Development Level

Tbio 338 | 10,625
Tchem 82 | 1,890
Tclin 28 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 11 | 260
increased or absent threshold ... 8 | 128
abnormal retina morphology 5 | 100
decreased bone mineral content 5 | 157
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
abnormal behavior 4 | 226
abnormal bone structure 4 | 131
decreased bone mineral density 4 | 126
decreased grip strength 4 | 123
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
hypoactivity 4 | 89
increased circulating alkaline... 4 | 119
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
decreased rib number 3 | 59
decreased startle reflex 3 | 48
increased heart weight 3 | 37
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal eye morphology 2 | 38
abnormal hindbrain development 2 | 24
abnormal iris morphology 2 | 12
abnormal maxilla morphology 2 | 16
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal tooth morphology 2 | 24
decreased body weight 2 | 174
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating glucose ... 2 | 121
decreased fasted circulating g... 2 | 49
decreased heart rate 2 | 10
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
tremors 2 | 34
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal femur morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal thoracic vertebrae mo... 1 | 16
absent pinna reflex 1 | 21
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased basophil cell number 1 | 11
decreased cardiac muscle contr... 1 | 5
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
enlarged spleen 1 | 26
hemorrhage 1 | 12
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased fasted circulating g... 1 | 68
increased granulocyte number 1 | 8
increased hematocrit 1 | 36
increased respiratory quotient 1 | 12
irregularly shaped pupil 1 | 7
narrow eye opening 1 | 15
oligodactyly 1 | 14
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small superior vagus ganglion 1 | 20
thrombocytosis 1 | 23
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

ovarian cancer 250 | 8,484
Cancer 240 | 2,346
psoriasis 227 | 6,685
osteosarcoma 202 | 7,933
glioblastoma 159 | 5,572
lung cancer 159 | 4,466
medulloblastoma, large-cell 143 | 6,234
diabetes mellitus 113 | 1,663
atypical teratoid / rhabdoid tumor 102 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 97 | 3,289
Multiple myeloma 92 | 1,327
invasive ductal carcinoma 88 | 2,950
Breast cancer 85 | 3,094
Rheumatoid Arthritis 83 | 1,160
malignant mesothelioma 82 | 3,162
lung carcinoma 81 | 2,844
Hypersensitivity reaction type II disease 78 | 235
pediatric high grade glioma 78 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,988
Arthritis 75 | 248
pilocytic astrocytoma 75 | 3,086
Ankylosing spondylitis 73 | 138
dermatomyositis 71 | 933
non-small cell lung cancer 71 | 2,798
lung adenocarcinoma 69 | 2,713
subependymal giant cell astrocytoma 69 | 2,287
ulcerative colitis 69 | 2,087
Acquired immunodeficiency syndrome 68 | 164
ependymoma 68 | 2,514
oligodendroglioma 67 | 2,849
pancreatic cancer 67 | 2,300
astrocytoma 66 | 1,493
primitive neuroectodermal tumor 64 | 3,031
interstitial cystitis 63 | 2,299
group 3 medulloblastoma 61 | 2,254
juvenile dermatomyositis 59 | 1,189
Behcet's disease 58 | 74
Juvenile rheumatoid arthritis 58 | 104
Multiple Sclerosis 57 | 498
Uveitis 57 | 103
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,956
Waldenstrons macroglobulinemia 56 | 765
Carcinoma 55 | 2,147
cutaneous lupus erythematosus 54 | 1,056
primary Sjogren syndrome 52 | 789
Psoriatic arthritis 51 | 83
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
adult high grade glioma 47 | 2,148
tuberculosis 47 | 1,557
Pick disease 46 | 1,893
Stevens-Johnson syndrome 46 | 78
ductal carcinoma in situ 46 | 1,745
colon cancer 45 | 1,475
acute quadriplegic myopathy 44 | 1,157
primary pancreatic ductal adenocarcinoma 44 | 1,271
Kidney disease 43 | 396
astrocytic glioma 42 | 2,241
cystic fibrosis 41 | 1,665
group 4 medulloblastoma 41 | 1,875
Takayasu's arteritis 36 | 52
breast carcinoma 36 | 1,614
Congenital adrenal hyperplasia 35 | 74
Liver disease 35 | 219
Retinal vasculitis 35 | 36
adrenocortical carcinoma 34 | 1,427
medulloblastoma 34 | 1,524
posterior fossa group A ependymoma 34 | 1,511
nasopharyngeal carcinoma 33 | 1,056
pituitary cancer 33 | 1,972
Anemia 32 | 252
Human immunodeficiency virus infectious disease 28 | 92
esophageal adenocarcinoma 28 | 737
Hepatitis B 27 | 103
Skin disease 27 | 65
active Crohn's disease 27 | 918
sonic hedgehog group medulloblastoma 27 | 1,482
Down syndrome 26 | 548
Atopic dermatitis 25 | 944
IGA Glomerulonephritis 25 | 454
Mammary Neoplasms 25 | 410
Primary immunodeficiency disease 25 | 52
acute myeloid leukemia 25 | 780
Duchenne muscular dystrophy 24 | 602
Leprosy 24 | 77
gastric carcinoma 24 | 832
spina bifida 24 | 1,064
tuberculosis and treatment for 6 months 24 | 686
Alzheimer's disease 22 | 644
Asthma 22 | 349
Atherosclerosis 22 | 275
Hemochromatosis 22 | 55
Prostatic Neoplasms 22 | 471
HIV Infections 21 | 100
Amyotrophic Lateral Sclerosis 20 | 431
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 499
Endometriosis 19 | 535
Intellectual disability 19 | 573
Vascular disease 19 | 281
hepatocellular carcinoma 19 | 532
posterior fossa group B ependymoma 19 | 1,530

