Development Level

Tclin 126 | 602
Tbio 108 | 10,625
Tchem 82 | 1,890
Tdark 33 | 7,003

Collection

Eligible Ion Channel Proteins 114 | 117

IMPC Term

preweaning lethality, complete... 10 | 633
abnormal behavior 7 | 226
decreased body weight 6 | 174
hyperactivity 5 | 108
limb grasping 4 | 35
abnormal bone structure 3 | 131
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
decreased bone mineral density 3 | 126
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
decreased circulating glycerol... 2 | 19
decreased circulating insulin ... 2 | 75
decreased circulating sodium l... 2 | 18
decreased circulating triglyce... 2 | 83
decreased eosinophil cell numb... 2 | 41
decreased rib number 2 | 59
enlarged epididymis 2 | 27
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating magnesiu... 2 | 10
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
abnormal cornea morphology 1 | 24
abnormal facial morphology 1 | 9
abnormal forebrain development 1 | 18
abnormal forelimb morphology 1 | 2
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pancreas morphology 1 | 6
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta vasculature 1 | 2
abnormal response to new envir... 1 | 8
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
cardiovascular system phenotyp... 1 | 35
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased B cell number 1 | 30
decreased NK T cell number 1 | 28
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased mature B cell number 1 | 25
edema 1 | 11
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hemorrhage 1 | 12
hydrometra 1 | 13
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased CD4-positive, CD25-p... 1 | 18
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating choleste... 1 | 53
increased circulating potassiu... 1 | 31
increased exploration in new e... 1 | 56
increased or absent threshold ... 1 | 128
increased spleen weight 1 | 3
increased vertical activity 1 | 18
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
respiratory system phenotype 1 | 2
small heart 1 | 8
small liver 1 | 8
small superior vagus ganglion 1 | 20
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
tremors 1 | 34
vertebral transformation 1 | 12

Disease

medulloblastoma, large-cell 142 | 6,234
psoriasis 132 | 6,685
glioblastoma 125 | 5,572
osteosarcoma 124 | 7,933
atypical teratoid / rhabdoid tumor 104 | 4,369
Carcinoma 103 | 2,147
pilocytic astrocytoma 100 | 3,086
ovarian cancer 93 | 8,484
oligodendroglioma 92 | 2,849
primitive neuroectodermal tumor 86 | 3,031
lung carcinoma 81 | 2,844
pediatric high grade glioma 76 | 2,712
Epilepsy 74 | 346
lung cancer 71 | 4,466
subependymal giant cell astrocytoma 65 | 2,287
astrocytic glioma 63 | 2,241
ependymoma 62 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
adult high grade glioma 52 | 2,148
malignant mesothelioma 52 | 3,162
medulloblastoma 51 | 1,524
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
pituitary cancer 50 | 1,972
Pick disease 49 | 1,893
lung adenocarcinoma 49 | 2,713
posterior fossa group A ependymoma 46 | 1,511
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,988
Multiple Sclerosis 44 | 498
cystic fibrosis 42 | 1,665
interstitial cystitis 41 | 2,299
Eaton-Lambert syndrome 40 | 40
General anesthesia 39 | 53
Breast cancer 38 | 3,094
invasive ductal carcinoma 37 | 2,950
Tonic-clonic epilepsy 35 | 47
ulcerative colitis 35 | 2,087
group 4 medulloblastoma 34 | 1,875
atypical teratoid/rhabdoid tumor 33 | 1,095
Schizophrenia 32 | 501
group 3 medulloblastoma 32 | 2,254
non-small cell lung cancer 31 | 2,798
pancreatic cancer 31 | 2,300
Local anesthesia 30 | 40
sonic hedgehog group medulloblastoma 30 | 1,482
posterior fossa group B ependymoma 29 | 1,530
colon cancer 28 | 1,475
Atrial Fibrillation 27 | 110
Intellectual disability 27 | 573
astrocytoma 27 | 1,493
Autistic Disorder 26 | 320
Long QT syndrome 26 | 52
Lennox-Gastaut syndrome 25 | 34
Bipolar Disorder 24 | 266
ductal carcinoma in situ 23 | 1,745
Epilepsy characterized by intractable complex partial seizures 22 | 28
Simple partial seizure 22 | 26
breast carcinoma 22 | 1,614
adrenocortical carcinoma 21 | 1,427
Alcohol dependence 20 | 107
cutaneous lupus erythematosus 20 | 1,056
Parkinson's disease 19 | 364
Status Epilepticus 18 | 85
active Crohn's disease 18 | 918
Nicotine dependence 17 | 53
primary pancreatic ductal adenocarcinoma 17 | 1,271
Anxiety 16 | 24
Brugada syndrome 16 | 26
Hypertension 16 | 287
Hypertensive disorder 16 | 58
Insomnia 16 | 20
Spasticity 16 | 26
gastric carcinoma 16 | 832
non primary Sjogren syndrome sicca 16 | 840
Neurodegenerative disease 15 | 383
Partial Epilepsy Treatment Adjunct 15 | 16
progressive supranuclear palsy 15 | 674
Alzheimer's disease 14 | 644
Cancer 14 | 2,346
Irritable bowel syndrome 14 | 59
Migraine Prevention 14 | 22
Pain agnosia 14 | 99
Panic disorder 14 | 55
Partial seizure 14 | 15
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,795
Dysuria 13 | 24
Heart disease 13 | 279
Hypertensive disease 13 | 193
Localization-related epilepsy 13 | 13
Sedation as Adjunct to Anesthesia 13 | 15
Urinary Tract Irritation 13 | 24
diabetes mellitus 13 | 1,663
primary Sjogren syndrome 13 | 789
Brugada Syndrome (disorder) 12 | 15
Neuropathy 12 | 210
Parkinsonism 12 | 19
active ulcerative colitis 12 | 477
nasopharyngeal carcinoma 12 | 1,056
Endometriosis 11 | 535
Migraine 11 | 79
Vascular disease 11 | 281

Tissue

Nervous System 345 | 18,561
Digestive Tract 344 | 18,473
Female tissues 344 | 18,647
Urinary Tract 344 | 18,444
Endocrine System 343 | 18,512
Liver and Pancreas 339 | 18,136
Skin and soft tissues 337 | 18,115
Cardiovascular System 335 | 17,958
Blood and immune system 331 | 17,995
Male tissues 329 | 17,969
Respiratory system 327 | 17,484

Target Family

Ion Channel 333 | 341
Non-IDG 13 | 11,971
Enzyme 2 | 4,146
Kinase 1 | 634

UniProt Keyword

Ion channel 349 | 349
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Transmembrane channel-like protein 8 TMC8 Tbio Ion Channel -1.45295 32.2 147
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Cation channel sperm-associated protein 4 CATSPER4 Tchem Ion Channel 0.06 0.89 32
Calcium homeostasis modulator protein 1 CALHM1 Tbio Ion Channel -1.62156 47.0 81
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.92762 876.7 339
Amiloride-sensitive sodium channel subunit beta SCNN1B Tclin Ion Channel -1.69464 46.7 245
Amiloride-sensitive sodium channel subunit delta SCNN1D Tbio Ion Channel -0.97159 8.72 179