Development Level

Tbio 58 | 11,445
Tdark 18 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
preweaning lethality, complete... 3 | 979
decreased circulating calcium ... 2 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged seminal vesicle 1 | 10
enlarged uterus 1 | 11
increased blood uric acid leve... 1 | 5
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased granulocyte number 1 | 1
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
small superior vagus ganglion 1 | 74

Disease

Carcinoma 57 | 11,493
psoriasis 52 | 6,694
ovarian cancer 25 | 8,520
non-small cell lung cancer 21 | 2,890
lung cancer 19 | 4,740
malignant mesothelioma 19 | 3,232
osteosarcoma 18 | 7,950
Cancer 17 | 2,499
Breast cancer 16 | 3,578
adult high grade glioma 16 | 3,801
cystic fibrosis 16 | 1,696
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
Atopic dermatitis 13 | 952
ependymoma 13 | 4,679
Palmoplantar keratosis 12 | 74
esophageal adenocarcinoma 12 | 737
lung adenocarcinoma 12 | 2,716
spina bifida 12 | 1,074
Astrocytoma, Pilocytic 11 | 3,081
Dystrophia unguium 11 | 53
Monilethrix 11 | 18
breast carcinoma 11 | 1,638
colon cancer 11 | 1,478
nasopharyngeal carcinoma 11 | 1,058
Pachyonychia congenita 10 | 10
interstitial cystitis 10 | 2,312
oligodendroglioma 10 | 2,850
pancreatic cancer 10 | 2,398
Hyperhidrosis disorder 9 | 81
Increased sweating 9 | 81
Sweating 9 | 81
astrocytic glioma 9 | 2,597
group 3 medulloblastoma 9 | 4,104
lung carcinoma 9 | 2,843
Abnormal blistering of the skin 8 | 54
Alopecia 8 | 115
Autosomal recessive predisposition 8 | 1,442
Blister of skin 8 | 54
Hypotrichosis 8 | 47
Kidney cancer 8 | 2,613
Skin bulla 8 | 54
cutaneous lupus erythematosus 8 | 1,057
ductal carcinoma in situ 8 | 1,745
primitive neuroectodermal tumor 8 | 3,035
Amyotrophic lateral sclerosis 7 | 451
Hereditary mucosal leukokeratosis 7 | 7
Highly variable severity 7 | 157
Leukokeratosis 7 | 19
Leukoplakia, Oral 7 | 20
Mammary Neoplasms 7 | 425
Nail Diseases 7 | 24
Nail abnormality 7 | 22
Nail dysplasia 7 | 52
Variable expressivity 7 | 157
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
invasive ductal carcinoma 7 | 2,951
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Breast Neoplasms 6 | 445
Epidermolytic hyperkeratosis 6 | 14
Keratosis 6 | 37
Onychogryposis 6 | 13
Pick disease 6 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
AMYOTROPHIC LATERAL SCLEROSIS 1 5 | 49
Abnormality of metabolism/homeostasis 5 | 134
Basal cell carcinoma 5 | 54
Cell Transformation, Neoplastic 5 | 97
Dental caries 5 | 164
Depressive disorder 5 | 409
Endometriosis 5 | 540
Epidermolysis bullosa simplex 5 | 9
Erythema 5 | 58
Flushing 5 | 60
Ichthyoses 5 | 41
Neoplastic Cell Transformation 5 | 89
Papilloma 5 | 44
Rotting teeth 5 | 73
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
periodontitis 5 | 293
ulcerative colitis 5 | 1,819
Adenoma 4 | 167
Contracture 4 | 96
Contracture of joint 4 | 93
Down syndrome 4 | 499
Flexion contracture 4 | 93
Flexion contractures of joints 4 | 93
Growth retardation 4 | 115
Infantile onset 4 | 238
Liver Cirrhosis, Experimental 4 | 769
Muscle Spasticity 4 | 195
Myopathy 4 | 185
Neuropathy 4 | 261
Parkinson's disease 4 | 392
active ulcerative colitis 4 | 764
posterior fossa group B ependymoma 4 | 416
primary pancreatic ductal adenocarcinoma 4 | 1,109

Tissue

Female tissues 68 | 17,400
Skin and soft tissues 65 | 17,230
Digestive Tract 63 | 17,369
Endocrine System 63 | 18,159
Blood and immune system 59 | 16,909
Male tissues 49 | 17,142
Nervous System 45 | 16,725
Liver and Pancreas 44 | 16,750
Respiratory system 43 | 16,393
Urinary Tract 41 | 16,678
Cardiovascular System 30 | 15,192

Target Family

Non-IDG 76 | 12,091

UniProt Keyword

Intermediate filament 76 | 76
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Keratin, type II cytoskeletal 73 KRT73 Tdark Non-IDG 0.20 0.40 87
Lamin tail domain-containing protein 1 LMNTD1 Tdark Non-IDG 0.00000 1.11 76
Keratin, type II cytoskeletal 2 oral KRT76 Tdark Non-IDG -0.28255 1.97 156
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Keratin, type II cytoskeletal 8 KRT8 Tbio Non-IDG -2.87670 710.7 1827
Synemin SYNM Tbio Non-IDG -1.91854 92.6 68
Putative keratin-87 protein KRT87P Tdark Non-IDG -1.99488 168.1 0
Keratin, type II cytoskeletal 79 KRT79 Tdark Non-IDG -0.60592 4.17 87
Keratin, type I cuticular Ha3-I KRT33A Tbio Non-IDG -1.01072 9.42 68