Tissue

Cardiovascular System 389 | 17,958
Digestive Tract 389 | 18,473
Female tissues 389 | 18,647
Liver and Pancreas 389 | 18,136
Male tissues 389 | 17,969
Nervous System 389 | 18,561
Blood and immune system 388 | 17,995
Endocrine System 388 | 18,512
Respiratory system 388 | 17,484
Urinary Tract 388 | 18,444
Skin and soft tissues 378 | 18,115

Target Family

Non-IDG 309 | 11,971
Enzyme 65 | 4,146
Kinase 26 | 634
Epigenetic 18 | 242
Transcription Factor 18 | 1,400
GPCR 7 | 406
Transporter 6 | 473
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

UniProt Keyword

Host-virus interaction 452 | 452
Complete proteome 20,114 | 20,114
Reference proteome 20,114 | 20,114
Polymorphism 12,039 | 12,039
Alternative splicing 10,512 | 10,512
Phosphoprotein 8,194 | 8,194
Membrane 7,179 | 7,179
3D-structure 5,887 | 5,887
Transmembrane 5,214 | 5,214
Transmembrane helix 5,194 | 5,194
Nucleus 5,156 | 5,156
Repeat 4,899 | 4,899
Cytoplasm 4,782 | 4,782
Glycoprotein 4,612 | 4,612
Metal-binding 3,614 | 3,614
Signal 3,487 | 3,487
Disulfide bond 3,472 | 3,472
Acetylation 3,372 | 3,372
Cell membrane 3,182 | 3,182
Direct protein sequencing 2,852 | 2,852
Disease mutation 2,540 | 2,540
Transcription 2,375 | 2,375
Zinc 2,340 | 2,340
Transcription regulation 2,309 | 2,309
Coiled coil 2,142 | 2,142
DNA-binding 1,998 | 1,998
Transport 1,964 | 1,964
Secreted 1,941 | 1,941
Zinc-finger 1,784 | 1,784
Nucleotide-binding 1,769 | 1,769
Ubl conjugation 1,741 | 1,741
Hydrolase 1,640 | 1,640
Transferase 1,592 | 1,592
Receptor 1,496 | 1,496
ATP-binding 1,377 | 1,377
Cytoskeleton 1,130 | 1,130
Mitochondrion 1,115 | 1,115
Isopeptide bond 1,112 | 1,112
Endoplasmic reticulum 1,071 | 1,071
Methylation 962 | 962
Developmental protein 943 | 943
Transducer 886 | 886
Calcium 864 | 864
G-protein coupled receptor 830 | 830
Golgi apparatus 819 | 819
Lipoprotein 813 | 813
Cell projection 718 | 718
Cell junction 672 | 672
Ubl conjugation pathway 669 | 669
RNA-binding 663 | 663
Differentiation 661 | 661
Activator 657 | 657
Cell cycle 637 | 637
Kinase 637 | 637
Ion transport 628 | 628
Protein transport 604 | 604
Sensory transduction 600 | 600
Repressor 589 | 589
Immunity 571 | 571
Oxidoreductase 571 | 571
Immunoglobulin domain 546 | 546
Magnesium 543 | 543
Transit peptide 535 | 535
Protease 531 | 531
Apoptosis 529 | 529
Endosome 488 | 488
Cytoplasmic vesicle 487 | 487
Cell adhesion 482 | 482
Signal-anchor 452 | 452
Olfaction 436 | 436
Lipid metabolism 427 | 427
Serine/threonine-protein kinas... 388 | 388
Cell division 372 | 372
Chromosome 361 | 361
Synapse 356 | 356
Ion channel 349 | 349
DNA damage 347 | 347
GTP-binding 338 | 338
Ligase 332 | 332
mRNA processing 326 | 326
Palmitate 322 | 322
Chromosomal rearrangement 320 | 320
Iron 318 | 318
Leucine-rich repeat 310 | 310
Mental retardation 299 | 299
Cleavage on pair of basic resi... 296 | 296
Neurodegeneration 292 | 292
DNA repair 288 | 288
Chromatin regulator 285 | 285
Ribonucleoprotein 280 | 280
Microtubule 279 | 279
WD repeat 278 | 278
Lysosome 275 | 275
Actin-binding 271 | 271
Mitochondrion inner membrane 268 | 268
Mitosis 262 | 262
ANK repeat 258 | 258
Extracellular matrix 258 | 258
Innate immunity 256 | 256
mRNA splicing 255 | 255

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0
HLA class I histocompatibility antigen, B-38 alpha chain HLA-B Tbio Non-IDG 1568.8 0
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160