Development Level

Tbio 42 | 11,445
Tchem 3 | 1,598
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased bone mineral content 2 | 151
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased granulocyte number 1 | 6
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
increased urine magnesium leve... 1 | 2
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

ovarian cancer 37 | 8,520
Carcinoma 24 | 11,493
Multiple myeloma 20 | 1,332
osteosarcoma 20 | 7,950
lung cancer 19 | 4,740
medulloblastoma, large-cell 16 | 6,241
psoriasis 15 | 6,694
glioblastoma 13 | 5,792
Breast cancer 10 | 3,578
Waldenstrons macroglobulinemia 10 | 765
atypical teratoid / rhabdoid tumor 10 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Cancer 8 | 2,499
diabetes mellitus 8 | 1,728
group 3 medulloblastoma 8 | 4,104
oligodendroglioma 8 | 2,850
Kidney cancer 7 | 2,613
Leukoencephalopathy with vanishing white matter 7 | 20
acute quadriplegic myopathy 7 | 1,158
dermatomyositis 7 | 966
astrocytic glioma 6 | 2,597
ependymoma 6 | 4,679
hereditary spastic paraplegia 6 | 318
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
non-small cell lung cancer 6 | 2,890
Autosomal recessive predisposition 5 | 1,442
Big calvaria 5 | 147
Brain hypomyelination 5 | 11
Central nervous system demyelination 5 | 28
Cessation of head growth 5 | 5
Childhood Ataxia with Central Nervous System Hypomyelinization 5 | 6
Decreased serum progesterone 5 | 5
Delusions 5 | 11
Developmental regression 5 | 95
Dysarthria 5 | 192
Epilepsy 5 | 792
Forgetful 5 | 40
Gait, Unsteady 5 | 29
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Lethargy 5 | 77
Leukodystrophy 5 | 55
Leukoencephalopathies 5 | 29
Loss of developmental milestones 5 | 95
Memory Loss 5 | 40
Memory impairment 5 | 40
Mental deterioration in childhood 5 | 95
Mood swings 5 | 77
Muscle Spasticity 5 | 195
Muscle hypotonia 5 | 571
Neurodevelopmental regression 5 | 95
OVARIOLEUKODYSTROPHY 5 | 6
Optic Atrophy 5 | 242
Personality change 5 | 23
Premature Menopause 5 | 31
Primary gonadal insufficiency 5 | 9
Psychomotor regression 5 | 95
Psychomotor regression beginning in infancy 5 | 95
Psychomotor regression in infants 5 | 95
Psychomotor regression, progressive 5 | 95
Secondary physiologic amenorrhea 5 | 32
Seizures 5 | 596
Vanishing White Matter Leukodystrophy with Ovarian Failure 5 | 5
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
primary pancreatic ductal adenocarcinoma 5 | 1,109
primitive neuroectodermal tumor 5 | 3,035
subependymal giant cell astrocytoma 5 | 2,287
Adenocarcinoma of lung 4 | 142
Amyotrophic lateral sclerosis 4 | 451
Astrocytoma, Pilocytic 4 | 3,081
Rheumatoid arthritis 4 | 1,191
adult high grade glioma 4 | 3,801
lung adenocarcinoma 4 | 2,716
sonic hedgehog group medulloblastoma 4 | 467
tuberculosis 4 | 2,010
HIV Infections 3 | 102
Pick disease 3 | 1,894
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
group 4 medulloblastoma 3 | 1,855
hepatocellular carcinoma 3 | 547
invasive ductal carcinoma 3 | 2,951
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
tuberculosis and treatment for 3 months 3 | 179
Disease Models, Animal 2 | 155
Neoplasm Metastasis 2 | 168
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
ductal carcinoma in situ 2 | 1,745
juvenile dermatomyositis 2 | 1,187
medulloblastoma 2 | 720
pancreatic carcinoma 2 | 562
spina bifida 2 | 1,074

Tissue

Endocrine System 47 | 18,159
Male tissues 47 | 17,142
Nervous System 47 | 16,725
Blood and immune system 46 | 16,909
Cardiovascular System 46 | 15,192
Digestive Tract 46 | 17,369
Female tissues 46 | 17,400
Liver and Pancreas 46 | 16,750
Respiratory system 46 | 16,393
Skin and soft tissues 46 | 17,230
Urinary Tract 46 | 16,678

Target Family

Non-IDG 47 | 12,091
Enzyme 1 | 4,145

UniProt Keyword

Initiation factor 48 | 48
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

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