Development Level

Tbio 1,003 | 11,651
Tchem 320 | 1,388
Tdark 260 | 6,593
Tclin 71 | 612

Collection

RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Target... 3 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 102 | 979
preweaning lethality, incomple... 60 | 499
embryonic lethality prior to t... 36 | 278
embryonic lethality prior to o... 35 | 239
abnormal behavior 34 | 298
abnormal bone structure 27 | 187
abnormal embryo size 26 | 220
decreased body weight 26 | 161
decreased lean body mass 26 | 135
hypoactivity 23 | 132
decreased bone mineral content 20 | 151
decreased total body fat amoun... 20 | 207
increased lean body mass 19 | 172
increased total body fat amoun... 19 | 134
decreased bone mineral density 18 | 126
decreased body length 17 | 101
enlarged heart 17 | 210
increased circulating alkaline... 17 | 122
decreased vertical activity 16 | 208
abnormal heart morphology 15 | 162
embryonic growth retardation 15 | 106
hyperactivity 15 | 148
increased startle reflex 15 | 112
decreased circulating glucose ... 14 | 126
decreased grip strength 14 | 116
male infertility 13 | 123
cataract 12 | 92
decreased circulating choleste... 12 | 93
decreased circulating triglyce... 12 | 79
decreased mean corpuscular vol... 11 | 79
increased bone mineral content 11 | 108
increased mean corpuscular hem... 11 | 96
abnormal seminal vesicle morph... 10 | 114
decreased neutrophil cell numb... 10 | 42
increased bone mineral density 10 | 72
increased hemoglobin content 10 | 45
increased mean corpuscular vol... 10 | 92
short tibia 10 | 97
abnormal gait 9 | 69
decreased circulating HDL chol... 9 | 68
small superior vagus ganglion 9 | 74
abnormal coat-hair pigmentatio... 8 | 64
abnormal eye morphology 8 | 68
abnormal lens morphology 8 | 81
decreased erythrocyte cell num... 8 | 62
decreased leukocyte cell numbe... 8 | 73
decreased lymphocyte cell numb... 8 | 83
increased body weight 8 | 25
increased circulating HDL chol... 8 | 80
increased circulating choleste... 8 | 66
increased leukocyte cell numbe... 8 | 47
prenatal lethality prior to he... 8 | 87
thrombocytopenia 8 | 56
decreased blood urea nitrogen ... 7 | 51
decreased circulating serum al... 7 | 82
edema 7 | 59
hydrometra 7 | 53
increased blood urea nitrogen ... 7 | 48
increased erythrocyte cell num... 7 | 39
increased mean corpuscular hem... 7 | 36
increased mean platelet volume 7 | 45
small testis 7 | 58
abnormal neural tube closure 6 | 46
abnormal skin morphology 6 | 50
abnormal spleen morphology 6 | 55
abnormal tail morphology 6 | 25
abnormal testis morphology 6 | 43
abnormal vibrissa morphology 6 | 25
decreased circulating insulin ... 6 | 76
decreased prepulse inhibition 6 | 82
decreased red blood cell distr... 6 | 41
increased fasted circulating g... 6 | 76
increased lymphocyte cell numb... 6 | 32
increased or absent threshold ... 6 | 101
persistence of hyaloid vascula... 6 | 33
prolonged ST segment 6 | 36
abnormal bone mineralization 5 | 38
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal retinal vasculature m... 5 | 27
abnormal skin coloration 5 | 25
abnormal vocalization 5 | 21
anophthalmia 5 | 33
decreased circulating alanine ... 5 | 47
decreased circulating creatini... 5 | 39
decreased circulating total pr... 5 | 49
decreased fasted circulating g... 5 | 65
decreased hemoglobin content 5 | 68
decreased mean corpuscular hem... 5 | 50
decreased startle reflex 5 | 75
impaired glucose tolerance 5 | 75
increased circulating potassiu... 5 | 29
increased circulating sodium l... 5 | 71
increased heart weight 5 | 62
increased hematocrit 5 | 46
limb grasping 5 | 41
long tibia 5 | 25
pallor 5 | 34
thrombocytosis 5 | 27
tremors 5 | 39

