Development Level

Tbio 216 | 11,445
Tdark 33 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 11 | 499
abnormal behavior 6 | 298
decreased total body fat amoun... 5 | 207
increased circulating alkaline... 5 | 122
abnormal gait 4 | 69
enlarged heart 4 | 210
increased bone mineral content 4 | 108
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased circulating triglyce... 3 | 79
decreased grip strength 3 | 116
decreased prepulse inhibition 3 | 82
hypoactivity 3 | 132
increased lean body mass 3 | 172
abnormal craniofacial morpholo... 2 | 33
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
abnormal tooth morphology 2 | 24
corneal opacity 2 | 32
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased threshold for audito... 2 | 26
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased bone mineral density 2 | 72
long tibia 2 | 25
prolonged PR interval 2 | 15
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal eyelid morphology 1 | 7
abnormal facial morphology 1 | 17
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal response to new envir... 1 | 10
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tail length 1 | 3
abnormal tail morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
anophthalmia 1 | 33
cleft palate 1 | 8
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased IgG1 level 1 | 8
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating phosphat... 1 | 27
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased startle reflex 1 | 75
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
female infertility 1 | 60
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased caudal vertebrae num... 1 | 7
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased coping response 1 | 4
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
male infertility 1 | 123
narrow eye opening 1 | 12
pallor 1 | 34
polycystic kidney 1 | 15
prenatal lethality 1 | 28
short tibia 1 | 97
shortened QT interval 1 | 4
shortened ST segment 1 | 10
small testis 1 | 58
syndactyly 1 | 23
vertebral fusion 1 | 23

Disease

Carcinoma 113 | 11,493
psoriasis 77 | 6,694
osteosarcoma 71 | 7,950
medulloblastoma, large-cell 69 | 6,241
ovarian cancer 69 | 8,520
glioblastoma 56 | 5,792
atypical teratoid / rhabdoid tumor 47 | 5,112
malignant mesothelioma 45 | 3,232
lung cancer 43 | 4,740
Breast cancer 42 | 3,578
Cancer 37 | 2,499
group 3 medulloblastoma 37 | 4,104
invasive ductal carcinoma 35 | 2,951
adult high grade glioma 34 | 3,801
ependymoma 34 | 4,679
primitive neuroectodermal tumor 33 | 3,035
Astrocytoma, Pilocytic 31 | 3,081
interstitial cystitis 31 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
cystic fibrosis 27 | 1,696
non-small cell lung cancer 27 | 2,890
Autosomal recessive predisposition 26 | 1,442
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
pancreatic cancer 24 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
lung adenocarcinoma 23 | 2,716
Cleft Palate 22 | 271
Craniofacial Abnormalities 22 | 151
breast carcinoma 22 | 1,638
pituitary cancer 22 | 1,972
Intellectual disability 20 | 1,016
ductal carcinoma in situ 20 | 1,745
oligodendroglioma 20 | 2,850
astrocytic glioma 19 | 2,597
cutaneous lupus erythematosus 18 | 1,057
group 4 medulloblastoma 18 | 1,855
Cognitive delay 17 | 608
Global developmental delay 17 | 608
Mental and motor retardation 17 | 608
colon cancer 17 | 1,478
Dull intelligence 16 | 645
Kidney cancer 16 | 2,613
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Poor school performance 16 | 645
Short stature 16 | 531
Holoprosencephaly 15 | 56
Muscle hypotonia 15 | 571
Schizophrenia 15 | 1,160
lung carcinoma 15 | 2,843
spina bifida 15 | 1,074
Microphthalmia 14 | 76
Syndactyly 14 | 88
medulloblastoma 14 | 720
subependymal giant cell astrocytoma 14 | 2,287
Uranostaphyloschisis 13 | 167
diabetes mellitus 13 | 1,728
facioscapulohumeral dystrophy 13 | 288
pediatric high grade glioma 13 | 1,064
ulcerative colitis 13 | 1,819
Autistic Disorder 12 | 364
Cleft Lip 12 | 141
Epilepsy 12 | 792
adrenocortical carcinoma 12 | 1,428
Obesity 11 | 678
Polydactyly 11 | 107
Sensorineural Hearing Loss (disorder) 11 | 284
tuberculosis 11 | 2,010
Bipolar Disorder 10 | 666
Glaucoma 10 | 239
Melanoma 10 | 711
Pituitary hypoplasia 10 | 23
Rheumatoid arthritis 10 | 1,191
Seizures 10 | 596
Septooptic dysplasia 10 | 19
active ulcerative colitis 10 | 764
aldosterone-producing adenoma 10 | 665
primary pancreatic ductal adenocarcinoma 10 | 1,109
Abnormally small eyeball 9 | 97
Cataract 9 | 297
Congenital heart disease 9 | 93
Constipation 9 | 181
Decreased size of eyeball 9 | 97
Infertility 9 | 188
Microphthalmos 9 | 100
posterior fossa group A ependymoma 9 | 468
Acquired metabolic disease 8 | 336
Breast Neoplasms 8 | 445
Broad flat nasal bridge 8 | 236
Diabetes Mellitus, Non-Insulin-Dependent 8 | 145
Diabetes Mellitus, Type 2 8 | 142
Feeding difficulties 8 | 127
Lens Opacities 8 | 231
Nasal bridge wide 8 | 236
Prostatic Neoplasms 8 | 495
Strabismus 8 | 270
nasopharyngeal carcinoma 8 | 1,058
non primary Sjogren syndrome sicca 8 | 891
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962

Tissue

Endocrine System 217 | 18,159
Digestive Tract 186 | 17,369
Skin and soft tissues 182 | 17,230
Female tissues 176 | 17,400
Male tissues 166 | 17,142
Blood and immune system 157 | 16,909
Urinary Tract 153 | 16,678
Nervous System 149 | 16,725
Liver and Pancreas 148 | 16,750
Respiratory system 130 | 16,393
Cardiovascular System 96 | 15,192

Target Family

Transcription Factor 230 | 1,400
Non-IDG 19 | 12,091

UniProt Keyword

Homeobox 249 | 249
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein notochord NOTO Tdark Transcription Factor -2.36366 209.2 26
Pre-B-cell leukemia transcription factor 3 PBX3 Tbio Transcription Factor -1.58292 36.0 183
Pre-B-cell leukemia transcription factor 2 PBX2 Tbio Transcription Factor -1.90701 75.7 168
Double homeobox protein 5 DUX1 Tdark Non-IDG 0.00000 0
Putative double homeobox protein 3 DUX3 Tdark Non-IDG 0.00000 0
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Homeobox protein SIX4 SIX4 Tbio Transcription Factor -2.31722 197.8 141
Homeobox protein Meis3 MEIS3 Tbio Transcription Factor -0.89952 8.38 256
Rhox homeobox family member 2 RHOXF2 Tbio Transcription Factor -0.72564 6.50 128
Retinal homeobox protein Rx RAX Tbio Transcription Factor -0.52554 4.68 205