Development Level

Tbio 44 | 11,445
Tchem 9 | 1,598
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
decreased startle reflex 3 | 75
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
preweaning lethality, complete... 3 | 979
abnormal behavior 2 | 298
abnormal sleep behavior 2 | 70
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased mean corpuscular vol... 2 | 79
decreased respiratory quotient 2 | 16
decreased vertical activity 2 | 208
impaired glucose tolerance 2 | 75
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
limb grasping 2 | 41
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal spine curvature 1 | 9
abnormal spleen morphology 1 | 55
absent adrenal gland 1 | 2
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
cyanosis 1 | 7
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased cardiac stroke volum... 1 | 6
decreased circulating HDL chol... 1 | 68
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased coping response 1 | 4
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Neurodegenerative disease 57 | 414
hereditary spastic paraplegia 57 | 318
Carcinoma 38 | 11,493
Paraplegia 38 | 74
ovarian cancer 33 | 8,520
Spastic Paraplegia 32 | 42
Autosomal recessive predisposition 30 | 1,442
Babinski Reflex 30 | 100
glioblastoma 30 | 5,792
osteosarcoma 30 | 7,950
Hyperreflexia 29 | 209
atypical teratoid / rhabdoid tumor 25 | 5,112
ependymoma 25 | 4,679
medulloblastoma, large-cell 23 | 6,241
adult high grade glioma 20 | 3,801
Intellectual disability 19 | 1,016
Monoparesis - leg 19 | 27
Spastic gait 19 | 23
Weakness of lower limb 19 | 27
oligodendroglioma 19 | 2,850
Progressive disorder 17 | 142
group 3 medulloblastoma 17 | 4,104
Astrocytoma, Pilocytic 16 | 3,081
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
psoriasis 16 | 6,694
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Neuropathy 14 | 261
Congenital pes cavus 13 | 88
lung cancer 13 | 4,740
Optic Atrophy 12 | 242
Small head 12 | 374
subependymal giant cell astrocytoma 12 | 2,287
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
astrocytic glioma 11 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
primitive neuroectodermal tumor 11 | 3,035
Dysarthria 10 | 192
Epilepsy 10 | 792
Kidney cancer 10 | 2,613
Muscle hypotonia 10 | 571
Nystagmus 10 | 317
Short stature 10 | 531
Urinary Incontinence 10 | 50
Atrophy of cerebellum 9 | 103
Cerebellar degeneration 9 | 103
Cerebral atrophy 9 | 178
Decreased lower limb vibratory sense 9 | 13
Infratentorial atrophy 9 | 103
Seizures 9 | 596
Slow progression 9 | 89
Sphincter disturbances 9 | 16
astrocytoma 9 | 1,146
lung carcinoma 9 | 2,843
pediatric high grade glioma 9 | 1,064
Lower limb spasticity 8 | 10
Overactive bladder syndrome 8 | 14
Pick disease 8 | 1,894
Urgency frequency syndrome 8 | 14
Urgency of micturition 8 | 14
group 4 medulloblastoma 8 | 1,855
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
Axonal neuropathy 7 | 27
Breast cancer 7 | 3,578
Dilated ventricles (finding) 7 | 121
Gait abnormality 7 | 135
Hypoplasia of corpus callosum 7 | 90
interstitial cystitis 7 | 2,312
Acquired scoliosis 6 | 281
Cerebellar Ataxia 6 | 304
Cerebellar Dysmetria 6 | 56
Cerebral palsy 6 | 40
Curvature of spine 6 | 282
Neurogenic Muscular Atrophy 6 | 139
Neurogenic muscle atrophy, especially in the lower limbs 6 | 139
Severe mental retardation (I.Q. 20-34) 6 | 99
Skeletal muscle atrophy 6 | 139
Strabismus 6 | 270
diabetes mellitus 6 | 1,728
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
muscle degeneration 6 | 139
Cancer 5 | 2,499
Congenital clubfoot 5 | 109
Contracture 5 | 96
Contracture of joint 5 | 93
Dystonia 5 | 164
Flexion contracture 5 | 93
Flexion contractures of joints 5 | 93
colon cancer 5 | 1,478
tuberculosis 5 | 2,010
ulcerative colitis 5 | 1,819

Tissue

Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Respiratory system 57 | 16,393
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 20 | 4,145
Transporter 2 | 473
Kinase 1 | 634
Transcription Factor 1 | 1,400

UniProt Keyword

Hereditary spastic paraplegia 57 | 57
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
AMP deaminase 2 AMPD2 Tchem Enzyme -1.74341 53.6 155
WASH complex subunit 5 WASHC5 Tbio Non-IDG -1.43182 26.4 38
Kinesin heavy chain isoform 5A KIF5A Tbio Non-IDG -1.69131 48.4 170
Kinesin-like protein KIF1A KIF1A Tbio Non-IDG -2.11552 130.9 37
Magnesium transporter NIPA1 NIPA1 Tbio Non-IDG -1.41490 24.2 20
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.87174 68.8 171
Cytosolic purine 5'-nucleotidase NT5C2 Tbio Enzyme -2.24348 166.8 144