Development Level

Tbio 895 | 10,625
Tchem 379 | 1,890
Tdark 295 | 7,003
Tclin 71 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 82 | 633
decreased lean body mass 32 | 195
abnormal behavior 30 | 226
decreased body weight 28 | 174
preweaning lethality, incomple... 28 | 260
decreased body length 24 | 108
embryonic lethality prior to o... 24 | 148
embryonic lethality prior to t... 21 | 187
abnormal bone structure 20 | 131
decreased total body fat amoun... 19 | 186
decreased bone mineral content 16 | 157
decreased bone mineral density 16 | 126
increased circulating alkaline... 16 | 119
hyperactivity 15 | 108
increased bone mineral content 15 | 92
decreased circulating triglyce... 14 | 83
hypoactivity 14 | 89
decreased circulating choleste... 13 | 85
abnormal embryo size 12 | 112
abnormal retina morphology 12 | 100
enlarged heart 12 | 111
abnormal retinal pigmentation 10 | 61
decreased circulating glucose ... 10 | 121
increased mean corpuscular hem... 10 | 93
short tibia 10 | 82
decreased grip strength 9 | 123
increased or absent threshold ... 9 | 128
abnormal bone mineralization 8 | 55
abnormal lens morphology 8 | 73
decreased B cell number 8 | 30
decreased circulating HDL chol... 8 | 77
decreased erythrocyte cell num... 8 | 43
increased body weight 8 | 42
increased bone mineral density 8 | 52
increased circulating choleste... 8 | 53
increased exploration in new e... 8 | 56
increased hemoglobin content 8 | 45
increased lean body mass 8 | 107
increased mean corpuscular vol... 8 | 91
increased total body fat amoun... 8 | 57
thrombocytopenia 8 | 46
abnormal coat/hair pigmentatio... 7 | 54
abnormal gait 7 | 51
decreased circulating serum al... 7 | 79
decreased lumbar vertebrae num... 7 | 62
decreased neutrophil cell numb... 7 | 37
increased T cell number 7 | 15
increased circulating HDL chol... 7 | 63
increased leukocyte cell numbe... 7 | 37
male infertility 7 | 62
prenatal lethality prior to he... 7 | 64
abnormal seminal vesicle morph... 6 | 47
abnormal vocalization 6 | 21
decreased NK T cell number 6 | 28
decreased T cell number 6 | 31
decreased circulating total pr... 6 | 41
decreased gamma-delta T cell n... 6 | 18
decreased leukocyte cell numbe... 6 | 54
decreased mean corpuscular vol... 6 | 50
decreased prepulse inhibition 6 | 52
decreased rib number 6 | 59
impaired glucose tolerance 6 | 52
increased circulating sodium l... 6 | 71
increased fasted circulating g... 6 | 68
increased sacral vertebrae num... 6 | 62
small testis 6 | 37
abnormal behavioral response t... 5 | 52
abnormal cranium morphology 5 | 32
abnormal heart morphology 5 | 51
abnormal skin morphology 5 | 23
abnormal spleen morphology 5 | 36
abnormal tail morphology 5 | 17
abnormal testis morphology 5 | 30
decreased blood urea nitrogen ... 5 | 31
decreased circulating amylase ... 5 | 24
decreased circulating creatini... 5 | 31
decreased circulating insulin ... 5 | 75
female infertility 5 | 34
increased B cell number 5 | 23
increased blood urea nitrogen ... 5 | 44
increased circulating potassiu... 5 | 31
increased grip strength 5 | 83
increased monocyte cell number 5 | 27
limb grasping 5 | 35
oligodactyly 5 | 14
abnormal locomotor activation 4 | 26
abnormal sleep behavior 4 | 63
abnormal vibrissa morphology 4 | 17
anophthalmia 4 | 20
decreased caudal vertebrae num... 4 | 49
decreased circulating calcium ... 4 | 33
decreased circulating glycerol... 4 | 19
decreased heart weight 4 | 44
decreased mean corpuscular hem... 4 | 34
improved glucose tolerance 4 | 56
increased circulating chloride... 4 | 43
increased circulating serum al... 4 | 25
thrombocytosis 4 | 23
tremors 4 | 34
vertebral fusion 4 | 23

