | 26
Status Epilepticus 22 | 85
primary Sjogren syndrome 22 | 789
Alcohol dependence 21 | 107
mucosa-associated lymphoid tissue lymphoma 21 | 480
Down syndrome 20 | 548
Obesity 20 | 616
Atopic dermatitis 19 | 944
Endometriosis 19 | 535
Heart disease 19 | 279
Hypertensive disorder 19 | 58
esophageal adenocarcinoma 19 | 737
fibroadenoma 19 | 557
pancreatic carcinoma 19 | 567
spina bifida 19 | 1,064
Anemia 18 | 252
acute myeloid leukemia 18 | 780
aldosterone-producing adenoma 18 | 664
Nicotine dependence 17 | 53
acute quadriplegic myopathy 17 | 1,157
chronic rhinosinusitis 17 | 512
glioblastoma multiforme 17 | 347

Tissue

Nervous System 621 | 18,561
Digestive Tract 619 | 18,473
Female tissues 619 | 18,647
Urinary Tract 619 | 18,444
Endocrine System 618 | 18,512
Liver and Pancreas 615 | 18,136
Skin and soft tissues 611 | 18,115
Cardiovascular System 606 | 17,958
Blood and immune system 604 | 17,995
Male tissues 599 | 17,969
Respiratory system 595 | 17,484

Target Family

Ion Channel 340 | 341
Transporter 166 | 473
Non-IDG 66 | 11,971
Enzyme 55 | 4,146
Kinase 1 | 634

UniProt Keyword

Ion transport 628 | 628
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.30895 191.4 20
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Ileal sodium/bile acid cotransporter SLC10A2 Tchem Transporter -2.60727 417.5 121
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Transmembrane channel-like protein 8 TMC8 Tbio Ion Channel -1.45295 32.2 147