Development Level

Tbio 68 | 11,445
Tchem 35 | 1,598
Tclin 14 | 613
Tdark 10 | 6,588

IMPC Phenotype

enlarged heart 7 | 210
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
cataract 5 | 92
decreased total body fat amoun... 5 | 207
preweaning lethality, incomple... 5 | 499
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
decreased bone mineral content 4 | 151
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased circulating serum al... 3 | 82
decreased vertical activity 3 | 208
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
abnormal cranium morphology 2 | 36
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal iris morphology 2 | 13
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
decreased heart weight 2 | 27
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating amylase ... 2 | 25
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
small kidney 2 | 16
abnormal femur morphology 1 | 14
abnormal head size 1 | 6
abnormal joint morphology 1 | 23
abnormal locomotor activation 1 | 16
abnormal pelvic girdle bone mo... 1 | 12
abnormal pupil morphology 1 | 2
abnormal radius morphology 1 | 8
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal rib morphology 1 | 10
abnormal sensory capabilities-... 1 | 8
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased monocyte cell number 1 | 8
decreased red blood cell distr... 1 | 41
edema 1 | 59
embryonic lethality prior to t... 1 | 278
hydrometra 1 | 53
impaired righting response 1 | 26
increased B cell number 1 | 9
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating thyroxin... 1 | 7
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
small heart 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 83 | 11,493
psoriasis 62 | 6,694
osteosarcoma 47 | 7,950
ovarian cancer 45 | 8,520
Cancer 39 | 2,499
glioblastoma 36 | 5,792
lung cancer 35 | 4,740
ependymoma 34 | 4,679
medulloblastoma, large-cell 32 | 6,241
lung carcinoma 30 | 2,843
interstitial cystitis 29 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
adult high grade glioma 27 | 3,801
atypical teratoid / rhabdoid tumor 27 | 5,112
group 3 medulloblastoma 27 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
non-small cell lung cancer 26 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Autosomal recessive predisposition 24 | 1,442
diabetes mellitus 24 | 1,728
invasive ductal carcinoma 24 | 2,951
lung adenocarcinoma 24 | 2,716
Hypertension 23 | 396
oligodendroglioma 23 | 2,850
pancreatic cancer 23 | 2,398
tuberculosis 23 | 2,010
Breast cancer 22 | 3,578
Astrocytoma, Pilocytic 21 | 3,081
Prostatic Neoplasms 21 | 495
malignant mesothelioma 20 | 3,232
astrocytic glioma 19 | 2,597
ductal carcinoma in situ 19 | 1,745
primitive neuroectodermal tumor 19 | 3,035
ulcerative colitis 19 | 1,819
breast carcinoma 18 | 1,638
cystic fibrosis 18 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Kidney disease 17 | 430
adrenocortical carcinoma 17 | 1,428
pituitary cancer 17 | 1,972
Hypertensive disease 15 | 292
Schizophrenia 15 | 1,160
Anemia 14 | 365
Breast Neoplasms 14 | 445
Depressive disorder 14 | 409
Liver Cirrhosis, Experimental 14 | 769
Mammary Neoplasms 14 | 425
Obesity 14 | 678
Liver disease 13 | 237
Malaria 13 | 160
cutaneous lupus erythematosus 13 | 1,057
Atherosclerosis 12 | 291
Chemical and Drug Induced Liver Injury 12 | 195
Heart failure 12 | 162
Hepatomegaly 12 | 285
subependymal giant cell astrocytoma 12 | 2,287
Atopic dermatitis 11 | 952
Kidney cancer 11 | 2,613
Pick disease 11 | 1,894
Cerebrovascular disease 10 | 238
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Heart disease 10 | 306
Melanoma 10 | 711
Seizures 10 | 596
Short stature 10 | 531
aldosterone-producing adenoma 10 | 665
gastric carcinoma 10 | 807
group 4 medulloblastoma 10 | 1,855
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alzheimer's disease 9 | 658
Brain Ischemia 9 | 110
Coronary artery disease 9 | 268
Diabetes Mellitus, Experimental 9 | 108
Endometriosis 9 | 540
Lung Neoplasms 9 | 232
Osteoporosis 9 | 363
Splenomegaly 9 | 190
Thalassemia 9 | 53
Vascular disease 9 | 319
active Crohn's disease 9 | 922
chronic rhinosinusitis 9 | 512
Abnormality of metabolism/homeostasis 8 | 134
Acute kidney injury 8 | 70
Asthma 8 | 385
Cholestasis 8 | 155
Diabetes Mellitus, Type 2 8 | 142
Dull intelligence 8 | 645
Epilepsy 8 | 792
Intellectual disability 8 | 1,016
Low intelligence 8 | 645
Mental Depression 8 | 333
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Reperfusion Injury 8 | 86
Rheumatoid arthritis 8 | 1,191
astrocytoma 8 | 1,146
pediatric high grade glioma 8 | 1,064
periodontitis 8 | 293
spina bifida 8 | 1,074

Tissue

Endocrine System 120 | 18,159
Female tissues 118 | 17,400
Digestive Tract 116 | 17,369
Liver and Pancreas 116 | 16,750
Skin and soft tissues 114 | 17,230
Male tissues 112 | 17,142
Blood and immune system 111 | 16,909
Respiratory system 108 | 16,393
Urinary Tract 108 | 16,678
Nervous System 104 | 16,725
Cardiovascular System 82 | 15,192

Target Family

Non-IDG 62 | 12,091
Enzyme 60 | 4,145
Nuclear Receptor 2 | 48
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

UniProt Keyword

Heme 127 | 127
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cholesterol 24-hydroxylase CYP46A1 Tbio Enzyme -1.84856 68.6 197
Peroxidasin-like protein PXDNL Tbio Non-IDG -1.10753 14.4 0
Hemoglobin subunit delta HBD Tbio Non-IDG -2.72143 515.2 30
Cytochrome P450 26A1 CYP26A1 Tchem Enzyme -2.44772 290.1 197
Putative fatty acid desaturase 2-like protein FADS2P1 FADS2P1 Tdark Enzyme 0.00000 0
Cytochrome P450 4Z1 CYP4Z1 Tbio Non-IDG -0.68998 9.87 74
Metalloreductase STEAP1 STEAP1 Tbio Enzyme -1.65454 46.2 322
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC Tbio Enzyme -2.73791 419.9 129
Phylloquinone omega-hydroxylase CYP4F11 CYP4F11 Tbio Enzyme -0.71213 6.60 96
Cystathionine beta-synthase-like protein CBS Tbio Non-IDG -3.25635 3246.1 0