Disease

ovarian cancer 800 | 8,484
osteosarcoma 746 | 7,933
psoriasis 580 | 6,685
medulloblastoma, large-cell 549 | 6,234
glioblastoma 499 | 5,572
lung cancer 444 | 4,466
atypical teratoid / rhabdoid tumor 375 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 344 | 3,289
malignant mesothelioma 306 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 270 | 2,988
Breast cancer 269 | 3,094
primitive neuroectodermal tumor 268 | 3,031
invasive ductal carcinoma 263 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 258 | 2,956
non-small cell lung cancer 247 | 2,798
oligodendroglioma 247 | 2,849
Cancer 245 | 2,346
lung carcinoma 244 | 2,844
pilocytic astrocytoma 243 | 3,086
lung adenocarcinoma 237 | 2,713
pediatric high grade glioma 234 | 2,712
ulcerative colitis 234 | 2,087
pancreatic cancer 213 | 2,300
ependymoma 210 | 2,514
interstitial cystitis 208 | 2,299
subependymal giant cell astrocytoma 204 | 2,287
group 3 medulloblastoma 201 | 2,254
astrocytic glioma 196 | 2,241
adult high grade glioma 195 | 2,148
Carcinoma 194 | 2,147
diabetes mellitus 187 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 181 | 1,795
group 4 medulloblastoma 172 | 1,875
Pick disease 169 | 1,893
cystic fibrosis 167 | 1,665
tuberculosis 163 | 1,557
colon cancer 152 | 1,475
pituitary cancer 152 | 1,972
Multiple myeloma 140 | 1,327
ductal carcinoma in situ 136 | 1,745
astrocytoma 128 | 1,493
cutaneous lupus erythematosus 124 | 1,056
sonic hedgehog group medulloblastoma 124 | 1,482
adrenocortical carcinoma 122 | 1,427
medulloblastoma 121 | 1,524
breast carcinoma 119 | 1,614
juvenile dermatomyositis 118 | 1,189
active Crohn's disease 117 | 918
posterior fossa group A ependymoma 117 | 1,511
posterior fossa group B ependymoma 111 | 1,530
dermatomyositis 102 | 933
Rheumatoid Arthritis 101 | 1,160
primary pancreatic ductal adenocarcinoma 100 | 1,271
Atopic dermatitis 98 | 944
nasopharyngeal carcinoma 95 | 1,056
atypical teratoid/rhabdoid tumor 94 | 1,095
Waldenstrons macroglobulinemia 93 | 765
acute quadriplegic myopathy 93 | 1,157
esophageal adenocarcinoma 86 | 737
spina bifida 83 | 1,064
primary Sjogren syndrome 82 | 789
non primary Sjogren syndrome sicca 78 | 840
gastric carcinoma 77 | 832
Obesity 71 | 616
Alzheimer's disease 69 | 644
progressive supranuclear palsy 68 | 674
acute myeloid leukemia 66 | 780
Neurodegenerative disease 65 | 383
tuberculosis and treatment for 6 months 63 | 686
aldosterone-producing adenoma 59 | 664
pancreatic carcinoma 57 | 567
IGA Glomerulonephritis 55 | 454
Duchenne muscular dystrophy 51 | 602
Endometriosis 51 | 535
active ulcerative colitis 51 | 477
fibroadenoma 50 | 557
Intellectual disability 48 | 573
non-small cell lung carcinoma 47 | 413
Prostatic Neoplasms 46 | 471
inflammatory breast cancer 45 | 404
mucosa-associated lymphoid tissue lymphoma 44 | 480
Parkinson's disease 43 | 364
hepatocellular carcinoma 43 | 532
Coronary artery disease 42 | 240
Down syndrome 42 | 548
Hypertension 42 | 287
Kidney disease 41 | 396
Atherosclerosis 40 | 275
gastric cancer 40 | 430
nephrosclerosis 39 | 329
Amyotrophic Lateral Sclerosis 38 | 431
Peripheral Neuropathy 37 | 303
head and neck cancer and chronic obstructive pulmonary disease 37 | 237
hereditary spastic paraplegia 37 | 313
Asthma 36 | 349
Cerebrovascular disease 36 | 231
Schizophrenia 36 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 499
Crohn's disease 34 | 304
Vascular disease 34 | 281

Tissue

Nervous System 1,589 | 18,561
Female tissues 1,586 | 18,647
Digestive Tract 1,575 | 18,473
Endocrine System 1,572 | 18,512
Urinary Tract 1,571 | 18,444
Blood and immune system 1,569 | 17,995
Male tissues 1,568 | 17,969
Liver and Pancreas 1,566 | 18,136
Skin and soft tissues 1,563 | 18,115
Cardiovascular System 1,554 | 17,958
Respiratory system 1,539 | 17,484

Target Family

Enzyme 1,352 | 4,146
Non-IDG 202 | 11,971
Transporter 37 | 473
Epigenetic 34 | 242
Kinase 8 | 634
Ion Channel 4 | 341
Transcription Factor 3 | 1,400

UniProt Keyword

Hydrolase 1,640 | 1,640
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Host-virus interaction 452 | 452
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Plasma kallikrein KLKB1 Tclin Enzyme -2.88472 708.0 231
N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 Tbio Enzyme -1.30374 25.3 78