Development Level

Tbio 120 | 11,445
Tdark 17 | 6,588
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 23 | 979
embryonic lethality prior to o... 13 | 239
embryonic lethality prior to t... 11 | 278
abnormal embryo size 6 | 220
decreased body weight 4 | 161
decreased lean body mass 4 | 135
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
embryonic growth retardation 3 | 106
increased total body fat amoun... 3 | 134
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
enlarged heart 2 | 210
hypoactivity 2 | 132
increased body temperature 2 | 9
increased circulating alkaline... 2 | 122
increased grip strength 2 | 41
prenatal lethality 2 | 28
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal maxilla morphology 1 | 17
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent spleen 1 | 3
anophthalmia 1 | 33
decreased IgG1 level 1 | 8
decreased NK cell number 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased lumbar vertebrae num... 1 | 2
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
hyperactivity 1 | 148
increased aggression 1 | 4
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating potassiu... 1 | 29
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased neutrophil cell numb... 1 | 46
increased urine magnesium leve... 1 | 2
long tibia 1 | 25
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 125 | 11,493
ovarian cancer 83 | 8,520
osteosarcoma 67 | 7,950
medulloblastoma, large-cell 61 | 6,241
psoriasis 58 | 6,694
Kidney cancer 50 | 2,613
glioblastoma 50 | 5,792
group 3 medulloblastoma 50 | 4,104
lung cancer 48 | 4,740
atypical teratoid / rhabdoid tumor 43 | 5,112
primitive neuroectodermal tumor 38 | 3,035
malignant mesothelioma 35 | 3,232
Breast cancer 34 | 3,578
Cancer 30 | 2,499
ependymoma 29 | 4,679
adult high grade glioma 25 | 3,801
oligodendroglioma 23 | 2,850
lung adenocarcinoma 21 | 2,716
Intellectual disability 20 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
non-small cell lung cancer 20 | 2,890
Multiple myeloma 19 | 1,332
diabetes mellitus 19 | 1,728
colon cancer 18 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Waldenstrons macroglobulinemia 17 | 765
astrocytic glioma 17 | 2,597
dermatomyositis 17 | 966
Autosomal recessive predisposition 16 | 1,442
juvenile dermatomyositis 16 | 1,187
Astrocytoma, Pilocytic 15 | 3,081
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Poor school performance 15 | 645
adrenocortical carcinoma 15 | 1,428
invasive ductal carcinoma 15 | 2,951
Cockayne syndrome 14 | 60
Fetal Growth Retardation 13 | 189
Infant, Small for Gestational Age 13 | 176
Intrauterine retardation 13 | 176
Liver cancer 13 | 604
Rheumatoid arthritis 13 | 1,191
Short stature 13 | 531
nasopharyngeal carcinoma 13 | 1,058
Pick disease 12 | 1,894
acute quadriplegic myopathy 12 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
pancreatic cancer 12 | 2,398
pediatric high grade glioma 12 | 1,064
Small head 11 | 374
astrocytoma 11 | 1,146
Cognitive delay 10 | 608
Fanconi anemia 10 | 56
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
group 4 medulloblastoma 10 | 1,855
Baller-Gerold syndrome 9 | 12
Cryptorchidism 9 | 296
Rothmund-Thomson syndrome 9 | 19
medulloblastoma 9 | 720
primary Sjogren syndrome 9 | 735
progressive supranuclear palsy 9 | 676
tuberculosis 9 | 2,010
Failure to gain weight 8 | 365
Hypogonadism 8 | 173
Pediatric failure to thrive 8 | 365
Photosensitive trichothiodystrophy 8 | 30
acute myeloid leukemia 8 | 783
cystic fibrosis 8 | 1,696
lung carcinoma 8 | 2,843
non primary Sjogren syndrome sicca 8 | 891
subependymal giant cell astrocytoma 8 | 2,287
Bloom syndrome 7 | 29
Endometriosis 7 | 540
Epilepsy 7 | 792
Melanoma 7 | 711
Microcephaly 7 | 166
Muscle hypotonia 7 | 571
Optic Atrophy 7 | 242
Warsaw breakage syndrome 7 | 11
Werner syndrome 7 | 29
breast carcinoma 7 | 1,638
hearing impairment 7 | 199
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Broad flat nasal bridge 6 | 236
Cataract 6 | 297
Cerebellar Ataxia 6 | 304
Endometrial cancer 6 | 311
Hypoplastic mandible condyle 6 | 275
Lens Opacities 6 | 231
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Nasal bridge wide 6 | 236
Seizures 6 | 596
Strabismus 6 | 270
ductal carcinoma in situ 6 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962

