Development Level

Tbio 36 | 11,445
Tchem 7 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
abnormal vibrissa morphology 2 | 25
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal maxilla morphology 1 | 17
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
decreased body weight 1 | 161
decreased circulating glucose ... 1 | 126
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating potassiu... 1 | 29
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
premature death 1 | 5

Disease

Ichthyosis 27 | 56
psoriasis 26 | 6,694
Carcinoma 25 | 11,493
Autosomal recessive predisposition 20 | 1,442
Congenital ichthyosiform erythroderma 20 | 28
ovarian cancer 19 | 8,520
Ichthyoses 18 | 41
osteosarcoma 18 | 7,950
Intellectual disability 17 | 1,016
Congenital Nonbullous Ichthyosiform Erythroderma 16 | 16
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
medulloblastoma, large-cell 14 | 6,241
Palmoplantar keratosis 13 | 74
lung cancer 13 | 4,740
Dry skin 12 | 75
Hyperkeratosis 12 | 50
Xerosis 12 | 75
Atopic dermatitis 11 | 952
Congenital deafness 11 | 185
Deafness 11 | 198
Hearing Loss, Partial 11 | 185
hearing impairment 11 | 199
Ectropion 10 | 38
Epilepsy 10 | 792
Erythema 10 | 58
Exfoliative dermatitis 10 | 24
Flushing 10 | 60
Alopecia 9 | 115
Autosomal recessive congenital ichthyosis 9 | 11
Breast cancer 9 | 3,578
Cognitive delay 9 | 608
Failure to gain weight 9 | 365
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Muscle hypotonia 9 | 571
Pediatric failure to thrive 9 | 365
Seizures 9 | 596
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Cancer 8 | 2,499
Cerebellar Ataxia 8 | 304
Hypohidrosis 8 | 34
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
cystic fibrosis 8 | 1,696
esophageal adenocarcinoma 8 | 737
glioblastoma 8 | 5,792
lung carcinoma 8 | 2,843
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
Congenital non-bullous ichthyosiform erythroderma 7 | 7
Keratitis 7 | 62
Sensorineural Hearing Loss (disorder) 7 | 284
Small head 7 | 374
ependymoma 7 | 4,679
periodontitis 7 | 293
tuberculosis 7 | 2,010
Cataract 6 | 297
Epidermolytic hyperkeratosis 6 | 14
Everted lower lip vermilion 6 | 54
Hypotrichosis 6 | 47
Ichthyosiform Erythroderma, Congenital 6 | 6
Neuropathy 6 | 261
Protruding lower lip 6 | 54
Short stature 6 | 531
X-linked ichthyosis 6 | 18
lung adenocarcinoma 6 | 2,716
spina bifida 6 | 1,074
Astrocytoma, Pilocytic 5 | 3,081
Cerebral atrophy 5 | 178
Chondrodysplasia punctata 5 | 41
Concave bridge of nose 5 | 195
Decreased tendon reflex 5 | 122
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Hydrocephalus 5 | 152
Ichthyosis vulgaris 5 | 11
Lens Opacities 5 | 231
Muscle Spasticity 5 | 195
Nystagmus 5 | 317
Optic Atrophy 5 | 242
Peripheral Neuropathy 5 | 134
Pick disease 5 | 1,894
Prostatic Neoplasms 5 | 495
Retinal Diseases 5 | 55
Sparse hair 5 | 59
Splenomegaly 5 | 190
Squamous cell carcinoma 5 | 129
Strabismus 5 | 270
Thin, sparse hair 5 | 59
X- linked recessive 5 | 110
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
interstitial cystitis 5 | 2,312
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
ulcerative colitis 5 | 1,819

Tissue

Blood and immune system 43 | 16,909
Digestive Tract 43 | 17,369
Female tissues 43 | 17,400
Skin and soft tissues 43 | 17,230
Endocrine System 42 | 18,159
Male tissues 41 | 17,142
Urinary Tract 39 | 16,678
Nervous System 38 | 16,725
Liver and Pancreas 37 | 16,750
Respiratory system 35 | 16,393
Cardiovascular System 32 | 15,192

Target Family

Enzyme 23 | 4,145
Non-IDG 17 | 12,091
Transporter 2 | 473
Transcription Factor 1 | 1,400

UniProt Keyword

Ichthyosis 43 | 43
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
ATP-binding cassette sub-family A member 12 ABCA12 Tbio Transporter -2.05873 115.5 66
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Sulfatase-modifying factor 1 SUMF1 Tbio Enzyme -2.21118 157.7 145
Arylsulfatase B ARSB Tbio Enzyme -2.51626 314.5 216
Ceramide synthase 3 CERS3 Tbio Transcription Factor -1.06194 11.5 105
Magnesium transporter NIPA4 NIPAL4 Tbio Non-IDG -1.20246 15.0 58
Keratin, type II cytoskeletal 2 epidermal KRT2 Tbio Non-IDG -1.64971 43.0 144
Sulfotransferase family cytosolic 2B member 1 SULT2B1 Tbio Enzyme -2.31607 178.2 185