Development Level

Tbio 22 | 11,445
Tchem 4 | 1,598
Tclin 2 | 613

IMPC Phenotype

abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased lean body mass 2 | 135
embryonic lethality prior to t... 2 | 278
increased total body fat amoun... 2 | 134
male infertility 2 | 123
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal kidney morphology 1 | 65
abnormal ovary morphology 1 | 7
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
absent epididymis 1 | 3
absent ovary 1 | 3
absent seminal vesicle 1 | 4
absent testes 1 | 6
absent uterus 1 | 1
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased heart weight 1 | 27
decreased lumbar vertebrae num... 1 | 2
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Klinefelter's syndrome 28 | 56
Hypogonadotropic hypogonadism 24 | 89
Cryptorchidism 21 | 296
Carcinoma 20 | 11,493
Delayed Puberty 19 | 97
Gynecomastia 19 | 64
Hypogonadism, Isolated Hypogonadotropic 19 | 71
Kallmann syndrome 19 | 33
Congenital hypoplasia of penis 18 | 176
Hypogonadism 18 | 173
Kallmann Syndrome 2 (disorder) 18 | 18
Small testicle 17 | 75
Abnormality of the voice 16 | 46
Congenital hypoplasia of breast 16 | 25
Idiopathic hypogonadotropic hypogonadism 16 | 21
Primary physiologic amenorrhea 16 | 55
Autosomal recessive predisposition 14 | 1,442
Decreased fertility 14 | 33
Decreased testosterone in males 14 | 28
Delayed bone age 14 | 136
Female hypogonadism syndrome 14 | 25
Secondary physiologic amenorrhea 14 | 32
Testicular hypogonadism 14 | 21
Abnormality of body height 13 | 13
Absence of pubertal development 13 | 17
Absence of secondary sex characteristics 13 | 22
Anxiety 13 | 136
Anxiety disease 13 | 113
Congenital hypoplasia of ovary 13 | 30
Depressive disorder 13 | 409
Erectile dysfunction 13 | 32
Eunuchoid habitus 13 | 14
Generalized osteopenia 13 | 99
Hypoplastic ovary 13 | 30
Increased female libido 13 | 13
Infantile uterus 13 | 23
Non-obstructive azoospermia 13 | 21
Osteopenia 13 | 99
Osteoporosis 13 | 363
Sense of smell impaired 13 | 21
Sparse body hair 13 | 32
Wide spaced nipples 13 | 46
Anosmia 12 | 22
Anterior hypopituitarism 12 | 18
Decreased bone mineral density Z score 12 | 31
Erectile abnormalities 12 | 16
Hypothalamic gonadotropin-releasing hormone deficiency 12 | 14
ovarian cancer 12 | 8,520
Cancer 9 | 2,499
Sparse pubic hair 9 | 31
glioblastoma 9 | 5,792
non-small cell lung cancer 9 | 2,890
osteosarcoma 9 | 7,950
psoriasis 9 | 6,694
Breast cancer 8 | 3,578
Infertility 8 | 188
Sparse axillary hair 8 | 28
medulloblastoma, large-cell 8 | 6,241
pituitary cancer 8 | 1,972
CHARGE syndrome 7 | 26
Hypogonadotropism 7 | 11
Kidney cancer 7 | 2,613
ependymoma 7 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
Astrocytoma, Pilocytic 6 | 3,081
Hypogonadotropic Hypogonadism 7 With or Without Anosmia 6 | 6
astrocytic glioma 6 | 2,597
atypical teratoid / rhabdoid tumor 6 | 5,112
group 3 medulloblastoma 6 | 4,104
interstitial cystitis 6 | 2,312
oligodendroglioma 6 | 2,850
Amenorrhea 5 | 58
Schizophrenia 5 | 1,160
cystic fibrosis 5 | 1,696
invasive ductal carcinoma 5 | 2,951
lung cancer 5 | 4,740
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
Abnormality of metabolism/homeostasis 4 | 134
Bipolar Disorder 4 | 666
Cerebellar Ataxia 4 | 304
Choanal Atresia 4 | 42
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nystagmus 4 | 317
Pick disease 4 | 1,894
Polycystic ovary syndrome 4 | 360
Poor school performance 4 | 645
Renal agenesis 4 | 29
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
progressive supranuclear palsy 4 | 676
Abnormally small eyeball 3 | 97
Decreased size of eyeball 3 | 97

Tissue

Nervous System 27 | 16,725
Endocrine System 26 | 18,159
Blood and immune system 25 | 16,909
Digestive Tract 24 | 17,369
Female tissues 24 | 17,400
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Urinary Tract 23 | 16,678
Cardiovascular System 18 | 15,192

Target Family

Non-IDG 17 | 12,091
Enzyme 4 | 4,145
GPCR 4 | 408
Epigenetic 1 | 242
Kinase 1 | 634
Transcription Factor 1 | 1,400

UniProt Keyword

Hypogonadotropic hypogonadism 28 | 28
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase RNF216 RNF216 Tbio Enzyme -1.27012 17.8 170
Leucine-rich repeat transmembrane protein FLRT3 FLRT3 Tbio Non-IDG -1.29335 20.6 58
Dual specificity protein phosphatase 6 DUSP6 Tbio Enzyme -2.22889 183.5 379
KiSS-1 receptor KISS1R Tchem GPCR -2.45158 266.5 223
Prokineticin receptor 2 PROKR2 Tchem GPCR -1.68331 49.3 155
Neuropathy target esterase PNPLA6 Tbio Enzyme -2.67941 466.8 159
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
WD repeat-containing protein 11 WDR11 Tbio Non-IDG -2.15685 142.6 65
Anosmin-1 ANOS1 Tbio Non-IDG -2.64038 424.6 155
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785