Tissue

Endocrine System 139 | 18,159
Blood and immune system 138 | 16,909
Digestive Tract 138 | 17,369
Female tissues 138 | 17,400
Liver and Pancreas 137 | 16,750
Male tissues 137 | 17,142
Nervous System 137 | 16,725
Skin and soft tissues 137 | 17,230
Urinary Tract 137 | 16,678
Respiratory system 136 | 16,393
Cardiovascular System 134 | 15,192

Target Family

Enzyme 92 | 4,145
Non-IDG 36 | 12,091
Epigenetic 14 | 242

UniProt Keyword

Helicase 142 | 142
Complete proteome 20,231 | 20,231
Reference proteome 20,231 | 20,231
Polymorphism 12,194 | 12,194
Alternative splicing 10,528 | 10,528
Phosphoprotein 8,216 | 8,216
Membrane 7,361 | 7,361
3D-structure 6,226 | 6,226
Nucleus 5,259 | 5,259
Transmembrane 5,228 | 5,228
Transmembrane helix 5,207 | 5,207
Cytoplasm 4,952 | 4,952
Repeat 4,916 | 4,916
Glycoprotein 4,623 | 4,623
Metal-binding 3,672 | 3,672
Disulfide bond 3,599 | 3,599
Signal 3,561 | 3,561
Acetylation 3,409 | 3,409
Cell membrane 3,390 | 3,390
Direct protein sequencing 2,872 | 2,872
Disease mutation 2,804 | 2,804
Ubl conjugation 2,439 | 2,439
Transcription 2,402 | 2,402
Zinc 2,356 | 2,356
Transcription regulation 2,336 | 2,336
Coiled coil 2,153 | 2,153
Secreted 2,041 | 2,041
DNA-binding 2,008 | 2,008
Transport 1,985 | 1,985
Zinc-finger 1,785 | 1,785
Transferase 1,782 | 1,782
Nucleotide-binding 1,775 | 1,775
Isopeptide bond 1,739 | 1,739
Hydrolase 1,654 | 1,654
Receptor 1,502 | 1,502
ATP-binding 1,380 | 1,380
Cytoskeleton 1,182 | 1,182
Mitochondrion 1,147 | 1,147
Endoplasmic reticulum 1,119 | 1,119
Methylation 973 | 973
Developmental protein 965 | 965
Transducer 887 | 887
Calcium 875 | 875
Golgi apparatus 838 | 838
G-protein coupled receptor 830 | 830
Cell projection 826 | 826
Lipoprotein 825 | 825
Immunity 717 | 717
Cell junction 709 | 709
Differentiation 703 | 703
Ubl conjugation pathway 684 | 684
RNA-binding 682 | 682
Activator 672 | 672
Cell cycle 647 | 647
Kinase 637 | 637
Ion transport 631 | 631
Immunoglobulin domain 625 | 625
Protein transport 612 | 612
Repressor 602 | 602
Sensory transduction 600 | 600
Oxidoreductase 571 | 571
Magnesium 558 | 558
Transit peptide 544 | 544
Cytoplasmic vesicle 535 | 535
Protease 535 | 535
Apoptosis 533 | 533
Endosome 525 | 525
Cell adhesion 482 | 482
Host-virus interaction 472 | 472
Signal-anchor 458 | 458
Olfaction 435 | 435
Lipid metabolism 432 | 432
Chromosome 388 | 388
Serine-threonine-protein kinas... 388 | 388
Cell division 383 | 383
Synapse 378 | 378
DNA damage 366 | 366
Mental retardation 362 | 362
Ion channel 348 | 348
mRNA processing 340 | 340
GTP-binding 339 | 339
Palmitate 331 | 331
Chromosomal rearrangement 324 | 324
Iron 319 | 319
Neurodegeneration 318 | 318
Leucine-rich repeat 312 | 312
DNA repair 306 | 306
Lysosome 301 | 301
Cleavage on pair of basic resi... 298 | 298
Innate immunity 291 | 291
Chromatin regulator 290 | 290
Ribonucleoprotein 286 | 286
Microtubule 281 | 281
Adaptive immunity 280 | 280
WD repeat 277 | 277
Mitochondrion inner membrane 276 | 276
Mitosis 273 | 273
Actin-binding 272 | 272
mRNA splicing 264 | 264
Neurogenesis 260 | 260
ANK repeat 258 | 258

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
E3 ubiquitin-protein ligase SHPRH SHPRH Tbio Epigenetic -0.99196 10.7 137
DNA repair and recombination protein RAD54B RAD54B Tbio Non-IDG -1.41173 28.9 153
ATP-dependent RNA helicase DDX42 DDX42 Tbio Enzyme -1.10894 13.3 60
DNA annealing helicase and endonuclease ZRANB3 ZRANB3 Tbio Enzyme -2.18014 154.3 36
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
Putative helicase MOV-10 MOV10 Tbio Enzyme -1.55297 38.5 121
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
ATP-dependent RNA helicase DDX18 DDX18 Tbio Enzyme -0.74619 5.48 53