Development Level

Tbio 101 | 11,445
Tchem 14 | 1,598
Tdark 14 | 6,588
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased total body fat amoun... 5 | 207
preweaning lethality, incomple... 4 | 499
abnormal snout morphology 3 | 23
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased circulating choleste... 3 | 66
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal radius morphology 2 | 8
abnormal ulna morphology 2 | 8
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased hemoglobin content 2 | 68
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased leukocyte cell numbe... 2 | 47
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
prenatal lethality prior to he... 2 | 87
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal pelvic girdle bone mo... 1 | 12
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased prepulse inhibition 1 | 82
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased vertical activity 1 | 24
mammalian phenotype 1 | 17
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
short tibia 1 | 97

Disease

Carcinoma 92 | 11,493
lung cancer 63 | 4,740
ovarian cancer 63 | 8,520
psoriasis 60 | 6,694
Breast cancer 56 | 3,578
lung adenocarcinoma 53 | 2,716
glioblastoma 52 | 5,792
invasive ductal carcinoma 44 | 2,951
atypical teratoid / rhabdoid tumor 43 | 5,112
osteosarcoma 41 | 7,950
Astrocytoma, Pilocytic 40 | 3,081
medulloblastoma, large-cell 40 | 6,241
non-small cell lung cancer 40 | 2,890
pancreatic cancer 39 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
Kidney cancer 36 | 2,613
breast carcinoma 36 | 1,638
ependymoma 36 | 4,679
malignant mesothelioma 35 | 3,232
pituitary cancer 34 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
Autosomal recessive predisposition 30 | 1,442
lung carcinoma 30 | 2,843
Cancer 27 | 2,499
adult high grade glioma 27 | 3,801
cystic fibrosis 26 | 1,696
ductal carcinoma in situ 26 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
ulcerative colitis 25 | 1,819
interstitial cystitis 24 | 2,312
Duchenne muscular dystrophy 23 | 601
colon cancer 23 | 1,478
subependymal giant cell astrocytoma 22 | 2,287
gastric carcinoma 21 | 807
oligodendroglioma 21 | 2,850
Liver Cirrhosis, Experimental 20 | 769
diabetes mellitus 20 | 1,728
group 3 medulloblastoma 20 | 4,104
adrenocortical carcinoma 19 | 1,428
group 4 medulloblastoma 19 | 1,855
Short stature 18 | 531
Skin cancer 17 | 469
nasopharyngeal carcinoma 17 | 1,058
primitive neuroectodermal tumor 17 | 3,035
acute quadriplegic myopathy 16 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
dermatomyositis 16 | 966
juvenile dermatomyositis 16 | 1,187
Becker muscular dystrophy 15 | 191
Pick disease 15 | 1,894
interstitial lung disease 15 | 298
primary pancreatic ductal adenocarcinoma 15 | 1,109
limb girdle muscular dystrophy 2A 14 | 213
pediatric high grade glioma 14 | 1,064
Degenerative polyarthritis 13 | 115
Hypertension 13 | 396
Joint hyperflexibility 13 | 78
Melanoma 13 | 711
Myopia 13 | 176
astrocytic glioma 13 | 2,597
astrocytoma 13 | 1,146
cutaneous lupus erythematosus 13 | 1,057
fibroadenoma 13 | 559
Hypertensive disease 12 | 292
Hypoplastic mandible condyle 12 | 275
Liver cancer 12 | 604
Mandibular hypoplasia 12 | 275
Micrognathism 12 | 275
Schizophrenia 12 | 1,160
tuberculosis 12 | 2,010
urothelial carcinoma 12 | 318
Acquired scoliosis 11 | 281
Curvature of spine 11 | 282
Intellectual disability 11 | 1,016
Kidney disease 11 | 430
Osteoarthritis 11 | 184
esophageal adenocarcinoma 11 | 737
non-small cell lung carcinoma 11 | 317
Cataract 10 | 297
Cleft Palate 10 | 271
Vascular disease 10 | 319
head and neck cancer and chronic obstructive pulmonary disease 10 | 239
Atherosclerosis 9 | 291
Cerebrovascular disease 9 | 238
Ehlers-Danlos syndrome 9 | 43
Highly variable severity 9 | 157
Hyperkyphosis 9 | 111
Kyphosis deformity of spine 9 | 114
Lens Opacities 9 | 231
Platyspondyly 9 | 56
Sensorineural Hearing Loss (disorder) 9 | 284
Spontaneous abortion 9 | 113
Thin skin 9 | 47
Variable expressivity 9 | 157
hepatocellular carcinoma 9 | 547
medulloblastoma 9 | 720
pancreatic carcinoma 9 | 562
pterygium 9 | 76
primary Sjogren syndrome 8 | 735

Tissue

Endocrine System 129 | 18,159
Liver and Pancreas 129 | 16,750
Digestive Tract 128 | 17,369
Female tissues 128 | 17,400
Male tissues 128 | 17,142
Skin and soft tissues 128 | 17,230
Blood and immune system 127 | 16,909
Urinary Tract 126 | 16,678
Nervous System 125 | 16,725
Respiratory system 123 | 16,393
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 114 | 12,091
Enzyme 11 | 4,145
GPCR 4 | 408
Kinase 2 | 634
Transcription Factor 2 | 1,400

UniProt Keyword

Hydroxylation 133 | 133
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Collagen alpha-1(XII) chain COL12A1 Tbio Non-IDG -1.36571 21.4 38
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Latent-transforming growth factor beta-binding protein 2 LTBP2 Tbio Non-IDG -1.22721 18.2 100
Collagen alpha-1(XV) chain COL15A1 Tbio Non-IDG -1.18716 15.5 74
Histone H1.2 HIST1H1C Tbio Non-IDG -2.01718 95.3 142
Histone H1.3 HIST1H1D Tbio Non-IDG -1.83212 63.8 66
Histone H1.5 HIST1H1B Tbio Non-IDG -2.13224 134.1 103