Disease

Carcinoma 1,080 | 11,493
ovarian cancer 805 | 8,520
osteosarcoma 752 | 7,950
psoriasis 584 | 6,694
medulloblastoma, large-cell 554 | 6,241
glioblastoma 519 | 5,792
lung cancer 463 | 4,740
atypical teratoid / rhabdoid tumor 435 | 5,112
ependymoma 372 | 4,679
group 3 medulloblastoma 354 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 348 | 3,291
adult high grade glioma 331 | 3,801
malignant mesothelioma 316 | 3,232
Breast cancer 309 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 273 | 2,989
Cancer 270 | 2,499
primitive neuroectodermal tumor 269 | 3,035
invasive ductal carcinoma 265 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 260 | 2,955
non-small cell lung cancer 260 | 2,890
Kidney cancer 252 | 2,613
oligodendroglioma 250 | 2,850
lung carcinoma 246 | 2,843
Astrocytoma, Pilocytic 245 | 3,081
lung adenocarcinoma 237 | 2,716
astrocytic glioma 227 | 2,597
pancreatic cancer 224 | 2,398
Autosomal recessive predisposition 211 | 1,442
interstitial cystitis 208 | 2,312
subependymal giant cell astrocytoma 204 | 2,287
diabetes mellitus 199 | 1,728
tuberculosis 199 | 2,010
ulcerative colitis 197 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 193 | 1,962
group 4 medulloblastoma 180 | 1,855
cystic fibrosis 171 | 1,696
Pick disease 169 | 1,894
pituitary cancer 154 | 1,972
colon cancer 153 | 1,478
Multiple myeloma 142 | 1,332
ductal carcinoma in situ 136 | 1,745
adrenocortical carcinoma 125 | 1,428
cutaneous lupus erythematosus 125 | 1,057
breast carcinoma 122 | 1,638
juvenile dermatomyositis 118 | 1,187
active Crohn's disease 117 | 922
Rheumatoid arthritis 107 | 1,191
Intellectual disability 106 | 1,016
dermatomyositis 103 | 966
Schizophrenia 100 | 1,160
astrocytoma 100 | 1,146
pediatric high grade glioma 100 | 1,064
Atopic dermatitis 99 | 952
nasopharyngeal carcinoma 95 | 1,058
acute quadriplegic myopathy 94 | 1,158
Waldenstrons macroglobulinemia 93 | 765
Epilepsy 92 | 792
Liver Cirrhosis, Experimental 92 | 769
primary pancreatic ductal adenocarcinoma 92 | 1,109
active ulcerative colitis 88 | 764
esophageal adenocarcinoma 87 | 737
Obesity 84 | 678
non primary Sjogren syndrome sicca 84 | 891
spina bifida 83 | 1,074
Dull intelligence 79 | 645
Low intelligence 79 | 645
Mental Retardation 79 | 645
Mental deficiency 79 | 645
Poor school performance 79 | 645
Seizures 76 | 596
gastric carcinoma 76 | 807
primary Sjogren syndrome 76 | 735
Short stature 72 | 531
Bipolar Disorder 70 | 666
Neurodegenerative disease 69 | 414
Alzheimer's disease 68 | 658
Melanoma 68 | 711
progressive supranuclear palsy 68 | 676
Cognitive delay 66 | 608
Global developmental delay 66 | 608
Mental and motor retardation 66 | 608
Muscle hypotonia 66 | 571
acute myeloid leukemia 66 | 783
medulloblastoma 66 | 720
aldosterone-producing adenoma 59 | 665
Hypertension 58 | 396
pancreatic carcinoma 56 | 562
Duchenne muscular dystrophy 51 | 601
Endometriosis 51 | 540
Hepatomegaly 50 | 285
fibroadenoma 50 | 559
Liver cancer 49 | 604
Asthma 48 | 385
Osteoporosis 48 | 363
Prostatic Neoplasms 48 | 495
Parkinson's disease 46 | 392
Skin cancer 46 | 469
Depressive disorder 45 | 409
hepatocellular carcinoma 45 | 547
mucosa-associated lymphoid tissue lymphoma 45 | 484

Tissue

Endocrine System 1,575 | 18,159
Digestive Tract 1,562 | 17,369
Female tissues 1,562 | 17,400
Skin and soft tissues 1,546 | 17,230
Blood and immune system 1,536 | 16,909
Male tissues 1,528 | 17,142
Liver and Pancreas 1,517 | 16,750
Urinary Tract 1,514 | 16,678
Nervous System 1,499 | 16,725
Respiratory system 1,485 | 16,393
Cardiovascular System 1,389 | 15,192

Target Family

Enzyme 1,355 | 4,145
Non-IDG 211 | 12,091
Transporter 37 | 473
Epigenetic 35 | 242
Kinase 9 | 634
Ion Channel 4 | 344
Transcription Factor 3 | 1,400

UniProt Keyword

Hydrolase 1,654 | 1,654
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278