Development Level

Tclin 126 | 613
Tbio 106 | 11,445
Tchem 84 | 1,598
Tdark 32 | 6,588

Collection

RFA-RM-18-021 97 | 328
Ion Channel: IDG Consortium (T... 95 | 99

IMPC Phenotype

preweaning lethality, complete... 17 | 979
abnormal behavior 10 | 298
hyperactivity 8 | 148
decreased vertical activity 7 | 208
increased startle reflex 7 | 112
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
abnormal embryo size 5 | 220
impaired glucose tolerance 5 | 75
preweaning lethality, incomple... 5 | 499
abnormal epididymis morphology 4 | 42
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
abnormal seminal vesicle morph... 4 | 114
decreased body weight 4 | 161
decreased fasted circulating g... 4 | 65
increased circulating triglyce... 4 | 42
limb grasping 4 | 41
abnormal bone structure 3 | 187
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
abnormal behavioral response t... 2 | 66
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal lens morphology 2 | 81
abnormal pancreas morphology 2 | 13
cataract 2 | 92
decreased cardiac stroke volum... 2 | 6
decreased circulating alkaline... 2 | 46
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased circulating glycerol... 2 | 16
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased hematocrit 2 | 46
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased neutrophil cell numb... 2 | 42
edema 2 | 59
enlarged epididymis 2 | 31
enlarged uterus 2 | 11
hydrometra 2 | 53
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased mean platelet volume 2 | 45
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
small superior vagus ganglion 2 | 74
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal joint morphology 1 | 23
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal response to new envir... 1 | 10
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased heart weight 1 | 62
increased vertical activity 1 | 24
prenatal lethality 1 | 28
shortened PQ interval 1 | 7
syndactyly 1 | 23
tremors 1 | 39

Disease

Carcinoma 274 | 11,493
medulloblastoma, large-cell 141 | 6,241
psoriasis 131 | 6,694
atypical teratoid / rhabdoid tumor 129 | 5,112
glioblastoma 129 | 5,792
osteosarcoma 124 | 7,950
ependymoma 123 | 4,679
adult high grade glioma 113 | 3,801
Kidney cancer 106 | 2,613
Astrocytoma, Pilocytic 100 | 3,081
group 3 medulloblastoma 96 | 4,104
ovarian cancer 94 | 8,520
oligodendroglioma 92 | 2,850
primitive neuroectodermal tumor 86 | 3,035
lung cancer 82 | 4,740
lung carcinoma 81 | 2,843
Epilepsy 79 | 792
astrocytic glioma 74 | 2,597
subependymal giant cell astrocytoma 65 | 2,287
Schizophrenia 61 | 1,160
Breast cancer 56 | 3,578
malignant mesothelioma 54 | 3,232
Bipolar Disorder 53 | 666
intraductal papillary-mucinous adenoma (IPMA) 53 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
lung adenocarcinoma 50 | 2,716
pituitary cancer 50 | 1,972
Pick disease 49 | 1,894
Multiple Sclerosis 45 | 540
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,989
cystic fibrosis 43 | 1,696
interstitial cystitis 42 | 2,312
Eaton-Lambert syndrome 40 | 40
Autosomal recessive predisposition 39 | 1,442
General anesthesia 39 | 53
Intellectual disability 38 | 1,016
invasive ductal carcinoma 37 | 2,951
pancreatic cancer 37 | 2,398
Tonic-clonic epilepsy 35 | 47
non-small cell lung cancer 34 | 2,890
Liver cancer 32 | 604
Melanoma 32 | 711
Seizures 32 | 596
Skin cancer 31 | 469
Autistic Disorder 30 | 364
Local anesthesia 30 | 40
ulcerative colitis 30 | 1,819
Atrial Fibrillation 27 | 124
colon cancer 27 | 1,478
Alcoholic Intoxication, Chronic 26 | 289
Muscle hypotonia 26 | 571
group 4 medulloblastoma 26 | 1,855
Lennox-Gastaut syndrome 25 | 34
Dull intelligence 23 | 645
Hypertension 23 | 396
Low intelligence 23 | 645
Mental Depression 23 | 333
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
ductal carcinoma in situ 23 | 1,745
Depressive disorder 22 | 409
Epilepsy characterized by intractable complex partial seizures 22 | 28
Infantile onset 22 | 238
Simple partial seizure 22 | 26
breast carcinoma 22 | 1,638
Alcohol dependence 21 | 107
Cognitive delay 21 | 608
Global developmental delay 21 | 608
Mental and motor retardation 21 | 608
adrenocortical carcinoma 21 | 1,428
Long QT syndrome 20 | 39
Parkinson's disease 20 | 392
cutaneous lupus erythematosus 20 | 1,057
Brugada syndrome 18 | 29
Cerebellar Ataxia 18 | 304
Endometrial cancer 18 | 311
Status Epilepticus 18 | 98
active Crohn's disease 18 | 922
Anxiety 17 | 136
Nicotine dependence 17 | 54
gastric carcinoma 17 | 807
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
tuberculosis 17 | 2,010
Cancer 16 | 2,499
Heart disease 16 | 306
Insomnia 16 | 20
Neurodegenerative disease 16 | 414
Spasticity 16 | 26
active ulcerative colitis 16 | 764
astrocytoma 16 | 1,146
non primary Sjogren syndrome sicca 16 | 891
Hypertensive disorder 15 | 56
Neuropathy 15 | 261
Partial Epilepsy Treatment Adjunct 15 | 16
progressive supranuclear palsy 15 | 676
Hypertensive disease 14 | 292
diabetes mellitus 14 | 1,728
pediatric high grade glioma 14 | 1,064
primary pancreatic ductal adenocarcinoma 14 | 1,109

Tissue

Endocrine System 337 | 18,159
Nervous System 315 | 16,725
Digestive Tract 312 | 17,369
Female tissues 309 | 17,400
Skin and soft tissues 303 | 17,230
Male tissues 297 | 17,142
Blood and immune system 286 | 16,909
Liver and Pancreas 282 | 16,750
Urinary Tract 282 | 16,678
Respiratory system 267 | 16,393
Cardiovascular System 225 | 15,192

Target Family

Ion Channel 334 | 344
Non-IDG 11 | 12,091
Enzyme 2 | 4,145
Kinase 1 | 634

UniProt Keyword

Ion channel 348 | 348
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G Tclin Ion Channel -2.16668 140.8 217
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.09649 1238.5 222
Solute carrier family 26 member 6 SLC26A6 Tbio Ion Channel -1.90119 75.2 94
Inward rectifier potassium channel 2 KCNJ2 Tchem Ion Channel -2.36978 224.8 221
Potassium voltage-gated channel subfamily D member 3 KCND3 Tclin Ion Channel -2.34610 217.9 162
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 Tclin Ion Channel -2.13205 136.0 202
Sodium channel protein type 11 subunit alpha SCN11A Tclin Ion Channel -2.46568 276.3 60
Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 Tbio Ion Channel -1.74365 53.9 92